Cc
C~iarlcs Ellis
-erle
relton
Fordyce
-r 4 ffj 7h
C LaPorte
Seelicfer
:1. S=:,~,rf
R.S. Wade
6 ~.
17 OCT 1768
.................
7 h~_ '_CnferenCe j.:=Z concerned w4t~t three m
ajor
themes
a) Smckin':- and Health
b) 1-r-~duc7 La-velopment
c) ~-r~:cess 7-asozarch
~ncrc wer-_ intons4-:= discussic:-is 'cut i71- was
agreed to
epcrt orly and participants undertook, where
necess-7ry, tc any background discussion for their
resoezzive munaz~_-=anz; collca.c-ues.
1. 1- is cls~~i- ca -umber of features of
-i F-: tlic biolo,14cal activity
cf, These incluve the
inccrDc_-a'_izn -,f an,2 CRS;, the fcrr,- of tho
z,=,Icing t~ie type of tobacco, the
presenc,i, of addi-_ives and the volu:ne of puff
taken in smckinz the cigarette. These factors
7..:~ll becorie -'_1crca-s-ngly important when
future
cigarettes are des--ned.
2. 1he b~olc-ic-l res-alts are also indicating the
imoortanc~ of both initiators and promoters in
S-Incke and this lead should be followed up
vigorously in the biological research.
Studies in instant condensate are show _L ng a
biological act_Jvi-.y towards mouse-skin of the
same order as that cf stale condensate,
s'i4gesting that tfte biological act--'vity is not
ti-me-dependent. The clear possibility of
produc-inp- cigarette s with reduced mouse-skin
ti.-logical ac-:ivi-". therefore beccmes of
grcater
i.-iLcrtance and a rnscarcli solution to tiie
whole
Problem is more 1-4:,ely.
BATCo document for Province of BritiSh Columbia 21
April 1999
CZ)
NO
ON


t
urcs C .i~
S z b,,? s t- i S
Re-scarci staff Siioul~~ dc~-;n g'aide lines
against
can be chosen in everyday
ccerations. 'altLou-!i -Incre may, -.n occasions,
be
c=';'I._iCt bet,.:,_,en saleatil-ity an:d minimal
biological
aC- -;j t,.-OpS Cl Lr,-)duct s~_-ould be clearly
a aZe -reassurance)
c i. arc, t -,e
b o (minimal biclcgical
acti-.Tity) cizare-,~e, tc be 11:ept on the
.T.ar',--'- for those zcnsumers chcosinz it.
rosult_z on ccndonsate from FCL
ellcr!~_'SISO Lh-at this ma:erial shi~-,,,,Id no
longer be
as waste ur-iliZation can be a
cc-risc-ious towards oroduc-11 imiDrovement. PCL
sl,ould '---e ccnsiderei as a 'gr_ade' and no
longer
us,2d lac_-oss tLe boa--.4'. k numb-~r of new
de-73'_o,)r-i2nts in 1--elc cf PCL and of
ventilated
b,- .;~ic~i m.~)ans the puff volume may be
r-c d i i :. c.-., be to Southampton for
assi~, at F_-ankfurt.
T - no -c f; z -i.-y t c u crstand the mechanisms
in-;-Cive'- i_!- ~*~Iort te--- tests in c~rder to
avoid
b.,~ i -.7 M4 '
_.,_-_d by rcs.1-S from ap7,arertly disconnec-.ed
_-7:r_r_ir_ical tes-s S~iould therefore be
examired al- thi! level.
it was rec:)-,n_is_,d tIa,_- there was a growing
interest
i emphyserna
n tfie area of non-=ic2r diseases, e.g. -
't--onchitis and the ca-_dicva_,:cular diseases.
interest
snou-d be mainzained In making non-inhalable
cigarettes
tut less-irritInting smoke may be an advantage in
its
own right, even thou7,~i it m-ay be achieved by
lowering
7-~'io ratic of nicotins to tar. The R6-acid
filter
ci_'~--arette in Germany could be ccnsidered in
this
Z'~tto!-iticr. s!~iould be :~irectc(~. to carbon
monoxide and
a: _'?-r-r,:~achinE stud-.- :)f t~ic fac-ors
affecting its
fc.rnia:ion and possit-c aliminat-4-cn by filters
or by
mcdify~ng combustion c~Dnditions should be made by
To th-J"S :?,iJ1, ond in the light of the
at-:itu-":~ to carbon talren by the German
L *(~s, 4---- LIc- ad-
Autbor`t antagr?ous to
U7
BATCo document for Province of British Columbia 21
April 1999


- -_-. f, -% C~, is --j t "
's . I cccs
:D r ma n w i I I
Arli nrooal
c r!-.t and that
-1,1,2 7 iI addit- ves to
I - _ t- ---e Cf , -
t :~ta,_ c ccrnbustion, ccmoctitors'
orcducts s~-_culd be mcnitor~.,d for this feature.
1 c_ In cl -i,:s pro-c!nin,~nt importance, the
charm,~cc-_--.- of nicot`nc S~icult! continue to
be
undcr and attention paid to the
pcssibie -:_-s_=,7cry of c-~~,cr subs,~:ancos
posspssing
the features of brain stimulation and
Strl~3S-r'-~,'_' WithOUt direct effects on the
circ,_,Iatcry systern. The possibility tfi_a~_
_C-_r.L'1c other substances to2ethcr mav exert
t1 ian cit!i4,;r separately `
synergism
s~.culd bc s-ud-Jed and if necessary t-lic
attention
Eepartmcnts should" be drawn to these
pcs3_;b_i__-_-i,,_s.
I- was, ~i-..:evcr, agreed that nicotine or
-.obacco
ex-ra-ts 'sh-ould iot be out in a part of the
ci-ret- the filt-Dr, where tliey could be
In dis-:-_,,ss-J_on cf dcvicos for the controlled
adminisz---tion of' nfcctine, the curront position
_- t~ - L
~z orojoct was reviewed, and it was
c
rc-j_uc~stn_; '-ftat Southampton should supply
some
LR_11L de-:4-ces tc the av,~rsoas laboratories for
i1. It was a~--rec,:! that filtcr developmcnts in
the
f~~turc. --r-3 likely to bc in tfto direction of
multiple, and probably triple, filtors. Some
risk i,-cul~ be involved in ihe introduction of
a now tv-cc of filter unloss this were health
cricritaia-d. It was agroc,_J that the detailed
invostization of solid particles, which might
be inhaled, should bc carried out at Southampton.
.As ar urgent, short t,,~rm project, Southampton
should develop a technique for measuring the
solid particles in smoke.
L., ---urin5: tl-~e discussion on Product
DovelcpmL-nt,
intcrcst was confirmed in the elucidation, in
deta-111 of how smokrrs smoko (puff profile,
voluino, c-tc.) with the possibility
i- I J cation of the findings could be used
-I - ~,pp__
t-~ idcr.-~J_f.y witti greater certainty
particular
s,?gmcnts in order to guide pre-market
sur%rc.- smoking evaluations.
BATCO document for Province of British Columbia 21
April 1999


co:-i s c r s c rid4 ng
s 5 rur')'~ s C
c .7:, -.;~-_y pocpl,.~ smcke
are 7),~ c I anJ part!,.- psycho-
10 C.- grced th,t ih
a, ere is a
nee, - -rt ()n I.h,- psychological
aspects., ~,..TJ t!ir. on these of shaDe,,,
cc ~ c-_tr, --c. of sr,.ckiri, -vchicle and the
pa c 1,, a ~: ~_- b: cxplorcd.
s-_%_--Stc,.- t!icro wer,_, still
.,i-_'tb.-3ds uscl to select samples
A t n t 1 i ppafd -.tic laboratcry
'r (: s;~ a r c:,- a g,~ sa-,,plcs strongly
preferred
b-," L min-`I-~ test ranci ratn'cr than to
l.... t' :,I oreferrcd by a majority.
11 ~as S~-Own t'nat sinokc-rs are prepared to
a ~J i) s r t c I a n c:-, c C fa c -, c r s su c
1~1 a s r r c s s ur e
J r i sr~ t L c c; -ar ~_ t t -~s of
drop slicul~! ncvertil--less
.bo for tcstinr~'.
F c 1 1c,. 1~ scLssicn o-
thc spocific examplos,
U~Lt 110 S~-FithUt-i-. smoking material
ca:-- t~: for product development unless
tlic. c-i Cal ct-J-7itly of its condensate is less
tctaccos cr PCL. resoite
rcport~,d by ':oritrea-l
cn -_i-in ;~cll and Laing modificd
a- axi-_,,l channol tllircuF~n a
.`.icl-~ascd packing acnsit-.,r -
was --o,,J to att,-~mpt to acquire
t
_J'Ol:- sum, because it
r:~prcs-~-s a r ~il t- ornat --*, -.,c approzach
to ci garotte
--'h i 9'. already has some p tent
a
prctocti'_n.
The adop-ion of"' a_-1 objectivp to -nake
cigarettes
whicf-i Y--*--'id condonsatos with lower
biological
act'vity Ocut which must sell on their ordinary
qu,-, 11 _` -- S ) r ~-_ e u c c s t h c- d c g r
c c s n- f f r o cd o m J. n
t-cr.m.- of -,astc, a~:c~~ptabil_J~y, .economics,
ctc.
in desitzn. B;_~causc of its importance
t~ir:,rn is a n(-:cd to expand
~2 ~:rlmiaat_icn -of thc (,-ff,,cts of
caz_ic-'_;s ?-i,, fla-7:lurs on th(, Cl,-,vour and
aroma
zmcl~c.
It was a:-cod it would bo unrcasonabli to ~_old
up thc. intr_-)duction of a ncw devolooment of a
naturc, until it had boen Drovcd
ccnc11_-.s t,_- N., of 1cwcr b-iolcEzicai
ac-tivity.
rNJ
BATCO document for Province of British Columbia 21
April 1999


b n
:'C' that the
0 t h
, C 1 1-:, ~Sting
C
f
r r C.
15. j~r_is _4!1~; -I:- c f t~~-: `_',~r-..ian
r-csition wit~i respect
t-~ ccum.-a--in, -.-Till bann~.d from tobacco
ma n~_zf a -_ t - k-~ fro-n -:12c be~_-i nn-ing of
1969,' the
fcr --I w!-11 -t'icu-ht -out
t :z-,:iIqu-_ i'~;r a-_Id_iI__Jvcs to ' obacco.
f a ct -~'n-:-, i s ncw a mcmber of EIBRA
p,_,ss--.-I-.- the val-idity of tests based
c~, and r,~asorilng to be
~iodr,_; a', accou_-11: of tl~ic proc~acdings
ccnf-rencc t o ckhoim ,
c- b.~t c. c t f c;-, s t _4 c id c s a n J e c i
d c d t !- a t
ci,i cf cc :--icid- r~,,siducs on tooacc~~ is
t
L s~ 'ry I a,!ticn, 7.-ih-_re possi-blc
71 C C r 4- en -..14 -1 Depart-ncnts cf
ilgriculturc.
j --C z-- c lie mc if o a s s ~- s s i n 7, t h
effects of
0 n t!-~ C 1,D, cal a c t i t Y c f s m c k
bc sont to all participants.
-~Jscusz-on on Prcccss Rcscarch, the
t ffcc-
I lot! 3 f ri r Yi t ".~ 13a c cc, i S
7 __*I'_-c-_ t~.,,D biological ac:ivity of
s ~.q C I, ~s a ncod to cl-cck the
tl~r, 3mckc from tobacco
I,pl this (--z--minatio-
ct~-_Or short _rm tests.
that the Group should be
prcpare,3 to c:--.r.Icrc radically new ways of
2 :IccC_sSLIIE tctaccc Such I-s forc---d agcing,
7 iircshing 1xricuzca tobacco, etc., but no
scocific zro,,csL,.]_s Wcrc madc.
it ...-as thLt the devriopiricnt aspects of
ci.g----.r manufacture: should bc left to Canada
a-rid
~.ustralia.
cvorail czniclusion of tfto Confcrenco was that
(~rceri sncul~ -,.rrit-~ an articic for the 'Iew
7 h- ~,mcrgcncc of' smokc chomistry
.icw :-,ciDnt-fic imagc of the
.in
tc'"accc -_'-iduS-,-.-.
%,,iri~_,us cn~ng~s in or.-,anisaticri wcr~,
cutlined
-~ff---:S in t,=s of communication links
Lr
r\-:
CY,
BATCo document for Province of British Columbia 21
April 1999


-I s i _,I a; d 7: n
D S :r
t
z C
s r
ncl i Ua 1
----------------
ULio cl,_-_:::~ cf_ --_ `,Dnf,~rcnce, a second
r=tL- t-)clc u,id~~r ti-c- --'aa-'r-ma-riship of
1,1r.
I
T 27=712. L r . 3 . J ~i and Dr . D . G . -7(-- 1
t on d-3 i d no t
na t -
--D--f,_ru_-ico might b.-~
tii.: L_ritr,D,4.uc,:_:Lc,i ~:_` ;=plc to
rcpresent '-af
C~I:. iJ rnLirl, res-3-_ countcre~ b%
Would intib4 t i-h,,~
L
_J fr-_2 s c Li Z 7 L 0 n -,, f c, a t ur e of
C I -_ ri H c o rif L, r,3 -.2 J t- 2 t t ~ r~ s u
g g e s t ed
,nI_ar:7c-i,~nt of tnc -nc,,D t was proprly an
in-company
it was t~ic coacurisus cf ccinion of' the mocting
that
Z~- pr~,scnt rapi C1 7 s' tuation another Group
Oonf-~rcncc slicuI~d Sc- :'_Ield i,-i th(,, next
six months
a- to ~cI4 ir Ln Cicrmany was extended b-.
'!icrr _::cttcr4f.
mcct_in:- discuss-~,,-; (~o,,rec of succcss with
th-_ Cori-Ccrencc aJ at'-,:---'icd its
obj(-;;ctives. Er.
-~ree!~ was thar_!:ed for tt2 wa-;- ~ie 1-~ad
discharged the
1'__'ficult r-clc- cf Chairm_---n zuidfing the
discussions and
Fcltcn for his pr~~santatjcn of the biological
work.
-7
L I
BATCo document for Province of BritiSh Columbia 21
April 1999