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BATCo document for Province of British Columbia 15 April 1999

DR. FLETCHERS SMOKING PANELS
AT R. P. G. M. S. HAM14ERSMITH
STATISTICAL ANALYSIS OF FIRST
TRC TRIAL
Ref. No. R. 395 25.4.73.
Author Passed for C irculation
Mr. M. W. Whittaker Mr. W. S. Paige
copy No.
-60
Circulation
copy Copy
No. No.
1. Research Manager 17.) John Player & Sons,
2. Mr. G. II. Ceffort 18.) Nottingham.
3. Dr. J. H. Chesterfield 19. Ogden
4. Mr. D.A. Jones 20. Mr. J. S. Campbell
S. Mr. L. L. Page 1.) Dr. R. V. Smallman
2.) (for IDL Health Liaison
6. Mr. W. S. Paige 3 ) Group, R. V. S. I JoMot
D. T. Wcotcott 4:) J. V. G. , D. M. C.)
7. Dr. 25 .)
S. Dr. A. Springall 26 ) Mr. J.V. Gregg
9. Mr. M.W. Whittaker 27:)
(To pass on to Pr. Freedman)
10. Mr. P. I. Adams 28. Mr. M. J. R. Healey
11. Dr. H. R. Bentley, T. D. B. (MRC Statistical Unit)
12. Mr. W. C. Owen, T. D. B. 29/34. Mr. G. F. Todd
13. Secretary, T. D. B. (for TRC Committee)
14.) 35/44. Dr. S. J. Green
15.) W. D. & H. 0. Wills, 45. Library
16.) Bristol.
C:)
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BATCo document for Province of British Columbia 15 April 1999

SUMHARY
Dr. Fletcher of the Royal Post Graduate Medical School
attached to the Hammersmith Hospital, has organised a group
of men from local GP's lists who are prepared to smoke exclusively
special cigarettes supplied by RPGMS.
The primary object of the tria'ls are to investigate
the possible changes in certain symptoms of bronchitis in a
group of men who change to smoking modified cigarettes. In
the first trial reported here three cigarette types were smoked
which differed in level of Vapour Phase and PM (WNF) ; the cigarettes
also differed slightly in nicotine delivery.
This report concentrates on the statistical aspects
of the results and any medical implications are left for people
who are qualified in that field.
Four variables were statistically analyzed, namely,
Cough, F. E. V. (Forced Expiratory Volume in 1 second), Sputum
and Cigarette Consumption. Large proportions of missing data
caused some concern about the accuracy of estimation of the
effects. After careful scrutiny it was concluded that the results
for Cough were reliable but that the results for the other variables,
particularly sputum and F.E.V. , should be treated with extreme
caution.
In general, the older men, the heaviest smokers, those
with the lowest Prior F. E. V. and those with the higher Prior
Cough, recorded the most coughing and sputum, and the least
F. E. V. Prior Cough was the most dominant factor underlying
coughing and Prior F.E.V. was equally important for F.E.V.
A seasonal cycle was suggested for Cough and for Sputum;
for both variables the response was higher during the winter
months. Cough and Sputum also declined over the duration of
the experiment. For sputum, this reduction was accentuated by
doubtfully low results during the last two months of the experiment.
Of the three cigarette types smoked, 'A" and 'B" (see
Appendix I (a) for details of the cigarettes) did not yield significantly
different results for any variable. Cigarette "C" (reduced
Vapour Phase), however, showed approximately 101 less coughing
even though 8% more of that type were smoked.
Significant differences in cigarette consumption were
observed during consecutive three month periods of the experiment.
A seasonal cycle was not apparent, but the consumption seemed
to increase slowly during the first half of the experiment and
then to stabilise. This pattern was similar to that observed
from an experiment which studied "Smoking Habitm ; as reported
in the I. T. G. Research Department report reference number R. 375.
Many interactions were significant and interesting
refinements to the general pattern of results were indicated.
Some of the more surprising deviations frum this pattern were
7
explained by unexpected cigarette consumptions and from the 7
results for cigarette C..
4h.
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BATCo document for Province of British Columbia 16 April 1999

INTRODUCTION
This report presents the results of a statistical
analysis of the data from an experiment conducted by Dr. Fletcher
of the Royal Post Graduate medical School at Hammersmith. The
statistical analysis was carried out at the 1. T. C. Research
Department on behalf of Imperial Developments Ltd.
The experiment involved men, with known respiratory
symptoms, who had volunteered to smoke cigarettes supplied (free)
by the hospital (via a market research agency). Three, specially
manufactured, cigarette types were used; they were identical
in appearance and in packaging. The main experiment lasted
for 23 months.
The primary object of the experiment was to see if
differences could be detected in the symptoms of bronchitis
in a group of man who changed to smoking modified cigarettes.
However, this report concentrates on the statistical aspects
of the results and implications of a medical type are avoided.
Design of the Trial (from S. Freedman et al. J. Nat. Cancer
Inst. 48, 1972, 1805)
The men were recruited from lists of 6 general practitioners
in the London Borough of Hammersmith. Short questionnaires
about smoking habits, cough and expectoration were sent to 6,000
men. Of these, about 600 men fulfilled the following criteria
for inclusion in the trial:
(1) age 25-54 years;
(2) smokers of at least 10 cigarettes per day; and
(3) a persistent cough and expectoration as defined by
affirmative answers given in the Medical Research Council's
questionnaire on respiratory symptoms. Men with a history of
chest disease other than bronchitis were excluded, as were those
with other conditions which might have affected the results.
Over 300 of these men who were willing to co-operate
in the study were visited by trained field workers twice during
the summer of 1969. During these visits, the field workers
administered a detailed questionnaire about smoking habits,
respiratory symptoms and other illnesses. Also measured were,
forced expiratory volume in one second (F. F.. v.) I vital capacity
(V. C.) , sputum-(as collected in a special container, by the
subject during the first hour of the day), and cough frequency
using a special questionnaire technique. During each visit,
the field worker tried to persuade the.man to stop smoking;
45 men did so.
The remaining men who wished. to continue with the
experiment were then asked to smoke exclusively, specially manufactured
cigarettes that were supplied free by the hospital. This was
the first occasion on which cigarette supply was mentioned.
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BATCo document for Province of British Columbia 15 April 1999

The men were divided into 75 matched triads (3 men
in the same group). Each group consisted of individuals
closely matched for age, cigarette consumption, cough frequency,
-and F. E. V. Each member of a group was randomly allocated to
one of three test cigarette types. Every subject smoked
cigarettes of the same type for the duration of the experiment.
The cigarettes were specially manufactured and
were identical in appearance and in packaging. They were designed
to provide a standard nicotine content with varying amounts
of tar and of constituents of vapour phase. Details of the three
cigarette types, labelled A, and C, below, are presented in
part (a) of Appendix 1.
The trial began in November 1969 and ended in September
1971. Each man was interviewed once per month by a field worker
and the observations described above were recorded. In addition
to the variables mentioned, each man was asked to collect the
butts of all the cigarettes he had smoked during the previous
24 hours; a special box was provided. These butts were analyzed
at the-Tobacco Research Council's laboratories to estimate nicotine
dose.
Data for Statistical Analysis
The variables analyzed at the I.T.G. Research Department
were Cough, F.E.V. , Sputum and Cigarette Consumption (per month).
The estimates of Nicotine Dose and the other variables were
not readily available for analysis.
For each variable, data for a particular month were
included only if a triad was complete. This action was taken
to overcome practical difficulties of analysis. It was unfortunate
since this added to the already large proportion of data lost
during the experiment.*
The number of observations included for analysis (for
Cough, F. E. V. . Sputum and Cigarette Consumption) was 3066, 2664,
1695 and 720, respectively. The complete set of data, consisting
of 75 triads over 23 months,.would have given 5,175 observations.
of the original 225 men, 30 dropped out for various reasons:
2 died, 3 were told to stop smoking by their doctors# 5 failed
to co-operate, and 20 moved away.
For further details of the data see Appendix 1. Part
(a) presents the coding used for the different factors (and
levels) of the data classification, and part (b) indicated the
number of observations under each factor level.
Prior to the statistical analysis it was thought that
the data for Sputum was suspect. We were, therefore, advised
to treat these data with particular care.
Whilst it is not possible to attach a figure, the
reduction in "power" caused b this additional loss of data
.Y
is partly offset by an effective "balancing" of the data.
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BATCo document for Province of British Columbia 15 April 1999

Statistical Analysis
A generalised analysis of variance was performed
on each of the four variables. The statistical model was
necessarily large and a complete analysis could not be
obtained directly. Instead, four separate but theoretically
linked, analyses of variance were performed on different
linear combinations of the three types of cigarette. This
was valid since each member of a triad smoked a different
cigarette type.
Details of the four analyses are presented
below in Table 1. Every factor was treated as a fixed
effect. The letters A,B,C refer to the three test
cigarettes and "ANOVA" denotes analysis (or analyses) of
variance.
Table 1
Analysis Details
r1111 I
ANOVA Statistic Main effects Some effects of the
Number Analysed included in model "Statistic Analysed"
Age, Prior (1) Each main effect is really aj-
consumption, interaction with one component of
Prior Cough, Cigarette. That component of
Prior F.E.V., cigarette (orthogonal to that
1 A-B Time Period (8 in Anova 2) is given by the
month intervals) Grand Mean of this analysis.
(2) The residual variance is
twice that of original variable
2 1/2 As for ANOVA 1 (1) As for ANOVA 1 with the
(A+B-2C) Cigarette component orthogonal
to that in ANOVA 1.
(2) The residual variance is
1.5 times that of the original
variable.
3 1/3 (A+B+C) Age, Prior (1) The residual variance is
Consumption, 0.33 times that of the original
Prior Cough, variable.
Prior F. E. V. _
Time Period (3
month intervals)
4 1/3 (A+B+C) As for ANOVA 1 (1) As for AN 0 VA 3.
cc
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BATCo document for Province of British Columbia 16 April 1999

A140VA 1 and 2 were conducted an within-months
comparisons, 3 and 4 were affected by the monthly mean.
Thus iit was possible to include higher order interactions
between all factors involving Cigarette in ANOVA 1 and
2, and to allow for possible effects due to time during
the experiment in ANOVA 3 and 4. Possible incre %ases of
precision of the estimates were obtained by effectively
extending the statistical model.
For each ANOVA, interactions between the main
effects listed were included according to the limitations
of the data and of the computer store. In general, more
interactions were included for those variables with more
observations.
From each set of the ANOVA--1-4, two analysis
of variance tables, labelled (a) and (b) , were constructed.
They are presented in Appendix II (a) . The ANOVA labelled (b)
were formed from the original ANOVA 1,2 and 4. To complement
too-., this, the ANOVA labelled (a), in which the possible time effect
was represented by 3 month intervals, were obtained. In each
case due regard was given to the different scalings of the
residual variance such that in the final tables the variances
given relate directly to the original variables. The effects
themselves were also appropriately scaled.
As a very crude check on the adequacy of the models
used, residual errors were also computed by pooling the "within-
cells' variances. Details of this are given in Table 3 of
the next section.
Mean values and standard errors were computed for
the main effects and for the significant interactions, and
Duncan's Multiple Range test was applied to these significant
main effects with more than two levels. See Appendix III for
details. The significant interactions were also illustrated
graphically as shown in Appendix IV.
A significance level of 0.01 was taken when assessing
individual tests of Hypothesis-. Whilst it is not possible
?00@'@ to be exact, it is estimated that the overall significance
level was approximately 0.05. That is, the probability of
falsely assessing one or more effect to be significant, was
approximately 0.05. The significance levels, based on individual
tests, are .summarised in Appendix II (b) . Where an effect has
been duplicated (that is, present in both ANOVA I (a) and (b)
the result was based on the ANOVA with the smaller residual
variance.
Reliability of the Results
In view of the large proportion of missing data
it was necessary to consider tile raliabiliLy of tile results.
Any statistical analysis of incomplete data must carry with
it elements of doubt about the accuracy with which the effects
have been estimated. Some bias in the estimates is inevitable
and, hawever sophisticated the statistical analysis, it cannot C=)
be removed completely.
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Of importance, though, is the extent of the bias
and an awareness of which effects are likely to be most
affected. This is discussed in the following paragraphs of
this section. Other reasons for bias, such as the possible
initial misclassifications of the men, spurious results
due to lack of co-operation by the subjects and iny artificial
element introduced by the cigarettes being free, must also be
borne in mind. These and other aspects are worth careful
consideration, bit they are not discussed further in this
report.
Two rather superficial observations might suggest
that the results were reliable. Firstly, the general pattern
of the results were as expected. Secondly, the levels of
significance for the individual tests-showed no significantly
low probabilities. However, the results shown in Table 2
below suggest much less reliability.
Table 2
Residual Variances
Variable Cough F. E. V. Sputum Cig.
Consumption
Source
of 1d2 d. f 2 Id. f . -62 d.f. d.f.
Variance Measure ?2
I ANOVA 1 5.37 988 0.16 846 17.6 218 44,116 538
ANOVA 2 5.20 9 88 0.29 84 6 26.0 218 37, 4 22 5 38
ANOVA 4 4.95 988 0.19 846 27.2 218 24,137 538
Pooled 4.62 942 0.15 805 23.6 188 -
Cell
@@,riance
In Table 2 the "Pooled Cell Variance", a cell being
defined as in ANOVA 4 (see Table 1), was obtained from the
mean value for each triad. The variances themselves, listed
under '62 were appropriately scaled and refer to the original
variable.
Since only complete triads were analysed, with each
member of a triad smoking a different 'cigarette type, one might
expect less Lias in Lhe effects t1wt involve Cigarette. Had
no significant effects involving Cigarette been excluded
from the statistical rno de I then the residuals given by
ANOVA 1 and 2 would be the same except for sampling error.
In fact they were significantly different for all variables
but Cough, though the difference was only just significant co
for Cigarette Consumption.
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BATCo document for Province of British Columbia 16 April 1999

in addition to this, it is also possible that several
significant effects involving Cigarette that were not included
in the model could leave balanced each other out over the two
components of Cigarette. In this case both variancos would'
be higher than the true residual error. A comparison of
rows I and 2 of Table 2 with the best available estimate
of residual error, shown in row 4, suggests that for Cough
at least the results were reliable. Again the results for
F. E. V. and Sputum were not very encouraging, whilst no
"Pooled Cell Variance' was obtained for Cigarette Consumpti on.
As a check on those effects not involving Cigarette,
row 3 is compared with row 4. Cough again seemed reasonable,
whilst the results for the other variables were disappointing.
Notice that for Cigarette Consumption. the variance in row 3
is much lower than for rows I and 2.
It is concluded that only the results for Cough
are regarded as being reliable. The results for the other
variables, particularly Sputum and F. E. V. , should be
assessed with great care.
Presentation of Results
Table 3 in th text, shais tile mean value and
its standard error at individual levels of each main effect
for the four variates. In Appendix II the final analysis
of variance tables are presented, followed by a sLumnary of
the significant effects. Tables of means of th main
effects and of the significant interactions are shown in
Appendix III. In Appendix IV the significant interactions
are also illustrated graphically.
It has been stated that this report concentrates
on the statistical aspects of the results and that implications
of a medical type are avoided. However, since many readers
will have received a medical, rather than a statistical
training, the following generalisation has been made
to enable a more appropriate presentation of the results.
It is that, Cough, F. E. V. and Sputum can loosely be regarded
000*,-@ as alternative measures of "bronchitis ", or perhaps- less
precisely of "chest Health' . Hence, it is logical to
present the results for these variables jointly.
Cough, F. E. v. , Sputum;
Table 3 shows the folluaing general results for the
main effects. Notice that cigarette difforonces are not
mentioned here. A separate sub-section is devoted to
Cigarette effect.
The older men, the heaviest smokers, those with
the lowest Prior F.X.V. and those with tile higher Prior Cough
recorded the moGt coughing and SpUtUILI and the least F. L. V,
Prior Cough was the inost dominant factor underlying coughing
and Prior F. E. V. was equally impurtant for F. E. V.
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BATCo document for Province of British Columbia 15 April 1999

Table
of Main 37'7.-,@%ct V--,@ns
variatc Cough Z. V. Cigarette Sput=
Const=-,ption
Illeasure 7 S.E. E. 7 S.E. S.E.
19 TS -
Factor Level
1Cj arette A 4.77 0.07 3.14 0 02 750.5 6.7 4.7711' 0.31
g
4.68 0.07 3.34.0 0 C2 'I'S 2 A. 6.7 5 .
Ell O' 0.31
C 4.30 0.07 3.13 0.02 .-07:8 6.7 4.6'71 0.31
.6 6 . 6 3 . 3 8
to'-N, g e 4. 3 4 0.05 I- 3.7 -01 74IG 0.29
2 4.33 0.06 1 3 . O, 0.02 7 9 9 4.5 6.61 0.2
'2-ricr Cig 1@ 0. 0 e. W.- 7117.5i! 7.6 4.10" 0-53
consumpt-fonI 2 4-: G _- 0.06 I OX C, 6.1 3 - 2' 2 0.2'
1056.7@ 6.3. 5.99 0.27
3 92 C.07 j 01 zi 0.02 -
Prior 1 I 3.73 10 06 3X51 O . 01- 753).4! 6.0 4.04 0 31
C 0 u, g h 2 5.40 10:05 3.1-9! 0.01 737.0. 4-.-S 15.50 0 23
4.78 '10.07 -.02 j 756.7, 5 3 4 . 56 0 29
2 1 9' 10:07 -.02) 7C3.7'. 5:3 4- 0:32
3 4:49 0 0 7 0.0'.. 5.55 0. 34
T I M3 1 1 5.04 0.07 3.13, 0.01! 759.8@ 6.2 06 0.29
Period (P3) 2 4.44 0 07 I 0.011 733.3; 6.1 1 5 35 0.42
3 41.29 1'0:08 3.12- 0.0211 7G7.C,,' 7.2 12.90 o.28
Time 1 5.29 0.12 2. 11 0.02,' 734. 9 5.72 0.47
Period (PO-) 2 5.15 0.10 3.13 0 0@1 772.Gi 9.5 6.01 0.46
4.40 0.10 3.14 0:021 773.63@10.0 5.22 0.58
I
4. 2 1, 'O.-10 O. 0 - 779.3@'10.9 5.06 0.63
C.O" 7 9 2 C 4
5 O."i 4.25 O.Gs
'LO. I
S 9 10.13 1 5. 2 3 0.84 1
3' -.0.7 4.61 O.,
7 4.22 1@0.12 0 . 0 37.4 .- 04
a i 4.0.5 @10.13 I 6 I 0 . 03 7 T.3 . 6 2 2.05 ';0.30
The fol except-Ions to the ,,:none.' oattern were
0,
observed r -.1 t:-c e,ffectz. Th e rd, Pr4 o=, Consumption u
yielded less, -c'- sig-nifIcantly less, C-putwm th.an
the lm-rcs@.-. 7r-Jo-- Conn----:n--p---Jon %nils-t- F.E.V.
-@n Cd --ic h-1-hast
roup re Co -dc r: 5 n-. - can 1--ly Ic!7..-7 sn!, tun Co
P r i o r F . E . V . S = ct: r. Th a Z' a = C o,-, q -- rz':. 0 Ci- a v e a --j
Co
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BATCo document for Province of BritiSh Columbia 16 April 1999

higher F. E. V. thar. did the lower Prior Cough group and equal
coughing was rec. '.-d by the two highest Prior F. E. V. groups.
The in. . ctions show further refinements to the..
general pattern. : igures 1,2,13,14 and 29 of Appendix IV
show that the majur difference, in Cough, F. E. V. and Sputum,
between the two age groups arose from the heaviest smokers,
those with a high Prior Cough and those with a low Prior F. E. V.
Also given by these figures, plus figures' 3,6 and 13,
is the suggestion that, for the men observed, both Cough
and F. E. V. were limited in value, in both directions.
Figure 4 shows th interesting result that coughing increased
with Prior F. E. V. for the middle Prior Consumption group.
Table 3, in the text, shows apparent seasonal
effects for both Cough and Sputum. In-both cases the
response was higher during the winter than during the
summer. For both these variables the response fell during
the experiment. However, this was accentuated by a doubtfully
low sputum during the last two months of the experiment and
by a sharp decline in coughing over tile first six months
of the experiment.
Figures 5 and 9 shad a sharper decline in coughing
during the exporiment by the lower Prior Consumption group
than by the'other heavier smokers. Figure 31 shows a sharp
increase and then decrease in sputum by the highest Prior F. E. V.
group over the duration of the experiment.
Cigarette di
Significant differences, in Cough and Cigarette
Consumption, were observed between the cigarettes. Cigarettes
A and B were not significantly different from each other for
either variable. It was particularly'intaresting that coughing
was lowest for cigarette C, even though more of that type
were smoked. See Table 3 in the text for details.
Figures 7 and 8 of Appendix IV show that the lower
coughing when cigarette C was smoked, arose mainly
?0", from the older men and from the two extreme Prior Consumption
groups. Figure 10 shows that similar coughing was recorded
for cigarettes A and B by most subject groups. The response
was consistently different for cigarette C. Also, the
difference in coughing by the two age groups is seen to
have arisen from combinations of the more central levels
of Prior Cough and Prior F. E. V. for cigarette C and from
combinations of the extreme levels of the same factors for
cigarettes A and B.
Figure 16 shows that cigarette C gave rise to the
rather high F. L. V. among the highest Prior Consumption group.
Figure 19 shows the difference in F. E. V. among the two age
groups to depend upon both cigarette type and the Prior C::>
C=)
Cough group.
The sputum response for cigarette B is shown by CDO
Figure 30 to reduce greatly over the first half of the ___4
experiment compared with little change for the other 00
cigarettes. N.)
BATCo document for Province of British Columbia 15 April 1999

Cigarette Consumption:
As stated earlier, significantly more of Cigarette C
were smoked than of types A and B. It is also shown in Table 3
that the older subjects and those with a higher Prior Cough
sinoked more than the men from the opposite groups. A
surprising result was that whilst tile highest consumption
was recorded by the highest Prior Consumption group, the
lowest group smoked more, though not significantly more,
than the middle group. This could account for the unexpected
sputum yield among levels 1 and 2 of Prior Consumption. Also,
the middle Prior F. E. V. group smoked less than the lowest
Prior F.E.V. group whilst all information concerning tile highest
group was missing. See 'Comparison with Freedmans paper'.
Figures 34 and 40 of Appendix IV short that the
higher consumption by the lowest Prior Consumption group
arose from the older men and from cigarette C. In addition,
figure 35 shoos that- the older men with the higher Prior Cough
smoked appreciably more than the corresponding younger
subjects with a nonsignificant reversal ariong th age groups
with a low Prior Cough. Figure 36 shags a similar result
involving Prior F-E.V. These results were consistent with
the general pattern outlined under "Cough, F. E. V. and Sputum".
In this connection, also see figure 39.
Significant cii in consumption wore observed
between consecutive three month p-criods of the experiment but
the changes did not. correspond with the seasons. Fi 37
shows the older mcn to have smokod increasingly more than tile
younger men as the experiment progressed.
Comparison with Prccdaian's paper:
The saine dal%-.a were also analysed by S. Freedman at
the I Modical School. 11is results were published in
J. Nat. Cancer Inst. 48, 1972, 1805.
A clear description of the statistical analysis
carried out by Dr. Freedman was not given but the results
suggest that no account was taken of the unbalance over the factors
caused by the missing data. Consequently a few results were
different from those given here@, but more important far less
detail was detectable. This lack of detail prevents a
thorough comparison of the two sets of results.
The analysis carried out at the 1. T. G. Research
Department showed a seasonal effect for Sputum; this was
stated as not present by Freedman. Apart from this minor
difference, excepting for Cigarette Consumption, were shown
or suggested between the cigarette means at different stages
of the experiment.
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-7
The large difference between the "overall" mean
values for Cigarette Consumption almost certainly stemmed
from the fact that the consumption figures for the highest
Prior F.E.V. group were not available for our analysis. By
comparing the two sets of means a very approximate monthly
consumption by the highest Prior F. E. V. group is seen to be 950-1000
cigarettes. This could account, for the very high sputum,
and the high coughing by the highest Prior F. E. V. group.
Figure 4 of Freedman showed interesting estimates'
for the nicotine retention by the three cigarettes. This
might suggest the even more. interesting result that for
cigarette C the coughing was less even though it had the
highest actual nicotine delivery. However, without confidence
limits for the nicotine retention estimates it is impossible
to draw any serious conclusions. In addition other aspects,
such as tip filter efficiency would need to be considered.
Conclusions
?01111N 1. From a statistical view point the results, apart
from those for Cough, should bo treated with great caution,
In particular, the results for Sputum and F. E. V. showed
signs for concern.
2. In general, the older men, the heaviest smokers,
those with the lowest Prior F. E. V. and those with the
higher Prior Cough, recorded the most coughing and sputum
and the least F. E. V. Prior Cough was the most dominant factor
underlying coughing and Prior F. E. V. was equally important for
F. E. V.
3. A seasonal cycle was suggested for Cough and
for Sputum; for both variables the response was higher
during the winter months.
4. Cigarette C (reduced Vapour Phase) showed
approximately 10% less coughing while 8% more were smoked
than for cigarettes A and B. Cigarettes A and B were not
significantly different for any variable.
S. Significant differences in cigarette consumption
were observed during consecutive three month periods of the
experiment. A seasonal cycle was not apparent, but the
response seemed to increase slowly during the first half
of the experiment and then to stabilise.
6. Interesting refinements to the general pattern
of results were shown by the interactions. Certain
unexpected results from the main effects were explicable
b studying the interactions.
y
- - - - - - - - - - - - - - - -
Research Department
2St-h April, 1973, --_j
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BATCo document for Province of British Columbia 16 April 1999

Appendix I
(a) Factors and Factor Level Codes
Factors:
CG 0 Cigarettes
AG 0 Age
co a V..$ Prior Consumption
PC Prior Cough
PF 00 Prior F.E.V.
P8 o o Time effect represented at 8
month intervals
P3 Time effect represented at 3
month intervals
Levels:
Ciqarettos
Filter PM (WNF) Smoke Nicotine Vapour
Cigarette Construction mg /c mg/ctte Phase
(25 ml uf values)
A Mono Acetate 22.8 1.63 Normal
B Dual Myria/ 18.0 1.70 Normal
acetate
C Triple miyria/ 17.2 1.65 >50% reduction
charcoal/ for most
acetate components
Age
1 25 40 yrs.
2 41 55
Prior Consumption
1 1 - 19 per week
2 20 - 26
3 27 - 80
eye
Prior Couqh
1 I - 4.5
2 5 - 12
CC,
(-n
"O
BATCo document for Province of British Columbia 16 April 1999

Appendix I (Continued)
Prior F. E. V.
1 Lt - 2.99
2 3 - 3.49
3 3.5 - 6
Time Period (P 8)
1 Months 11 - 13
2 14 - 16
3 17 - 19
4 U 20 - 22
5 23 - 25
6 26 - 28
7 29 - 31
a 32 - 33
Time Period (P 3)
I Months 11 - 18
2 19 - 26
3 27 - 33
---------------------
co
-.-4
co
CN
BATCo document for Province of British Columbia 15 April 1999

(b) Numbers of observations
Dopendant Cough F. E. V. Cigarette Sputum
ar. Consumption
CG A 1022 888 565 240
B 1022 888 565 240
C 1022 888 565 240
AG 1 5 3 5 46 8 180 90
2 4 87 420 385 150
co 1 237 214 135 28
2 418 371 216 104
3 367 303 2 14 108
P C 1 4 6 4 4 1 4 220 8 2
2 558 4 7 4 345 158
PF 1 32 3 274 287 95
2 3 3 4 2 83 278 78
3 3 6 5 3 3 1 0 6 7
1 114 9 6 6 6 3 6
2 16 4 15G 8 7 3 7
3 168 1 4 4 7 9 2 3
4 155 14 5 6 6 2 0
P8 5 1 2 3 101 8 9 17
6 95 7G 77 11
7 112 9 4 6 9 9
8 90 76 32 87
I 392 350 203 93
P 3 2 3G7 3OG 21.0 4 G
3 26 3 232 152 101
C:D
C-4
--J
CO
---4
co
BATCo document for Province of British Columbia 1 5 April 1999

Appendix II
(a) Analysis of Variance Tables
Tables (b) were constructed from the original ANOVA
1,2 and 4 and Tables (a) were obtained from the ANOVA 3. In
each case the variances were scaled such that these tables
refer directly to the original variables.
-----------------
CD
(--j
co
--_j
co
co
BATCo document for Province of British Columbia 15 April 1999

Analysis of Variance Tdhl@
Source Sum of Squares D. r. Mean Squares Variance Ratio
Age (AG) 60.52 1 60.52 12.79
Prior Consumption (CO) 162.98 2 81.49 17.22
Prior Cough (PC) 1090.75 1 1090.75 230.51
Prior F. E. V. (PF) 30.64 2 15.32 3.24
Time Period (P 8) 485.32 7 69.33 14.65
AG CO 55.25 2 27.63 5.84
AG PC 0.40 1 0.40 0.08
AG PF 67.46 2. 33.73 7.13
AG P8 33.28 7 4.75 1.00
CO PC 265.06 2 132.53 28.01
CO PF 185.85 4 46.46 9.82
CO P8 150.32 14 10.74 2.27
C PF 50.02 2 25.01 5.29
AC P8 35.54 7 5.08 1.07
2F P8 77.85 14 5.56 1.18
Error 4509.58 953 4.73
(-P4
CO
-_j
CO
BATCo document for Province of British Columbia 16 April 1999

Analysis of Variancp Tahle -CQLlc-h (b)
Source sum of squares D. F. Mean Squares Variance Ratio
Cigarette (CC) 49.55 2 24.78 4.79
Age (AG) 61.25 1 61.25 11.85
Prior Consumption (CO) 161.28 2 80.64 15.60
Prior Cough (PC) 1142.22 1 1142.22 220.93
Prior F. E. V. (Pr) 35.46 2 17.73 3.43
Time Period (P3) 305.00 2 152.50 29.50
CG *AG 64.87 2 32.44 6.27
CG *CO 122.92 4 30.73 5.94
CG *PC 27.28 2 13.64 2.64
CG *PF 53.30 4 13.33 2.58
CG *P3 7.64 4 1.91 0.37
AG *CO 60.91 2 30.46 5 . 8 9
0.22 1 0.22 0.04
AG PC
AG PF 69.07 2 34.53 6.68
^G P3 21.92 2 10.96 2.12
@O PC 285.65 2 142.63 27.63
CO PF 191.41 4 47.85 9.26
CO P3 74.86 4 18.71 3.62
PC PF 59.19 2 29.60 5.73
PC P3 2.78 2 1.39 0.27
PF P3 31.25 4 7.81 1.51
CG *AG * PC 30.98 2 15.49 3.00
CG *AG * PF 7.51 4 1.68 0.36
CG *AG * P3 66.40 4 16.60 3.21
CG *PC * PF 61.52 4 15 38 2.97
CG *PC * P3 13.97 4 3:44 0.67
CG *PF * P3 30.55 8 3.82. 0.64
CG *AG * PC * PF 119.27 4 29.82 5.77
CG *AG * PC * P3 30.64 4 7.66 1.48
CG *AG * PF * P3 80.73 8 10.09 1.95
CG *PC * PF * P3 162.26 8 20.28 3.92
Error 15332.57 2964 5.17
C=)
CO
BATCo document for P rovince of BritiSh Columbia 15 April 1999

Of Variangg Tabl.1, - F,r,V, (n)
Source Sum of Squares D. F. Mean Squares Variance Ratio
Age (AG) 11.26 1 11.26 60.51
Prior Consumption ICO) 15..63 2 7.82 42.00
Prior Cough (PC) 6.03 1 6.03 32.50
Prior F. E. V. (PF) 271.95 2 135.98 730.56
Tine Period (P8) 1.17 7 0.17 0.90
AG * CO 2.04 2 1.02' 5.49
AG * PC 5.73 1 5.73 30.80
AG * PF 7.80 2 3.90 20.94
AG * P8 0.54 7 0.08 0.43
!CO * PC 1.41 2 0.71 3.78
co * PF 15.12 4. 3.78 20.31
co * P8 2.52 14 0.18 1.00
* PF 1.29 2 0.65 3 . 4 4
* P8 0.90 7 0.13 0.68
* P8 2.64 14 0.19 1.01
I-rror 152.43 819 0.18
C=>
CO
--@j
BATCo document for Province of British Columbia 15 April 1999

A of Variance Tabre - F. E. V. (b)
Source Suin of Squarcs D.r. Mean Squares Variance Ratio
Cigarette (CG) 0.30 2 0.15 0.71
Age (AG) 12.01 1 12.01 57.19
Prior Consumption (CO) 17.34 2 8.67 41.29
Prior Cough (PC) 6.45 1 6.45 30.71
'Prior F. E. V. (Pr) 292.43 2 146.22 696.29
Time Period (P3) 0.07 2 0.04 0.19
CG *AG 0.19 2 0.20 0.95
CG *CO 6.73 4 1.68 8.00
CG *PC 5.55 2 2.78 13.24
CG *PF 2.50 4 0.63 3.00
CG *P@ 3.66 4 0.92 4.38
AG *CO 2.27 2 1.14 5.43
AG *PC 6.10 1 6 . IC) 29.05
AG *PF 8.06 2 4.031 19.19
,AG *P3 0.05 2 0.03 0.14
*PC 1.56 2 0.76 3.71
*PF 15.82 4 3.96 18.86
CO *P3 1.85 4 0.46 2.19
PC *PF 1.42 2 0.71 3.38
PC *P3 0.25 2 0.13 0.62
PF *P3 1.13 4 0.28 1.33
CG AG * CO 1.66 5 0.42 2.00
CG *AG * PC 4.17 2 2.09 9.95
CG *AG * PF 2.13 4 0.53 2.52
CG *AG * P3 0.33 4 O.OB 0.38
CG *CO * PC 17.26 .4 4.32 20.57
CC *CO * PF 23.57 8 2 . 95 14.05
CG *CO * P3 8.22 8 1.03 4.90
CG *PC * PF 23.22 4 5.81 27.67
CG *PF * P3 12.02 8 1.50 7.14
CG *AG * PC * PF 3.39 4 0.85 4.05
CG *AG * PC * P3 0.40 4 0.10 0.48
CG *AG * PF * P3 8.24 8 1.03 4.90
CG *PC * PF * P3 5.29 8 0.66 3.14
Error 531.90 2538 0.21
CO
BATCo document for Province of British Columbia 15 April 1999

Analysis of Variance Table - Sputum (a)
Source Sum of Squares D. F. Mean Squares Variance ratio
Age (AG) 262.34 1 262.34 8.68
Prior Consumption (CO) 563.83 2 281.91 9.33
@O
Prior Cough (PC) 302.10 1 2.10 9.99
Prior FEV (PF) 172.84 2 86.42 2.86
Time Period (PS) 1080.94 7 258.42 8.55
Error 6831.73 22G 30.23
BATCo document for Province of British Columbia 16 April 1999

Aulmr-li -a of Varlanro T,-i
Source Sun-, of Squares D. F. Mcan Squares Variance Ratio
Cigarette (CG) 12.24 2 6.12 0.26
Age (AG) 289.49 1 289.49 12.28
Prior Consumption (CO) 825.83 2 412.91 17.51
Prior Cough (PC) 159.36 1 159.36 6.76
Prior rEV (PF) 51.39 2 25.70 1.09
Time Period (P 3) 1231.53 2 615.77 26.11
CG *AG 31.18 2 15.59 0.66
CG *CO 14.38 4 3.60 0.15
CG *PC 189.72 2 98.86 4.02
CG *PF 88.82 4 22.21 0.94
CG *P3 437.89 4 109.47 4.64
AG *PC 441.76 1 441.76 18.73
AG *PF 66.91 2 33.45 1.42
AG *P3 0.73 2 0.36 0.02
*PF 4 6 .9 8 2 2 3 . 4 9 1.00
*P3 56.85 2 28.43 1.21
PF *P3 686.36 4 171.59 ?.28
CG *AG * PC 285.21 2 142.61 6.05
CG *AG * PF 139.04 4 34.76 1.47
CG *AG * P3 268.96 4 67.24 2.85
CG *PC * PF 8.48 4 2.12 0.09
CG *PC * P3 676.70 4 1G9.18 7.17
CG *PF * P3 301.96 8 37.75 1.60
Error 15418.16 654 23.58
eon",
C=>
00
BATCo document for Province of British Columbia 15 April 1999

Analysis of Variance TPI, I r, Con (a)
Source Suni of Squares D. F. Mean Squares Variance Ratio
. - I
Age (AG) 496110 1 49G110 21.0
Prior Consumption (CO) 36466612 2 182 33306 773.1
Prior Cough (PC) 194491 1 19 8.3
Prior FEV (Pr) 192234 1 1922`14 8.2
'rime Period (P8) 623865 7 80124 3.8
AG * CO 1954212 2 977105 41.4
AG * PC 1559692 1 1559692 66.1
AG * PF 875157 1 875157 37.1
AG * P8 494118 7 70586 3.0
CO * PC 165735 2 82867 3.5
CO * PF 471416 2 235708 10.0
CO * P8 474626 14 33902 1.4
PC * PF 1154325 1 1154325 48.9
* P8 145934 7 20848 0.9
?,@* P8 116198 7 -16600 o.7
--Or 11981431 508 23585
CO
---j
BATCo document for Province of British Columbia 15 April 1999

AninIvsis of Variance T,-.)-)le Ccnsumotion (b)
Source Suin of Squares D.F. Mean Squarns Varianco Ratio
Cigarette (CC) 467536 2 2317GS 6.6
Age (AG) 511152 1 511152 14.5
Prior Consumption (CO) 41056782 2 205:ZU0391 526.9
Prior cough (PC) 276365 1 2763-G5 7.8
Prior rr.v (PF) 212113 1 212113 6.0
V.= Period (r 3) 139538 2 697G9 2.0
CG * AG 78817 2 39409 1.1
CG * CO 1970947 4 492737 14.0
CG * PC 167498 2 83749 2.4
CG * PF 622926 2 311463 8.8
CG * P3 479804 4 119951 3. 4
AG * CO 2137018 2 1068509 30.3
AG * PC 1723991 1 1723991 48.9
JAG * PF 976642 1 976G42 27.7
eOlNG * P3 246951 2 123476 3.5
-0 * PC 202071 2 101036 2.9
CO * PF 416466 2 208233 5.9
CO * P3 338461 4 81,615 2.4
PC * PF 1306150 1 130GISO 37.1
PC * P3 101157 2 50578 1.4
PF * P3 101672 2 50836 1.4
CG * AG * CO 43721 4 109303 3.1
CG * AG * PC 220229 2 110114 3.1
CG * AG * PF 255412 2 127706 3.6
CG * AG * P3 182362 4 45590 1.3
CG * CO * PC 199131 4 49783 1.4
CG * CO * Pr 818546 4 204637 5.8
CG * CO * P3 837817 8 104727 3.0
CG * PC * PF 301276 2 150638 4.3
CG * PC * P3 646964 4 161741 4.6
CG * PF * P3 116874 4 29219 0.8
Error 56853108 1614 35225
U-j
CO
BATCo document for Province of British Columbia 16 April 1999

(b) Summary of r. Values
In the following table
represents significance at 0.05 level or less
0.01
0.001
Each lcvel refers to individual significance tests.
The der) of freedom quoted re to the numerator
whilst that for the denominator in effectively infinite. Due
to zero observations for one level, whenever Prior F. E. V. occurs
for Cigarette Consumption the degrees of freedom should be reduced
by multiplying by 0.5.
CAD
---4
BATCo document for Province of British Columbia 15 April 1999

Cough F. E. V. Cigarette Sputum
Consumption
Effect D. F.
Variance Variance Variance Variance
Ratio Ratio Ratio Ratio
Cigarettes (CG) 2 4.8 0.7 6.6 0.3
Age (AG) 1 12.8 60.5 21.0 12.5
Prior Consumption (CD) 2 17.2 42.0 773.1
17.5
Prior Cough (PC)
1 230.5 32.5 8.3 6.9
Prior FEV (PF)
2 3.2 730.6 8.2 1.1
Period (P 3) 2 29.5 0.2 2.0 26.1
Period CPB) 7 14.7 0.9 3.8 8.6
AG CO 2 5.8 5.5 41.4
AG PC 1 0.1 30.8 66.1 18.7
G PF 2 7.1 20.9 37.1
r14G P8 7 1.0 0.4 3.0 1.4
20 PC 2 28.0 3.8 3.5
CO PF 4 .8 20.3 10.0
CO P8 14 2.3 1..O 1.4
PC PF 2 5.3 3.4 48.9 1.0
PC PS 7 1.1 o.7 0.9
PF P8 14 1.2 1.0 0.7
CG AG 2 6.3 1.0 1.1 0.7
CG CO 4 5.9 8.0 14.0 0.2
CG PC 2 2.6 13.2 2.4 4.o
CG PF 4 2.6 3.0 8.8 0.9
CG P3 4 0.4 4.4 3.4 4.6
AG P3 2 2.1 0.1 3.5 0.0 (2)
CO P3 4 3.6 2.2 2.4
PC P3 2 0.3 o.6 1.4 1.2
PF P3 4 1.5 1.3 1.4 7.3
'G AG CO 4 2.0 3.1 *
CG AG PC 2 3.0 * 10.0 3.1 * 6.1
CG AG PF 4 o.4 2.5 3.6 * 1.5
CG AG P3 4 3.2 * 0.4 1.3 2.9
CG CO PC 4 20.6 1.4
CG CO PF 8 14.1 5.8
CG CO P3 8 4. 9 3.0
CG3 PC PF 4 3.0 * 27.7 4.3 0.1
CG PC P3 4 0.7 7.4 4.6 7.2
CG D P3 8 o.7 7..1 6.8 1.6
CG AG PC PF 4 5.8 4.1
CG AG PC P3 4 1.5 0.5
CG AG PF P3 8 2.0 4.9
CG PC PF P3 8 3.9 3.1
-CO
BATCo document for Province of British Columbia 15 April 1999

Appendix III
1-1--ans and Standard Errors
Estimates of mean values and standard errors
are presented for individual levels of all main effects
and for each significant interaction. The results
from Duncan's Miultiple Range test, given only for the
significant main erects with more than t@vo, levels, are
represented by continuous lines to the ri(.,Iit of the tables.
A line linking turo levels represent!; a nonsignificant
difference at the O.C)i level.
---------------------
C=)
*NO
BATCo document for Province of British Columbia 15 April 1999

COUGH
Table 1 - Grand Moan
Mean (x) 4.59
No. of obs (n) 3066
Standard Error
(S.E.) 0.04
Table 2 - Cigarettes
n S.L.
A 4.77 1,022 0.07
B 4.66 1,022 0.07
C 4.30 1,022 0.07
Table 3 - Age
R n S.E.
1 4.34 1,605 0.05
2 4.83 1,461 0.06
Table 4 Prior Consumption
n S.E.
1 4.16 711 0.08
2 4.68 1,254 0.06
co
3 4.92 1,101 0.07 1 co
BATCo document for Province of British Columbia IS April 1999

COUGH
Table 5 - Prior Cough
x n S. E.
3. 78 1, 39 2 0.06
F 7- 2 5. 40 11,674 0.05
Table 6 - Prior FEV
x n S.E.
1 4.78 9 6 9 0.07
2 4.49 1,002 0.07
3 4.49 1,095 0.07
Table 7 Time Period (P 3)
Me as ur x n S.E.
5.04 1,176 0.07
2 4.44 1,101 0.07
T3 F 29 789 0.08
CZ1
C:>
2.
BATCo document for Province of British Columbia IS April 1999

COUGH
Table 8 Tire reriod (P 8)
Measure
Period x n S.E.
(P 8)
1 5.29 342 0.12
2 5.15 495 0.10
3 4.40 504 0.10
4 4.26 465 0.10
5 4.52 3G9 - 0.11
6 4 . 79 285 0.13
7 4.22 336 0.12
8 4.05 270 O..13
Table 9 Age Prior Consumption
Prior 1 2 3
Cons.
Age Measure
x 4.26 4.30 4.47
1 n 405 609 591
S.E. 0.11 0.09 0.09
x 4.06 5.06 5.38
2 n 306 645 510
C:)
S. E. 'O. 12 0.09 0.10
co
co
C:@
3. Nj
BATCo document for Province of British Columbia 16 April 1999

COUGH_
Table 10 Age x Prior F. E. V.
Prior 2 3
F. E. V.
Age Me as ure
x 4.25 4.42 4.36
1 n 240 408 951
S. E. 0.14 0.11 0.07
5.30 4. 5 7 4 . 6 3
2 n 729 5 9 4 138
S.E. 0.08 0.09
Table 11 Prior on x Prior Cough
Prior
Cough
1 2.
Prior Measure
Cons
R 2.76 5 . 56
1 n 540 171
S. E. 0.09 0.17
4 . 2 7 S. 10
2 n 594 660
S. E. 0.09 0.09 c:::)
x 4.30 5.54
3 co
n 258 843 co
C=)
S.E. 0.14 0.08
4.
BATCo document for Province of British Columbia 15 April 1999

COUGH
Tab Io 12 Prior Cons, x Prior F.E.V.
Prior
F. E. V. 2 3
Prior Measure
Cons.
R 4.50 4.20 3.78
1 n 189 282 240
0.16 0.13 0.14
x 4.34 4.63 5.07
2 n 39 9 32 7 528
S. E. 0.11 0.120 0.095
x 5.49 4.65 4 . 6 2
3 n 331 393
S. E. 0.11 0.11
Table 13, - Prior Consumption x Period (P 8)
Period,
(P 8) 1 2 3 4 5 6 7 8
P r io r Measure
Cons.
x 5.30 5.08 4 . 22 3.92 3.75 4.01 3. 2 7 3.73
1 n 8 7 114 117 105 87 6 3 81 57
S. E. 0.23 0.20 0.20 0.21 0.23 0.21 0.24 0.29
R 5.01 5.13 4 . 2 3 4.38 4.70 4 .9 7 4.69 4 . 32
2 n 135 207 2 16 195 14 7 108 1 32 114
S. E. 0.19 0.15 0.15 0.16 O:Ib 0.21 0.19 0.20
x 5.57 5.25 4.76 4.48 5.12 5.40 4.70 4.10
3 n 120 174 171 1-65 135 114 12 3 99
S. L. 0.20 0.17 0.17 0.3.7 0.19 U. 20 0.20 0.22
co
CO
5.
BATCo document for Province of British Columbia 16 April 1999

COUGH
Table 14 - Prior Cough x Prior rEV
Prior
FEV 1 2 3
Prior Measure
Cough
x 4.19 3.70 3.44
n 327 420 64
S. E. 0.12 0.11 0.09
5.37 5.29 5.54
2 n 642 582 450
S. E. 0.09 0.09 0.10
Table 15 - igarettes x Age
Age 1 2
Cigs Measure
x 4.45 5.10
A n 535 487
S. C. 0.10 0.10
x 4.19 5.18
B n 5 35 487
S.E. 0.10 0.10
x 4.39 4.22
n 535 487 C=)
C C-->
U-4
S. E. 0.10 0.10 ---4
L co
co
6.
BATCo document for Province of British Columbia 15 April 1999

COLTGII
Tni,i lr-, Irj CicT,11-
Prior 1 2 3
Cons.
Cigs. Measure
x 41.39 4.60 5.32
A n 2 37 418 36 7
S. E. 0. 15 0.11 0.12
x 11.22 4.69 5.14
B n 2 3 7 4 1 8 367
S. E. (.15 0.1.1 0.12
x 3.87 4.74 4.31
C n 2 37 418 36 7
S. E. 0.15 0.11 0.12
Tab!(- 1.7 Prior sorption x 7 reriod (P 3)
Prior 1 2 3
Cons.
Prior Measure
Cons
x 4 . 9 4 3.94 3.60
n 282 249 11;0
S. E. 0.14 0.14 0.17
x 4.90- 4.54 .4.59
2 n 49 2 4 47 315
S. E. 0.10 0.11 0.13
x 5.28 -;.b3 4 . 6 7 C::)
n 411 39G 29 4
3
co
S. E. 11 0.11 0.13 co
BATCo document for Province of British Columbia 16 April 1999

CW7i-,
T- b I 1,'I
F-V
2
A 57 5 _2
0.30 0. 32
4.06 4 XG,
5,7 52
0.30O. -,@ 2)
n 57 52
S 0 O . 3 0.32
Prior collf--.1I =
Prior FEW = 1
C3 2
1
5.45 G. 09
A 11.2 1.02
so 0. 2 C2, 0.23
x 5.20 6.17
5.38 5. 23
C 11 2' 1 02
22 0
e 0 .
Prior (!ou:-.'i 2
Prior FEW 1
Continued..........
co
co
8 .
BATCo document for Province of British Columbia 15 April 1999

CO 'Li, G'.
Cj.,-,:IrCttCn pro t! cou"11 Pl-iol- 1"I'V (CoIll-intled)
e 2
Ci
6 6
a e 0.27 F 0.1118
x 3.66 3.69
B n 73 66
S 0 0.27 0.28
C '73 6 6
0. 2S,
0. 27
Prior COU."It = I
Prior FEN = 2
2
5. OS 5.912
A n 1 02 93
0. 23 0. 2,1
x 5. 0,23 5.781
B 1 W 9
0. 2-3 0. 24
4 - 956
5. 0 TS a
C 1 02 95
0. 23 F 0.24
Prior Gotrlh
Prior F;JV 2 CD
CO
Continued .......... CC)
CD
CO
BATCo document for Province of British Columbia 15 April 1999

e
C i
3.374 . 36
A n 1.012
0.21 0.-3
3.15 4.40
B 11.3 1.02
F, e 0. 2-5
.5 7 3. O
C 1 i3 1 02
O.;>l 0.2.
Prior Cough 1
Prior FEV 3
1 2
C J. r,
C-0
K
A 7 9,
O
o. G 0.27
5.5-1 5.27
119 L 71
0.2G 0.27
4.15
5.90
C '79 71
L 0.26 0.27
Prior Cou.-:, 21
Prior FF',V
co
co
lo.
BATCo document for Province of BritiSh Columbia 16 April 1999
M@@

C 0-L-I GR;
T:.blc V" 7. Pcriod (1-3)
Prior
Cir; 2
..1.65 6.17
A G -9
0. PI,
31 4.36 6.29
it 5 6.9
-50 0.27
U 0.
`3 5.'
4 U U
5B 69
0.30 0.27
Prior FEW =
Period (113) =
2
4.35 5.91
A n 55 67
so 0.31 0.28
4.20 5. 8B
D n 55 67
0.310. 2 F3
- 5. 47
C 55 67
1 0.28
CIO 0.
Prior 7" 2
U-4
Period (P-;) 1 -@j
60
Continued......... Po '
CD
BATCo document for Province of British Columbia 15 April 1999

C i,. U re L t 1' 1. J. C) I 5. Fl. lo "I I "'V, ].@c - an'Unu@:d)
U o JI
x 4 ?3 6. 02
C 2 7 5
t po
2 L)
71 4.41 5.67
11 62 75
75 5.57
C C, 7.5
0.29 0.20,
Prior
Period
0
2
cic-S
3.27 6.36
A 11 53 63
_e 0-31 0.29
B n 6j
53
!7 0.31 0.29
3.79 .89
C n 5j
0.29
031 _j
Prior FRV = 1
PcrioO O"; = 2
contimled............
__j
12 - co
co
BATCo document for Province of British Columbia I 6 April 1999

@ ,,
Ci 2
4 .91
6
3 0 5. 53
D 6 5
0.@)1 0. 2,13'
77
4.93)
C
65
03 0.28
Pri-Or 2
Pei@iod (1-3 2
Prior
Ci 2
4.02 5.04
A n 61 73
se 0.29 0.27
i 3.48 .5-39
D n 61 73
0.29 0.
3.09 5.03
61 73
0.2) 0-27
Prior FEV 3
@eriod (113 2
C:)
Continued.........
co
CIO
BATCo document for Province of British Columbia 15 April 1999

01@- r;
C:i -ar et t r--:7, x A"t- J r. I-i0j.-
-i L
CJ
Y9
4 5, J
0.
0.
5. -57
5
C 4-3
0.
SC,
Prior F@@V
Poriod 3
Prior
2
T"
3.11 5.65
A 41 50
0.36 0. 32
3. 83 4.75
B n 4 1 5 0
S e 0. 3 G 0.32
3: 3. 20 4 .62
C 11 41 50
0.36 0.32
Ynior F'-"V 2
C=)
Poriod 3 C=>
co
.......... co
14
BATCo document for Province of British Columbia 16 April 1999

C 0 V,
C (Cont-inu-0
2
7 Al
0
4 4
0.311 0.32
Pr i o r FEV 3
I'cr '10 (I 3
15 CO
co
BATCo document for Province of British Columbia 15 April 1999

T
F. ;. V.
TLiblc 2-0 !:can
F)
1:0. Of (n).
T. "LA. r.-!I 1. t c. s
too,,"
1 A C)-)
6 0. 02
C 0.0 Li,
Table 22 A,!:e
Ur O
n
x
3. 23 1 4. O 0.01
2 3.01 i 2 6
Table 23 Prio-o Conc un n. t-
Prior .
x 11 S. e.
-5.25 642 0.02
2 3.12 1113 0.01
'00 O. a2A
'3 2.90,
co
co
16
BATCo document for Province of British Columbia 15 April 1999

Table 24 Cov;@a
--C IUI C
Co t"
1 2 r 1
C1
Table Pcv.
C: I; U 11 C,
P. JL"'
1 2.4 5- P ? 2 .02
027
8-@ 11
-3 9 (,13 C) 1
Table 2t'-') (23)
-Urc.
0
3.13 1 OZ17 .01
3.11 921 .01
12 696 .02
co
17.
BATCo document for Province of British Columbia 15 April 1999

27
.T'L'
4 0:
oj
el"N
.03
To.
Co -I
1 2
@-30 3. 2c^) -5. 1 2
3 3 9 5-76 4 G 91
o. 0:,
o.? 0.
3.07 2 9 .6 2.86
2
30@) 5-7 1 420
0 . C. 02 0. 0
F7,1- -21
18.
CC)
co
BATCO document for Province of British Columbia 16 April 1999

TI-ble '29 Co Lt-ll
)r
1 2
JQ
C.
70
Pv. V.
T -a b- ior 1
V. 2
O UTI 0
2 07
C.
0. 0'-'@ 0. 02 o. C,
2. 2@ 2. 00
2 5 29 1 I'
0. 02 0. 04
-LO -.0 2-
co
co
19. co
BATCo document for Province of British Columbia 15 April 1999

t r
Tablo 1 j or C O.- @j.(-,,, IT
Prior
p 1@
V.,
1 2
A
279 5
0. 03 0. 0'-@ 0. C)
C). o2 U.; Q. C) 2
2. 0 Q
C
("I 0. (11
Tablo Prior
hcior
----@O rn, 2
C i
3. 30 3. 1 5 2
IL n 214 3 J,
0. 0. U."
3 - 20 3 - 1 4 2.89
21 4 '5 7 1 'jO3
E e. O- 03 C). 02 0.03
j. 1 7 3. 08 3. I 2
C 2i4 1 37 1 303
0. 03 0.02 o. 07
co
co
lo.
BATCo document for Province of British Columbia 16 April 1999

F. E. V.
Table 33 Cigzi:c'.-,cs 3: Prior Cough
Prior
,QZ@cjh 1 2
Cigs Vezlsurlz@
3.02 3. 2(-
A n 4 15 4 7 3
s.e. 0.02 0.02
2.9 8 3.08
B n 415 4 7 3
S.e. 0.02 0.02
Z@-
x 3. 17 3. OS
C 11 43.5 4 7 3
0.02 0.02
Tablo 34 Cigarcti-cs x Period (r 3)
reriod
'-- 1. I I 3 ) 1 2 3
cigs. J'Casurq
x 3.18 3.20 3.03
A n 349 307 2 32
a. e. 0.02 0.03 0.03
3.10 3.02 3.18
349 307 232
B.
s. e. 0.02 0.03 0.03
9 3.10 3.12 3.15
C
n 349 307 232
'02 I. 0.03 0.03 co
co
21. N-)
BATCo document for Province of British Columbia 15 April 1999

P.
Tablo Prior ,Ouf,ll
At,
ci-
71
CI
2 IS IS
Prior
0. U5.
C 0. 03 0. 05
WI
C 2
0. O. O'
Lf7e
-- - @ 1 2
7 3. 23 -5.1 7
n 250
P2-.i or
C* O. C-07 O. (,..A
coat;h 2 1
LI n 250
Q. 0.
N 3-359 2.9,9
C 31 2 @-) 0 27
0.031 O. 03
co
co
I'D
22.
BATCo document for Province of British Columbia I 6 April 1999

t t 0 2- 0 LZ.-
3
2 1 2.82
3 1 91
1 7", 1 A. I
100
O. C)5 O. O. O"t
3.31 2.95 2 .
B 1 00 1 7@. 1
coot O. C?5 O. O-a)- O. 0,1-
3.07 3.02 1 3. 1 0
C 1 00
C". C., O. 03 0.04
Prior cou-11 :-- 1
1 2
S LU.,
3 - O7 3' .1 9
A I 1 162
0. o.;-. 0. 0. 0-1
I
B n 11 4 1 01 0 16 2
0. 0-1 0.04
25 3. 24 2.89
C ('3 IG2
0. 04
O
Prior Cou,,,,,,h 2
C:)
CD
co
2 3 co
M.3
BATCo document for Province of British Columbia 15 April 1999

P. F. V.
Table 37 Cil;n-ro'k-Ites '-,'3,1-or 7- !'--'Lor F.E.V.
Prior
coils. 1 1 2 3
2.57 1 2.54 1 2 . 8
57 1 11 9 93
Prior I 0.04 0.05
0.06
F.T:".V.
2.6(
2.41' 2.12
C,
n 57 11 9 91-@
Sec. 0. 06 0. O", C). C) 5
x 2.48 2.34 2. 54
C n 5--( II 9 CD a
0.06 0. 04 0.05
Prior
Coil.,;.
C i@c; -'.I I 1 2 3
c I@r @0@ !
- '5-1 7-1 ..).79
L x 1, 3 - 02
A 11 9 4 85 1 05
'00. 0.0@ 0.05 0.04
Prior -
P. E. V. 2 x -3. O.-I 2.99 -5 - 65
94 105
0.05 0.05 0.04
F
3. 2.92 3.64
C n 94 P, 5 105
O& 0. C5 0.05 0.04
co
CO
rll%j
24.
BATCo document for Province of British Columbia 15 April 1999

V.
(
ior
3
2
4. 21 I 3 31
6 A,
I GG 1 Co
r3. e. 0.05
Prior 0.00- 0. 0..i
5. 97 3 . 851 3.61
L 7. . I
6 4 166 100
O. C."S C. C),: 0.05
.-g 0 3.67
4.12
x 3
C n 64 i 6G j 1 00
S. 0. 0. C6 0. 0.4
0. 05
25. co
co
N.)
4@b
BATCo document for Province of British Columbia 15 April 1999

P. I,. V.
Table `3 x Yrior Od
Y. r
i 2 3
C C'C;!
I I 09
'143 113
6
Period=l 0. 05 0.04 0.04
3. 26 4 2.92
88 143 1 1 8
0.05 0. 0", C. 04
3. j2 3.1 C) 2 .97
A, 3 1
0. C)5 0. 0,1 0. C,:t
Fri or
T
x 3. 23 3.03 1 '71.08
A n 74 1 29 105
S*O. 0.05 0.04 0.04
3. 233 14 2-) .67
Period=2 B n -714 129 105
o. e 0.05 0. Ont 0.04
3.22 3. 14 3.00
C n 74 120, 105
3. e, 0.05) 0.04 0.04
co
co
Nj
26.
BATCo document for Province of British Columbia 15 April 1999

V I., IT
Cirarct4- Friol, 41"onsur.-) !- J co, ri o. -1`3
(Co II iI 1-,-1
Prior
Con.,;.
2 3
IL 1 9 2
C, O
O. 0@,
0.
Feriod=3
3. I r O "i
7-
33 1 11 5 -5 8 0
C,. 06
I C' - 0.05
el"*.,
x 3.22 '3-1 4 3.01
0 n 53 96 80
S. C. 6:06 O. 05
co
co.
27. rSI-)
CN
BATCo document for Province of British Columbia IS April 1999

I. '-' .,-.V. -
Table '39 Cow 1r-JIor
Prior
Coujh 2
ci:;S
A r, 1 C, L) 17,4
. . ........ ..
See. 0.05 0.03
20
1" 1 (',O 174
0.05 C,. O
x 2.42
0 n 100 174
0. 0.05
Prior P. E. V. I
Prior
Cou-h 1 2
3.12 2.95
A n i24 160
0.04 0.04
3- 05
.j7c 2.95
B n 124 160
S. C. 0. 04 0.04
2.80 3.25
C n 124 iGO
O. 0@, C)
04
Prior V - 2
CD
co
CC)
28.
BATCo document for Province of British Columbia 16 April 1999

W.
Prior
coll-II
2
i7r.
A n
0. (..-i C) 04
-7 5
I
L
B n
0. U-11 0. OA
3. 90 3.90
C 192 1 33
L. e. 0.03 0. 04
Prior P. E. V.
co
co
N.)
co
29.
BATCo document for Province of British Columbia 15 April 1999

Table 0 OJ. X l').'j C,
P-Aor
COU,-1I
Uro
-CaS
1 G
2 1 93
0. 0. 011, 0.03
5. 00 3. -'J
1 56 I C"3
0.0,1 0.03
3. 07 3.19
C 1 5G 1 93
0. 04 0.03
Poriod=1
Prior
Cough 1 2
Ci azure
7 3.1 2 3.1 4
A n 14 5 163
S. C. 0.04 0.04
R 2. 95 3.24
3 n 1 45 163
0.04. 0.04
3.07 3.16
C n 1 45 163
0. 04 0.04
Period=2
co
co
r%
30.
BATCo document for Province of British Columbia 15 April 1999

C i Y
Prior
C j.'. 2
Ur 0
n
C. O. c- 04
0. Olf 0. 04
t
3. 04. 5. 21
I
C 114
S. 0. 0.04
Pcriod=3
co
co
31.
BATCo document for Province of British Columbia 15 April 1999

,7 I., ir
41, x
O 2.-
. F. V.
C j. 2
Andres
101
0. C. @i
2. 3.3 3 - 06 3 S,13
D, 1 1 A i 01 I
0.04 0. 05 0 - 04
2.42 3, . 0--3 3. 01 C)
C I " 4' I 01 1 34
0. 04. 0. 05 C'. C)
Perioe =I
Prior
33 - C 2 3
,
7 2.53 2.96 1 3.40
A 9 5 9 5 11 7
s. e. 0.05 0.05 0.04
x 2.27 3.1 0 3-0,2
B n 9 5 9 5 117
S. 0. 0.05 0.05 O 04
2. 53 'I 2. 90 3.84
C n 95 9 5 '1 17
0.05 0.05
Period=2
C:)
co
CC)
32 .
BATCo document for Province of British Columbia 15 April 1999

rct x Prior F.E.V. --- '-2cr-40d (F3)
(Continucd)
Prior
2 3
cic
2.31 3.19 3.91 1
A n 66 87 79
s. e. 0.06 0.05 0.05
-x 2.63 2 - 84 3.83
66 87 79
n
S. e. 0.06 0.05 0.05
7. 2- 407 3.03 3.94
C 87 79
6 6
s.e. 0.06 0.05 0.05
Pcriod=3
--j
Cx:)
co
3 3 .
BATCo document for Province of British Columbia 16 April 1999

Talde 42 F.' ir
C 2
-:CUSU:00
n
0. L)'7 0.016,
C@
2. 5"; 2. `5
C n 46 54
L F -"-- --
S.C. 0.07 0. C6
prior cou,-,@I 1
Prior F.D.V.= 1
uxe
I 2.63 2.43
A n 23 152
S.C. 0.10 0.04
2.64 2.34
B n 23 152
s.e. 0.10 0.04
7 2.43
C n 23 152
s. e. 0.1
Prior Co - 2
-1 CD
Prior F.11"'.V-= 1 C:)
co
co
LJ-4
U4
3 4 .
BATCo document for Province of British Columbia 16 April 1999

Cir7l.rOttO.-, @.71 -Priol- (Co lit i-.-. tic III )
2
3.01 2.94
A 70 53
Glee 0. O 5 0. GS
x 3.05 2. 03
3 n 70 53
0.05 0. 06
s e.
3.15 2.77
-- --I
C n 7 0 5 3 1
IS . e. AFFECT
Prior Coix@;, := 1
Prior V. = 2
Age
CIGG
I .e Ins ure 2
3E 3.29 2.91
A n 37 1 23
s.e. 0.
3.18 2.96
B n 37 1 23
S. e. 0.03. 0.04
x 3.12 3. o6
C n 37 i 23
s. e . 0.08 0.04
CD
C:)
Prior Cou,-!,,,Ii = 2 (-J-4
I---j
Prior 'F. E. V. = 2 co
co
35.
BATCo document for Province of British Columbia 15 April 1999

X PriO," .1'-'-.LOr (COr1tir-LICd)
1 2
I o3 3.66
30
0. O-I 0.00-
x 3 --c-Jr)
B 16 2 30
S. e. 0. G"L 0. C3
x 3 - 84 3.%53
C n 0
S. C. C). 0,1 0, CIO
Prior covi-I" = I
Prior P.L-.V.= 3
Ci-S 2
1
4.02 3.93
120 1
A L
0.04 0.14
4.023. 66
1 28 10
0.04 0.14
x 4.18 3.75
C ri 128 10
C). 04 0.14
C>
Prior COO.--11 2
3
Co
Co
L^j
Ln
.36.
BATCo document for Province of British Columbia i6 April 1999

F. 7.
T!, b1c. x A;- "Irl or O."'. P C-ri od (1'1`5@
1 2
@1.7
32 82
0.0
S. C. 0 - 05@@
2.53 2.34
B n 32 52
S.e. 0.09 0.05
2..115 2.22
C n 32 82
0.01,13 0.05
Prior F.)-,'.V. = I
I'criod (P3) = 1
Ci 1 2
Y 3.13 2.096
A n 41 60
s.e. 0.07 0.06
x 3.11 2.91
B n 41 GO
o. e. 0.07 C). 06
R 3.18 2.&5
C 41 60
0.07 0.06
Prior = 2
Period (1,5) =1
co
co
37.
BATCo document for Province of British Columbia 16 April 1999

Puciod
C j I 2
1.1caSUVO
3.91 3.92
0.11
4 .02 3.74
B n I 16 1.8
C.
O. C),o. i i
4.10 3.71
C n _71 1 6
0.04 0.11
Prior F. B. V. = 3
Period M) = 1
C i ep 2
2.63 2.28
A n 21 74
0.1 0.05
2.42 2.42
x
B F n 21 74
M 0.05
2.61 2.28
n 21 74
S. 0. 0.1 0.05
Prior
Prior M) 2
co
co
LA
38.
BATCo document for Province of British Columbia 15 April 1999

2
IL
3). 2.70
A
59
3.15 2.34
i 36 59
IS. 0.03 0.00-
C 13 -9@
C IL 36 5.9
-T-, " L
s. e, 0. O-Od 0.06
Prior P . E. V. = 2
Period (P3) = 2
C it's 2
3.94 3.86
A rl 102 16
3.0. 0.03 0.11
4.05 3.65
B 102 El 6
o . e. 0.05 0.11
4.01 3.75
C n 102 b 16
S. e. 0.05 0.11
Prior F. . III. V. 3
Period @1`3) 2
U4
-j
39.
BATCo document for Province of British Columbia 1 5 April 1999

C i7s 2
2 2.55
h 1 6 9
0. i ij0. 0-7
x 2. G7 2. 1 G'
D 1.6 49
3. e. .0.11 0.07
2.63 2.27
n 1.6 49
0.11 0.07
Prior P. E. V. = 1
Period (P3) = 3
Cig 1 2
3.16 2.91
A n 30 57
s,e. 0.0,9] 0.06
'R 1 3.03 2.92
B n 30 57
S.e. 0.03 0.00,
3.15 2.90
C n 30 57
0. Of-'IO0. CO-
Prior P. E. V. = 2
Period 0,13) = 3
co
co
40. co
BATCo document for Province of British Columbia 15 April 1999

C i 2
7.-
C.
C@.7,
72 7
0. 0- 0. 17
3 - 9 42 3)7
C
'12 7
0.05 0.17
Prior
Period 3
co
co
L.J-4 ,
BATCo document for Province of British Columbia 15 April 1999

V
Tabl@@ 1.1
r,o
2
C,
5 2
n '77
0.05
2. 5 G 2.51
B n 37 77
0.05
x 2.39 2. 52
C n 37 77
0. 08 0.05
Prior I . E. V. = I
Period = I
Prior
COLI,;",-,l 1 2
Keas ure-@@
I 3.02 3.07
n 45 56
see* 0.071 0.06
T.
2.90 3.12
B n 45
56
o @-e. 0.07 0. 06
x 3.00 3.09
C n 45 56
0.011 0.06
P 2.- i o r V . 2
Poriod
400
co
42.
BATCo document for Province of British Columbia 16 April 1999

i r
i0r C);,
0
rio r
cou-'Ji
'I- .1.03
n
0. C). C)
L'S
0. 06
0. 05
9B
X 3 cL-,-7,
n 61
C, C)5 0. 06
Prior P. T.. V. = 3
Period = 1
Prior
cour-I
2
2.48 J_ 2.43
A n 35 GO
0.08 o. 06
2.31 2.53
35 60
0. Cs 0.06
2.34 2.55
C n 35 60
0.06
0. OL'
Prior F. E.'.1. = I Lr4
--1-j
Period = 2 co
CIO
43.
BATCo document for Province of British Columbia 15 April 1999

o
P3 C,
(t i 2
n
0. 07 c). c)6
3
4 3, 5 2
0.07 0 . C, G
2.97 1 3.07
C 4 3 5 2
S. 0. 0.07 C. 06
Prior = 2
Poriod = 2
Prior
Co 1 2
C i
easu:
I 3.72 1 4 .08
I
A n' 67 5 0
s. e 0. 06 0.06
7 3.90 3.84
B n 67 5 0
s. e. 0. 06 0.06
3.85 3.93
C n 67 50
s. e. 0. 06 1, 0.06
C::>
Prior P. E. V. = 3 CO'
Po riod = 2 co
N.)
4 4
BATCo document for Province of British Columbia 16 April 1999

C it-:., .r 0 11-LO:3 .-rior I%.oU.-."--, r -i
;.rior
Coll-II
2
.17-;! Li r cl
2I 2.63
7
C@.
7: 2. 4
2 El, W
O. w,o. 0@,3
2.4 7
C 28 7
s,e, 0.09 0. Ca
Prior P. B. =1
Period = 3
Prior
cou:;.,i 1 2
c,,@..,;ure
2.90 3.17
A n 35 52
S. 0. 0.03 0.06
7. 3.03
B n 35 52
0. C-80. C)6
2.94 3.11
C n 35 52
s. e. 0.08
0.06
Prior P. B. V. = 2
Period = 3
co
co
45. QAJ
BATCo document for Province of British Columbia 16 April 1999

-A U
2
cou"11
(@q
0. G9
.82 S') E"
n 51 28
0. C,, -) (". @-9--@
Prior F. 3
co
co
46.
BATCo document for Province of British Columbia 15 April 1999

.1 .7'1
!'O. of 01,2.. (I.)
C@. %3
Trtbl c 4G Ci Zal-@-' U
77
5. o'@3 I' 2,10 0.31
C C, 7 2,10
Table 47 !.r:c-
LC
1 3. 333 270 0 . 2" C,,
2 6.16 450
Table 48 - Prior Consumption
rv@ior n S. 0.
L4. rIj 811, O. 53
2 3.33 31 2 0. 28
3 5-9191 324 0.27
UQ
co
co
4tb-
47. Ln
BATCo document for Province of British Columbia 15 April 1999

SPUTUM
Table 49 - Prior Cough
11@easur@e
Prior n s.e.
Pr
h
I 1 4.04 1 246 0.31 1
2 5.50 474
Table 50 - Prior F. E. V.
lleasur@,,
Pri@
or I n s.e.
F. E. V.
1 4.56 285 0.29
2 4.19 234 0.32
3 5.56 201 0.34
Table 51 - Period (23)
Ur
3 n s.e.
1 6.06 279 0.29
2 5.35 138 0.42
3 2.90 303 0.28
Table 52 - Period (PS)
Measure
Period x n s.e.
1 5.72 108 0.47
2 6.01 ill 0.46
3 5.22 69 0.58
4 5.06 60 0.63
5 4.25 51 0.68
6 5.23 33 0.84 (-#4
7 4.61 27 0.94 co
CC)
8 2.05 261
BATCo document for Province of British Columbia 15 April 1999

Prio--- O L) t.
COU-11 2
O'/
n
C
'5 2'
2
Period
2
C t
7 o
A 27 C) -5-3 301@
0. 29 i 0. 41 C. -11 -2,
2. 1
B 3a C) j
0. 29 1 0. /. 1 0. 20'
7.13 -.O.
x 5. 5,1 5. 07
cold,
C n
27 9 1@8 03
S. C. 0 9 0. 41 0.
------------
co
co
49
BATCo document for Province of British Columbia 15 April 1999

Tr@lulf-, 55 ---rior 1". V. Teriod
2 3
Prior.1
P. V
4.F-.l A. C7
I 11 1.17 75 93
O.A5 O. 56 0.50
S.C.
7 - C,', 1.05
2 3 'D
0. 5.! C * 7,,' 0..,:6
5.32 6.77 3.59
3 n 24
0. O
C2 04(11
Tab1c 56 C--, ---'ctte x -,0 rrior Cou,-,i
Ct Lc., 2
2.52 5.57
4.5 _@7,-
2. V9 5 - C, 1
B YL 46 36
0.72 0.31
2.745.11111.
0 45 36
S. 00 0.72
Prior Cou.-Ii
Co
Co
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50.
BATCo document for Province of British Columbia I 6 April 1999

Fit
2
U. 77
1 4
0.73 0 - 4 5)
4 . 4,3 7.1 4,
B A. 4 11 4
0. 7,71
3.81
x
C Y, 4 4 1 14
0.73 0.45
Prior Courh 2
Table 57 Cirare-11-te x Prior Cow-h x F-criod (P3)
Prior
2
6.35
A n 23 70
C,
0.58
4. 2G 8.46
B n 23 't 0
1 . Oli 0. 5 8
6.15 5.7.6
C 23 70
1.01 0
co
Period = 1 co
51.
BATCo document for Province of British Columbia 15 April 1999

2PUT-Ul":
T a b 1 e 5 7 t e C Ti o,-l 3
2
ci!C2
L71 5 - 56 5 -.16
A 15 2
T-
SC eo .25 0. C6
t
4 . 2 5'. 7. C-f
B n 1 5 3 2
S . e 1.25 0.86
x 4. 2GS G . 2 567,
. . ....................
C 1 5 3 2
J
s e. 1.25 0.86
Period 2
C 1 2
x 0.80 5.01
A n 4 4 5 6
0.6
0.73 5 1
too*", 4.53 1 rg
B 6
0. 11'@ 0. G 5
i .399 4. 205
C 44 56
s . e . 0.73 0.65
Period 3
(-J-4
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co
52
BATCo document for Province of British Columbia 16 April 1999

CIGARETTE CONSUMPTION
Table 58 Grand Mean
Mean (7) 770.2
No. of obs (N) 1G95
Standard Error 3.7
(S.E.)
Table 59 Cigarettes
ure
x n S.E.
A 750.5 565 6.7
B 752.4 565 6.7
C 807.3 6.7
5
Tablo GO I c
ure
n S.E.
1 746.6 540 6.6
2 1155 4.5
-A
Table 61 Prior Consumption
ure
n S.E.,
737.5 405 7.6
2 716.6 648 6.1
co
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3 1056.7 6 42 6.1 -1
5
BATCo document for Province of British Columbia 16 April 1999

QIQ,iMU-"TTr
Table 62 Prior Cough
Measure
Prior
Cough x S.E.
1 75 3. 4 660 6.0
2 787.0 1035
Table 63 Prior F. E. V.
u_-e
n S.E.
1 756.7 861 5.3
2 7 8 3. 7 8 34 S. 3
Table 64 Period (P 3)
ure
n S.E.
1 759.8 609 6.2
2 783.3 630 6.1
3 76 7. 6 4 56 -T 7.
C=>
co
54. co
BATCo document for Province of British Columbia 15 April 1999

Table 65 Period (P3)
ure
n S.E.
1 7 34 . 4 19 8 10.9
2 7 72. 6 26 1 9 .
3 773. 6 237 10.0
4 779 . 3 19 8 10. 9
5 79 3.0 26 7 9 . 4
6 79 7. 9 231 10. 1
7 73 7. 4 207 10. 7
B 7 7 3. 6 96 12. 2
Table 66 Age x Prior Consumption
r
1 2 3
tire
637.2 719.0 1083.6
n 117 213 210
S.F. 14.2 10.5 10.6
837.8 714.2 1029.7
2
n 288 435 432
S.E. 9.0 7.4 7.4
co
55.
BATCo document for Province of British Columbia 15 April 1999

","I Gi?
Table 67 - Ace Prior Couqh
Prior
,Cough 1 2
Age treasure
775.6717. 5
n 34.8 19.2
S. E. 8.2 11.2
731.3 656.5
2
n 312 84.3
S. E. 8.7 5.3
Table 68 Age x Prior F.E.V.
Prior
2
Age I @Ic 'I s u r e
701.5 791.7
n 213 327
S. E. 10.5 8.5
SE 812.0 775.8
2 n 648 507
S. E. G.o 6.8 C:>
c:>
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co
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56 . 4@-
BATCo document for Province of British Columbia 15 April 1999

Tab la G9 Agc m Pc..,rioe. (PC)
iod
1 2 3 4 5 6 7 8
Ure
R 714.7 778.5 781.2 725.5 7C.O.0 770.0 690.5 732.8
1 n 78 87 75 6-.3 07 63 57 30
S. E. 17.4 16.5 17.7 19.3 16.5 19.3 20.3 28.0
754.1 766.7 766.1 833.21 CIC-6.2 826.2 784.4 814.3
-J
2
n 120 174 162 135 180 168 150 66
14.0 11.6 13.2 11.4 11.8 12.4 19.3
S - F- - F--- I
Table 70 - Prior Consumption x Prior r..E.V.
Prior
F. E. V.
1 2
Prior Measure
Cons.
R 725.3 722.6
n 156 249
ell*,
S. E. 12.3 9.7
'R 723.6 683.0
2 n 351 297
S. E. 8.2 8.9
'9 3.021. 3 IOG5.0
3
n 354 288
S. E. 8.2 9.0 co
(-n
57.
BATCo document for Province of British Columbia 15 April 1999

CTC-A.M--TT-,,:
Tal, I e71 - Pricr Cough x Prior r-'.E.V.
Prior
Prior 1 2
cou@;!! castle
7 770.0 7 '30. 0
318 342
S. E. 8. 6 B. 3
!Z 7 36 . 5 8 37 . 6
2 n 5 4 3 4 9 2
S. E. 6 . 6 6 9
Table 72 Ci x Prior Consumption
Prior
Cons 1 2 3
Cigs Measure
719.0 737.1 995.5
A n 135 216 214
S. E. 16.2 12.8 12.8
5z 727.1 720.8 1009.2
B
n 135 21G 214
S. E. 16.2 12.8 12.8
F. 7 6 G . 3 691.8 1023.2
C
n 135 216 214
S. E. IG.2 1,2.8 12.8
co
co
BATCo document for Province of British Columbia 15 April 1999

CTCARETTF CO':rl;".I'T!(:jl
Tablo 73 - CigarctLus x Prior 11. R. V.
Prior
F. E. V.
2
Cicjs M!anura
732.5 7G6.G
n 287 278
S. E.
R 769.0 735.7
B n 287 278
S. E. 11.1 11.3
R 7G8.7 847.0
C n 287 276
S. E. 11.1 11.3
Table 74 Cigarettes x Period (P3)
Period
(P 3) 2 3
Cigs asure
SE 766.9 773.6 711.2
L- I
A n 203 210 152
S. E. 13.2 13.0 15.2
2 727.4 750. 8 778.9
C=)
11 203 210 152
B co
co
13.2 13.0 15.2
[@S - ` -I i@-I
59.
BATCo document for Province of British Columbia 16 April 1999

CIGARETTE
Table 74 (Cc
Pori od
(P 3) 2 3
Cigs I I a as U OL,
785 2
n 203 23.0 1 -52
C
S. E. 13.2 13.0 15.2
Table 75 Cigarcttc!3 x, Prior l('n Trior F. E. V.
Prior
ons
1 2 3
748.7 G46. 5 1015.9
A n 52 ils 117
S. E. 26.0 17.3 17.4
7. 699.2 681.0 1036.4
B
n 52 118 117
S. E. 26.0 17.3 17.4
7 723.9 781.8 1077.2
C n 52 118 117 -
S. E. 26.0 17.3 17.4
Prior F. E. V. = 1
6o.
CO
C-n
CO
BATCo document for Province of British Columbia 16 April 1999

CONSUMPTION
Prior
2 3
R 686 .8 747. 3 1058.0
A n 83 99 9 6
S. E. 20.7 19 .2 18.9
R 740.0 716 .4 1063. 4
B n 83 9 9 96
S. E. 20.7 19. 2 18.9
37 826 .1 726 .6 1111. 3
C n 83 99 9 6
S. E. 2 1 9. 2 18.9
Prior F. E. V. 2
Table 76 Cigarettes x Prior Cough x Period (P3)
1 2
720.5 759.7
A
n 78 125
S. E. 21.3 16.8
R 725.2 757.66
B n 78 125
S. 21.3 16.8
x 1782.3 812.5 Period (P3)
C n L 78 125
16.8
S. E. 21.3
BATCo document for Province of British Columbia 15 April 1999

CIGARETTE CONSU"'PTION
Pricr
Cough
2
Cigs Ncastirc
x 709.G 81.7.6
A n 62 129
S. E. f @0-7
7. 788.5 742.3
n 82 129
B Period (1,3) 2
S.E. 20.7 16.5
801.4 840.4
C n 82 129
S. E. 20.7 16.5
Prior
ugh 1 2
Cigs II-aasure
771.1 724.7
A n 60 91
Period (P 3) 3
S. E. 24.2 19.7
T 691.9 807.5
n 60 91
S. E. 24.2 19.7
7 789.4 821.1
n 60 91
C
S. E. 24.2 19.7
U-4
co
--------------------- 00
62.
BATCo document for Province of British Columbia 15 April 1999

AP2endix IV
-ion- in Gr;,@)hicaJ
latcrz,c4
The interactions werc rL:;..-)rr:.,;cjjtcd in the
following way for case of interpretz@ticn. Notice that
the band attached Lo a point on the right, hand side of
each graph rclirust-nits an approxim.:t"o 95Z confiif!nce interval
of the interactio-1
As an CX,!T-11n1O, COLS-1--40-27I ho m;:!.in
effects shcaed tli@T,L_- coding 1,1,11 thc A@:a Group
and with the Prio.,.- Consvinntion Gr,@',LM. The iiii.craction between
Age and P-rior th,@,
that the diffurcnc@_, in coughing be1'_-,-.1c,-.n the t%,o aqC groups
increases with the Prior Conscu:-q-.1tioa group. It aiso sho"Is
that the oldcr from the Prim, Conz,,-,;:ptir-,i
group coucmed les's, but not si@jnificzl,j@'_-Iy tl-x,:,ri the
currespondiiig YOUI)(;,-'17 RIOTI.
This ir! Eti;:'-hcr co:rplic@.tcd for ititurauLiuns
involving morc facLozs, but the said princii)1-c-. are
involved.
-------------------
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