~~~~~~·s~G i·! r ~Y' 81 "'' ·· ;Y·r ~~Lr. Iv I ii ~R3~B3Jiiltll'~P~cnu~p~lm~Flr·e~Ppmu.u -P~~! I ·1: 1FU~mP'~P-~~~·i~Tr~f~Fi I 'asu~l Usouronrrr ·, 111 '' ·S~IM[n~lL~ORT'l')ltYlre( · -ePrWTSCI~1:MMmWNCI tl - q~w~·~a:k~smlra ~yjl~PP~L'%I~,~Wjh';E91 L · ~iE~ ~S~UIU~t~i~h L,~ aul O N Y ClibPDF - v~~fastio.soni iesca::h Sabora:o~v Bcpor: le~ 1~ C0D' QO~ IV I~PS~IAL TOBAeCO I~RODUCiS O:V;SiON O~ IsbjCO Im. RESEARCH WIORIITO1Y ~1O~I~At ResJ~rt~ I Dlvu~~nc~ arwr asolr or 2ai :ouccp r~ar' i ~t· Ill:lllllll.;:i(l~··~1.1···1 ii RESULBCI! CO1~FEiLF~C~ ijB Montreal, Ouebec, Cards II (k~p~t 18-]0. 1910 1~ :::::~:::~~~~~~~~~~_~_~ i . ~-- Section A Editedbv: r~A,Sl!th tssuel by: 8.5. ~~de Ol~e Issued: Je~ry 41 !973 DTSTRU~T~Of: 1 libtarj 12 Dr, I,W, Hughes 2 Hr, R,Y. Cibb 13 Dr, B,A, Sanford 3 ~r, R,S, Uale 14 Dr, R,A, Sanford I Or, 7,A. Smith 15 R i D Department, Australia 5 Or, S,J, Green 18 R i D Department, Australia 6 Dr, S,J, Green 17 !!r, H,E, Sottotf 7 Dr, S,J, Green 18 )(r. B,E, Sottorf 8 Dr, S.J, Green 19 Hr, J,E, Sis~cg 9 Dr, D,C, Feltoa 2(J nr, S.K, Kcshava 10 I)r, F, Hsslaa 11 Or, F, Saslam Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Zllt TO~CCO CEB!S:S IESPICE C05PZStE ~on:re~l, 9~cScc, Cln~da Oc:oblr :8-30, 1970 This su~~r~ report eovers Plp~rr 21 :o 31, end 13 to 17 of Sectioa A, Pipers 1 to 20 ore covered in Rtscarc~ ~bo:~torl Raport No, 130, Section I sanrerv retort is bciaX pre?~rrd by ~, Joha Elnrt, of Itw L II11LIOP Tobleeo Corpor~tfoP, The editor t~ot~ Mrs, L, Rfpaau sad li~I e, Clrley for the photP~r~ph~ durinp the Conflrence, lad ~r, C, ~~cobs for prlp~rinR the prtntJ~ I1DC~U~MS 21, The isolatioa lad fdmtiflf~r~on of ~liylp~eno!a lad Arvlr,!triler Il~lleurrll Subfr~ee~oP of Ci!ererte Snoke Condcns~tl, R.L, Tiller, 8.3, Strange end P,L, Slcdm~, 22, The ~diifcltfoa of Selsctsd ~iochmic~l Prooertfls of Qpnae er by be bl oi 4cLn! h~~ n~·r l~llndict I,t, StldPn eod 1,1, I·e~~ ·· I 23, Itrc:el to Alter the Ildleint Properties lad ConpoJition of Ci~Pf(t:C S~kC bV the UII Of hdd!tivcr. I, !~~r!t:, R.I, Stl~~, E.O, StrLa;;e end D,C, ~fllt, 9r, rct~SPlic Dc~rlbtiol of DlhldrPctlafcotiac in the Rat, roffe! 8, ?I~eh·, Ir~, fd·rd I, ~o~~n end Berbcrt b~ril, Jr, 25, Efferr of robeceo Snoke Coadeasl:es on Rrdu~eLn~xid~tioP CompoundJ vfth Plrticul~r Icfsrcnce to hscorbate ~id~rion, v.H, ailtaoris sad ~,A, lllsbet, laf!ueaoe of Iqaopt Extrlot of Ciqorette 9~1 CoPdea~~te op Iloronll·IndP~rd Clocer. K,L. Svdnor, 27, ExPcr~en:tl Inve~tfRtr!onn on the Probl~ of Pl5sive Smoking, E.P, ~irkc, 28, fluc:l~ln end Fluormt~cne~ in CiRarctre S~okl, C, Ilr~h~ sad D, BoIfnnP, N ClibPDF - v~~fastio.soni J, Idenr:f:estion of Certain T~r~·onff::e ~7~:OEar,0?5 it. Cijiarer:e SaPke Condensate, fiei!, ~.S. Ireland, F,J, Srhu!ft and A.~.:;oears, Ji. ~he Wiltty 31 Cd~~DII-ll 10: Aseer:~ft,.n~ P:lctl:sot-koCat Relationships in C::arct:e S:~ke, 9,D, Carpenter, r.:, Cager, Jr., R,H, lie:aar. and R,F, ~avjon. 31, ClgJrette SaPke Fonaleien Stu~:es, rI Smdke B!srrihut4 and 1YlifisSrelm Pyrolytic Cogc?it:on of Added 10C-xeneho! (U), Fobert u, Jeni.!ns, Jr,, ~:c~ar~ H, Sevnan and h.K, ClaPis, 4!, 3cqradation of p,p' -SDt :n Tojaceo Sraokes, Part Ii, Tie ijcn:fIica:ion and IEr~a:io: of Yblari!e ngIaCatieo Irsducts ai p,p' -DDT !n ?,,' -~3T ~:ee:ed Tobacco S~ica, SoDra and Sarrv ~, 5:1e·~3*;31 41, The Fomatio3 of hthpi Ch!or!:e in EorninR :iqarLttas, P,.E. Johnson, T.E, Sa!:h and .',i. byes, Jr, IS, AcCivetcd Carjpn AdsPr3r!en Properties for organic Vapors, I, Arotlat!e Coapounds: !.2bcls one~ and ~dh S, ;'est, bi, A ~oCel flr Fil:nth ~ Cellulose nee;ate .Fllters, ~, i, Re~nolds. II. ?!le Partlcula:~ le~ov;l Effici;·~y r~ Ccliurcsl bceratl ~frra:s. C,E, !;c!:h, Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ;I '~ I. · . ..: :: ·· · ·· .'..~ :·· '·' · :a~! .·. ·:?.~.; ·. ~·' *1:n!i :ra 5F :·l:all Il·vr:1! p,li~ ~urr c.dl~~··ri .~e~ ::K :,llpo·;a:~ ;tagin an 11:i :·LII~~~ .I. :?!~i~?*lu!: l·~~·llu:r:y!lul~Ji: :~·:!yl·sc!hyl?b'~~,I; !·(:$l·l.bai· Ikn~ilin~im ·· ~ar yhlPPil ~h 01 Ircisl illllh~l 5av,e pi Ih~ inon ; i:pr~lo~:l.? )rsy::llr J: luuu Pra~arl s! Ir.~ Inl~ st i33ul~~l, th~ i~ul~r Jf 411.·11. fract ,na:iotl of the neutral substances in woke condensate show that .tllnou Lljelic rcr!vity occurs in the nitromethane fraction, which contains P~H, cl:ln~nts, be~lyl es:ers etc; aer!vity is alse found in other subfr: ,ns, Slide i - :h5 par:!t!onina scheme far condensate fne~~ooaeiw. The smotl :Pr,iensnre vas keat frozen before being ftnerfonatad, Tbe neutrals Eouse:.tut!C about 2Sf of dr roral eondeasare, Slide 2 - The e!ur!on scheme wed in cPl~m chromatography of the neutrals on si!icic acid, The 252 bcntanepct,cthcr fraction contained 852 o: eh bePzo(a)pprenc, and by g,l,c, shoved 480 peaks, · Slidel - F:actionation scheme used on the benzene eluate, The DHSO subfraction from this contained 5,62 of the neutrals, Slide I - the ~acrctp of elut!an by veight from the silicic acid eolan, s5odng 1?0 fractions. ~ost of the weight vas eluted with TZ ether in ~eazene, Specific attention in one part of this vork was paid to fraction 21, eluted with !00: benzene, Slide 5 - A gas chron~rtogran of an al!qllot of fraction 25 bn a SE1O/Ghtelosotb, :he I aones (shom) vere ,hen :e~hmmaeographed on e second celllmn, Slide 6 Cas e~romrogrclph of tone i (n slide 5) on a collrem of Carbouu 20H on Che~Posotl3, nL numbered peaks were collected in glass tubes and submitted for I1 6 ~S analysis, Slide_l - Arplnitr!!es identified In cigarette smoke condensate, found in fraction 25 (toc! 2), Slide 8 Uky! phenols identified also in tone 2 of fraction 25, Alkyl ~henoL vere I!so ~lu:!ficd in aone i, one of ria bei~R skPtolej ·· Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 _ _·_I~_ _______ C: IL ·· "; ~x 9 ,· ''' " n O~ an b ~ ;E o e-. r ds=, U * '' ~I "·~ s t·r Nll~b~· U Y .hi a ·o , ~t '1:e "~u '~ Y -O o:: i '·~ "· .n ~-· r r n~ Z O·: Y Y 8~ z r Y iYg o U ~R W I IL 1 Lu r c c? 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S!id~ - leoftions of sulohydrjls, Thin is no evidence for the foatfon of diners, Slide 5 - Reeet!oa aid in detenainltion of -JH coawundo, Vith Ellmen's reltent Ibor, Ihly sipl 1 colwt uhleh i~ rl~lurtd, Gvaaldl end thioFyenote lleo rwce to I~e ~tarflrenfc, Se,ureted end Irlrorltld ~ldlSlde~ elro interfere, 511ds b - Possible l~rhls contributinD L whole 5Dol;e (reections (o) end (b) alld he nornollp expected), Iedox potentiols Pre reported b~ the outhors int ]reer, Slide 7 - This shove rac other redor s?eteDs, Slide a - lleoetion loll ~~( vitb DCLP, 31s 11 tipe dependent, vith ~I beinl the Pin contributor, The trenour pLH fra ~cstltl- filter cillrsttel shoved less redoCiPg oEtiVit]r then tht from POP- filter ci~~tlttl~. Slide 9 - Illctt·ce:ic leosurenentl on filtered end unfiltered rblle Ibv rtroo(cr rdocPI ootivitlr for the ~pclr phle then did the dye, sli~lP~ - Ieoct!on Ibdol possible I~~nt of in~o~ont!lt -SB 1'o0pl (f0r II1~Ctilit!) on filter eotton fr· esr In Ot!~·s Lbor~tory, UnTort~~:ely rtr ~!Jult:nfi 3eterial hid e stronll ~lrlic ,OdOUI, ClibPDF - v~~fastio.soni t2·t Slide_ll - Protocol for the exocr!mentr (2·ntrrobCP23le ,,it!, ~~"'~~~ ~i''J "]13.~lthl0blS- Slide ?2 ' ~Lparm~iri~, btl frjl di!i)llLI m.ef il~mll. Chareoal reprcseats rbe cPaero!, Plain CDltbll se~d ~he best for Slide 13 1 Thfslists relrpant PLb115 Of U1Df~ipB WX PrOPBlkS Of vlpccr pLse ~nd partieukte phase, Slide 1 Slide T"~ ~ ' Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 i.-~ S1:Ce i Si!dr 1 Slide I Slide 6 ·1· ..·· ·?: p·'··· ;b. L-E ~jlXi~ 'F~· " ~I~I~I~I~I~I~I~I~I~~'. :-r "' `7: :n '~''~';·Wu'·, r. 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(OUde miraing). ~l~'~:esulrs fron u3;reatei, no~-fil:Pr e!s~nti!s. a:rC er 3 eDCltO!~ I:: all tie follo~!iitn stir:ss, ~il::!~i· ~er,rat- :i~ ~i3e ord!2at! :tlresen:s t'ie Cise rau!rec! to wP:e t"e ci·arp.t:p to ~ .·~ w LIUtt le?zth. ~lain in eac!1 of t!lr eX~erinsntS. :idraeel ~~ero;iic!~ sis w!ded d;tr 45 afxutes (at A), to detzmine easi!v ozid!saSle cm:ccenrs, an? ~Pre ?eto·i~e at added at 5, Slih 3··!lotof rate of e~:anoe lo,r ?u~f, :.1· ~rca:est c~aEoe occurred bec:cn ti:e seeor.ri and t~e iour~~ 7U:!$l ~I:DI:·:C final ~uff, osifation :sa·~, feslite tile fact that ~i:~o~zn 2as Se!nr: ~asser:, i"l:e effect of diffe:??,: ozibanrs as :ahacce additives ~as li!en ex~:na~ , Sl!~e i - b:e effect of lj? ~~ ci i?" a~l:ope· ~erox;le, i~er? ms ver rirtle effect, Ir0j;lbiv because it qS too u:!sta5!e, Sl~r~l- cr, a pi bc.lavlacral!iu, added ~ ci:o?P!nr;i. 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T.nC :a~:jl: iIt yavp. a Rste ~!t`; i?crels~i rrli~cis· ~cririe·: (Ic:1 ~I~·~:f~. ··:!:1::a!), Sljd4 i" - rffs: or t~~tC'lf~DP~ Ir~i:~_:l ·, rr.::L: c]r·liucrlcs of i(p)P ;:·:, nicotl~P ar.~ 1~~?;1~, :n~' ilCt!dS26 ~B *lr, 10S6!b!v partly due to aansfer of Jd~iti7c, 1:e~l:il!?, ~ic?tl~l delivery is red~:eed jp "?::, alL::~c~otr. ~a~is:~~ ~~ i~c:las~l S~l~ -:tfact of snEiu- :il!OS':15.:?:S I:I:::21·o ar~lt! On de!!ve:ie~ of "II (Increased !(lr), ~(a)~ (i~e~·assl ~,:, :!1:::ilt !dr·cr~sPf 35:),:!1~T.c!s li:CtCdSSd 311:), :On:je s::I~·, it ~I.1~ :n*clullclIcl :,::: nC3c:ion occurs I:! t'lc first fOFI ~cfls, at? ~~i~ r?~ue:io~ c~n?sr ;·? r:~2"'i :; ;l~~iti'JCS. 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Slide 1 The separation schece for smoke condensate collected at -BO'C, Slids 2 - Subfractionation of nelt:oi fraction B1 after c~ro~etogrsp~ on Florisil column, Slide 3 - chemical composition of neutrar sultncrfan 81, Slide 4 ' L b show the r~our in!:iatinl ctiritp of Illh sub!:aeions, and c shows the fraftidna:ion of 31h by cohrme choPtognphg, slide I - list of major compounds in t~n~ur !I!tiaelng fractions Ilh 71-/8, Slide 6 - Sist of major compounds in hwour Inir!atinR fractions Jlh 55466, Slide I - Scheme for isolation of fluercan from drl smoke condensate, Slide B - Cle separation of fluorene concentrate from I large scale separation of dgarctrL smoke condensate, Slide 9 - Fluorenes i? ffpare!:e smoke (amoun:s), Slide 10 Ihe scheme A isolation of fruar~nt~enes from dry smoke condensate , Slide 11 - Cas chromatoqram of fluoraethene concentrate from a forge scale separation of cigarette smoke condensate, slide 12 - PlwraPthenes in eiga:erte smoke (~ouats), Side 13 - The possible mechanism for the formation of B-methylfluoranthene in tobacco smoke, i-,2·, and J-scth!.!f!wrsnthacs ~n formed from the corresponding methy!afenap:lt::~lcIle and iso;renc, and, 7-nethglf luotanl~ene from i, 3-pentadiene ad ace~phthalcne ... 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Slids 1 - ~he fractionation scheme of neutral fraction, i Slide Z - ~further fraotionation of Pitra~c~bne fraction obtained from neutral fraction of cigarette rrmoice, Slide 3 - Isolation of smoke components b! gas thromatography on pol)r-m-)benoxylene PPE-tO, Slide O - Cas clrromseographp of smoke components on Apieton-t, Slide S~C - Separation and isolation of methllfluoreneg and diolethylfluotenes by gas chromatograph), on Apieton-l, Slide 7 · Relative Intensities a some mass n~mbcrs in H,S, of Saethylfluarene, fluoreoe and the isolated mixture, Slide 8 - tist of identified alkgl flwrmes in tobacco smoke, Slidi 9 - tist of identified dimethylfluorenes in tobacco ~Ploh. Slide 10 - W speetra of isolated and authentic Z~eehylfluotene. Side 11 - lR spectra of isolated and aut;lentic 2~methJlfluonne, Slide 12 - IR and U,P, spcfra of 3·oLthylfluorene, Slide 13 · t~ specaa of isolated and authentic l;nethglflwrene. Slide Ib - IR spectta of isolated and sPthenlic laethytflwrenr. Slide 15 - IR spectra of isolated and authentic 2-methylflwrene, Slide 16 - I9 spretra of peaks i), and 78, Slide 17 - lR speeaa of isolated and authentic t-phenylnaphthalcc, Side 18 - ~ and W sFecti?otblnto(b) oaphtho~.l2,1-d) .turan, 00511B10t Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 SUde 19 - '::ce:-r~: f?~~'?~ cf :c~ts(tlal3t:ie (: ,l-d) fu~sn, (b) (2,3·d)isose:,;:·; (I.?-C)ise~arr, Slide 20 - ill and ~~ s~ee::a or icnrc!~inaletaf (!,l-d)lumn. Slidc,Z1 - identifica;!on o! fcrana ~· i!.:,, L'i' nod rnilsllln spcctr~. Slide 22 - I~ spcct:j of isolated a:t aur~cneic 2-phmylindenr, Slide 23 - renta:ive !dcnt:f!ca~ion of a!kltr-2·phenyl!ndencs by IIV spccrra and re~mt!qn tfw on c~ronatograms. S1:de 1 e, S1!?C 2 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ::~: Slide 3 Slide I I~AJC~YS'Lli~.C'IICaC~Yr~LI~`·;IK.~T · . 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C_ . · · ·· ·.. ··I.~.T.·I Bar~~L1~~-. ii~·? ~ · e P L, 1 S i Y 1 · ··--··· ;· I k · ·~(·i~ · . '· I'~' "·r~ .~ 1~1 a~·~i:~r;l;~L··~:·'i " - S1111 13 Slide 11 "' ···:~ . ~iil~ ·~·; :k51'i :1 :·~ .iu ·I~ "`' ·`''' ·; · ...,., ~ ·ul: 'J)h ~E~;ti6Y~b~ a ... ·I: :r 'i" -U ·~····i·~ ·s; r ·'r· .;·:~: P '~ t ·~": ·;.;*~:~c~F~e ~t~ .· d a f f :: '''?41 ~1 "" ~~:a? i' ~' ·'IL ·: ~·· _i I a.ra~ C1 ;; ·~'· *·,·li. 'T'i"! O N a m O a Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 l(i-j S!!de lj Pi" r·MFI RI·i: ··~ " ;3; 9!~ "' ··· ··11 ·· · -· ~·.-. :y' ·: , I,. ,I-- , _- ;·~s · ~3 ·· ? C '· ·~.·. ~s~ ~~:: ·-. i; ·" " '' l;i ·~. · ;1 ··: *!· .~: .·~ " : rr- -- i I~ ·.. ~·· ,.. " :·'·I *, ?:.~ 5 I:` 1 ?r. I ··I,? :·· I· ~······~ """ ::7 ~-ii ,.· ... .· . .Jll· 4 r ·· r I~ ~··· :t·: ,P· i: I' I .~ '* ·: I ·· L· :. ··· Slide 17 Slide 18 - ·~· ·~'.': ,~~, '!n· · ·I " '· :r ; ~i·: ~·'~·~ L~L~ ·";`SC ~ ~;·· *. *. ~e ; :y .· · :J; ·: : :' ~ ·· \- : ; "-··- .' ~C4-=·: t 1 1. i rl i .., ':1 P ; d "" '' '~ ·s ILi" i R :· " · 39 2 ."~ C * I~ la~n : * ···-· ~· ·1 ·· ·'~ IIIIl -Ym -· ;~·;~ C ..I 1: F·c~· *·~L~ ''' .Rr s ta: ~ O fC~ N ·1 i: 1. : ·· :' ·~~C1· i·~i~~h:-'llb~*·l~~k· :11.5 ~~ P ~T:r''l;aP! ··~h*. ~L~~"f VI O U1 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 C'iie 2'? *''' ·)· i s~i·I ·I·~ . "" .., :d~il~Y36~x~CPW ~6~8 i, ,, f'.*:C 1' , r· ·Du ~i '"t:r* ir, ,:mi·p-' L :·~ :8'· '"' ~··· I :··~ -·· -··-L~F .. *II: ·.r. ·: .,··::: F~ -· Tj~ `·' ·; RI i: ci~ u n ~·..'D: L: ··' `r ~.~u'~SIC~hlB ~~C~ CJ ; *. O "" D I:: .~ C~ ·~~ ~5- 'C ·~ 'I : ': ·· n i. ··:~T~C *·:: ti~ ,·'· ·. P ""f · 1. . ;..· .., ~ Oi ~t rc~." '' "C"'' C·~ o ·;; -1 ,,.I ii ~11~:'···: ~. 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Yl~~nJ *~ *~ n~*LI*n!Cc'Y ~*lr··IL* ~u~uu~: L1~·~G*ULIUI~ LHI*UL Y~ L·LL~;j yi~ FM~~h L·C 5. * C~ IOn~~~ y[ ~d*1 IiY Lr ~r~~ mr· ~ i" L~THY, Ylci~~T kl ~I;L~r CU~)~U ~~'*F Slide 1 - 56rtic of epperetuo for Isellrint dietributioo of n~ioleti~itt io Pbll ~r. BY1 I Slide 3 - Totll octivitt liettibPtion io f~e :illrcetr, Slide 1 - Citltlete buet Icpthol coneeptretiop, Slide I · Puff-bl-ouff ~I dll~sg, alias a - aaltrr ·ob ooelyoio Ichr. Slids 7 - ecllcctian ellel for rlllil of P~ltrr I~ (phorolnph) , Slide d - Olose-up If JooWnS had end eeietl rral of ~ida~~~ r~~, Slide 9 ~ ke chrolltolrephic coin, glide 10 - D~ttfb~t~ of ~cei~ig io aa:nlt:l· Jake, Uoiforp k~lllfl of the ooloouodo ·Id io veri iEportlor, lhe ·rln twod thec ebe td~ca rod d#I lot fn~lt Hnrhol, 41,91 of ell. l~h~ll~d athol vee rra~na is the ~irtn· a~l, Ildeltnr ~b debt tile, Jotl : leper ]1 vee prclatltlrfon Peper 30, Iqlt 31~ 111 It· prltio·l~ ee the Itb Brmtiprl lobeeco Scientilic ~plll ill Uog, iD 1910, ....- .-.1.-~ -. --,-.,,.~ 80~1iP10b ClibPDF - v~~fastio.soni Slide r 51~11; z~l~u~n~ '* lug; .~ c.: ''' ;~:~'';:'t' ··'"·": ~3~~~ ~5r~I~ I.u··.,a I-.;.?n ~;,, '··~ -:ls~L~PI~L~Z~E~.~eT;i ·.·· ,· · : ,.,..-.1 i : L. I)~.*. ·?, ~· W I ~··.. ·:'' '· W ;·I r .T.'·i U o~ v, ~V) C O I. ~b~ I- U VI !~ 1 O ". 3 :1 a3 ~x a: ~P_51w ii vl ~ ,... ~o I it .. 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Ee~:(!l ~C02 i:.v ·· ~ ,;I ·· .:: ··\···· :·14 ~' "' ~.··,I: r ., S!!de 10 :·I ~~~·cs:: ~·- ~·l·:~"~:·:R ·~: .. ~2~4: ~·1::~ 'P - 3· :t:i ~? P~· ICI·. ~ ,· ·~''·~u. . h.~lt: ; O IV Ui Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 3c·1 " ~ · '., "'- ':""''·· ··` . ''·1111 ..:, li"":1 :· ,.·I ..~ · . I 11111'·:'.1 : .'·'.:., ,I! ,1.1·· - . r · ,.: ·· ~.·. , '. i;·., · .: . !..:··: F:··l!'n': : ~~~,, ~,,. ~ ~~ I:·I~'·.· '* r .'·, ii .'..~ , · ·.· ·~· ,' .,~ ..~ ~ :..i~~ ·~:~:: :.: ·.I'!I. "'I I'. '.:.'::'. ~~' : ':':~· ':`''. .' '' '':. .:r ;~:ll~]yr~· iJ11111I· 1 ,I:. .:. ~ :(.ly · .I 1(,1:..1~· d1'.11) '11 ;··. ;IIIICY· j :· .r.,·lyr·.l " · ..I· l.'li L!;.I;·· LI.II·llul:l 01 Ip;· ~UI') :II ..:*..· ·I(: :1·.,.1~ 1.·t1·1 ... :·!. .Il·i~ 11 11111~11.::~1~1 .:·;,1·~':1.1.:11: [": "'' " "' ' :..'"I"'. "I' L;~··. Il!ldrlll· ~~~r :ula~LiOli 1131 Kh 011*11 1·, Ilile 1 - Composite temperature profiles for same palt of cigarette, and puffing cycle, Thr complexity of these illustrate why pyro!ysfs studies of tobacco are of necessity so far removed frw stl:Cies In uhich the tobacco is smoked in cigarette form, Slide t - Contributions of dotriacon~ane !a:adioae:!vin of salasttcan smoke, S1ICcl · Contributions of sugars to mainstream smoke in per cent of total radioactivity applied, to cigarette. Slide I - Cross distribution of radioactivity after smoking, Slide 1 COM~c'~i!i: IEMPEAPSURE SOR SPlrlE PSRI' OF c~cnR~:E hi~~,:j PI;FFIFIG C~C1E :I1IR PVI~ 90(rC g25'e i4 · J;rle ·; -a t~d O1 i': 99~:·: pF9 ~)rl fi' ac~e gLC ni~ r , Q6'C --. olrC ;i i x a o h, a u In [V Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ::-' e:i~e i Slide I 4 O TV Y U1 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ~_~___ __ ._. Ij.! 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Slides 1S2 Proposed mechanisms of the fona~tfon of 71PI -DDI pprolyJis products, Slide 3 - Cpparalus for burning tobacco, S!idr 4 - lipPataeus for recovery of ncrby! chloride, Slide 5 - Chro~ar~gran of sample containing methyl chloride, on 3: OY-17 column, Slide 6 - C'nro~amgrua of Ea~pk containing methyl chloride, on Sr SE·30 column, Slide 7 Relationships bct~crn the amount of ~,p' -DDT incorporated into tobacco md the amount of methyl chloride found in tobacco ao~e eoPdcnsatls, No correlation was found, it was considered that CXJ radicals pick up chlorine to fon the chloride, Slide B . ~pararua for recovering chlomfon. Slide 9 - Chro*tegram of a sample containing chloroform, on a 202 Carborxcollmmn. Slide 10 - ehromatogram of a sample coneafn:.ng chloroform, on a 32 OV-17 column, Slide 11 - Racoverg curve for chloroform, Slide 12 Relationship between the amount Of PIPI ·PT incorporated into tobacco and the amount of chloroform found in tobacco BDIO/LC condensates, Chloroform via found to be dependent on the amount of DDT in the tobacco, Slide 13 - Lcoorn curve for diehlo:oneth~ne, No dfchrorgethane as found during pyro!ys!s of DDl-e:eareC rob~c~o, Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 t!!de 10 . C'nroF.aeop:e ai a sar3:e EoE:aie!nq e~io:aje~:ele and Ftlorotalueoe, on a j: 0~.::;~1C4t. S~de !5 . C~iroa:oSrae ai 1 sa3i( O" a 3:: g-30 eoluan, ;oeta~ni31 cUorobe~:ne, Tne presence of chtcrobentcne d c~loreeoluene uas not aroved conc!usive!y, The? vere fou:~ i:, ot:v o~e sample, Slide 1 Slide Z I~ .*fii~~ Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 L!·] Slide 3 S1iCe I Slfdl 5 Slide 6 N Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 *lli S!i~e 7 I:it~ I ='~" ·''· ·' : I3~1~C~bL~ q~a~me~k·i~·~ i · ,·-· ·--- Slide 9 Slide 10 ii ·I~t~F~S$Z~BI ~e~J~e~iaca~s~%ls~ii~e~~ a i~ O N "·': U1 Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide ~1 Si:de 1~ Slide 13 Slide 11 3 I O Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 :j.e Slide !j CI O N ·J U1 \D Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 44-r Y' ~d tC~.r~ci, L L1~, P~~i: U1I* :a,, C,3·, ;·L~U~ bl~i! ~3i. 912 a~~ '·~ l~sl~ ~ nw~ra ~bi~ ~n~r~ L=:.; :~~~d la~~~~ td14·~ P* ~~I Cr~l·~ *IrM~ ~*~ I~ Ihl~ r~rlh: F~lr~ ~e ld~ ~Ld~L CCBUI U, Li~li :~I ~L1Y1~L Le~:"' ~* ~~ ~icr, ~a~l~ ~CPa ~knL y*, ~~. aL~*p~ L~a: ~~I L~ LLI~ UUU: *b~ ~~~~ ~~56~. 1~ ~~*11·11·9 U LL~*wn~·~ ,~~ j Hallbl~r ~r vl*c~~J :bL L~~ I~; 1~ 5 LP*Ur *b~ j4ni~ ~~d Lr uu E*unll ~Cd·$ L blr a0 tpn~~~ ·~ er,,,, r~*~~ *Lne y~gLp ·yl I~Y Y~d3 L ··~1L·UI:Y* ~I IUU$~ ~kl Cu* YY~R.Yr~:u *~( ~I~ I:*i~ u~lru*:p~~ au UnHI ~a~ LLn~. Plu~l* *~II QLnC J~~~ jb d~ aR~ ~ ~ ~r~~~ nuh~L k~ ~*I b·lni* U~ Y~~Lr 11 UIYUI ·~~ ~Ln~. r~u~l *, o *alrh~~ Lu] u,, hnPdle )~* ~SU* ~I zn ~lr r···~. ~~ c4lltl pqlr follo~l, O N P U N O ClibPDF - v~~fastio.soni - --'~c"c- I- R, 1.,;3'.:'33" a". T~ 2, Sr.:i'.j:, iro:n! 1 ~illi~-.~3n Mac:~ CD:35rt..,.;, 531 a, E. Zs~~:,:r., Zcolgic~l an'! Sissysre:s Analysis Dlvisj3n, L::rl!e ~"T.3:t~l Insri:~:~ I~ Bcuserlpr 3· s:s·: for p:cjfn:rtic~ e::~· 21!tb Tsjacco C~s:ists' ~c:21:c~ Con:c:~~:c, ~:3~::Cil, P~cbcc, Octo~c: ~S·:3, 197'·, -1 -~-~--3-~1 ' btroC!c:i~~ ~Bpl e'ni3:idi his been icn3:n to be a ca~)cn?ne of cigarette ~~cl~~ since 1916, be: n~~i:E his hern rcTartcd on ~~I~ it gets tie:c, TLe pc~:le sf t~fs paPor is to Trcscnr proof that at least sole of this m~eEyl chlo::Ce is derfvel fron chlarid~· ion, and also s!~a7 that this eontlibucio~ is p:i=ri!p to ~ic· strcai~ j,nal;c, Additie,! of Cil!Frid~ Ion to To'Jacco Tne first slid· (Slide Ij shws the c:fccr of added nlgncsirn chloride on ~zi~r,:rcr~r, citerc~b S~13!:C (!elivcrios 05 E:~r! ChlD~:6C tt~ Ctht~i~~ ·-- I SeICJ YBD1; ~:j! 3E31;e iron sic cieer~~:cs of rach saa~!e k·~: ccl!r~r~! in a plastic bt; ul.eS ;··lon in~c:n~i stzna~r?, rn~ an~lysc~ i? p:aZrtt:t~~ tclar:~:e 233 c!lrs?la?~~:ap:1; 33 a PosT:l: col~i~, i~~~ l~f[ nu~l~: rcslts, sj:aisal fro:: sq~r~!~ 5:l31;j?cu, Sil(lV a E~!r ef:rct of c~lc:idi: ip:1 co:!:r~!!: on a5ac:3 co~~~tiji!:~g. Ih! S!cad vi~h 0.79l c!i:orilc:::r· ::5::E::.P(I control t.i':~EEO ed de cli::: s;rT!:s ~cre p:cpcrcd by s~n.~i~: ~;:~ous :Ilu:icns of nei!~t;i~ ch!o:ide o::~ this ;~f tobacco s2mTi?, 010333::(:3 i;! :~is f~)f:il:ICill UC:C 14 ~ in leagth, noa·fi!~r:, L~~ szltt~ unde: sza~a:d ;1v1:4·e co~~!r!sns to a by:: !cnZ::1 33' :S tn. k'id~ eercr:in~ blcn~ chloride content k·e fln~ th: ~ctb~l e~:1:t~? del!vs::c: increase sl~~iiic~nely~ Ettc3a de!ivc:ics also Esae3r t3 !x:czse stiEhi!y, ·nt it z?llet;rC that frh~:ne cJu!d Is urd as a' intc:nll 1:2t?Lr: to CDr:4;:;~~~1 til!DridC dclinries fo:,~lf a·~5~r and tobacco cc~as:ibiri:y ehanen, E~~nr: Fa~ sc!ee~d for this ?c:~ost since it is eluto('. 31333 to m~~hg! chlc:ide 17 :hC eC an:.lY$is lnl the Ic!ivi~ries are. cbrp?l%~lt i:! Ir3Ci;llSe, 6? nf~: Jli~~ (Sli~~ 2) sio~s a plo: of ~~~:!nca? 5~t~y! c':,loriCs deliveries ff:srs t~l~al blend chloride eoil~c:l:. ~ rclnrions~ie is dvio~sly prescnr, Be n~~ s~;le (S!:de 3) shcvs the suc ;y?r of plot esi~g f~~~c· corrur.~$ a~~yl c~'oriif d?livfr;es. II~ ci:ce!.le:!t !i·?·::e!rti333~;, is shc!Jn. 'I~e s!op~ c·i this !inc and the ei~~:e::e lerehts al!n eelala:io~ e~ e~rori~~ ion fsnar:ior! to r.;in;tru:.! 5,:~f:~:~1.1 ehlc:ils, 2~~ t:!is to be ?.!t~. 6e:ua .Ip, t~e ca~ve:si05 Us: Sc still nore e~iici?;: si:.C? so," of til?,~r~gl c~!s:..dr: fo-ri ail! be k is s:~c;~:~;; s·skc, 03::3: c:i!c:!c~t::; l:t F·% soSf~e ct.:o:i~l on ::1a ci~ltrer:p. j!r-' ~ti·~ i!ilSilCL·2!· Cf ::liS SZi~·ll ···.··i rs O N "' '''~*"~" ~''~"""""'~"' U1 N Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Ir us rx:c~~ iic !i:~ to l~:a :2y:fn! bl:-d rr~.,~::. i. Wi!! not 0:$5 ~~ FIP4 ~: rf~:ECt :O ."'" I~.2: Scr~ tr. :r ~ ··· -· P:c?ET. .,t~C~C~, c:il·r ;.!2t:l:;l e~l~rltr. s:~c~:cs:: ~~·· C:::3:;:.t iJ~ 2:C f~l?cs;rd ~I d?rt i;;;:; TCEEirr. L'~C.IIL aj ·:j:m:c!:c·e *~...J fill0:ilt ill $::~!:~ :.5 ~·::ivc~:'a· ci~!o:is!.rii:' i?.s·.r~l~lils, E·;E pu~ll;ZrC Icvcl~ of Li:::2 ieSi:::i:;c~~ on COr~:~,ei~l ci~?:~r.tCj a:C too !oj: to aoco:!nt for L3:C t~~ 2 st i:action oi th~ =3thjt! cilor!~s in ei~are:t~ s,3l~c. · :G3diOC:1E:lezi l':~·?fr- j:~I,If5 Anc:hrr e~~c? of !~:cn!inina the cJa~c:sip~ ei dlsride ion ~o p~:l:y! chlo:ide in a cip:c:ts is by use o:(rb~dioar!ve ch!e~id41 io: t~:s P1IPOSS 1:2 sflfe:cd ~cct~on ecri~~:ian, using Be 2-tcC:~z,r: 3·crtl!e hscarch P,fJe~or os an inee~se ssllr:f of th:zzl ncu~rons, Tne t~i~n~:or~:ioas of iqte:p:t art: il~ustratcd in the nc~~ sr~t~e (Slide 4), A ~ss 37 e:i!?rin~ atom In rk rcec!or core vill eaptc;t i nc·tron with a capture pT03?3rli:l !#D3s section) of ,43 barns, Excc:5 cne;ty is ~?EediJ:elg relc~s~~ by a cz~:c;e g~laa n~ c;it~ an enerel· of 6,11; 1aV. ~~s capcure g~~% ray is ~llg P;~~21$ Or ~rZni:cde 11012 ener2ct!e than any ci~·:lr:~l bc~Cs to et!orinc, and rsIee2e pi this Cr.~ r:.jr inptrts rnoc~ :~eci! e~3~:ntlm to tie J" C! r~o~~:o ~!~st it out of t;:3222vot a!cale it 21".1: ~C iC, ~us paGiPa~tj·~i· chlo:in! atn~s frorl my source rpe csseneiclly a!~ 3rc:cal Is eWori~e io·. jsF' hr.: e :Ic!i li.l~ Di 37.3 mial;·l hlC ~n!:I;::s 5?1·! Ccc:~1::!;icin ec LE~ 8ive b ;:lid: is s:t3' 3'Yl3 int~n~e 21!;·r~ :;)s a:E 2150 E?itCCd in ti:jS t:e:lelo:. :tio~ to ~:!el: t~E eacrgr 533);5. The are iioi:~~?: nlJ !I iso~o~e of c~!::i~~ a!s3 apt3yn.s nc·::o~s, s~l r~leilr~3~e cf:fe· ~·,!c sL~n. 3332 rescl:in: ;50 C!, ho;:·vcr, hasa half life of 33Ci,r133 yo:s !22 ei!l only bcta nys ~~!fp it dCCDiTI5Sr_S, Sine. !~r t:dlSf0xti(l1; aCC ShO:M fOr soiic~ vlic5 Dives 2~ Fi:h 1 hLlf life of 15:13~'.E, It C~1C:20CS bes cissi;o~ to aive ~i~r stcl!e "1Ei~~ Scvz:r,l c~c!*·:il Qa- :C~31:? P!IO $!FE~ O;I iJ tjiS ~iailSf~T.!I.:iPT,. O rr 33 21, Assqs IPr C1 aa~ ~ are by ec~ :cy jpcc::o;2;rtry crmjsz. 3 ~ 3 inch S~i (~I] ~~:; ctvs~;l. ;hf 1,64 C: assay, and th~ 1,37 XCY Si=~ :a' ~I!S USCd ~~-1@;ui~" Yl?i !Y: in: 2"': rille (cl:te 5] s~o~s 1 scsl-.:lr 3f die SB01:E CD:!BC:!EII :tiie?c:!ve ciilt:er:al, 11! r~~kici nehlne P25 I 3~C.7D:: Irt sy:lnZe r·~c·;ac r~~: i:5- a Ila!rcicl a·:c~:ir !!-~:::ieg e:?a:zrcs, Tais sys:n cllo::s ~e:!~c·' o: so:E miastrer~ ~c~ ;i~:5::rra: 5..01rc, ant s?sentcs pcr:ieui;.:e S:!;.Sc ;,,,,:,;: ~:Z Va30: ~CIC 5"31'.2, It 15 C?CCISt:y to Li5e tP~ ..: c: j;!s i:. EC::lhbli~: to aeeo.~s!ij~ E333il:C Se3!ttlioc o' Cenbri~~· :I!t ~tr:iccLte rd F1'3: ~!SC5 F10:i' ~h:OcZ~ [t:: lit:S::~l: eP!lee:il- rl~::it·s vts mi~ui~d a: lli --b:111 3v9r D~~ lire: ~e: tij~ :El etl oae·~:c· oatbo:i ..~ ·, uc:e fe·d ;s cliefr tl:.ss: co~lete:clr:v9.r of C! at this :' r·:C ;11 s-)~d ariu E:atla:t F":!:FB ea·~' ar, ci c~~ t~a·~~c~l 3;1 0f 3~ 'I! V;I.CS ?3: Gi~~tC. b: · means ehkide containing a small f:actfon of radtoac;ivL chlorine, O N vl N N Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 me x~: slide (S1Tde 6) t~?~3 :r?~l!3Ck::l'iC~: iT~nSiS:;FSC!:S:3: a filter ci~;r~;~e fE:.i: l::h t~f:.::5 ~!icii El ;:ratiat?C in t:lt reactor core for one nlnc~~, 'lo acc~piisl;:hi3,;he ~o5~:ce .L:C:h one S~;r,fi!~c: eiE~rc:~e Tt::,r"'! t!ic-c:s of tj,jt :o':acco Vel~ then scr aside as rdio:e:lv:::l sun~~lj, t:!? tile :c~::ic?e: us n~e ictl;a 54 r· filter e!g;:ce:e or. a eo~~~e!:l ro!l-yo~1··c::~ t?~"r~[u;, Calculations of tracrfc: ciiicie~y s:e jesc~ E~ the :ad:o;c:ivi~y ojet~~e Jeantsrts, ~n~ I:oa these R est!'l;:te f~~: t~C ci~c:~:~e had i,! r.illion CI counts pcr;i~ute~ The Euias::eau ~~s: pb:i~ transfer rc.F::lts (3,5f) agrees d:h the result of the eupclin:nt in c~lch ~~:es~ ch!oriCe ras added to t~le ~0~1P.C3 blend, Lprisinelg, the sidcsttean vn30: ph~se transfer ~s considerably lo~ilr; most other 5t!01;C co3~on~nes are tr:aier:d n3re effectively to sidc;tre~ s~o~e than to pe;ilstr~:~ s~oXc. A second eiearet~e c·Os prertrcd by the ac: 3r3eh5urcs an:! ir:91:d tJrth tt~~ nainstrc~:lvr,por I1l4SC :.r.0~:2 hcin:: eollccrt~~ in a plastic bag containing 30 cc of ~n·ctlve a·thy! Fhrorl·i~ as 2 carrier, After :~3~iq a 130 cc aliluct o::h~ gas and transferring it to a carbon trap as 2 standard, r~e rewin~r of t"r v~~~r ph·s~ a·?!e us PIT"? into the inlet s::u~ of 2 gas chrar:l;ot:snh w~lo~int a 1/2::~:cr Para~ak ~ eo!u~ and ur;!n~ nitrogen as eh:: carrier S~s. A t~ll~cel ch:o:,~:~gtas, o~~~is·! ri~h a eSt·~s! cor~h!eeiviry detector, is ill!!str2tet in t~: ~c·e 8!i.de (Sli~~ 7). ~!i!c:~? plal: ojrz!ner' is broad at tails badly, m·t!:j·: c~lnriCe it :ilL1 p~l.y ch!c:i~~ c~qoud d~ici: FI!1 bp cru:fd I!lir S:oo, 'I~C GC C9eQtC vzs ~53r~ eh:ou:~ tro crrbon traps in series and tlleIl c~s tss~~i·l for C!, T~~ rcj:llrs of :i;is czprie~a: are prescnrc~l if. tile nc·:rt slide (Slide E), 2nl .ri~~~ :~~t: csses:irlly all of the ~in::rt.s c:l'or 3lass acllvi~~ is ~rcscs; i: ~El:11! chlo~:~c. n:e total ~ins:rc~l:~ va;lor ~1!~~~ transfer, cPlajs:e~ ire ebe 100 cc zliouot and tL oall to'::.cc(l s~an~ll:ds, was I.i~ o; the total cigarette df:!vi~y. Pc no~ hP~ CD:t~ljEC!:P?iCZ! 3~iilS:rE2' Va3or pt!aE: transfer results of 3.5'1, and !,U, hodljfi.n; base" on the total act' lvity in :ie cigarette, nSntsic e~ln:ide s~~ripcnt ;cs?t~, 2,11, incororati30 al blend c~!o:il~ iclo rinstream Sr.3i:r! methyl chlc~idc, is brsse on the vci~r. of chloride ion in · that portion of the cigarette !~:c~ ~?s eocf~·il:i during s~p~in~, and ~culd~hace to be w~lea? sli~rl; to out I: on :L, S,e:? baSif ,, thC:P.lla:L:iu! results, Fher, we cscs!d~: t!;:r t~e a~if~~:ive :rans:e: data are f:o;;~cliir.js of single ~:l~es~i· ci~·r~ttcs, 2~~ based on cP·~:tl~ rrnults ire s:j!!~ a!i~c~ts of cigarette ~fheccl, the a~rscai in :esul'r is 6ost, 503? d~~:lon~l e~?s:i:·n:s ~ere ~de i:, ~ilic;z nn.u~w·ac;iv~rc? soCiu= chloride ~:s !Pjtii'l~ df:~ the center CL thr :0j3Cf3 C3!~i~nl d 10 C! syrin~p. ~j ~E~1 for iT.jC::tO?~, me cigarette and syringe ?!~3get are held s:ati3u:r ~~i!s ?!;l!i~~ ou; tl:~ barrel to t:i:ie~~ cniloe ~is::ihrion lo::~ 8~ L;I~'~ of t:Ie rsi?ec3 c3!·.t.i. fic results rl these e:!?erirents are presentc: in 1:15 n::!t Silt: C;:i~: 9), :r.?Si ~~!o SiS!f: 1~ Tie tan!:r::C33:tS are I~Ch !JYo.: e~i~ !0u1G for EiSB:C:teS E~~ vtth i:r;rl!;:c~ :ob:ec~, T~i~ Lp?a:s to be :~· 1a4t!: of vary i!5h scG!c, r~lc::~~ !ct~!r (1,::~~ site of al?;iu:I9?l i. . II Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 2, I:er;:I~::o sir.s::ce 51to::.o, jo:i: ?r::ie:la~e an" valor, is apis pr~3:rd on: ~:L~::~::l p::.i·:;:arfe:, sed jy a ~ole orlc: of r·jn;aSc. 3, II1Cioc~;or!ne is r:en:fc::e~ ~:Joli: tt:i:e as E:fcc:jvc!y as r~dicr·o;li~:n to lo:h r~i!!s::5:r- an", silcsrrcan par:ieulzte phases. T~lls 27!ea:5 :D be e s~plc:cmlt aI tie feet Lhct scdiu~ ehlorid: is Lss v\ll:.ri!e then other r'r.lorY? sa!;s k~hich are present ic~!late!'y altc: spi~:ins t!!e c;ea:~::r· 4. Essa~itl!.y rll of the ainl::a~ va~e: ~ase ndio~ctttty is present as rr~hyl eh!o:~de, Diseuf~s:on bnlat sc h~vc! iwo~strated is the ro~:ion oi' ncthyl cb!orlde from chloride in tile toheco b!cn", end prcfere::!it~ eans:cr of this scthyl chloriCe to pr;us:1·e~l ciglrettf ah?. It rs a!so fo3nh thae ohlori(!e ion I;ransfrr 2153 tVOTS tile Film~::CEI E3!iC~ ID atttspricC to aplain th~ p:·ic~~,:e ci p::$l chra~iPe for a!n· s::e~tl ns~r·, i: i!: tcqcing to s;y t'nr: Its ;P:;·i~:ioil ~;o~ c3toride ion is ~c~ c::c! ei,'iciCnl at the hi:s pu:TS·~ t~1.3~:Lt;l'C5~ ~O:;i:VCr, VC hCIC FZn~ th:·s :ra a~n:cci;ble Fun'ieics of ~":~! c~lc:id: ilrllcl larin2 ro~e:cl 0' lur~hc:aorc, inco:psrzc;ol: pgal~:l: a::a;sc!:~~~cs 5cn·n UOFC ant jj: of ~i5:j I! DlOdllCt iodine into r!srhvl iod!dr ~cHnls one or the nora inrraeroble F~35?0;j in rc~e;~l tcehnolo5r. This iest:;icc!c~ p~ac~cds pid~ rfaso:1:5!e eIficle:lcl; cFa u!ilitlna t~r: o:ga~ic 7o!c:~::rs :' ~Sifa; air, k'e a~;lst ePn:li·~r, then, that a!! that ~e l.o.: I!!153 for certain is the sac of the r~ihyl chto~ide in 5301~~ is de:lved f:or~ et!o:ide ion, The processes ir.7o!7c/ in this r;ansfoea~ron bile n3t yet t:cn dcterr~ixd. Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide 1 EFFECT OF elE~D CHLORIDE. ~N ~ET~IYL CHLORIDE DELIVERIES ~icrognmt p~r Cielrette ~ Chlatile eH3 ct st ill Wi~ld ~:ICI EfilSII: 3921!a ~~!l,lle Pus' 0.79 2W 312 204 5.5 120 315 377 32;, ` 5.7 157 392 r,OA 332 5.8 1.25 CZ? $17 41 6.2 Q IV 'S1 N VI Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide 2 O 9 C, ·$ ;203· I o a r -·----7 1 2 16 ct" in el?ad O N P VI Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide 3 E,00 300 i 5: o 103 o 1 i S;, el"· in 81Pn:I Q ·vl N Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide I Z n ~ P1 N I~ Nr~ a *I; 2 n n O m rG tIII r I, c. Q " o: F; O o Z I o s r 1~ E C O 2 h PI M N O N U1 N CO Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide I II Z t; t mi 1. j/ O o J O u E o > z t Ea B O CI U U1 N Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide C 'TT(F~~SF[R fiiSULT:- II~IRkllnTE[I TOBACCO 0,0x eH,CI l.oa CI··k -~> 1.)x CI" 1 i 5\ r~,i· "--i---·' 0.9 E CI~ To~21 1.GS I~f~~n Ci;El~i!e it 1.1 x10 G ch 92.3% CI' Std. A 1357 eln:k0 Sld. C 1335 rl~lls: L DelDS 1.64 ~LY B~M n99 from 38g, · ·' Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide 7 w i! a O J r I] O m J I Z o r C 'L lu :: Z LL O z O ~~-~c"' ~----' 4 -I O v, O 11 r: o ~~r,~ ~- -ce ' 'E O 8 U VI IfJ Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 SUdI I :; 5fE ON O D X aa II o a r r·t r h r r X a a' a' n O '' i' a 13 to a n w f a a 4 Ir r z a a r P 5 "S PD II b ,Elf r ." U O " L o M tEE Y1 aa O " EE ' lo a ~00 t O INO L~ O : ;n~ m D Urll I Y C o Li ' t a u e " 3 a a Q E i,, o~ nPI u ~ Z U?1 ~o o rpM s .* O N I ~.··· U1 Crl N Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Sl!dL 9 3 " N N O R c0 n ,n N e~ 30 ~Q Zz lu n o ?I f6 O u: O 'o oo o e "I N dd dd d o v, Y r a r ;I: 51 ~1" U El ) I C U u 1? 00 UI LO B 'R~ rn cr " OM 00 O O D " dd dd d o: z * hr 0O 00 0 N 00 00 Z od dd i lrl I \I/ I~ U cm %~ ~% i t: a n~ · I a "O'Z~ 85 ,, ,, o i;! TV U cn c~J lfJ Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Slide 1D RaI ,···~ '" ; :·; LL~1!J1\ ··;9I· ···~ G: i ·r hI~ '· I .i' bn ca s $, i: C~ W ';h0 (1c r~? a· o'''·~ C:)'g iic, .i \ ~~ d O C A 'ilD 1~3 %3 c'3 6 .1 F. 9 ~O 1~ ·e it ~ a ~~ aI1G;a ·1 =I o c1 d. 3 s d o ·1 n 3 ~1 4 ·a a?j s C;1 $f\C) r·~ (i CI` dj ~S ~ j;5 U j~S1~ 1 ~·' Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 tj.] ·bb I h~O tnp.-~-~ I' ~';~·" A ~E la.:l~u~ 1 LrL a·6 ·1 ~~ L ~,~ L~L ~~a106·, Ir,, Llrtd ·' i*l~ ~roaq h d ~' MnB Cd~s I~ UPI ~e I~, Lb, bn: ~a~l*~I "*~~ at ~~e l~~d· ~~I~, d *I*al ~~~I br *~~ ~mn,"r r~**L II CI~ ~wldl 'C19 ~ rl~U* ur~ n I*hl·l '~tr (1*16·1 I*Ur p ~.,,k, Lle·p~ r4~nal d~·d· 1! d ·t~k ·rde 4~~ · r~r·~* n~l·sl :~~ ~l·(·lb, n~#· L·YL~ *1 I~s~·n h d~r*· ~L, M~n~·, ~~ pael md~l· ~6·1*1 LPIIC ~1 1~111 Odl r~lnel 3 rr~l~ (p~ ~'"*1~ 686111 3· dl I~r b*~rl ·I ~·d~ ~e cqletr p~ylr folla. O N Y ClibPDF - v~~fastio.soni T:IVAT~ C~~ ADSORPTION I~ERTLEI FOR ORC~YfC VAPORS ~TS03Ce~~. Pc PII Of adsorbaats for fil~lttl snoka filtration rl clrcacy n~lPltcd in tbc thirtial. (1) Tba rigoifioant usa of od5Drba:,:s as 1 e~~m~ of eilul~ta ffitlt~ ul~ Illrtld ~out 15 I"t''lo. There Ire only a fcx roPorto nfldll so~~nipt r5~ ~d~o~ri~ proprr~isr,of wt~ltld ocrjon tDvaFlj the eilataeta s4oka caoPan~~, ~lthopgh tha sDoka pt~reir cod eonpoaitions v!rc rlportldlJ i~eifiad(t)(3)(1) (5)~ Pa ula of aotivatod cl:boa typer vac crrivrd qirie~lll md alt Ifftcd ~t~i~~rfon has t~P plua t thc p~lt, Irlilr ~adi~l by tillsb*~ (6) e~~l~ltcd bllitltilllf id~tifild SdQII cdlo;Ptioa c~*iQ fo: ~csr~ldcb~6, rrolc$, isopr#lc, bdtole ~olfiat ·d Pitroya di·idl, hovlrlr, Pa cac~n~lrion of :hcsa cqw·tl vaJ ordcrf of upftudl hiClt than rlalist!e vallas of intataJt in cfl~~tte s~l f!:;ntf~. With this papar or ~bllk~l~ it i! Ittqtld to rhor thc qulntitttiva tl~i~ti~ of adsotption propartiar of ~c;fr~ttd cliDoas tovard ~ll~tld iql of tdpafoo ·6e c·~tiqrt~, ~PIU. ~e Trpsr:ftl of eha activated eab~l usod Ire Iho~ ip 111 four cl$opl atc ptobctl of lotth korioan aa cl~oal varc Illw~~d to I~IIIIDt oolDaroiall]r ClibPDF - v~~fastio.soni .1. significant raw materials and were used in identical particle site Cis;ri5u:ion, similar to the lost eo~anly used granule size range, Some of the carbons were impregnated. As adsorbates, Sermwha~ deviating fromthe abstract title, cyclic rather than aromatic compounds were used, The compounds and their significant properties are shovn in Table Sc, 2, ~urme~~ pyuD ROCE~RES. Ihe determination of adsorption isotharms were performed in an evacuated flask containing O,Sg of the carbon specimen, where incremental quantiries·of the adsorbate were introduced end. the pressure differential was measured after the e6uiltbrf~m was est~b· i !ished, The equipment Ms thermostated at 35'C, The dynamic evaluation was performed using a Yarian gas ehrom· a:og:ap'n equipped with an automatic sampler, the coh~n material vas ChroElosorb W, the hydrogen flame ionitation detector vas used, ;ne carbon sample holder and the flow rates were set to produce total gas residence times within the carbon Ded similar to the range occuring in carbon containing cigarette filters, The flow diagram is show in Figure So, i, The'column temperature was 98'e, le dilution and generating air was at 300e, Tne signal from the flame ionization detector was plotted on an i, N, Speedomax recorder, 3e aue~~ic sample timer was set to give clear separation of the sample peaks, Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ·3· 2tS~3::OT Ol ~; 1Sa~ L, !FJ!~3r:s Dlfl ~J c~ui;ari~ Id~or7ti~ (~dsoqt:~ i~ot~emd dete for lall:4 :oilclc, Ir·, l~:hrl4r· ~1 eYo'.44e4l ire rla a I:ZIIM ZL 4 i, I, Z ·66 Ilcccllklp st e~lilori· droadep C1:e shovs e'ne uxinull ldlqee oopoolty It~hd:e 1~ ~e ;;r;!eu!~r Id~o~~tl cmcmrrl~tpa end tenperrture. Bda: tasP rdi::oob due to Ciib~i· ·d bb~~lic eff(ets,:he Ilropdon c4*10 ie e!voys Ilrl Ih· thl IbillrB c4w10. ~~a, Irvlrei significat cEtec~J ore shovn by :hi~ detn, 1~ If ~P ~Ol;mCI of ~1WI~I carjoas es elole to the ~c~uli c~- csn;dml Is por~~lk PI IdlOPtiDS LO~LLCI Oi IWLI Oi th~ ~~lur:sd eer'ooos aolr Iseb oe~cr in the Pallerci r4pler ~ieal~g ;blr diGlrmt olrhons are Iqcrior et dif!crme lGlaiplte conccr:ltf0Js, :~::~ri~ odsorgt;o;i dotl em be n,d far iniriel seleet!op of:~t oerjon ~L h lacnL ~~ bel; c~d· is t'oe ope dti dr lilLI: ~IPptiin eqei0 1; the coael3tp:e of crt3i~tcl ~le ::~lieioq tLC~OPII~ dl Illt~L~(OtCh·tC fp rite e ro~e to I~~ the hiDhost tcDti~ of de edsarbed ~oL ·kh~tl brr re Ifibracn i the Ipkdl oi be telt ~~lo:l;tr,rhll m tL ealr it is ai~t thot in de r~l of ts~c! ;aj.l I pd IO cpn i·d erdllrrUI Ilrla Iradp ~: ~~ I~lorj,~, evolu;reC ;heo ;tl other tvo c~~ont Clcboa ·i: N ClibPDF - v~~fastio.soni __._ _ ·b· i; Ecx:.~~ ct:jon ;:: !o ~Jltlslactery for ~tsoqrioJ from la EOj:fSE:J::03 ptJ 5;:C~S. O~e rffr,if!oar,; oblml~:on 1J t~~t the riv I~rlri~:l Pred can he ineletlPt, ~I for Ir ehe ~d~ogtia prPlctti~r Ire coo· cs~el, if ~he Iotivltinf oonditions Ire properly se!ecrad, aoeh ~~ 111 el ;v Eldll Lrl ·0d bllC E~OPL rtjllttd fP the fct typo of ee~cpt bor the rti~lr~ e·6~cl·I ulrl rclscrld !~ at elle to preQce itllid p'nala ore, vide pore crbm (IiI) ad 17 aothcr core, Ilr 7hirl ore, P~rroo pore caboP (:T), ~, tc~ o::·, roeoifi;ls rlv ~tlriol to Ic'nieve tlllet%l ildsorption :r :~c!crat ~YS~Y.fC ~OP~I~ ~ ~e ~~if brlldt~lh flnlr for batcnl are ;ho~ on F:esrs To, 7, ior fOt· r Figure So, 8 ad for c~lola:~n~ on I!~re So. 5. ;he EIC of 1C;itl;ld CI~OP LI I C!lll;el i!:flt EqOPlt !~ ~ th! :aa!; of fixd bid Idrorp~ia, in b!l cllc, the Idlodlec ;at~in:ag cl;:ilr far (c:lalttl aar) is iPtrodlerd into tho i:~o~rr (fftaret:e filter containing orrbotl) ad rhreo dirtinet cCEo:S~:a concentra:ion Iectiona vill occur, Ia the first Icction, 1: odiorS~te cor·:r~tion epuilibrium dt; be erte'oilrhed bl~g :jl far aC ~o~id IE:IIF( ?hlll. TP be Iteal reotion, which ii ;!c;u~ :rt~lfcr t,oc t~e IdSdSL:C oonoontTotion 1111 Z~~J~ ~~ ~: db LLt~emn~p ~' mn~ nl ClibPDF - v~~fastio.soni __ __ ·I· ~:i:~ s~ct;s: csn:1::r ~s ~CrorS1:o. ac i~llh ant sha7e of the ~3 :5;c~~f cn the i~so:ja:e ch~roc:lriJtica, ehl pro)lrtie~ of :ts :Css:jcn: ant t~e csnditi~l (tqcrl:url, vlloeity, Ire,] of :5~ 7:ccetL ~~ Iml:~ of slc;:· tVo, the PCI t:·lflf tone, otce !OEPC Yili ;:lllrll the 1CIO~SQ; 5dl at 1 Icloci0 lich toltnls :ineat',y on the cl;:ie: gee residmcl tLe in :hl odaorblr, :o ~~ou;ht rc;ltioalb~ bena the Idlegtiop irobl~ VI1PII pi tac IPrfos~ce rdl~ dpnfe cond::!oas, the hr· dp~ic :trsnlJI ~acre~:r vltl cotCoc;cd at ~c~ at cePc~aerle!Po of ;Le Selac:~ ad c7E:913t~nl cqar4snt~. L i: can be relP ire rj~::iie:crl bSrc~~:~ro~g~ earpl rSqll, and the cLys ;:. tj, o:;er Of jlle :kOll; II~ICI~EJ, the ClelPt:lttOP It Ifch ) i id~ i:, ·d·~l ii ng ~l:lt ~e 611~L pi the 33 i; cl;b!:Jied, its rate of ~otagr cm be found ad the rlq3!rlG Idro~tfon oe3eOity to: Ifff~~rcl at any tioe) cr be CI;CP!P;1C i~;hC l~~lT doerD~d ~ the folloving. ~t 3!~~r~;Q 01 ~~ ~ Cr~ IOI~UT, (p) at ~je !::Z tool th:ouirh ~e ~Glo~~: 1 t$e vill he rcwhcd d~ ;~a adro:5ate cOneent:ltion it ffrst detectable it de outlet co:cs:r;:iPJ. ihis t~l ir lelrll:I taicrrcd to at breekthrough ;~1 "4~ 1::" reaohinD tbit IOiDtl the ldsot'Oete conoent:ation in tSr exit lis increlsel until it rllchls the arr·cl eonoeotrltion 'J · ClibPDF - v~~fastio.soni ·6· ;: case 3i;j'l~~:;:ca; Pds~:ja:e concentration distribution t:lo ::tter'.al balance can be q:essed for tte na~~ i: ·sr~:: of I:Z ":" a; t~ich poiat thL 1dsorjer section has isot~eca; ;t?;citr, rn case of aonsyr,e:rical concentration distribution, :::e;:c; ~iler de breithrocgh curve m) has to be kegtated to fid "t", ~~ rate of movement of the ~n in an 'Z" length adsorbet can sa .oet by ecuation (1) I::s eV;denttjlat to s~ze an atsorber,:~e iM critical Va1UeS are r~C Igpti of the mass transfer tone '~,", ad its rate of mcve· =L:: "~". ~~s~ :E'C ~j,,, can be obtained from the material balan~e "d"t'"'b'" iiW;1OYe~ellt Of ;he adsorber, 35 material balance is cs;a5;is'ned in ik folloving manner, In = ~" ;en~~~'5" cross section adsorjer containing '$" gram adsorbent. 75:;1 ii SI)ace (~orosi~ " "'\ ·- -'--"--- -~-~ · I ~a LU)UI~?LI in;o a wllrme ratio o:'%1L ;:avs;r a:'Y" vo:;;netric velocity, v,lh· vC,t - LS I" C, (2) ~~~:~ 'P " iso":s ibe vol~Po/veigh~ adscr;lticn cq;c;q, The first ~q:essfs: on ri~e right Side of :t~e equation is the adsorbed adsorbate, :~d second ex)ress!on is rSe adsorbate in the gas pLsI contained in :ta ;o:t vc:·z,e. PI fV Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ;::c;s~ (?I can 50 :ea:rcaed to express the quantity of the :Liss:31:~ cPn::;ntt jp ;,Og or' ~e ;r;ror~er,c: y :SCa:.:S Co, j~p~ ~P (3) d iSB 1Sn rp jy ~Ja:ic:iqi ·~ V".I Fc. o uSt d? 3y:!a:ranting equation (3), the "t" value expressing the :ss~~c~a. tatetiii jaias;e can 5e obtained: t·tS V.; ~Fcl (Z) VCo :;::;::: s'~js:i;o;~n~ ee~uat;on (~j into equation (1) the rate of ~'~TZ =sv~a: can 51 d3:ain~~: ·-. I e,~_ly 1 V - "" ·v' (6) ; 6 (y,, , ECo! Vom t EC 1 '4 ~~3:i: Ilv"' is ~'ne true ve;oci:y r~toua'n the adsor'?er disregarding :::p:;;;;JSS by Idrot)~;on 4nd F CDE' Is s~oe 5y ~F~atios (6) ~e tate of novemant of the ~3~2 is L ~~C;i03 Of the linear gas velocity and the;;:;o of the adsorbate :s~~~a::;;ion in the adsotbet. m case of fixed gap cowosition ";" Is a:kear :unetion of "v", and II1II deterr;ines the deviation m case of linear a(tsor3tio:. isot5ens "g" is ~caz:Ca; (t3.Us "U" aisci f:e~-, the gas phase cos7osition, in -~jsr I:ae:lcai adsorption application, the adsorption:sothern is ;saJx Et the value of "c" leaeases virh increasing partial pressure o~ eke ~l·o:j~te causing on'Jlaease in "u", In general, "q" can ~~ Ce:cr,~cC if t:;e appropriate adsorption isothera values ate ilOF, ' Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ·6· :~I:~~~:X~CT O~ ~i :~tf CT ~ Q, 5~ :cr,:~ o:;'r.e ~Tt can be determined ex)erimentaliy to · rsiirl· rji · O.i i8i :~L) 0.5 in ~fe :~as~ hand divider is the degree of saturaeion in t;:e ~Z if :fe breakr~rougb curve is sya~et:iez;. ~~ val;:e of lZo" cas.;lso be obtained by ssr~lishing th ;~'~~" required lot the m to travel its o~ length'Zo"~ 10·U at . (9) Js, :h .ength of tie ~f is a c'naracterist4 of the adsorbate 3e vi;uc of '%:" increases vith io· ;:~:si~g ais velocity, adsorja:e concentration and te~nperature. ,o:;ke:;i t~a:ac:criration, 'h'e" Can be plotted ai:kt .c':'~' "~111 ST I'U", 10*·"*· S~p:J So. :O shows such a ~:ot, ae shwa deviation is asswed to 5~ el;;sed by 3a·sraadg state eond!t!cns ooel;ring under the simulated ;i~c:e:~e iil:c: short residence rises. Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 TABLE h'O, 1 Carbon lype I II 'III· IV ~ax ~terkl eoconur Coal Wood Wood Surface Area m21g 1150 1275 1100 i100 Pore go;tne (nicro) o!lg 0,7 0, 75 0, 75 0, 7 I~irtic:l Sire (V,S.Sleve) 12 x 30 12