·_ · I __· __ .3 II-··.0-~· U1 hi ~utllne of (elk by ~, ~~ Hierd Group tip Icilvitii~ in rii onse to ricoi~tnd~tlon~ of lenulit lodias The inltistives stteed It the Chsirpen's CAE conferenee in 1913 focussed very much on epidemiologicsl issues, It wll understood thsi chcri IDitilliV)I YIII in ~ddirion to the Group Research Ictlvliiii, HY telk vill cover the letter, For 111 out Group I~D projects ve heve gone to sole lengths to decide the business objective Ih~e is being eddressed, In the S6H ores ur ore rispcndin~ to, pr enrlclpeLlip rrguircrenti of Refuletory Authotltici, ly this toro ve peen those luthorleiei, offlciel or unoffici~l thdt edvlse CcvarPacn~, 1I11 to Iiliil~rlon or Influinci public opinion end thus, our eooiuiir. (A suiPar! of importene recent report~ from Ielulitory iluthorItlrs publiihed vlll be livia,) In terms of the ~saociatioa betveCP ective sloking end dilelse, little new h~~ emerged in these reports, elthough sole enti-sioking orl~nliition~ ere csrrying out or funding resesrch into Icchanis~a of disi~ics such as lunt cencer, The Alericen Heilth loundetfon, for in~tincc, hes e substentiel prograiie of reselrch into tob~eco specific nletor~ifni~, including their possible role In elterlnl Ocnerie rllteriel. Under the iuipices of Group RLD re fund fundii~otil reseerch into lechenisii of ~rokinl-~ssoci~tsd diic~ica end saveril reputsble Iedlcel dcplrcllntlllnltirutII, The lejot theme, hovivet I of the reports from Regulitorl bodies is releted ~o Environnentll Tobiceo Sloke; in sole It 1s the only theme, i, Envlron3entil Tcb~cco Sloke This lest yeer hes seen conildcribl~ esceletion 01 the Pesiive Sloking problem, vith crtcniive covcr~ge In both populsr end scientific publicatlanal The entl-sloking lobby seel to hive svltchid their ~ttintfon sllost totilly to this subject, tridlng on the Inolivi issues of the effect of siokers on the non-aloker, These hevs driwn verloua eDnelusionl shoot )DsI1J1e eiioclltlopi betveia ITS end disease, notvilhstlndind the frillry ol cpld~iiolollc~l eechniquer io this ~ra~~ The tssl( of chill~n~lnl apidiiiololy uill he covered bl Dr~ Ihornlon. lt 1s ilportint to locur on the iii~ppr~hiniloni surrounding ETS since these ~r~ proving e touter of erroneous conclusions by tho~i Pressurising to restrict siokers' ftiidais~ ClibPDF - v~~fastio.soni ·2· One ilpor;.ant tourer of error in oany external publications slepi floa the assuPprlon that data Pcaiurid on cigarette IldeitraP IIDLI ean be used directly to describe salient smoke con~enttatloni ~nd composition, In fact, eTS is guile different from SS, The very act of dilution of SS leads to cheiical changes; ve also have shown that chemleal reactions occur in the ETS for some time after the cigarette has been extinguished, The deposition of sloke particles on surfaces is ganerallp Ignored In the poor ~rudiLI that so often generate media interest. Nicotine often used os a marker for cigarette saoke has been shown by BAT work to be IOX lover in ETS than In the SS e~uivilcnt and decays very r~pidly~ The use of SS values far nicotine as a basis of extrapolaticn to human uptake from ETS is quite wrong, ETS is uldelg portrayed as a iajor pollutant in domeitlc, working and social situations. Our research is gathering data to help sec iTS in context in this respect~ Background levels in non-smoking situ~tlono for CO, HO hydrocarbons have been found which equate to ocasutcd r: vels from 2-8 cigarettes in an average room, Ye have Jurreptlously monitored nicotine In a Variety of situations where smoking u;l recorded and found generally low concentrations (3-38 ugli Other materials (from cooking, polish, ecc.j made a considerably greater contribution to the overall burden, Roberton has stressed the relatively minor role of ETS in the so-called "Jick-building" syndrome, In loec studies on efS, there Is, for instance, no Lnovlidge of dose whatsoever beyond noting that individuals are married to a smokers. In terms of direct nessurement of huPan dose, the problep of finding an appropriate nsrkcr for ErS raiih~ kel' In our future work, we shall aim for true particulate barkers (remember nicotine chcoieals are being gathered). It Is worth noting that eORESTAI the official scientific body of the Tobacco Indusety, has set up task forces to define means of measuring both SS and ETS and, at least in this area, the principal elgarette Penufaceurrrs are so far pulrlng together, publications The tobacco Industry is by no means silent on the issue of passive smoking and EtS. RJR and Philip norris Ire both Very active In the scientific area. Bit is similarly active, we have three recent publications including one paper given in a key conference in Tokyo last year, Three more papers are about to be published based on BAT research and we shall present the keynote talk at a conference on Indoor Air pualfty in tendon this lear, The TAC has produced special publications on the general and scientific aspects of ETS, very recently having seen the draft of the Ith Report of ISC, Tie called a Peetiag uiih the Minister of Rcalth to protest the poor s~iLnei and the proposed anti-stoter line proposed by those responsible for O the report and for ricppmendlng ietlon. I Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 -3· future Work Strategic ob]rctivci!· The overall obfectives for the BAT Group Work programme on ErS were foraulsted st th~ Ii,~lna In WoPtreil in Xovelber 1981: i, To let ETS in perip~ctive by providing Peaningful scientific dPt9t 2~ To refute inaccurate Jtateienta lade about BTS~ 3~ To identlf) and, I! poaalbre, Piniilse subjective annoyance either through cigarette design options or by aon·elgariria solutions (i,(, veotilatloa, cte,) ~· To be able to romPuoicare a compang view on ErS. 2~ Product Hodlffcations The Regulatory Bodies consider product modification policy sueeessful~ They conclude that lover dcllverg is responsible for teducrlon in lung cancer (ignorinl eoPpensatlon, conveniently). They are now addressing further modifications required, As an example the lSC identifies: 1~ Hainstream - tarlnicotine i. t.T~S~ So fat we, and the Indubrry in seneral, have pursued an Evolutloeorl approach, Eert~inll in teres of overall deliveries, In teres of iaiaitreep, as overall deliPcrles have fslten, the tarlnicotine ratio hss also fallen gradually, Attempts at cigarette modification to reduce visible SS have rested on novel cigarette tissue but total SS cao be reduced simply by reducing tobacco weight burned, The announcement by RJR Chat they propose to launch a smokeless cigarette stakes out a totally Revolutionary approach by this companyI A suPlary of keg points telating to this product will be given, Bar ResDonaes BII has launched a project In BbY, the ein o[ which is to define a spokeless product (bur with sole LPPIOVePLnts over the Reynolds' concept) by late 1988~ Group funding for 1988 amounts to C~5 mnl if this ~xplor~totl phase Is successful, this will lead to I ver~ large eoiPttmene of at least SZD PP over 4 1111) to cover R1Dlcapitil coat to teet matket stage, This is our Revolutionary approach, Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 -4- Y1 slee see Ppper~uoirlrt lp se evolu~lPnPrl spproaeh bat baled on rapid axttipol~tion from [Pdil'i POIIlIDR, Ye sntltlpete " product uith ~LtY 10Y till PDrlel nfeotlne eod v~~h improved ~~t lu~tlry. A projicr has been inltl~~cd at Southampton along these lines end e budget of a,S ma fot 1988 has been eBrled. Once aBain, aignlficaot reaources will be rcgu~tcd if this project is succeisful, for both of these projects, the potenei;ll of tobacco biolechoplagp ~o ctaaiL 8lgnific1ntlg litfanni eobeceo Pcrl~rie~ could be In Impottant dtoenifon~ ALH/OET 18th March 1988 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111