CLINICAL AND INVESTIGATIVE MEDICINE
APPENDIX I
MEDECINE CLINIOUE ET EXPERIMENTALE
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cardiology THE NORPHOLOGIC -FEATURES OF CHRONIC BRONCHITIS: A UASSESSMENT
cardiology JBK Rullens. ER Viggo*, TL Vrlgbt*. PD Part, JC Roxx Untrq. b J1.
Clinical Ruedy). VBC Pula Res Lab. St. Paul*@ Rompital, Vancouver. N.C. ll
Pharmacology Since chronic bronchitis was defined by the Ciba Symposium in 1959 as
Pham%acologie
Clinique -chronic or recurrent excessive mucus secretion in the bronchial troe'.
Devtlopffwntal sucous gland enlargement rather than inflammation his boon the gene@rally
Biologyaccepted pathologic yardstick of cbromic bronchitis. To reassess tjliie
&ologie De is
c*wcopperrientpatbologic changes to chronic bronchitis we studi*d'largel and small: air-
Endocrinologyway pathology, emphysema scores and pulmonary functio: 1:120 Patients
EndocAnologiewith mucus bypersecrettan and compared those values t 2 control$ bf
Esildemiologystakilar'age and smoking history. All subjects were patients undergoing
Epid#miowgieresectional surgery for isolated cotn lestoat. Measurements of lung
GasiroenTrologyvolumes. flow rates and diffusing capacity were obtained pre-operatively
Gastroeni Wogoe and the specimens were processed for quantitative morphology. Cartll-
Genetics aginous airways were graded for inflammation involving the muc
rAntliQue "$:it' tal
glands, gland ducts. interstitium, smooth muscle and nerves and 0
Hematology inflammation @care wag obtained by summing all atz values. Airway istru-
boArnatologle ctural components were measured using a digitizing board. The seveitty
pertiension of the small airway pathology was established and the emphysema eatima-
knimunology t*d. Chronic bronchitics bad significantly greater sucomal and total
knerturiologle inflamation to cartilaginous airways greater then 2mm (PC 0.05) as well
infectious Diseases
Maladies as gland and glazd duct inflammation in cartilaginous airways gr*at.or
Inlectseuses than Ama (p< o.oS). 3io difference In mucous gland size was preattaL.
Metabolism The measurements of small airway pathology. amptlysens, and pulmonary,
LVIlabolisme function were similar to the two groups. We conclude that cartilaginous
wephrology airway inflammation rather than mucous gland enlargement best separates
hophrologie Chronic bronchitics from controls. Supported by KRC of Canada and D.C.
Neurerscierices Lung Association, and the Canadian Tobacco Manufacturers' Council.
Science& Nev"A.
Orcolop umbel of abstracts. poster sessions
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BATCo document for Province of BritiSh Columbia 16 April 1999