Imperial Tobacco Limited Po Uol 21Q, Hartrlilfe, Bo(ol 85993111 iii Telephone:om itlttU Telex: J(~. -Cjr:;:i"B urd I~c~fiber 1987 , GhlJ/GWI'S ~37 P~`EF,E~NE!, tt , Iv',C, 4en Dr~ R~E, ~oxal! Dr, d.J, ~ebes Dr~ a~ s~mtm Dr, H, C·~isc:1 Dr, A~ ,c2rin9al; ~ir i 9~ ~:iCp Dea: Cc::e~~e ~:lck·ig the request Irade at the last RC, I have prqra:ej tc;a ~ccaen:s for discussion cn the subject of the future direction of this Cc~it:ez~ The first covers a sluinary of the E discussions to date; the second covers x~e questions which we may like to cwsi~e~~ 2:either dccwen; is sez~: to ~ comprehensive. I have tended to ignore I~'s past and current position and ~ave adopted a 'clean sheet' type aFprcach, Eoth nrj dccL~er,:s StC~ld be read in conjunction with Helmut's paper,'nt~ich was tabled a: the last meeting, 45st wishes for ~ristmas and the ~w Year, Yours sincerely, I) G~R~ Wocdman, Inrc~~oaed in En~lmd No. 18601111 RrgiLnd Oll~r: Ltdillr, Bnr~ol ~ Hnmn TtuJI Corn~~ny O~ Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Df~r ccrulwr wa Drs~sIa ~-BV\RCIICCE~T~~ Introduction ale Research ~~ttee regularly discusses the sjor research issues laei$ me Idustry~ ~ls paper highlights the rain points arising from recent discussions and tas been prepared at be request of the new Chief Brutipe of TAc so that the current TAC research activities can be discussed and reviewed and, if ~Fpr~riate, updated, me intention is also to re~iol the current Committee ~rki$ Group structure which supports tile Research ~ittcs, with a view to ensuring that it remains the Pit effective III of progressing ~Hp 1CtiVitiOl. me sin ~soa~;~ittec activities can be divided into a number of broad areas, nPc:v: 1~ 2~ Product ~ifi~tion/I~~ 3~ Effects of S:t~i~ : Sociolcqical k~ts~ 4. Bbiq & Be;:~I/CPty of ~ce~ ~e aia points :risd during Research ~ittee discussions on each cf these areas are c:~en tvlow. i, It was agreed tha: the most important single issue facing the fdustn currlntly usa th: of m~ me sin pestioP was h~ w ~lld al~ta our resources: if:3 investigations cencerned with the masition of ~, or with dosiat:~, either ambient measures or measures with hues, or into health cff;:s themselves, for example e~ddolgy, mis problem is being tackled by most, if not all, of me major companies ard/or trade ass~iations ~o~ the world, ard it was felt that a degree of kprldwide ~c:~ination us necessary to both canplement ongoing ~;t anl to develop dcr! relevant to the Ul. Because resources are not limitless, d~licl:ion should be avoided unless pertinent to the 8~ ;n addition, c~ordf:aticn of the developnent of techniques could avoid liaste of resources, me value of c~c:j:sa:ioc has been raised previously, possibly ~~ ~n~~, but no a::icn has ~a~ taken, mis area has de: covered in some detail in the dccwnent entitled '~a ~e of Science a ~e ETS issue - November 1987", and this provides m:~et backgrolpld , ClibPDF - v~~fastio.soni _ ~____ -2- 2, projuct Modification mis area can he closely linked with the Ir~ mo fourth Report Fight well indicate a number of areas which the ISC believes rmira~ further nxrch, d we will n?ea to axllidor how to re~ to ;heaa. Ina fruitful discussion can take place when we hat seen the report. However, there was a strong feeling that the Industry was lnlikely to agree to a further ~ million pr annun funding of the ~~ under the current structure, bearing in mind the lack of results to 8te~ Sir Peter is ~n to went to cllange the terms of reference of be hust, and the I~ustry night Hell wish to reconsider its position in the light of any c~ngc~ there is clearly a legal/Folitical issue a well as a scientific one, particularly if it were suggested that ~e industry should bvs a greater i~olvaant~ Concern was expressed, hut mt necessarily shared by evorpns gt under be na, work is being carried out to d~c~ in vitro teats for tar qnlity~ me Idustry is very concerned at the meaning of these tests ~ has axprased its views to the lSC, and theser it is believed, bye been let with a considerable degree of ~rernt~ h danger is that oe ~kars rich~ a such tests to rank hrds and tha-, their bra, althouch invalid for such ~~sss, light be used uncritically alongside the current tar :~lcs, 3. Effects of S;~i$ : S~i~ical Effects It was felt that work on such talcs as negative correlations and the rololbenefits 0~ nicotine urs korth plrsuin3. HaJ Id kp:k Ibht continue to be pursued us left ~n~ 4. boki~ & Hejlt~Duty o! Cere ~~ of Care we a ~ttor for individual manufacturers ~ mt for a trade association such as ~~ With regard to ~kin~ C Health itself, this is such a vast area that TAC das not have, d cannot bye, the resources to ~p~e d~ what is alredy goina on worldwide. mb value of the current spofsors'nip of research work us discussed in terms of its ~jeetires, it was felt that ~ slloulC continue to identify gaps and ~~iel in the smoking and health area and then decide what action ~Pld bll~~ This reqllires reviewing in detail the relevant scientific literature worldwide ~ pti~ tile views Of TAC and Irdustrj consultants. It kas p3inted at that if a area for research us identified then as long as appropriate or relevant research we being dcctSan by a mnFetent l~ratoV scmewhere, E need not undertake additional research but would need to keep abreast of the fi~i$a of the already ongoing tessar~~ ~en it came 0 srxlnsoring research then this should concentrate a filling tile gaps or ananalies previously fdentifid, mis could require seeking, directly or indirectly, requests for grants, and how this should he plrsued a would need to be ~siderd~ R ClibPDF - v~~fastio.soni -3- 5~ Ad hoc Iffder ad hoc issues Mtters slrh as fire-safe cigarettes were discussed, and it Has felt that apart frcm'Keeping in contact with ongoing research k0tk in the Is, no further action kes require~ at present~ GmJIGFJI5~ 34 7,12~87 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ~rio~a Sore ~ues:icns wilich might be considered bj' the Researdl Ccrnittec~: ~i~erall 1~ ~ the companies believe that pursuing research under tk,e I~C ~rella is still worthwhile, or would Kxnpanies objectives be ate likely to be achieved by either plrsuing their aYTI research or working jointly with cne or ~ore like-minded research companies through the use of negotiated joint research contractsl 2. 'nhat an the individual mnpany objectives - are they the same - is there ccr;cKm grourd7 3. ~ic~ n~~c:1 information are the companies prepared to disclose about their own c~oing non-mmnercial research activities, arrl 2~ what stage - ?lann~$, doing the study, after the study or only after plbli~ationl 1~ i~r~t should be the objective of the research work: (3) ~l·as~ring levels of various ca?cc~ents in ambient atmospheres, ii so which compcnents and why? iS) ~ understanding of the distribution of smoke mt~cnents in ~bient atmospheresl (C) ~le3suring how much h~ans actually are exposed to unler various oc:jitions, if so how should it h done, using lo;ni:torrng packs or urine/bleed sample analysisl (d) C~cd epidsiolcgical studies? 2~ Sr~uld the aim be to put the 'risk' fra EIS into ccn:;l: with other 'risks', for example e~osure to radiationl 3~ ~i;ould ne do its own thing or ensure e~ordiMtion/ccnpatibility with c~cher c~,cloing research, if so how should this be crganise~~l N~3~ :'or all the above see HG's note of ~cge~r~e: 1~87 : "Se Pole of Scier,c· & the e~S issue". Prcdcct I·lc~ification i. EBI much ;rare rcxxn for reducing S~T is there! ke we Yepared to accept,'can ~Y~ realistically achieve a further 15% cutl 2~ il*e there any alternativesl 3~ em much effort, if any, should be put into evaluating tests for tar r?alitl:l 4. ~F,at is to be the industry's attit~e to the TRPT1 what level of invalvaat would the mnpanies kantl P Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 -2- 5, Bearillg in mird the Gwernment rhoist is to measure 'cier analytes', should 17LC do testsl Note: Mudl depends on the recommendations of, and future discussions with, the ISC following the publication of the Fourth Report. Effects of Smakira : SaiolESigl Effects I. Wna~ work should be mdertaken cn de 'hnefits of srroking'l 2~ Is it best done on a ~T~C or C~n~ny basis (singly or as a joint programme agreed by tkp 01 more com~anies)~ Soki?g& Health 1~ Is TAC adequately set up to monitor sMking and health ~ric worldwide do He know what is going on, or do we only find out w~en work is plblished7 2. Co we have a satisfac~~ry TRC mechanism to search cut ~i~a:ies, or do we cwltin~e to rely on irdividual crxnpany inputs? 3~ How do we tackle anc~nalies without either doing it ou~.ca!ves or seeking external brdies to undertake specific work? 4~ IZ1 we c~tin~e to sponsor fundamental research work, or. ~ ad hoc basis, or do we seek cut grantees in areas of particular interest, or do we work in these areas at a117 5~ In the ccnteut of 'imaoved' health effects arising out of the past ard current prcduct nc~c~iiication prcgramnes, should. TAC 'ce Indertaking any co~rt analysis work in line with the ISC activitiesl GRW/CCJ/5~35 16.12.87 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111