r
for'.,
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r
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i - and L! I .1
Jnprfri .1 T oh i - --n -.!7nda Ll
JSIO ';,.. Anr,.@
Montri - L 30
cook,
Dear !'I . Lapt., I Le,
L
IL n r., -rly three ye;i- -;ince your xnp.tny Generously
T,rovid-! Lo i my rerearc, ncern-ing ,nu c:!rtUores-Piratory
eifPL,1- of n.-CvL11.nkz. D,., de!::, especi-illy the Medica;r,-. probler,
of lxl- %,Par. a fal r b i i -.-.,rk has becn' -@-vplished' !-!d it seemm timely to
send you a pr@-Z; erk r
Lind
@ir-.t vc-,-r wau spo,@--at on acc-,itint SVCLinf,, up
g
new cqilprenr. f,i Lais rh. There wo,_T --isidcrz-b; -.- d II I tculty in oaza14t1.,p;
t. -i rt t.!,. -i !-.I a ptire and -Ele scilu@ '@-n . at the company that.
had @i::iplivd t!, pruduct in San F, -11isco iiad St-ni- ont of husircss.
Kc,we%. r, ot,r Q- F Vha:---.:ist at rhe home-:, ; was iUie to -Iakul Up Cie dru-. I
t-onf i,;c-.,t in C @rrparatilsn to inject Jf intc
[lave bet 1@.
I-L,n - -s at care! cath, as yt:L. I already had drinc Pxperlmonts
%ic cc! potent i use!-.! ret;-.11,s Would ;.P had frM.
III VAS area,
cor c - r I. :at Lng tl,,@ e@fects - --.icot.:-.- on 11rravs -in.) small lus?,
ves." " I S
-r;r@- k-f 1969 Dr. ---id Cotton joined the laboratory as
(00@11 a re-,it-IrrIl ft' !>---n work on t))- r irdior: -pirZ:Lt-ry ef IF cctr of n tcrftlne
pr-21li-isly reports.! t%&v iearcl t t: smoke izutcly
the Pulmonary f I,:-;; II--- ioity. This wn., relt I%e due to sma3l vessel con-
strlr-tior In ........ @-er, as thf-re --,-ora sev - L uncerf-ainci 4-s in the
mr-tficids used. t-, -egin by r ing sonc- of thesc studios. In brier,
we fvund no el c! -1 r 11 Imortary di-.f Z!v
capority f rcxr Ole inflation of Cie
"J II.-Nrmal -Rubjt The di f fusing cnvarlty of' 6 nour@!als
SMOKC of 2 Ci.- -CL
was studied 1-1 rc L- I nicotine I -4- ::-tion.% on%f 1)@..in I!,) -- ignifficnnr chnnge
was 06served. Nw- vp -t! Ili-ble to fill:-' .-ty effect of Figure smtke rr
nicotine inha'itiol.- - smaLl lung
).,I- ;Previously been %I--. -n that cigarette smoi-c acutcly
tiir, resi-,' 1r.. 'It, in lun; airwayr. has i:,@(-n 01olig.1;t: to @-e due to Par-
L LCUlat C Mat! --- I '.I L' ne'--, rather it: ph-v----%co I ogi -: cf rect of Ili. -t ine. To
.-r-iMlicy we !If. Measure airwn-. re- 1--t.%n-i- udti-1!1-:
!Iv- hvdv re and a f t :nhaJ-lL1uii---- have, carl-'ed nt'.L >1
L;1%@_ Z. -.41 in r -I -i I vo' fail I - ; - ;Ith e-rosting i-0 -1-texpect, -1 respi! r.,
(.he awl-TO-Cl.
Jn nir-
ill no atgniff. arr ronnint.#-18,1, r
Wo.__
BATCO document for Province of BritiSh Columbia 20 April 1999

?!-,: -49M&N 9: . . :. -
3 ot.
.VC "Pen
t,:sE inp, AL U 01 I AlUim.&I-.4 L:iv 4-,L.g i L
s,tjge--.t-1, thilL Indiv Ilia., II I- n dLff#!rlnr. dreret-9 r,-.-tAv.1tv w1dch
tray tic t I n lit t n nicol rest I i n II Ir C! t i I y r o., t I I., v
t t. la r. tr
o i n L t..-;
to-sI: th'! clfr@_--t i.Ci
tlil, SI jytni L i :,i;i L 1,@,
j re- I r
a'- r,. CoLLOV .11-ill
a 1.10jec, -C I. I .1ta:
1: I, - , - w;;
Wk-l-LITIF, IL A7 hy - i oloi, Socic In I'-,U, an Lnc!,--c a cc-,), ol
C!j r alls t @t L Cr. S@113 -as t cm the 1, :-%-riztl
Cr-1rIL, a crE-'. Eu L'@ @,Ic -:131 --.'.)1iC3Li:-n nuw be"c'
pi Fired.
As a result L-[ :un I '.I t,.,e uzed your grant ovei: a
picriod of a 7', 1 2 than 2 year-, of gin ly into.-. If-I. I be U cvv.
tl-..,t the ;.@:ar ',.-is en cd %-- I cons' le I-;efu.' progruno- in the
dnL area of functlon. AS (ILSCILIE34W
we .Jm fu-.t',.. studl. in z". I and grati-fil if tile Jr-,)cri:,l
Tt,;-;.cco Ct-r - wr .,J .:nsV-_ r su:.r t!,A's r.-search. I would be
plc;;Scd to d: ;ss thi:, -jit;.. v- ;r, ner r Pry further information
you may requi,
_-r-l -;Incerely,
.J.H. SLIRGE@ 4. D. , F. R. C. P. (C)
A?@soriate 1'. ..:,-!qqor Of ;-Iedicinc,
i4re -,,,r, C.-.I@iarcspirr;itory Laboratory,
r;-,e ntreal' -eneral !"c%pital.
Copies
1. J.H.B.
2. Dr. L.r. Cheson(lv
Medical Direvo:x 01' Hez`h !:--,rvi
Imperial,
3810 St. Ant-@!re
jHr. rM
BATCo document for Province of British Columbia 20 April 1999