University of MAterloo
~Z!
November 7th, 19 7 3'.
The Director of Research
Imperial Tobacco Company
Research and Dzvolorment gnildinq
734 Bourget Street
14 ONTRFAL,,.. QUEBFC
Dear-Sir.:,
For several years I have'directed a research gr6up
i'n the
University of London (England). our research
problems are
arious, and lately we have been applying modern
thermodynamic
V
-and also Raman methods to compounds of biological
importance.
In. particular, we have been concerned with
collagen, and. masure.
ment-of, inter alia, denaturation'enthalpies. I am
therefore-
writing this exploratory letter to encraire
whether you feel
that it might be mutually profitable for us to
meet to discuss
problems of mutual interest." Isuggest this since
some'.of our,....~,~
results, whi7ch I mention below, are.of direct
interest to
-studies on the effect of smoking.
Some months'ago, through the courtesy of Prof
d'ssor'Forbes
-of'this department, I was provided.--.with
samples of human lung'
co-ilbtgen.. ..These were derived from:autopsies
on patientsmith.
kn ories, including,-in ~some'cases, smok inq
habits.
own.case hist
-related'chang4ii in the
_-Ye-a-re interested, in correlating age
a- _h
witli oiu~~Meawj ave
_tbat_=der Certain conditi6ns these measurements
Are sensitiVe
iit~iaz f f etdht- --ol ladens, .. To. _w
methods for ~i tere
:.considerable surprise ageu
f,.-..-a-.-patie-at'--known.,,to be
1 Z, q'
--a- he'airy smoker -(65 years of -age, 40 years
smokin -, -3-4 packets-.,.. -
p,.er dayY -showed-no detectable. dif fro."i-that
of a patient J~
-story -G:LV iqi a~rdiAAL1,
-9 f 17 year$. of age and no:,smoking hi en e C,
_1 _".'importance of natiVe dol-lagen this is-
most "teresting, -though
I -are preliminar'
-should -emphasize -.that. these 'results y.;
however,
.:--::E have-_ ju4t had. a further rep6rt -of
similar contenin-from my.
.::ki~~?ratory,.,
-U 0 1 6 '
"IL -MY
it i:s -my. intena66 _trot Kl~'
d hence.:j w6tild va-lue aiscussioh with-any
me~mbers of your.:,,
On
-to: Om 'ma -_sinize -shall.,be,
"institutio thii i,
n wh y be of _ntereat, t
~.An North Americ~a f6r t;ome-- months -
...Yours ~sinCeTLAY*-i,,-.
~M
302057093
BATCo document for Province of British Columbia 19
April 1999