8 MMY WAF AT- DrItimbfterissm, Tobaces ft.LWp
I DOUT54MV.
DO/*= JAM Ann-Wo IL997
A POSSMr AT-TERVATM --'U
or. Katie of Los sngelos ban bean Muffaff0d an
research Oft the
medical and ZEFM aspects of ONE. go h" sh- that a
major component
of Lee Ugelso smog is aliphatic hydrocarbons from
gasoline engines and
patrol canneries together with photo-ozidation
products of theme
lvdi.c-eh-a # e.g. opmIdes osomides, *to.
Atmospheric pollution also
comprises P0170YOUG ercnatL hydrocarbon of the
MRSTAL type adsorbed
on wut partial*@. it has been dwm b7 several
grompo of makes that
DORSTAL, wbou adsorbed ca goat, is Inactive as a
own of ZEN= ZDtJm
has suggesteds
a) net alip4tis hydrocarbon oxidation products mw
produce
ZMIM on their own exacunt.
b) That the aliphatic hydrocarbow and their
oxidation products
W act as Noluting agent', acting on Seat particles
In the
bronchi and liberating POSTAL &U. In a fors In
w1hich theY
may booom* toed for pathological obangem In the
banal OeUs
of the bronchial epithelium.
Totinip theory Is elaborated In a Review article
In 0 'ZFTMM'
Research" (at prevent with Miss Vlatt), and
includes the Idea of the
InhibiLion of eilinry actim in the bronchi by
-14pbstle hydrocarbons,
thereby allowing the eluting action to occur
undisturbed by sucous
searstione.
It occurs to me that this theory ".t be the basis
of an
Alternativu Hypotheelep which miebt explain the
sawdrg causal relationship
between ZVM and cigarette smoking stattaties.
It is generally agreed that of the constituents of
cIgRrette
smoke which are Imova to produce Z?CrMM on an
experimental basis in
antmalop none a" present In smoke at a level at
which they become
effective agonts. There is, moreovers a
dirtinction to be drawn betum M-
PW urban and rural ZPM rates which, to Pome
workers at least, points to
IL-29 a atmospheric pollution as a major factor.
(See 11* g. Campbell & Stocks,
VW" P.H.J. article comrarIng Liverpool & Warth
Wales). If atmospheric
pollution is to be hold the moor Pourco of DORSTAL
and like corpoundep
then there arises the question so to how
siCarettes are Implicated, MA
erhaps of greator point, 4q pipes and cigars are
less Implicated.
The levels of DOWTAL any be lover in Smoke from
these, owing to lover
I
o*mburtion te-Vornturval but See I.T.Co. rerUto on
'ALffs. Mim
point to Irrelvvant however, if t1iVEncoe of
DORSTAL Is external to
the rocker - tobacco mrstee.) 1%
Consideration of Ketin's them a has suggested to
me that the
eluting action of allphatis hydrocarbons,
introduced into the bronchi
from the flames of cWwtte lighters, mW be the
Oftual relationship"
betwom cigarettes and OPM. 7h9 use of cigarette
lighters has bow
an the Increaso In the last two or three, decades,
and my parallel the
rive of EMM. Pipe smokers do not gMV= use
cigarette lighters and
so the umber of those subjected to the alutLng
action of hydrocarbons
would be lose.
Atoosrhoric pollution from gasoline fumes from
care would be
a secondaz7 factor# which could explain the ZErW
f1gures for nou,-onakers.
It is possible that the T.11-I.C. statisticians
and librarians
know of figures by which this hypothesis may be
tested. It is also possible
that the tboor7 has been canvassed provicuely
without any comection being
demonstrable or that, it has been disproved. An
Informal WRUU7 to
the T.M.S.C. would reveal this more quickly than
would an extensive
literature search.
BATCo document for Province of British Columbia 2
November 1999