-4/:
Februar7 2. 1960.
1. D.
Lzmser-rc~: &
1 r_-C=t's Park Rzad,
SOGth&Aqt=,,
Dear Hu;;z:
go were Weed wet interested to receive yc---
letter of
j4 muaz7 19 sad the &c=MPdM71A4 re"rt an tb& visit
to Fabriques de Tab&c-s
Fr-fes, Serriaras (IkucMtal). As Dr, reltva has
poizted out, thay bey*
coeglar-oly sc-.&Vpad theiz- ideas outlined in
their ori;izal patent clAim.
I would that the praccicAlity of even theizz sew
process is very =x-%,
in doubt botk f, the standpoint of efficimac7 of
a=-.-.act:L= and cost.
It would~ L%dc*d; be interesting to know wboother
Hatth&7's work was cm-
&uczad ce tir from machim extracted or laboratory
extracted tobar-co.
As I d6ink you kaw, we have recently started using
an LwatApic
dilution teci~( v& for datermLining bv~v:ze. As a
result of this
tachnique, we feel we esm place coasLderably
=zazer relimce thm formerly
L'-~ 44ta we obtain. The following tAbL& couLains
data obtai3wd
with the L"Capic dilatics method emd these data
Ladicats that extractica
cd tobacco with kz=sna 6oes sot cause &my rwreater
re,4-=ti= of be=--pyrand
t== it does of the total particulAc& matter.
CigArvttex v-.e,>cred fr=:
a-b,-x;tzxe extracted tobacco uzextracted -c?1Da-=
3111: ~LSMIIOO cicts. Z.3J 2.62
ot;. tax/cigt. Z4.Z 7-3.4
B? P?2 Of tzr 0.55 0.?5
T'-c of rxtract- renowed in this cime was 4= based
on the dz7
vei_-ht of tob&c=. It will be noted that the
rtd=ti= in tar in this
experiment is ocay 14.r.. The avaraga reductica
for these cigarettes
daterzi=,ad by coostszt smoki over a tro-year
period for biological
testing, was 20% but timrs warsi occ&&Lmal
variAtijmu to as low as 15% and
&A high am M wkich we cj= only attribute to either
of tkie
G:Mtraction MA/ar in the cigarettes; themselves.
Deteralutimi of the
benzvyreze c=tants of tlmes,4 ta" were czrried out
but those analyaos
.
-4
L
C).
N-)
BATCo document for Province of BritiSh Columbia 20
April 1999


Z' 17", 2.
wmm czda ba!c-.~- w st=tad cr. t!:4 isoto;:Lc
dLluti= tach=Lqua~ Ue=4 we
kw-sitzte to qu.;U rzz=,. a=rrrq--' the r"4ts zoot
AQ
not fun'?Crt Bc=et G zz--'t C"f- to 6. 501
redmctim L-- polc7clizs if
La6wC4 Ok note tha 0W.-recttom 214 sarzila
realactLen of 50 to 80'.~). Va wOU14 also Add t
M=t Of TC=at&ft 4ZZ-1 Sr.B3t=tLZt&2 OUX-S,
dlthov,-h they hXVa
hz-l or--- Or mro uz Latmad *=:-cptL=I.
T:,cidc--tally, just to keep the
r-,--- tt-- vcrt = the affect ot an tl:.--
bcmz,--_-=A r-=t=z C.! =z~;z vz-I sot Ame by Dr.
G. T. VriZ;it but Ln(k-
pez.~.=tly by Zzatr-- &~d o,=a.lves.
wrL4ar--e a! the ratio a! ber,-7rez*-tz
total p&rtS-u,-t* =:tar wes Ivy laug-taru
bLoloZiral tests recj=tl),
czoplat.ed ca our bmhLlf b7 r--. Gilms aLf the
Ontario VettrL-Ar7 C411t~s at
Guelph. Zoch a=?- Lsd=tion tests Vers run cc CA
all& UiQ8 for
a period of ab-oat 75 ve4ls. VlaoLe tar* f--Ca
ciZarettes made with bnnm*-
=t-.zct&d xr-d &=-c==r&ctvd tcbaccoe "re applied
at the saw rata. W
sLg--'-fi,cxat dUlf-ramcALs Lz t!ae respoLs at tba
nice to the turs oc--.=ed vb,.u
appli&d an tb4 aquLl b44is. It Ls important to kLm
vbAtbar roulk-'s
tc=4--!Lry tests are It-ei-_ ect b-y uzimg tk=
sa=e wei.;~Lt of tar or Lm
tkw ratio of t~w vaL#Xs of Mrs pzrod=ad Ivy tba
=tractrd and am-
Lz--Zzzt.ad tr~---x. We QQL4 t~-&t ~.~ttbayls
rasclits were reported per
IDO I= cf tcib-ac s=&&d' ca-d om ch-s b~asis am
would, thera!cxe,
*=;ptc -t tjo Uzd a smaller a=xo=Lz af bencpyresa
in t~m- szok& of extracted
tobace ci-=attas.
We rtP--2M&d bc=zet and cr-L&LuiLl
patazt clai2 (LppUczI-'-- Do. 36&X, to
Coxammisalth of A=tr-.ILA)
that 5C lbs. a! tcbax--= (at L4' . sioisture) we"
wash" vLth csrb~=
tatmcl-larlde for ism Um-- at ro= twM:?er&mzr*.
Aftar &U :be
bulk 0! the Walremt, tba tvb&C= was first
Air-dri*d and t-It= it Vots
cocol-ettly aff solTezz b,7 p"Zin a C=---Gnt Of
=*Lst air over &
i-z* Im-fer 0! tt6-- tc;~'A oycrzmlz~.t. M244
troa--t LIZ* aid& up out
ef thact vz4.s=---a lo=zz. Alter =4 veez=d of
equil-11-r--ti= tkL--
hzd ct=Lnad tLe Ses-- =isr-= C:=t8= as that of
t-IW C=rrol cb&c-
Lot!~ c=---cl =! v,---* =a4& into -.t-.uL&r
cL:---ettas of
J&e::t-*-!-! vcL-Lt =4 a%--' m=L*d ande-r
fd4--tical cvo'ditizas.
Zzz-Atz : T!xld c! c=----=ti 1.31 (ctry 6--cL-)
3.6%
tr--: 4.5.
=WE,- -4c tinct C.6'.
c=tr=ted t-0bzC pazze&sod a sigatficr--tly bctter
filliz~; c&.p*--it7 as
uez-survd by tha aathc4. Tb4 compressLam test on
tL-a ciZ&retr--A
dLd not y!Ald a dUfferezea beoree= t~* a.-tracte4
and cxmtral
c-.I-=crtaj bec--Lze t!i-- stxndz-rd de-riation of
the-sa results was qtLite hl&hp
but the geap-ral tr=ad was fo-. tlLa extrazted
to1bacc-o ctgAratt" to 1pe firmr
Wh &_-r"s vith tL%-- rr--Mltz fez tba fillinz
test.
BATCo document for Province of British Columbia 20
April 1999


9 ;~q., Fek=-w--y 2, 1%Q,
3.
As a ea-ttar c! L--terastt we would aLs* mmti=
that tba !L111- -
&ad c=;-.SzzL= taz:a CM a-b==24 &--=acted P.C60,
R=d C!Zmertttes ='d ca
the c==013 &~WW04 a Alz--~Iz=tly PLS-~ fillin
C&?&cit-7 f= tho
extractz4 tchacce &A well as a st;:~'-tly p-"rr--
reaUte:=4 tz caz;rres-
SiDc f= the ax=aczad cizarattes.
the use of net~qla=a chloride as a s*lv=t we k"t
carrL&d out such ca extracticia *! tbbacca in a
SGZ!Lutt dLf,-Ble. 6.31. of
extract was obtairm-.4. so cizr---stras were m4a
from this to6ac I bct.
fro& the c=m= c! extract abuirmd, w1hich
represe=tz a reLatively onall
inc.ru~&* ower Libe yield of a a-hax=z ax=ractian
(4%), we vwld not
expect t~sa b4=--p7-rz= Ln t6a scoaa to b-c
redLw--d tty a=7 siVnifiju=t
ammsat over th-at of the tar reduction. in
addician, we wo-uld sot expect
a sirray e=action of the " used Iry Isrukown mbd
Bamet to ax-.T&ct as
--I, as a Sox!Llart =t--wtL= and hence we would
not expect *Ltb6ar tk*
tar reduction or UonzMma c--d=t!x= b-y thei:-
wathod to b~e too diUareat
f-.cu that of a a-bezzaa ascraction. You Willp of
cours4, roalizza that we
are speczlatin a little bU baxa~ the amly coacrete
data we bzve Iming
tkw- 6.5: cd &=act obtained.
Ik would vary mwc!L apprraciats being kept
Lafarmed of =7
furtbar devalopunts n= Lag ex=&::tiza procas"A,
the off&c:s of
extractian an the polywiclear hydrocA;tb-= coutent
of the snake and t!m
biologizal activity o! dm sock&. In Wticalm:r, we
would ~,e most
interested ia tbw anomt of extract raxow*4 by Soaa
t & rieukam's proco",
if you &Uould ftud it act.
with kinUst regarda,
Yot=s Sincerely,
L. C. LaPorte,
2-,IAP--A An
it. S 'j kda (2)
BATCo document for Province of BritiSh Columbia 20
April 1999