WOOD" GOOL11490 23 A Samery, 1"I Dre Lan visited 16& Do Motablidweat m jazatu7 U049th. Re is & lecturor, teaddag donietry t0 PAdIftl DWASRUS at MIS 01801011 Ustitute of the UrAywrolly of MAW# Dwmrk* ISO has bow MAIM fw the past rw yoare on pr6blow connected with %h* searesitlen of tOUSSO, sucks, and Me publisbed wwwral repars dealing with Unperst,06 d=ine the combustion of cigarettes, cigars *M pipwp wA Vith *a deterrination of the amount of benspyrwo aW ather aromtie pGay4YO210 hye"carbons formed &wW *.a pyro2yals at diftwent toVerstum of allpbiLtic hydroaarbons, isolated from cigarette wtabs# or of a o4od' spft*Uo aliphatic kqdroca:ftn# dlowtyl. More reeentlys be has tooew Interested In two otbor aspects (a) the products of the forMw Pyrolysis of aromatic polyaplie 19droewbons (b) the pyrdlytle products of the pbytewterelso He feels that the possible ro-cambustion of condensed aromtIs b1 ftoaarbons Is a greater souros of danger than Is benspyrene ItsWo Be dains to have Iodated onall mounts of pb7tostwolo fron Waco:* (I soda), In the leaf of wMah thW we kwm to oesur. Theft stelvi substances aft hydroaromatic ;z.~.Asp closely related to "esterols Vitamin D wA the bile acids. Re van questioned as to uhsther be wuspeateOp or W famdo rothrldholanthrens In MA prodwfto* (This to a Aron" carcinegmto polywelia lqdroeu-bon OhIch am be dwivwd by pyrol4sls of cz~p BATCO document for Province of British Columbia 2 November 1999 - 2 - certain bile rte!ds, ooge cholle acid.). Dre 14&,4 aftitted that vlh-1.26 the tho-j&t had occurred to hlnp he b-td been un&Uo to detect the promenee of this outstance* He was shown all the equipmmt used by the Smoke Oroups Mrors the autott-naker to the romrdiqg zierophetometer PM the various techniques ftployo4 were diem-seed at longth. The dprEers were orphasised of using only much techniques as ultra-violet opectropbotw?etry for tto Identification md estimtion ef rdero-quRntitioup of Pmtertnlo In tobace-3 e!"ke and to with VAR. The R,-rllmtlcms to whieh Via, rethods Md been r-it vare Wlained, --o.g. "fronW tur! nbfte.W of ellmrotter, atteqqpted 4mtslyriep ate., ond Dre Lwi appc-trM to 1-o D-premped with the v,,rk arr! the reaults to date, go rarpntad is enislyst MUM lcmrer they btirnirg terTeystiwo -or a ei Motto ard van interertt-1 te) learn that so fnr ire ~#td rot been able to sable" V118 remit. He luris newr, in fact, worked wit', tobareo bit hfto eonflned him atterition to r7rolysts, in a tub* furraeo at varlo-je ter--eT-at,xrcw, 1-f the ludr-,hrbons he bas extracted ftin stubs. His roeftrf-hen to date have boen entirOy uraided PA be 19 seohi"g a Zrnrt to c"-pr the majOrY of a girl technician an aesistart. It was roUted out to hir that his conditions of formtIon of bonzMenm etc. vero high],y artificia2 aM h,%rMj roe-ambled thirse in a eiMrettoe Ile to-,u,.A that ti-io ILwmt of benspyrime forned fell off shaTly with earreare in ryrolyris t"orature. The incoralaterey of this obses. tion with the reciarOod grrater am=t of BATCo document for Province of British Columbia 2 November 1999 - 3 - benspyrone rer gm of tobacco eorbusted In Vie ftoo of pipe Onake (forned at a relatively lover tv-rerature) was disetweed vithaft vT fim conaluttlon bobig reached. Pis veparatton of arcmtie polyryelie WrocRrbotia was In agreement with the ennller findirgs by Dro Hurhas and his te~rerpLttjre reftinamotits -tweed with thomof Mr. Crorahav. fie had not earTled the on-t2yuls of ne"marmerts to the en" Oegre* ar ifnov ftne at IRA D.9 nor hoO he -Mor "One % K" r _Oerr -el thn effect of ronAuetion itlerg th!~rnoemtpln I .. A ot boon vo mirb interorte4 In nbrnlitta y0iiqrs ots in f1mOing rm,!!My evrr,rnble cm0ittmiln f'rr h1m 1,.TroYyr-in er-r.-rimentr. Dr. Y-~m t-.-rrrrrt,!1 1.r%t-!rvst In t1- v-rk rf !AM"n Ftrd Ceoprr "rd )in-,M V) rr-i tl!-n r-n his rel.?,.rn to Y!, ime tsien nnititt to rptrin to 11--v Ntt-4!M-1. Tlr? q!ifrt1--n of in tol-neas a-ni-n irnw dircunp!r-1 ar-1 be ime inforri-I nf tbe a'.Yoffernont ulAch Dr. Vrrtlt.7 artl the writer MA formrd nf t-14,7 v-rk of Nyrneb rind I.Teul,.". at Laurrinn-v. Y!e nFreeA that on the flinry evIA-mes whirli tllf'y f'.7tMA, he vnuld melt 1-9 prer-ared to accipt the Memnes n-V 01.9 ri!-i.Rtftncq In V"kae Ps raired the queatten of the work of' PnPA art-1 film afinoelfttes, Welt led to a r1locuesion of the metbe-On useA to prorlum 1,,?prr Ot-Ire" and tho eatl"-tivn therein of ben2ryrers 1'.Yy 1vth thece &M thi French vmkrrs. The ralatiounhip boWeen the mrimis Eroul,s of French urri-ro (Cust", Vuu~41clp 1.^.t-2rj-nt, Royer) was errlainod. Fe vas urr,~ttf to raise 016 roirt with tby-.m, rince tile rnrpr to ocrib-,Pterl in a Metly rrtifiet-ml rrvint!r. Dr. Ln-i reened to ti,ink th,%t at,-!orv1,-r19 pollixtf.,m p1s;v R 'big BATCo document for Province of British Columbia 2 November 1999 - j# - part In the cancer preMsep and apperently boo boom U71ng to Intered 01 ammon Into doing a sUtIstleal study at the -M meow sweetion for GM=Affs Ube pass thrVU6 on undoweand VALbMY suttee (in topedhRMI), go mooed partleaUrly 1"ressed by the vark of M+Ax and FoU In Lee Anpl"# vh= he visited during b1s stoy In Canada mid the 14-9*9# Tbey have studied the formation, composition and biological effects or *MR. engine SAMMtst Sue Its had hoped to glean Information cc IwrWI9 vork at ToroatN and of a0mrs vhom he visited In the V.S.p e.g. Tennessee ftstawi* at Ktqmpwtv Teenn.j. Vynder at Neu York. Lam was very reticent an these sapectel he slained vM little )mnwIwIga of Vhat Writ-hb via doing beforep during or after his aW* Re fild remark that he thought Wright's method or atterptbne, to separate 1".1ce eatoemate tw Means of Pieria $Laid precipitations vR,,i rather foalish. ir-mentioned tbftt Wright had two, Indifflo Vorking for him anfi that he felt their vnrk to be unrellable. v9 formed the itTreavic% poesibly orronemsp that hie stay :in Mood& W not been altogether hqW* On the vhole, Ian Impreened us so a sincere an,4 honest vorl-,mr, vho 15 a reasonably Sao chwist with considomile experienes in t1le fractionation of the aromatic VaIML-Uc hydr*mrbons by cbrautoL-nrbra, BATCO document for Province of British Columbia 2 November 1999 ~ft 5 - Kin further vork waidd appear to to alcog the Uses uwd4med above. Be eartaUdy meme to be vwtlW of amis flunclal mWert and waomagenwAs ftwe he has not been Was In gem%ll to devote bb wbole t1w to research# the *xtM% of his work to date in very pralawdew. The hdp wideh a --gwd assistant audd give his would be emsiderables Althav* his work ~-;Js odr "mefted with cdWettes remotely (at one rvom# so to speak), nova seep he Is =q1wIM patbusys wbich we relatively =t"Mans but which amdd have a bearUg on the proUnne DI,T/VC/46D 0 ~ BATCo document for Province of British Columbia 2 November 1999