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NEW YORK, N. Y. 10017
(212) 867-3700
SOME FUVIOUS AG.3 CTGAMME SMOKING STUDIES
1952-58 -- Hammond-Horn stidy of 187,766 men ages
50-69 in
nine states, 44 months of follow-up: first
prospective
ttudy to usLablisit epidemiological relationship
between
smoking and lung cancer; documented hi0er
...total death-rates for cigarette smokers.
1959,.to present -- Hammond et al: ACS Cancer
Pkevention Study
,in~rolvlng .1,079,000 men dnd Women over age- 30
in 25 states;-
studied environmental relationship.to cancer,
includin1g,
smoking habits.
..L964.-- Reaffirmed relationship ot Hammond-
Horn. data-.L
cigarette dmokinZ to -1~ing cancer; extended
Implication of cigardtte,smoking to other bealth
effects'
--s-ente d hiatclidd pair stud
re Y.
p
2966 Established firm relationship'of cigarette
smokin
i s e a's e s' and'deitti rates;
dbeumented'.relatiopship
-~t -in- en;, added. e~~ den~:e.
of cigarette -smok and - doat r. -es 1400
of relationship t7o deEree'()f li%halAti6h, age
staited smoking.
1961 to. present HpuPA6nd, Auerbach, Gar:rinkel, a
t al.: Series,
or_pathologtcal stud-i -~&n 2hi"
--human IT9~4fo.=_ _Ix.~)i1c al
and other tissues- in' relatl-on :LcL- smoking.
babits.
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BATCo document for Province of British Columbia 19
April `1999


96 ? -1~26
clationshi,
Of 2moking habits to..
Cal
C. pathologi
changos in -tr cheobrcTjj::jjjal tre
M63 Showed.effects of clearette smoking on
fibrosis and
emphysema in the lunk parp
!IQ65 -- Demonstrated tissue and cell. changes in
the e. sophaeus
caU.Sed by smoking.
19-6-8 Showred effects Of vascular changes
(thickening of
walls of arterioles'and arteries) In a number
of-organs
ln.,.relatiOnship to cigarette smoking.
12 L-O Showed effects of changes in the larynx in
relation
-.to cigarette smoking-
-1967 to pregEint __ Alierbach,
Hamme'nd,'Carf1hkel et al studied
the effecis of cigarette smokine.gn dogs.
1 7 Ptoduced epphvsema-in dogs-
L967- ~~ubjected to cigarette
smoke.:(Preliminary studly)
"1677 DemoAstrate6 litstologic changes in- d-o'
as' b.roachial.
Wbes caused by elgare tte'zMpk.A'zZ,, .(Pre ry -qt
=jy
771-
L
302058315
BATCo document for Province of British Columbia 19
April 1999