MEETITIG WITH THE TECIM1CLL SUB-C01VITTEE OF TIM
7.I.ft.C. AT P'FCIU4011D
14 n,r 5th. 1958.
Presents Chairmani Dr. Harmer (Amerionn Tobecoo
Co.)
Dr. O'Keefe (Philip Morris)
Dr. Du ruis ( v 11 )
Dr. Rodgman (Reynolds Tobacco Co.)
fir. Stephano (Staphano Bros.)
(Larus and Bros.)
(United States Tobacco Co.)
Dr. 11ockett (T.L.R.C.)
fir. Hoyt ( a
Vr. Coulson (I.T. Co. Richmond, Va.)
Dr. Bontley (T.H.S.C. - I.T. Co.)
Dr. Felton - B-A.T. )
Mr. Raid - Carrerns)
Dr. Tuckor (Brown & Uillinmeon Tobneco Corp.) wrs
absent, as
wns the representmtive from P. Lorillard & Co.
The meetine wao opened by Dr. 11nnmer who
explained that he
had called it in order to meet the pnrty from the
T.M.S.C., to learn
what new irSormation had been Clenned end what the
present feeling of
the party was in reeard to animal testirg of
cigarette smoke fractions.
It would also afford on opportunity for a general
interchnnee of opinions
on the Ceneral question of 11oalth.
In the event, it became o rpthcr one-sided nffair
and some
members of the Technical Sub4ommittee of the
T.I.R.C. said nothing
throughout the whole meeting.
The rensons behind the visits to centres of
rescerch an
biologiael testing wero rouChly sketched out end
then Dr. Bentley gave
an account of his visit to Professor Green (Yale
University)p followed
co
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. Oor
by details or the vinit to qar Harbor. Dre Hackett
mentir)ned someone
at Bar Harbor who was studying the implantation of
lung tissue into mice
nnd ercrairocl ]low thin was proceeding.
Unfortunntely, thio vne vork
nbout which the. T.11.1.C. perty had not boon told
nt Bar 11,3rbor.
rolton sny-l Raid then gave rn account or Buckle
precent Vork
nt Nj'fnlo, mentioning the criticiams which. Dock
lied mnde of Wynder in
reg!2-ml to the e:,-porimanUi on tobricc,) wrixes
nnd extrnoted. tob-%cas
Dr. llodUnnn volunbeared Win ertro infoxv.-.Uon
thaL Vyrder had found the
smokc from cxtrnet0d tobeaco ponreFsed orly 10"',
tho activity of ordinnry
m-ndize Olen jurlt,,ed 1~y tile cebrc,3o-ir gland
cul-presai.on test; homyer,
this result rir: r-A confir-mcd b.: -!.-.In
p-litting, terLa, Wilch bidicated
a 10-1 of netivit-Y only 30,', Ic,,-:: thin Unt of
orlirnry --noke.
Tho diuctission turned on wt-y,-, rY,El inf~rnv of
biblogicn-1 testing
of smoke nrd srlok- rrvctlova Prd dircreet
affort3-.were mado to enquire
uhat bio1or!1cr1 work vni-lotis menler conp-niou
war" doing, if at all
W; without succern. Dr. Urrmer volunteered the
information thFtt
ilnoma yer-r-, nro", American Tobrcco Co. hed
undertrtl-nn oomo biolokical
V-efingt with ii0tterninate resulto.
It wis thtin appnrent, tl!nt the T.I.H.C. were
toying with the
idea of eng,-r,,Inr IlioloGical Pevcs-rch
Lrborntoriev Inc. (Dr. Freddie
Ilomburger, i1ostan, ilass.) to cun-Juct va-io
q-imntitstlve tesUng of mmoke
condenst-tes. An effort wss mnde to get an
independont anscooment of
11 onbargorp it tht:i robit. The judri-eA, irzs
given thett Ila lins probabty
a conrctetfl,p bljL noll- rn ori!i!-!-I, Ne hau
dovolopol an C:7
C-J,
n1 tet-nnti,te tuc'oni-.jue to skin F.-iinting; ho
introduces a a,inll air-bubble
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-TK5(-
-3
tar
beneath the skin, into which he introduces the
substance to be tested,
thereby avoiding conteminstion or oxidation.
In the subscTaent general discassionp Dr. Hockett
played the
mr,jor role. Ile mentiored thet a cortnin strain
or rats produce cancers
if their diet is deficient in nlecin
(nicatinamide). He, tbererore,
postulvtod a process in mar. in which nicotine
degradation products
in cig-iratte smoke may plv3r a role en
nntagonisto for nincin. fThere
is no evidence, boxiever, that lurg enncer is a
mAnifestntion of nincin
deficiency in nnn-7.
In further discussion of Wynder's studies on
samoica fractions,
Rod&-ian stntcd that the hithly native fr,-ction
of rMoke, which Wynder
hnd mentioned in his pap?rz, hid now been lo!~t.
An attempt bad been
mEde, by an Indirn post-doctorstc woe-er with
VriCht in Toronto, to
separate this fraction by furthc-,
chro-intogra-pby on eliLmina columns with
the result Thai, tl.c fraction had beer. lost.
Jklthouah '"lodgmen was not
clerr albout h-jw it had been lost, the imprDosion
wan gnined that it
wes by adventitious oxidation or decomposition on
the column, rather
than b.-I accidental spillage. rain is then rather
reminiscent of Bock's
experience in purification of woke. "odgman added
Vint Wright was
unwilling to repemt his m=moth prcpnration and
Furification.
After thT meeting, lReid and the writer were
approached by
Du Fi;.is whi enquired whether, if the made n
recommerrIation that on
scientific grounds biological tc3ting of smoke was
desirable, it was
possible that the T.M.S.U. might cvl-.e a Grant to
the T.I.R.C. for them to
put the project out on a contract bssis. He
offerwl to approach Q:)
Dr. Eockett and 11x. Hoyt there and then to eound
them out concerning
CO
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the likely response the T.I.a.C. would make to
such a request. This
Suggestion was, howeverv successfully stayed off.
During the meeting, the Techzlicnl Sub-4.amaittee
vere told,
that both at Buffalo and Bar Herbor, the party had
been told that the
~mcrican tobacco firms did not seem interested in
the heolth question and
had zoL ppid cry visits to research centres
engaged on this work. The
i:Lpression hed been gained that a few, discreet
visits would be welcomed
no evidence of a serious sppronch by :.he
Industry. Tho implicatiors of
'the tnti-Trusi; Laws were explained orce more,
but Dr. Hinimor added that
naybe the Industry had fallen over backwards in
the pRst and that perhaps
thetime wps ne,virg wh,3n i more positive attitude
could be adopted.
Dr. liockott added t1int he kept in close touch
with what was in progress
at the variouo resenrch centres.
OD
t1 i
C7
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