Cony for: Fi le 461)
R. A.
SCHINTIFf"t- CMITROL 61'r"T., 1. 1y. HuGUIES
1-,.:H/VC/6'2-
14 th AugtiRt, 1964
Dear Ray,
ACETYL COUMARONE
reoff has rsssed to me your lite-ries on the
toxicity of the nbove con-,ound. We hnvi~ nn
rLIIljShCd
information nvailable on the toxicity leveis.
~~or~-rrs --tich as Kitaf7awn and lwn~i hpve shown
that it has physiological nction similar to
coitrarin
bjIt It TMICh lCitiVity. Other anpIngues of
min-irone linve been found to exhibit sor,~
neqtrn!7enic
activity simil-ir to that'observed in the
tsoflavo!lo
and cou-iRrin inrin!-.. As I underst.-ind it, t)lr
i 'jq- oF
cou-nirin lizas bron t-arred on the t-rotinds of
it. heirc,
carciiiopenLc, and rcrtainiv vit, finve nn
iTifnry-tatimn
Itere on the circinopenicit), of the benznfiirnn
mplecule,
which is the h-isic mciety of cournrnne. Unwever,
I
wntild suppest thnt sJTJCLN sicetyl cotu-inroiie
Ymnv be
physioloFicnily -Ictivev it VI-luld fie sensible
to linve
so;e check tests carried nut before its use c-in
be
agreed. I eyrrhasise that this is just a Personal
view and probably Ceoff will add to this wken he
returns. Consequently, I would he pratnful if you
would t:tke this note as inerely nn intermediate
riece
of infornation for your own use.
Yours sincerely,
C.c. II.O.Anderson, Esq.
j
File 46D
BATCo document for Province of British Columbia 12
November 1999