RESTRICTED] L GROu;- ENTRE -Aq7R 26AP-R= .............. S, - ~ . I Dr S J. G)I-f,(!Y1 GGROqt~ ROU" 'N 26AFRI;~ .................... Dr-1 R. A. Saufnrdi F" Her?% 11. Sf , ttnrf t t I Dr-.1 r. svr.hofor J I-Jr. 7. ?q, (:2j)jj TRE R- G ........... ............... S' . . . ................... ... j S" ......... ......... . . ............................. ......... '. - R. S. W, lo ii '*!)'.~ S - Candl isli ( C ( t 1- 1 - V 1111r. C. J. 1". de'siqueiraj, , j '11rin I. D. B Ov Mr. R - G. Dr. T) - G. Felton Dr. F . jjj.S 13 Dr. Gre-c-ii outlined tbe r)bjecti.v(;,,s of t1le nalnely to advisr-- t1le T01-)~-,Cco Division of B-AT with s P o 0-:i zi I reforenco to tile fC,rthccmij,g 110t Sprij,&f:; (11 :_ a) A-SuMPtions for D.ivisional planning in flic fie](i Sweiring and 11n,11til b) Research and develcipw(nit til-ogr- jjTjjiC,,3 necessary to aclaic~ve Divisional plans in the key areas: of Smoking and Health, Innovation and Tobacco. c) The disposition anij organisation of Divisional 11 & D resources - in particular the role of Tobacco Division 11. Q. , R &- D aDd 1;hc roles of R & D in Associated compallic's 11 ffatt~!rs rolt-~vlnt to il & D wliieh require rcsc)'Uttj~)n at thp jl~d "rrin~s coalrol-611CIC and to to Divj.,;~nn;"l N, c7N BATCo document for Legal Services : Health Canada 22 October 1999 -inn] Ill.- oil 1.11o rto Divisicall Board pI. III duLail 4 a) Smoking and ITt-alth ,n: r b) Developmcnt of Products and Teclinulogy C) Production facilities It W&s,felt that- thd f0if;,14'.ing '.-r; had not been. adequate-ly covcrr~,!!- Poini j.) Although niertine wi.11. be con sidered by sum- doctors to be less harmful than tt~r, there will be increasing recognition by some inedical. authorities th'at smoRing is, a nicotine dependent activity. This will, in part, cordition attitudes to nicotine. ii) There will be an increasing tendency to nssociaLc, specific smoke constituents with particular diseases. iii) Although inedical authorities will continue to advise smokers not to inhale, they will not be inclined to press such as pi-oductL, (lesigne(I to for any specific develoriment.s limit inhalation. iv) Other than the--sectors presently involved, ihe rhc1nic.,11 industryils now expected to sit on the fence in relatioi, to .the-introduction~of new srn(king matcrials,, I(A and Celaliescr, on.-the other-hand,, are expected to seek avenues for a more agF7s.sive approach; 11. 1 _.; 14,z v) I Product modifications will be seen by the anti-sinokers as an indication-of increasing sti.ccess, but a body of responsible practical doctors will recognise this as progres.-s in the direction tbey desire. via) In_tba- feresecable future, iVe. shall be aljl(-- to with all Loblcco cigUl'OfAVS, Call thitt ("IM be (1011C, %V.[1:1I substittif:c,~-, in smoking, and health tcrin::.. ON (-n BATCo document for Legal Services : Health Canada 22 October 1999 Vi.0) A.1 Uiw!t-,11 !u-) (I I I i. if h I -I kt. I I I.,) I! r" I C, I Iv ~:o t tic smokin I?, aj, (I th 1) I-o) I I cm , ~.(.Jcnl t i Eic I cJ I WiLl I give risc to Produats s0c)) to bo bov.11:1110-i. I.-jy soma authorities vi-l:F) There is a reqvirenon't for inor!a on the effects 'of smoking*, in- order -thn I. any ber-efits, rmty be identiric.A. This applins narticulsxly in ihe social and7psycholngtcal fields. 7,1 We must lx~a~n how.-to niake ethical and sciuld ho'll th claims. 'X) I-lore effort should be devotcd to nicotine'/ its nnalogues and. th'e.-ñdentiffed- irrjpr~rttjit chemi cal substances, in cig-aretto smoke. There is a gcod case for carrying out short torm .inhalati:on studies on nicotine for comparison with tobacco, and -possibly for Lie dtr,,(!T,)j)nEnt of ver . Y I ow niootino cigzlx- ettes for the, -4-4-_ a t4.-f-!:ed susceptible minority xi) Cons ti.oTi should be given to the problo-nns aris-ing frc4A.-passive smoking. xii) It %Vqs felt thatt' ~:Iwrc wn'~ a n(-c.-.d to plan activity in the following areas in order -to meet with the requirements of the planning documents:- .. . .'.' '..' . I ..' .!.. . . I . . . .. ell a) Clear avd-responsible stat~-ments on the case in favour of.smoking b) Ef-,f or tra ~t-q-taeet requirements for growing leaf wiLh modified chemical cotin)osition C) Research 1-oneraltly into additivcs and flavours ".to 4 4:1. 0%, BATCo document for Legal Services : Health Canada 22 October 1999 tho nm"H.111~ "mc) h(")JI11 front -itt Jlio 1J."A., Cori now il ror"arrLq Cir, nllrr~111-_f-iusll of J.ow (1~ ('.1i 1. wi=r I.o 5 mrr, or tar I major st-cp fumv.1.0 and possiblyJargely solving, tho problem-.- - A programme of rvork co.,.-,tiv $28 'over five years _i-s now;proposod, which -xill ,pp?-ovii c(.-rtain 'bacl-'bolle, I-L, 'A 'cnT_ n n be safelv apnli-ed -to -1ox 1. ,~additives or. flavours a d w ici T-. I de-livexy -e.,,c t r~vd-.d -111 d- =-rm ildcri--t ob+teecy -e-Ig axe t-t e~, acturc -ill then hn _Crce to comnc~tc! 1xit.11 ton. finnuf. .3rs flavours on such basic proditc-ts. 4. Passive smohing ~ittitudes- are a growing -serious vrohleir in UW U-S'. I'lit'l m9lly St..Lc~ ]'.,ills 'at present under discussion almed a t I imi ting ~,.inokj ng J n pnblic P luces . In an offort to counter this, Stanford Un.--~ersity has -tcceptcJ D. contract to I develop 111(~ans Of J*ilf:a.-~:' I ri Ill; Hlo levels 0.1 Po"I.-IntJor), flvom aigrarette smoking, in the onvilronment. Similar problems ar'~ developing in Canafln and Gor.-wny. 5. In Canada, the -Pgriciilturqi Aepai,tinetit of, the Government has a. project on hand, using sliort tprm tests, to devise a -safer cigarette. This project will examinee, amongst others, cigarettos containing Cytrel, AMF shcot, Schwoitzor Sheet, but not NS.M. i. .) i 6. Both ill Germany and in Australia, Govornment pressurn. is movin,-, to require inore smoke constitupnts It) bo roportcd, Possibly 0?1 tll~-- packe't. it, :1-ddilloll to Mr, nicof:;nt.,, carl.-,on monoxide and nitric o%iriv: iijtros-nmino-~.', pcs-~-ioidos, alid aroinat.i.e. Polycyr1i.c. :11-r- boing, 41t:. BATCo document for Legal Services : Health Canada 22 October 1999 t- I'v r i 1--; 1. :11 Lrfilj) 1-s Lo cci,4i i it(! a nipm I) or or stio, a(-t*,,-,,,i I,*,!. 1'.Icl (;I- aw! t ah I A I thotigh iin at toj~p. I. jnt,~-, hr(-,,n nridn to w,-jj,,jit I 1jr-! various ir-Qisurod eotnpoutid!~,, C.- %effective means of cLi*-i-t~=e~:-e~.~4.ut--,~.Liiiiig c-i.ffarette products- and may well sprend to cthcr countrJes. 7. Iflovc%s towards smoking and health legislif-ion in Brazil are expacted in mid-1976. This is likoly I-o fo.11ow the U-S and Gcrman pat tern . an d --tho . i ndust ry -I.e3 e:zpectnd to core--P(jf? warnings on proditcts in due cour~--,e. 8. B-AT has Given notico of its oppcjsitjo~ to the proposed U.K. ordcr, which ixuld bring substitutes and additives to cigarettes under the control of the fledicines Act. This -opposition if-, Jikely to be successful itt the short torin, but control of tobacco products I),,- law is anticipated within about two years. 9. ip- REDACTED Co BATCo document for Legal Services : Health Canada 22 October 1999 10. The iiir-od was j dvii t i 1* 1 od fo- Mi 1 1 ll:ul k I advis.ory s(:rvice un ajid ticalth wal-u!rr~', Wa" capabl-c oT fairly rapid re-ELC-Lion -to and.,,.rft,3~,s -broad and anticipatory i-ti--i-ts approach that devolopod by thc Group's NorLh American corapetitors' Companic..-, were asked to set out in detail their requ-i-reinontp, in this field. ( 11. Cons i'dern b le in-terest was shown in ttio prodtLat- activities of R & D Southampton and it was; afrrecd that a four % ~nonthly reyiew would be cirei,.4.ttted 12. Jt is the view of the Conf erenbe that the Group~ shozzl4l continue Ito suppftrt -the docision taken at Mcrano.',to renort carbon monoxide delivery internally in mg per cigarette, where this is possible. It was agreed that, for the. futurc~ consid!~,ratlon k'.-ould be given to the inclusion of studies re1,tt(:.,d to cardJo- vascular disea.-P-among the objectives ol*kLI f e S v. i (-,i ce 7, 14. The- progress of short term inhalation work in Southampton was reviev;cd success of the devclcipcd tocliniques irr xohi-evdng~=". adequate dose; of smoke to the 1ung~ c-oiAr'asted wi-th-tb-e--lac-'-~-of-suc(-.ess of previous worhers in this field. It--was reported that ihe teeliniquci and e~juipniunt were in ecinsiderable demand from both our competitors and ee-workers; Publication of the details of the technique was going ahead. Lt-was relt that the de-velcopm(nit had dolavod tho prorrc.,ss of 148H thrnugh the 11K lltzid.cr Committee .1-33tage III procedure by. highlighting shortooi-aings or (-he raeth0d.-, '111 1.0lVr t-01-171 i.nInwint-inn -Itirlivn hy ICT. ON BATCo document for Legal Services : Health Canada 22 October 1999 0 0 Cr% r%j CD BATCo document for Legal Services a. Health Canada 22 October 1999 <~ 15. En wr(Tor T) satisfy U.3. opinjon, in pni-f-ictilav ilio comr10 !I: Ch.Lngns in lung mithojogy arisilig, I'l-0111 tcrm itkimlation work ImL", bc ermfirmc-0 ns non rorr~r,.jb!;!jn.-1Tavk-. an y.-- r. rc de n c e- i n h s i ~- - P r o 1 e s . In considering the o[ futurc vicirl, in life scioncos, it was felt thit Hie immurliate nood lvos to delineate the c,;.tremc!~, of pi-o(juet changr(-*~ which could bo -(~Ucctcd' particularly ir 1.11c of lov., 0('11.V'---T-Y cigorettes, e.r_,. ventilation, A er~pails.lon and high E-Ificiency filtration. '-Che of the -. '' 17. Although 1 t'- can be argiu~d nhnt Hunter Committee anJ i4 in the U.K. . probably the legs.1 and rthi-C.0 roquiremonts whicth would need to be met in othvr a S j-opt.%rtod that this '. . . .. V I. f , . .. L vionv was Pot. necessari ly in. line Yi.th. all opinion, in the U.S.-,- for oxample. I F, . The role wad futurc of the Group Biologic.,~l Resetti-ch commt4ce was Critically rC':1eVv'.td. I t Ivus agrcc-d that in addition to the discussions which talru place at- the Group Rosearch Conferctice, the Diroctors of Rescarch ot. their reprcz;ontatives awet at SCJUtIi,WVj)',:0r1 A once a year, in order to PIIL~- ;I MOY-e aCtiV'10 PLrt iii Hhe re,~;o1ving of priorit.os anFL-eceLs For 1.11- .1 j)i*ugrvamme and obt.jir4ng wide;'eommiLmcin. to 'hc-, i3l:mned worl-, ,%,,rtj(-jjj..,tj:jy on tho pz-,rt of No. Vs-. 41- GN NJ BATCo docUment for Legal Services : Health Canada 22 October 1999 _I;_ 19. Tllv proposod cross-ovol, WfIfIrillic-111. wa~; This Is.,11111(!d at. jr-oln toijacep vigaret'l.c.-i to tDo!7,c, cont-ftining subs. I-A f.11 tor, t)y 0on,-,MMr!:, wc-ki-R, resul t in 111ort).ksed ri!~ths. of Current*un -LI e rstLllidjn~,' Of Hic development of cancers sugg~jsts j thmt. two steps, initlattoii and proi-noLion, aro necessary and are developed by different chemical subczta:nces. there is concern to- Lansure that ',Ilth0II,-h S111,01le fl-=,SLII)f~-.titaLc~- ~q love in iuitiatJoIrpotonti.al, it could 1w highr,-r th;in tubacco smolce in promotor activity.nnLI thati tharefor,-,, a combination o-f the two in s(:~quence could be undesirable. I t agrced that this. it cannot he rcsolvc-d without an experiment of thi~ type tabled, but full coirmittincnt to %; carrying out t I ho test could t3ot be obtained. Neanwhile; the results of VIC croFF,-o\-(,r e.,,I)criwilt, usinfT cigni-etto and cigar tobaccos, would be awaited with interct.;t. 20. In Gerr-inn switchiiip, j: y C'Z-rri(-d OUL V. by Schie/elbe-in on the cardio vascular effects; and compensation reactions of liuman.smrilers switch.in.- from high t to low dL-I-J--ary cignrn-tt~zs and vice versa. 21. The .-possiblo centralisation of whort term tests such tas NMFI, sebaceous .-land, cydt.eine indoN, hyperplasia, inhalation promotion and the Amos muLagonicity tost was proposed. However, it: was 1111-ally ngrovd that with the Possible exccl-ition of these tests do not transfe- Pasily or qviuhl.v uwl t-hat.. thc-ro L'Ot-0. HIC action 1k."Is to .111.0w thew to cont-.111w., operatioll in the centi. vs in 1'.111 i (1) Choy aru CIII-rently svt 111). 41:- ilk Nj NJ BATCo document for Legal Services : Health Canada 22 October 1999 U-i A 22. The work j.n F" P: W on cj,~vol(,pijr- noij cowhu:,Libl~.- ;t .. ot., - cigar(A.U.-i fi]'[(~rs iti now eowplot.o. / In c>rdt.-r to hol-pi'LlIc I options on non Lobacteo smoking materinls, wi0ch aro av-ailab)u to the B-XI' Group, &s-ep&t-r--A.4--f*@w_-.eTb+L- anJ to it) ta4~n -.a /.4, co.rnpp-t-I.-tive-pofil.t-ir.7n,. it wFI-3 f0lt of non combustible fil.'Ier nhol0d In the short-term.. No tr-rtg nn.sc for capital investiijent in seni.-conitnercial plsnt at this stage. 23. The otiv,-ent view on compotitivn Lobacco substitnLcs is that NSM i rnoA aettertable than Cytrcl in biological. torms apa-r-t-Crom its high carhon moroxjdr~ d~_,Iivery. clnc~"' i.C I-lot both, of the-,o matra-i.als: arn currently being in the U.K. 24, '~J!c Cl ory MIIII plant will. go into the commorcial Production of VRT for IFD fit 8uptomb~,r 197G. A Tor arrrecment on thc patent pos,-ttinn livs bt:un disv-..~;wd V.,ith Schiveit,-,er. This involvcs- of i_-If~tonts. !I] Brazil, a czoreflil!..study is being inarie of the various alternatives which are available relating to the construction of a large scale plant. In aevelopiw-nft worle, an exercise is currently to design a small 500 tons per annuin plant for- intiller -compraiL-s. This will not necessarily be basod on the I'oudrinicr type machine. 25, Germany is cnrron~ly (-.pcrirlwntiti~; w i t 1-1 -;jIC(It produced by Schwci tzor cr%nt.-Oning 20' chalk vild 57 wood pt? 11). This is a 0110,11301' pvc-durt 'with atti-activc, coI;:mwI.Ci;11 po:.: j. hil i t. i c CYN BATCo document for Legal Services : Health Canada 22 October 1999 r i f 1" 1-111 f' I R, ' 1~ 0 1' rs L-til f Ujig, on thn rnacLlon of :anokcrs Lo prodiscA!-, -wLlh 'k- to-nd 1.0 LI-y W tako 111ore smoke rroln low (I~Aivf~ry prodl, * C t! i- - 4 -J! ...... T over short periods of time. A.T-I)tL L their rc).-;rjonr-.,, ovce lorgor acelintatisation is notteloar. resu-IA's f havo heo'n-41btain,4 ol- t:))n repollp'o. of sulnhr.-I'S 11.0 of wri-Idely--mr:k4 wiLb rqr)re-.P-1-ese-3-y oil trolleproducV3 27. With the conti nulnrr L or d-1, i v,!-y cigarette brands, FL prc:Ssi_)~, Col- --the efficiency 4rj.1ters with go,;-d ts %.-L a r 1 perties i,.,. r-, ci.e-, iden tif ied.. 28. Attempts shou-Id be rjvtdc~ to jn0%,e lway from t1je cu.2:rent ail hoe approach to f Ln v o i i r d,:~vv. I oirnez It , nar t j cu I ft rl. y i n t e 't-i" is of the (Invelol.)l1tont of T1-'LV(Jur!-; 1~,;r low clu'livery SeieuLif~c jruthads nc-(A Lo he develonc;d for the identification and comparisoa of fl.- 29. Tile availability of high porosity cignretto r:q)er in various countries for the proditetion of low dolivory cigarcttes was revtowcd. 1"rogress in tho inanufacLurc of such Par)er.,; is particuLarl~ advanced in t1jo 11 d I, t! Upe was agreed th.Lt similar devcJopillont"s should be ono-ouraged ()?I the parl. of the Grcup's suppliers elscwhere iv the world. Pnpers of hij.-,h naLut-;O pol'o."Lly are fx) r'!(tili.Lato th':~ Droduction of low ent-hoil :11ollo%ido 30. jO ropol't-ed to bc j ns 1-111 i I P, t o r, I (I I , p: t, - k C' d C i f o t f oc; I i I U; r