P j -v(y or V tol. 0 - :..-IiIJ0111ce of --.air ty-tt?w of t.,-juvi.-o 1. On Irith Novcn-.',---r, It-712. in n prn-gramme 1- t1la Tomorrow's lVorldsm-ic:;, N31-- telmisfnn pitt wit :I i-rc%,-.rnnmic, Mmvil to Imbf on the c-f the S'-I.C'r. advice to the Gommirctit to publish rt tnr :-wI le,,otinc leiMic Lable for cig-rtrcttes (ApInnelix A). 71ic basis of ilia doubt was (1) sh0w. 113, L.A. FIS011 :11'Ll UIC ].Ito Protesco r R. 1). r1assoy. (11) Studic. ',y Dr. Ilraven and his coil--a-gucs at Plymouth. (Ili) Thc fa,@-A that. ui(-W@v Is more csrily :thsorbcd froill nn alknlinc Finoke Vian frc i.i nn acid ono so t!-:i 1 iiihalation is unnecessary. VV) Loutcr hic!dcutx of lunc, cancer in "rance than In ilia U. K. (v) Lower In,@id-,nec of cancer in ilia U.S.A. ilia in ilia U.K. L3 M) The fact Vint French rjg.@rcttcs nro vilade of air-curcd tobacco With a low simir (vi 1) The face that.Amvr1&,7nn cl-arettes emisist or np to 50171_@ ziir-rurnd tob2ceo and hn vc, a siz tr contcnt ut,ty half that of U. K. cim-troUcq. 2. On VW. Nm-i, nib-r. vrin 11tv sundray Tinit- - i,tiblir-hed nit nrtlele comring, intich tbo r,:-.-r growid on it!: froil! p:t,-,c (Apymr-lin B) h: imporl:mt It) I-xo "The OT rhat. b-t-wirc I( h,,%,%,r to Im., !failed. nnd is In pr.-tctive inlinic-d it, a Israel, alkmliiic --iyiotc (u-, in rtori-mily ck..riveta from alr-cttrcil, -.-trilar toljn@-no) is less art 'Lo 1011- c-nncer thnit -,(.-all r- ;:ts nor.:r-liv tinr;ved frorn flue--cur"ad, 'ThC r.11-1 1, 'I- ThA civil Cq,-I c:q--,Ukv It-.- it;!lAn'tion, t;-.c r-a.-fl.-c f.-vni air-currd, ICnV ilt,ttl spw-' fit (.1-1. C=) BATCO document for Province of BrltlSh Columbia 20 April 1999 4. In the prerow i:@cmwnL v- A lReview [lie W.Mary -J clavc1op-nesitc; hi lie - nrca. D LXamille thu neleWilit. evidence for pailitn (I) tv (vii) in liarngraph 1. C. necommend -I courr- at .action for con-,idt-r.-Ition by T. S. C. A A bril-l' 16,A-v of rolm-ml 4evelcirmcni- S. On 24. 9. GF) 11-c Lift- 11rcfesnor R. D. Pnnsvy p, @-Ecntcd I Mp,-r -at a mcet int-1 of the Brit-31i Assocla(inn for Cancer'Rescarch in DubUn at which lie described Uw) prcUininary n@,sttlts of experiments ill v.,hicli he c%poscd grotips of 12 rats to ilia smoke frorit (-.I) cigarettes ninde fiorn f1tic -rkircd tot%LcCo and (b) cignrcit-n ninde from cigar tobnevo. Po al_--o doscribed th-a- exp-crinlents in which Crours of "(I mice wcre p:0-1-1dwith MC condcnsmte from these hVo types of cigarecti.,:;. Via result;: of tooth fhc:@c exi3vilnicniz; wcrc first dcscribcd in print In the T.R.C. Review (if ?activities 100-C-G btf' not in n rcgnilarscicntific Journal tuitil 03c Dritich .1%ledical Jouniil of 23rd October, 1971 publi.%lind a pnivi- by n. D. rlassay, 'Al. Blaclonorc, 1). NVnrbr;-k- and R. Joncs.(Al-J,)V1)dfx C). on 19. 11. GS, the sanic refMCs wcni prcr--:n(cd ai. a mecting held at (lie Clicster Beatty at wbirb GFT. Sir Charlcn r1lin mvi FJCn were present. The minutes of that mec-1mg (1) 3 - App--ndix D) to Gone axtcilt rcncct the criticism which the Avoric riii ire on ibal. occ=@ ion. 7. On 14A. C(, Passcy, Plack-morc w- I Lamb presented two piperr it -I niccibir- of ")C 11, ilin'! for Cavil.- r "r--wch nt Nol-thig' ic than )l TI i-crente.1 at D-.-!-I:n @itcd ngrtln tc.,,,, ",cr with the rectills of I furilicr ex:totimen'. In it-,- v@:pci-linctit cignrett-s little of V%,rlay tabacco I-rovcd to lie -r: uoti - ill.-gh: from cf:- x tobaccn. More GO w:-.,,-. sald to K% lit' In Ire .-.,hvn cl-nr tobncv- oitgarcUr!; ware smoked th-ri whcu 6,--:-'TCUC tollif-C.- V-s vmrn r-molmlit thri-C-rort. mjf-C-led illo -"-tl:lf:is or CC) by Mit Ci, i i results ro,,Itl he explw'- on the W-tc., H"are-tten. ()n (,III,; occ.:., -,I, (lic at-thurs pohi,k .1 oil, 0rit centers',: of 0. BATCo document for Province Of BritiSh COIUMbla 20 April 1999 3 eigarctte tobacc(i 7 0. 3 c1pr tobacco O. 31'V, Durley tobacet, 1. 0111 They went on to rclatc lung cancer incidenec in d, ffercot couiltries WWI the sigar Content of the fcbaccos norn,.%lty srnoked ill those cowiLrics and found that Oic higoller tire content Vic lilghor Ilia it!vidcnca (if hin- canurr. Tht, results of the Second rnt exjvrbncnt -Ind tl)-- sp,@,rt,lat irwi oil th-3 sirmiricance of tho outwar contrid wor., rallied fit (lie Annual rwloirt of tire British X'Anpirc g. Cancer C..-PiTriign fv-- 100. and n-nin In flio 11171 r. M. J. I,-.tl;cr (scc Appondix C). 8. The socov-1 r-r the 1-:11crs nt Notting-ham wn-z r)rvr@,-nIvd by Divid Lainti, a collcaaue of Profm--sor Lynnf, RcId at the Unia. and C, wit)) 01C r".111"'Ing'k-al cb,angen i-i file 'i-nis (.-.,;postal ',it sincr'M"-fvcv-'.1tc V@fcrcnt tobaccos. Accord-.'rC to reports! by T.R.C. sciont;,;ts (4t: 1'r-eting (1) 12030 & D 1231), it is evidont that lung disease was a -crious complication in nll rats. Loss of Cilia. CT';(!! -1111 Ir.-p-1-plasia, squnw@m.--- nicOpInsia, increased init,:)Uc activity :-.i) I chaii-c.- In the Ivriplicral lum, %-,-ci.- pronxincnt in rats to cigamt1c, -(,@,Wccv !:niokc. In ratsa expor-nd to r i,gar sinoke, on the othor hand, hyporplasin and lo @:.' of cilia -were not ass-fivin't-A with squnmous nictnplasia and In ri I,: exjr;nt s! to T'Surk- tobacco tl,,: vc was no lose of cilia citf,er. A full T,anib's paUio'.ogjcaj in Passey's rats haq never been pulplil .!red. U.N. for thf. con! 1-01 or r4y in tob.-irco, InJillia, 11!70. Me :.'ational Rese.-rch anti Dov. I-jjmviit Corpnralion appro'-Owill the Indivir,x-0 U.N.. inawaracturers askirC for a Ic-clin-Wal and com-nercin], Rescssw-If. of Me :t1bj^C-t of a provisionni. pf, :if .p.L.-il-tenuon tj-.cn otit, iw 'DC-1) %valid) C-%!- 10101-11 rjlrjjj,V ,II(- 1-111 r 1'. .% 0 fj smolm or c-;,.-,rcttc . by incorporatin- svi! such ns urca and cm W-fin "I. It. C, rvplicd to tell.,; rcqli :-: o"I -11alf or the to the rM ti-A thc it 1:--ir rovered by the i.-I -It - IV it- Pt curriciuntly Inwcl 10 jmt:"y Colillcil n,ly intarcat ill it. C7% BATCO document for Province Of Brlt!Sh COIUMbla 20 April 1999 T. 11. C. ri 1-.1 lit T. It. C'm AUj'Ix)l-1 Of P r, :-or :r---irch Itas 11cen conrillc(i if) ille provision of frini sioriv. ri-.:r,-ctzr,,d tolywco tird cilaretics nianuf:i@-turcd v.-tiolly rjoin eigar 1--hnc.-. 'I'lic Council's irvolvenient in Illis work was reported in Cie Revionv of Activ itIcs, I V,63-GG (pn-r. 35). T.Tt.r,.q d,,eiri-ti I., inr,@ tint I,, ri Anis nt 11. ri-t-ito Wlicn Pi-of. B. 1). 1'.i.-scy first doscrik-1 the resu!,!, of hi:; rcsonrch in 19G5, the T.R.C. Exccutve ("oinmittre to provido nnn%vers to thrcc questions. The fjuc@ntions, toge(her wi 1he replit e! f rom T. S. C. wore -is foll(Avs 1 . Q Are Ilia conclusions: by 1':-srcy in IT'S palvr 111kv)y to be valid ? A P.-u--rcy has not carrictl ou, his in rt wny that 'LlfrjCfCn(1)'CXC1Ud2S Vic ponsJbility of serious bins, so that it is Impossible f- zny whather or not his resulln were valid. 2. M TSC agreed witli Pnssey's request for 10, 000 Cipm."tes ? ;nr, which might be met A in view of die difficWt. by vc f- isal. 3. Q Shotild TT'ZC do !)la type of -xnrl: flint 11-igsey propossed to .1,) with the-1c cicarcitcs jy@ a biztier way nt lint-ro- ttc ? A . 1rhaLation cxpcrimenLs will 1,: cnrried out with rlurle3, ci-arattes at Mirrounto in cotirsc Ird other 0 experfmcrits linva The Inhalntiaii @-npcrimcrdn refc-i-rcd to in ann%-cr .1 have, of entire, not)-tinferialin-d. BATCo document for Province of British Columbia 20 April 1999 ]I Critiqu 12. Two full