RESTRICTED
Reference No.
C2. 1
Research Conference, Canada - August 1982
EFFECT OF REDUCING DELIVERY ON CHEMICAL
AND BIOLCGICAL PROPERTIES OF SMICKE
Dr. L. C. F. Blackman
Backaround
The UK Independent Scientific Committee has indicated to the Tobacco
Advisory Council that the analyses of smoke components other than tar,
nicotine and carbon monoxide will feature in the forthcoming (October?)
3rd Report of the Committee. We also know that the U]K Government
Chemist is planning to monitor UIC brands for formaldehyde, acrolein,
NO and HC`N - most probably on a routine basis in 1983. It is not known
in what form, if any, the results will be widely published. The Finnish
Government Chemist has for some time been monitoring Finnis- brands for
the same components, plus cadmium and lead.
The MPOC, on 30th July, 1982, agreed that GR&DC should analyse the
major UK brands to establish where BAT stands. The possibil 6 ty of GRSDC
undertaking a similar survey of major European brands will b; considered
at a later date - (The advantage of having a common methodology was
recognised.)
Over and above this growing interest in gaseous and vapour phases, at
a recent ISC/TAC meeting, the ISC indicated a renewed interest in the
'smoke profile' or "tar quality" of present-day cigarettes. The
Committee appreciates the massive amount of e!.Iort that has been
directed to the biological activity of smoke over the past 25 years,
but feels that with 19806 technology it may be possible 'lo identify
significant changes in one or more of the commonly regarded Inasties"
though the Committee has not indicated just how many of the c 3000
- though in smoke constituents are in their view potentially "nasty'.
By coincidence, we at GRGDC had asked ourselves the very same question
only a week before th. ISC/TAC meeting.
In simple terms, we asked the question: "As the no tar level is
reduced by filtration, ventilation, or a combination oi both, how do
the deliveries of selected 'nasties' diminish - at the same rate or
faster or slower?' Further, if significant changes are identified,
how do these relate to the biological activity?
Taken to the extreme, these questions could amount to a tremendous,
virtually open-ended, programme of work. It should be possible,
however, to design a feasible initial programme: for example, to
design and manufacture cigarettes delivering 30, 20, 16, 10, & and I mg
tar from a limited number of tobacco blends (e.g. !Ilue-cuced, US blend,
European blend) and to analyse an agreed selection of smoke components
(those cited above, plus nitrosamines, phenols, benzpyrene, etc.),
using the most sensitive techniques we have, e.g. KPLC, MR.
It is proposed to discuss this proposal in some detaill at the Conference
with a view to implementing a programme in 1963.
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C 196.' Ortush Arncmcan Tobacco Co. Ltd. This -nust not be copied at -ti;o*n,.-
Co
BATCo document for Province of British Columbia 19 April 1999