Interim Report In the recent addiction literature, emphasis has shifted away from an exposure model, suggesting that drug (particularly opiate) use engenders a powerful urge towards subsequent compulsive use, to adaptive theories, proposing that drug use is an attempt to adapt to chronic stress of whatever origin. This shift has been prompted by an accumulation of evidence which cannot be accomodated within an e.@posure model - the fact that casual use of opiates is relatively widespread, that some heavily addicted groups (Vietnam veterans, e.g.) show only moderate levels of recidivism after induction into civilian life, for example. Metabolic theories, such as Goldstein's proposal of a fundamental opiate avidity in mammals, or the recent claim that repeated exposure to opiates might create a long-term incapacity of the body to synthesise endorphins,their endogenous counterparts(Snyder, 1977), have proved not to be viable. Nor have conditioning theories, the other influential approach of this genre, whether these employ a simple positive reinforcement or avoidance learning model, or more formally developed models, such as Solomon and Corbit Is opponent-process theory (Solomon, 1980), which integrates both elements. Adaptive theories, which appear to violate conventional wisdom about addiction, view drug use as a coping strategy, a means of handling distress, whether this is due primarily to inadequate person- ality, a need to reduce physiological or psychological pain,as a means of dealing with social stress, or as a response to a violent or hostile environment. Adaptive or coping mechanisms include opiate use, smoking, drinking, over- and under-eating, 'Type Al behaviour,the overuse of denial. Considerable evidence in the current literature increasingly supports this view (cf. Alexander and Hadaway, 1982). A similar theoretical shift is observable in the literature dealing specifically with smoking, and, to a lesser extent, alcohol use. Arousal modulation theories of smoiing maintenance propose that psycho- active drugs such as nicotine are used to enhance performance when the individual is bored or fatigued, and to promote 'psychological comfort' A when he is anxious and/or stressed. There are indications that the particular drug used is, to some extent, a function of the person's social experience and expectations, drug availability, cultural sanctions on drug use, and so forth. It seems a reasonable inference from this that if an habitual user is cut off from his source of supply for whatever reason, he will migrate to other, more readily available drugs. which produce essentially the same effects, a finding which has been recorded with heroin users (Wishnie, 1977, e.g.). C:> r_j (-N t__j BATCo document for Province of BritiSh Columbia 13 April 1999 This is the background to the proposed research. A study by the present author, with J. F.. Golding (in press, Behaviour Research and Therapy Monographs) has reported a range of biological/psychological variables predicting smoking prevalence rates amongst adolescents in the age range 11 - 18 years. Subsidiary analyses, which were not reported, suggested some tradeoff between smoking and other drug (alcohol, solvents) use - although the exact nature of this was not established - as a function of the 'steering' factors mentioned above. Such migration was seen as an attempt to maintain d psychological 'steady state', this applying particularly to groups expressing high levels of anxiety, psychosocial discord and stimulation seeking. The present study attempts to test the polydrug hypothesis. A questionnaire has been constructed, consisting of two sets of items, which have already been pre-tested. The first set includes items which, from the previous study, proved to be predictive of smoking and drinking prevalence rates (anxiety, stimulation-seeking and so on). The second set is concerned specifically with aspects of drug use - the range of psychoactive drugs used, availability ( in part a function of age), cultural/familial sanctions, perceived effects of drug use, effects of health education programmes etc., i.e., with the whole gamut of factors which appear, from the literature, to be relevant to a migration hypothesis. In the first phase of the study, these questionnaires will be administered to groups of approximately 200 Ss (100 boys, 100 girls) in the 14, 15, 16, 17 and 18 year old range. Multiple discriminant/ regression analyses will be computed, comparing the psychological and sociocultural profiles of non-drug, single drug and multiple drug users, the latter group including those single-drug use 'rs who have emigrated'. From these analyses, it should be possible to isolate those factors which are relevant to migration, given that such a phenomenon occurs. Note that the non-drug group will be limited in size, since it will function solely as a control group. A microclinical study of selected Ss (approximately 100) is proposed in the second phase of the investigation. These Ss will be intensively interviewed about different aspects of psychoactive drug use. The interview format and content have not yet been decided, as these will depend to some extent on the resultb of the first phase. in general, however, interest will focus on the nature, timing of, and the -Bob BATCo document for Province of British Columbia 13 April 1999 3 psychological and sociocultural factors relevant to any tradeoff disclosed from first phase data. The sample has been selected, the non-standardised items pre-tested, and testing planned to begin in February, 1983, when schools recommence. November 29, 1982. G. L. Mangan U-4 LJI BATCo document for Province of British Columbia 13 April 1999