2dLC SECRET Note to E,A,A, Bruell, Eaq, Aide l(emoire forvisit to BATCT, 10,B,B1 II Evolving from their early work on tobacco plant improvement, Hamburg R6D are becomingly increasingly involved in plant fell cultures and their pbill~y to convert siiple nutrients e~g· sugar to high added value chemicals, 2~ So tar, uo~ld experience in plant cell fermentation of this type is very limited and Is certainly done on a small scale, perhaps up to 500 litres I would guess. 3, Supported by a grant from the German Government of OH,B ~illionl BITCF have buitt a plant at I\hrensburl vhieh Las a carSade oI reae5ors ranging from 15 lil5es to 750 litrcs to 7,5 a to 15 m and ultimately to 75 m , This last reactor is very large fndeed~ The successful operation of these [erpcntors Is a significant step, particularly since the contract with the German Govenment still has two yeats to run. This plant is being built and all stages of It have been proven operable, although by no means anyway near optimlsed~ This is a very significant. step to have achfevcd~ a. BATCF are obllgeC to report their findings to the Government on a continuing balls but alter four years they will own the plant and patent tights (v~!ch may be shared with downstream marketing companies), 5~ The plant cell system currently being used is Echinacea Purputea which is capable of producing a pharmaceutically reactive compound known as xylo-glucan, This forms part of the know-how of lomaphatm, a stall but elite pharmaceutical company, Vhae lamburg have done Is to develop the technology for the production O[ this raw material. 6~ The rau xylo-glucan is performing very interestingly in animal tests las I am sure will be outlined to you during your visit) and could be vorr;l several billion Oeutchmarks in market sales value to Lo~aphar~ if clinical trials, now agreed, are successful. BATC~ would hope to get 1SX, Special Doints 1. BATCF need to probe very strongly the issue of product liability for the raw material supplier (vhich will be their role), 1, Inevitably, the adT role in manufacturing this rav material for toPaphatm will come to the public arena, Initially this is likely to take place in September at a status review of the project by lomapharm to the Government and will be then more publicly exposed in November at an exhibition, jl AI i, Heard AIIIDET 10rh August 1987 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 U (p a * 9 'C I yr U (I I r u O O r ii a I~no I 0i IYI YP U I* 3 * II O u "I(I ~Clu o u 0 O w i O a O 3 Y P Z O I I ~I I O a 3 o e I p Y E y I O 3 3 3 I X I I i 1 $ L L O O L r a I $ 3 * u s I Y O i U e 3 L h O O B U U ClibPDF - v~~fastio.soni _ I_ BAT CP Production Technology for plant cell Isterials Marketing o[ products Phamaceutic Agtichesicals Ftavoute Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 S1CRI'I Note to EIAI~~ Bruell, Esq, BlfCF Biotechnology Project The biotechnologg project that BITCP have been conducting over the last few years on plant cell culture as a route to added value chePicara is making excellent progress and l would like to brief you before you visit them on 10th August, To that end, I will coPe into Hillhank on the 10th August in the hope that there Pay be an opportunity to Peetl The principal points to lake are that the project, which will be called Project Rappa,firstly, has proved that large scale fermentation of plant cells loots as though it Fight be feasible, and in this respect, we could be 5 gears ahead of USIJapan and, secondly, the particular plant cell system currently being used is generating pharmaceutical material which has given dramatic results in animal testingl I cannot stress tha absolute confidentiality of this work to which, of course, I have been sworn by our SctPaP colleagues, but they will present this information to you at some stage during your visit~ Dr, Erichsen has discussed this in very broad outline with Br~ Sheehg~ ~J~· I~('a~ t~ Beard (Oictato~ by A,L. Heard and signee in his absence by his secretary] ALIIDET 27th fuly 1987 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ·2- il~ili~: i::il i I:i:T Rl~Olil jr I.L. I~iiiiO 10 Bi: bt~lahnl · :6·15 :ULY 101! I~ The new progrsPPe has I group of 1-2 tear projects of a Ihart·tetP type together with 40 projects of " 2-5 year nature, all are Partet-oriantated, The 1-2 tear projects are agreed and Ponitoted by the ~Vb CoPrittea with Hartetlng, leaf, production and R~O involved t The 2·5 tear projects are steered by the PNA (product innovational EoPlfttCe, chafrad by 0 voP Spacht, 6, Vhilst Pore detailed noter on topics representative of the BATCF areas of apecial expertise are given in the Appendix, the foilouiog euaPary pofnia ply be useful: Biotechnolonv CPvLrn~cnt has agreed to 502 funding-support for a very aPbitlous project to scale up to 75,000 litre :roP 300 litre the slee of the plant call feroantor, Ihe know-how, patents etc, will belong to BITCT, Opportunity is high, due to the unique position which BITCF would have, but the risk is also high, so tobacco cell work is possible under the Co~ern;eol agreePent, work afPed at direct tobacco use of plant cell technology will continue using the small reactors, it will be ilPportant to ensure adequate effort for Group needs, Flavours BATCF are achieving success with a range of new research initiatives, the aile of which are entirely prag~atle · Iechanistic understanding Pay follow later, Treated cocoa shells, pectins, lignins and sulphur-sugsrs all look proPising, Produce IoPovatioas BATCF have four iPportant filter projects which, vhilst neeting their own strategic goals, have Group potential, Al I general coanent,'l have an unease that in aoPe areas full use of CRLDC past ex3erLrPce it pot bting tllPn, el.applat I~ to be probed ~rc: 1·? i, A po],yprop)lene filter coocept, I I? 1' IT~ ii, Fibrl LnttusioP iron tobacco dust - d~*r where GRLDC hle B~BX expcrlcnce, ~'* i" iii, SliP cigarettes, Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111