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by details of the visit to Bor Harbor. Dr. Hockett
mentioned someone
at Bar Harbor who was studying the implantation of
lung tissue into mice
and enquired how this was proceeding.
UnfortunatAly, this was work
about which the T.I.I.S.C. party hmd not been told
at Bar Harbor.
Felton and Reid then gave an account of Book's
present vork
at Buffalo, mentioning the criticisms which Bock
had made of Vlynder in
reg,ird to the experiments on tobacco wexas and
extracted tobacco.
Dr. Rodgman volunteered the extre information that
Wynder had found the
smoke from e.-tracted tobacco possessed only 10%
the activity of ordinary
smoke when judeed by the sebaceous gland
suppression test; however,
this result was not confirmed by skin painting
testog which indicated
a level of ectivity only 30.`7 loss than that of
ordinary smoke.
The discussion turned on ways and means of
biological testing
of smoke and smoke frnctions and discreet efforts
were made to enquire
what biolorical work various member companies were
doing, if at an -
but without success. Dr. Harmer volunteered the
information that
nsomo yeers PL-o", knerican Tobacco Co. had
undertaken some biological
testingg with indeterminate results,
It then was apparent that the T.I.R.C. were toying
with the
idea of engnging Biological Research Laboratories
Inc. (Dr. Freddie
Homburger, Boston, 1'.ass.) to conduct some
quantitative testing of smoke
condensetes. Dr. Homburger was described as "no
shrinking violet" when
it came to a question of askirg for money or
charging for work. An effort
wqa made t) get an independent assessment of
Domburger, at this point.
It was opined that he was financed in his now
venture by his private
c:::)
C::)
C
BATCo document for Province of BritiSh Columbia 2
November 1999


- 3 -
incoma, but thnb lie was always ready to increase
this. The judpent
wrs given that lie One probably a competent, but
not an orig'"l, worker*
Ile has developed an alternative technique to akin
painting; he introduces
a small air-bubble beneath the skin, into which he
introduces the
substance to be tested, thereby avoiding
contamination or oxidation.
In the subsequent general discussion, Dr. Hockett
played the
ripjar role, and, to the writer at least, seemed
to be more concerned with
explnining swry fneta thnn in discussing the
meaning azzi implications
of biolo.-icnl results. Ile mentioned that a
certain strnin of rats
produce cencers if their diet is deficient in
ni"cin (nicotinnmide).
Ile, therefore, postuInted a procars in mon in
wbich nicotine Elegradption
pr--,ducts in cigr-ratte smoke may ploy a role no
antagonists for niacin.
fThero in ro evidence, howevers that lung cmneer
is a manifestation
of niscin deficiency in ma--7-
In further discussion of Wynder's studies on smoke
fractions,
RodGman ststed Vint the highly active fraction of
smoke, which Wynder
hnd mentioned in hie papersp had now been lost. An
attempt had been
made, by an Indian post-doctorate worker with
Wrif;ht in Toronto, to
aepnrate this fraction by further chromatography
on alumina columns with
the result that the fraction had been lost.
Although Wepan was not
clear about how it had been lost, the impression
was goined that it
was by adventitious oxidation or decomponition on
the column, rather
than by accidental spillaeo. Tlila is then rather
reminiscent of Bock's
experience in purification of mooko. Rodgaan added
that Wright was
unwilling to ropnrt his mannoth prepnrntion and
purification.
BATCo document for Province of BritiSh Columbia 2
November 1999


-4 -
After the meeting, Reid and.the vriter vere
approached hr
Du Fuis who enquired whether, if the party made a
recommendation that an
scientific gvounds biolooical testing of amoke was
desirable,, it vas
possible that, the T.H.B.C. might make a grant to
the T.I.R.G. for them to
put the project out on a contract basis. lie
offered to approach
Dr. Hockett and Rr. Hoyt there and then to sound
them out concerning
the 131cely responso the T.I.R.C. would make to
ouch a request. This
auGgostion ims,however, ouccessfully stayed off.
During the meeting, the Technical, Sub-Committee
were told,
that both nt Duffnlo nnd Bar firrbor, the party
had been told that the
American tobacco firms did not spem intercated in
the health question and
had not paid nny visits to resenrch, centrea
engnged on this work. The
impression had been gnined that a few, discreet
visits would be welcomed
as evidence of a serious opprosch by the Industry.
The implications of
the Anti-Trust Laws were explained once more, but
Dr. Ramer added that
me,rbe the Industry had fallen over backwards In
the past and that perhaps
the time was nearing when a more positive attitude
could be adopted.
Dr. 11ockett added that he kept In close touch
with what was in progress
at the various research centres.
The overall impression which the meeting produced
on me was that
the representatives of the various conpvnies
mere1jr attended for what they
could learr, rather then to moke any positive
contribution to an Industry-
wide problem. It was difficult to picture the
course of a regular
meeting with no member prepared to contribute
arlthing concrete to the C=>
discussion.
03
BATCo document for Province of British Columbia 2
November 1999