I~· :·· ~ BRITISH AMERICAN TosAcco Copy Request Form Request Number: 1 Organintioo: Physicians for a smoke free Canada I Request Details RrqultDat~: 11~~111111)1111111)111)11111111~111111111111((11111111~111)1))) File Number: ,,&,,a!,L~2r,I,I~BOX Number: zsC 111~11111111)1111111(I Page Range: First Page i 1012 IG1 IB 17t IOI\ Iq Last Page ~ IZ16 18 !~...................... Requested By: (Print Name),~ III Details below will be filled in by Depository Staff Only II Copy Details Copied By: ,,,,,,.,,.,,,,,,,,nlIr~~ll~l·llllll·l··l,1111·1·1111111·11·1 Date: ,,.C~I~ :I-/l~lllllltlllltl IIITime:.4~2~........... 111111 Copy Checked By:,,,,,,,,,., ...........~ ...............~~~~ ~~~~~~~~~.~~~ Date: ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Time: ,,,,,,,,,,,,,,,,11111)1111111)( III Delivery Details Checked By: ,,,,,,,,,,,, ,,,,,,,,~III~II, Date: ,,~~~~~~~.~.~~~~ ~.~~ Sent By: ,,,,,,,,,,,, ,,,,~,,,,,,,~..... ~..~~ Date: ,,,,,,,,,,,,. ~~ BatCa document far PFSFC 1 March 1999 '; 4 .I I·~ n~ · · ~·J Cr.l3t: I a: k (1 ·P1· See Distribution Below: '$:'~RIE. Thorntoo, GRIDC, Southampton, ,E: RETIKPNI16D ;:.i 29th July, 1982. DR, Y,L, gNOTT I enclose a note ~ritten after a visit made to Dr, V,I, gnott C, it Ottaa. ·i~Y~Jps RIEI THO~~TOE (Dietated by RIE1 Thornton, but signed in his absence) EPcl, j Oist~ibution;- Dr, 1lC,F. Blackman Dr, M, Oldmae Mr, A,I, Heard Mrs, B,g, Comer Dr, C,I, Ayres Yr, RIS, Cede Dr, g,0, gilburn Dr,. PIJI Dunr cao~l~o a~n~a~ ~d: 50JU1198~ )tc~ O ~ Sekn bj: ·*I IC~m·ll···llr· I~LC Co ~TJ 3 BatCo document for PFSFC 1 Wlarch 1999 ,,1 g~ ~r~gcant Prn PBIVITE anD COIPIDBRIII1 VISIT BEPOBT Visit to: Dr, v, Knott Boyal Ottara Bospftal, Ottara, 'Iuthcr: Blgl rhornton Date: 14th July, 1982 ClrUlbtiOP: Dr, 1ICIP, Bliehnao Mr, IILI Beb:d Dr, CIII dvr~S Dr, [,D, IilDPrn Dr, Y, Oldain ypg, d,I, Comer Yrl 8,81 lade, Canada Dr, P,JI Dunn, CaPndb BHr/IPg/l6D BBth July, 1982 BetCo document fer PFSFC 1 Yarch 1999 ,I, I1ECird ~~L~dr~qt lisi~ Dr. ~Ylott, RolllOttlr~ B4spltll, Ottl~~. Present: Or, t, IDOtt Ir, 8,8, Iide Dr, B,B, Thornton 1~ Dr, [nott is 9urrantll a (nPtce of tbs Clf.Y,C, Th, purpose of the oisit ras to discuss his nee Ornpt rpplicitian, phlcb is ior ~ iilc-Jsnr study, I bad ~et Dr, Inotr beiorc, both It the Cbol~oad SIeLiot Beh~~ioPr Coafereoee (1977) and also, nith hay Cooer, It the eaaierePce an nicotine held by S,E,I,T,A, in paris in 19181 II Dr, Inotf's east recent proposals ior a iile year longitudiPrl study (1982-6) have already beeo discussed extenslpelg at C,T,Y,C, aud in CPLDC, Tbe 018. Companies in C,f,r ,C, hare decided lot to support the po~ proposals, ehich is esseutiallp In IEG IrJ,ss- oept oi children (age 11) and the relation of these Deasureoents to subse~uent soolring habits, Ho~ePer, I,f,P, and Bothsins (Ilrgely Is a reslt oi I risit by P.F. Bro~o) Ire, in priPcipla, in iapour oi aupport. 3~ Bslore Idlving tile U[( I discossed the Proposll eitt d.I, Cooer (Klp nod I had loa~ed It the E6 patterns of smolrers rad noP-slolers in collaboration ~ifh Dr, (:, B1nPle oi 8t, Brrtbololcs'o gPspltal) and I,D, lilbura eho had a~de 8ll88tStionS lor the PP- Iradiny of spPipePt, II PlOr~Ol It lls suggested that the protocol lould be flpro~ed ii s~bjacts ~ere re-analysed at the,nd of the a-tc~r study, hopefully, this beipre- and after- study lould dllol~rrlte that smol(ers' hhC's altered It the I1II rate as aoa-spolrers' BIC's rhieh ~alld be tood ,lfdtnae that sPoking r~s not addictfoe, Tbfr had been inferred iroo the BI~ study (eolparison of the 88G's of slolerl lad noo-slokera of sililar apes) but could pat be definitely pro~ld, Ilso, the differences iu sro~erp and non-smokers noted in the Bit BtPdy eoald Lrps bean hue either to diiilrlaer bltlsen the subjects in the tlo (roups, or to an acute of ~O~ipg, Otherrlse, the protocol is d,tliled nnd relsPllt, ~· as trpeeted Ir~ Dr, ~aatf, (8el rlso section 6 ior proposed extension to protocol), St ~POIPl~f Dr, Inott said that he nos rilled to Idd epPipPent to 4 Ibltp~l brain-stem response, ~e~ll considered to be di BltCo document for PFSFC 1 Msrch 1999 " ~2Sa;rz~ ~tnt~aR~ BT~ -a- considerable importance in this ores, This sould add about 525,000 to the cost, It nas agreed that, since the study nas going to last five years, this equipment should be included in the proposal, It would not be possible to alter the protocol at a later datel lith regard to the equipment suggested by Dr, Kilburn, Dr, Knott said that his most recent proposals for eqripPent lar(cly Inticiplt6d Dr. [ilbatn'6 suggestions for improved methods of datal~cqai~ition, and had been made after discussion nlth ggG experts. It sas agreed that Dr, lnott trould base his application on his onn list of equipment; it tpas considered that this FPas entirely satisfactory for the so~ltais·eaPis- aged by Dr, Inott, Analysis of the results eloeahere ~as considered unlikely, 6. ETHICAL PBOBlgYS One of the advantages of carrying out contact research is that any ethical problems become those of the OniieroitylBPPpital rather than of the funding orgpnisation, In the present case this is particularly important since children are to be studied, and their ~io~ioglnonlpPo~iPg habits determined, The accept· ance of the proposals by the Ottata School Board rod by the Royal Ottnrr hospital is important. The former have already agreed to them - the latter are expected to (aad must do so:before the project can continue), rtthiP these provisos, and providing the C,T,Y,C, food the Royal Otta~~ hospital (rather than aott directly) the project should be as sell isolated from the tobacco industry as can be reasonably arpected, ~ projeet supported bg the Tobacco IndPst~g is potentially open to attack by sntilsno~ing iaadil ientalists; ho~evar, the agreements noted above should be sufficient for the ratlonallylmioded, P, GBIPBII COYYE~T Dr, P.J,CI Boa, in discussing likely future pressures on the industry, suggested that 'nicotine as In addictive O agent' ~lo a likely threat, The present study is likely Ba~o daeument for PFSFC 1 n9ah 1999 ;;;" RestiraS d8m~pmrat CdJlr -3- to demohstrate a constitutional basis for smoking, and a lack of chronic (5 gear) effects on brain activity. Both would be useful pieces of information beating on the fact that smoking is not addictive, and as measured by EM; not harmful, However, it should be borne in mind that it is not a certainty that these results nill be establisbed, The sample size (300) is relatively small and there is alaays the possibility that the differences nill be lost in noises, It nill be important to quantify, as far as possible, the anti-smoking pressures on the children. ADDENDUM 8, RET undertook to obtain information from Nicola Cherry (L.S(E,) on subject re-call strategies in longitudinal studies, C~jlo~P ~N )·E· TIIORHT(O (Iritten bp k.E. Thornron, but signed but in his absence,) BatCo document for PFSFC 1 March 1999