7th March, 1958.
Dr. L. C.-Laporte.
it was unlikely t1jere was just orie potent
carcinogenic agent In smoke whose 1,resence made
it dangerous and whose removal would render smoke
innocuous. I Incline far T"ore to the view that
any connection that smoke might hsve was of a more
general nature, represented by the summation of a
long series of slit@ht irritations -7hich were only
important when happening to a Farticularly susceptible
person, 1hore Is a great difference in outlook that
follows from these two attitudes of mind which would
have a direct bearing on the type of research we
should sponsor. If term Tiere a re-iote chance or
a single potent agent then meticulous and detailed
chemical annl@@sis of the syrolce would be required,
couFled with the study of various pre-treatrient
On the other
methods to remove the precursor.
viewR the problem is far more of' reducing the tar
while preserving the effects and the
taste, nnd hoplnir that the soluti-)n to our im-!@ediate
Froblem will come from advance in cur knowledge of
cancer as a whole. 1111S WOUld cerry as a corollary
t1i3t. this industry's supfort shoold be quite consider-
ably to fundamental mrittcrs connectcd with the cell
and mlint leads it to behave abnonrally. I should
hp rost grateful to have any of' your ideas on t1ils
Subject snO, to put me In t!:e picture, how you feel
thou@@ht over on your side is developing.
71ith kindest re6ards,
Yours 31
(Sgd.) Charles.
Copy to:-
E. D. Anderson.
C=)
C71%
01%
co
BATCo document for Province of British Columbia 21 April 1999

ihIVAM & G"d-IDE1111AL.
I-rot" :- S'lr !hnrles ;@Ills,
7th "arch, 1958.
Ur.
Irpcrial Toticro Co:7q--iny of Up,iqli, Ltd.,
I..". Vox 65i".),
3810, 'St. Antz%ine Direct,
!.TNIMAL 31),
Canada.
Dear Leo,
It sce,79 a Ion -. tl-@, nince I wrote t@-_v
jou end I nri tnNIi:'1 tl,e oF_V-crtvn1t,: to do s,@ now
bocni,se of a re-nric tknt k@v,@h Arider!7cn made to ire
the other dn-.. !:a soid t1int you 1,9d I:elDn looking
nt V:e moults T Irn-trnst-crit of' t,2bt3cco by
hoxnrv@ or cynlo-hexane nn-1 the effect it
hrO en t"10 tAntO. I rnn ti hear that,
whiln Y(ri found t':;c tnste nll.crnd it.rqs not dia-
sSroesblo. l s,!rjr1r_e.1 @@:cniinn, If my mpi,.iory
is.r4tjit, the azlloin@!l ecccunt-3 c-g-intlng frorm
.0ynder statod the tnnte oLJectl-intle, but
Pugh Anderf-@nls r --ant3 -n V,lo -.-c%v. t!lqt thin
viris thic to dIrty verseln or fntlvx-@ t-) re-rove 9@-,me
imriirity cn tlle Isirt -1, t;!i@ triple !7!.:) did tfc
e.rtrnctlon work for hirt.
v.--! very lntrl,-,,,-d nnJ -.7vild bo
most It yr@u v-_-uld !_Zinc i!:.-:! nuch inlomqtion
as ynii nre nhl,.@ abcuL ire @,,f your investi-
Entl-_,rs In this field, nnd -,liTrt, you think it may
talre yon. Po you yot.rstlf believe t!,-it there Is a
definite relation between Vio car,c1nc.,ie,iic acti:@n
of the condensed tar as veaiurcd by wouse reaction
Ftn(-' the Frosenco or absence of t;.e hexano extrnet?
':hct',lc,r I bive sn f r,,@urlqtlori for It or
not I ?inve, up' to tire ro, ., -,?ni, hold tha VIOW that
(ON
C7%
BATCo document for Province of British Columbia 21 April 1999