[Al THE TOBACCO INDUSTRY AND ITS IMPACT ON SCIENTIFIC AND MEDrCAL ATTITUDES AND OPINION Despite the almost unprecedented amount of worldwide research on many aspects of smoking and health - both by the tobacco industry and by scientific laboratories, universities and hospitals - the overall picture remains inconclusive. The research findings continue to raise further questions, and to maintain the 'general controversy'. It is not simply a question of the precise definition of causation - as stated, for example, in the Sth Edition of the Van Norstrand Scientific Encyclopedia: 'Causality is the hypothesis that a precisely determined set of conditions will always produce precisely the -same effects at a later time.' but it is the direct result of the conflicting nature of the evidence. Over the past twenty years, the Tobacco Industry has successfully defended more than 100 law suits in the US&. An important aspect has been the lack of proof of causation. But throughout this period, the tobacco industry has remained essentially quiet on the basic issue - and this attitude has been widely interpreted by the external world as a sign or an admission of guilt. In reality, however, as indicated above, much of the publicized evidence produced in this period has been and still is inconsistent and inconclusive. In raising, as it does, further questions, the research to date serves to continue the general controversy on the smoking and health issue. Notwithstanding the contradictory nature of the evidence, certain views have been advanced that there is a risk to health that is related to the number of cigarettes smoked per day. As a result of these views (albeit challenged in certain medical/scientif ic circles), many Government and health authorities have recommended that cigarettes should be modified to give lower deliveries of tar, nicotine and other smoke components. _01W r%j P10 BAT Co LTD - MINNESOTA TOBACCO LITIGATION -2- The public have heard these views, and a substantial number of consumers have also shown an interest in products with lower smoke deliveries. Accordingly, the industry has developed and marketed an expanding range of products, including those of low delivery, to serve the evolving markets. Now, after some 10-20 years of increasing use of lower delivery products, many Governments and health authorities believe that there is evidence from epidemiological studies that such products are indeed associated with reduced risk. [Fig 11 if this Is in fact so, one should note that only future studies can give evidence about present day products. (Pigs 2 & 33 At complete variance with the hypothesis that lower delivery products are associated with lower risk, is the view of some medical authorities that there are reasons to expect the reverse, ie that lower delivery products might carry a higher risk. Such attitudes might partly be motivated by an overwhelming desire to discredit smoking: but over-compensation by the smoker for the lower smoke content, and the inability of filters without ventilation to reduce carbon monoxide, have been cited in support of the view. i While on the subject of carbon monoxide, it is pertinent to ,.not that with the advent of ventilation - which started more than 10 years ago in the USA, but rather more recently in the UK - the carbon monoxide land indeed all other gaseous components of cigarette smoke] falls directly in line with the reduced tar content [Fig 4). One may also note the autharative conclusions of both the UK Hunter Committee 1979 (Fig 51 and the US Surgeon General 1981 EFig 6]. Returning now to the epidemiological studies, it is a fact that neither the statistical evidence, nor the alleged link ,between smoking and health, Is universally accepted. Thus, a number of eminent scientists, past and present, believe that the association may be explained by, for example: - genetic predisposition] [Fig 71 - personality type. I - environment/nationality EWHO Europe Study Fig 81 co - Vitamin A [Fig 91 BAT Co LTD - MINNESOTATOBACCOLITIGATION -3- Moreover, some US and UK researchers, who in the 1950 1 and 1960 Is noted that in some age groups of white males the lung cancer rates had already started to decline, predicted that the lung cancer rate of other age groups would start to fall in the 1970 1 a - irrespective of any change in smoking habit. [Notably Dr G Gilliam in the US, and Dr T W Lees and Dr J R Belcher in the UK.] other examples of the confounding evidence relate to the fact that incidence of lung cancer and heart disease does not show a simple relationship with smoking incidence. Thus comparisons may be made of, for example: Continent to continent - heart disease vs smoking incidence [Fig 101 Country to country -WHO study ot lung cancer in European countries [Fig 8 - repeat] State to state in USA -heart disease and lung cancer vs smoking incidence. Notwithstanding such examples of genuine confounding evidence, the critics of smoking often compound the situation with statements or claims that are either unsubstantiated or - in some cases - blatantly false. Some relevant exampi6es are given below: 1) A medical A-Z Encyclopedia that is currently being published in weekly issues in the UK by Marshall Cavendish Ltd states - apropos cholesterol and heart disease - "that there is no point in doing anything [(about diet)] until a person stops smoking, as this will counter the good effects of any other measures'. This seemingly authorative recommendation to the public is certainly at variance with the results of the recent Norwegian study repeated in a The Lancet*, P 1503, Dec 12th 1981, which showed that while the risk of heart disease decreased when serum cholesterol was reduced, there was no such pronounced decline as a result of reduction of cigarette consumption. 2) The same Medical Encyclopedia specifically indicts nicotine as the cause of arterosclarosis and heart disease. But in another recent article in "The Lancet' [page 775, October loth 19811 Dr Nicholas Wald et al reported findings under the title "Serum Cotinine Levels in pipe smokers: evidence against nicotine as cause of coronary heart disease." CX:) rNIJ BAT Co LTD - MINNESOTATOBACCOLITIGATION -4 - 'The Times' report of the article on 13th October completely changed the emphasis, however, by using two sub-headings purporting. that carbon monoxide was the cause. [Pig 111 3) Finally, for truly outrageous reporting, we may refer to the Editorial article from the 'Sunday Observer" of 6 tb December 1981. [Fig 121 And then contrast this statement with the real-life measurements of Hinds and First taken in typical smoking environments. [Fig 131 With this background of controversial evidence, and increasingly unsubstantiated or misrepresented claims,-what should be the approach of the Tobacco Industry? Is there now a need to try to get a better balance in the debate on smoking issues? Certainly the statement on page 117 of the 1980 EJICC document 'Guidelines for Smoking Control' is definite on the subject of the credibility of the tobacco industry. 0..... this refusal to admit candidly to the health hazards of its products may be cited as proof of the tobacco industry's lack of credibility on all topics'. BAT has given very serious thought to the above questions. The subject is complex, and it has involved very close working of top management with the Legal (both millbank and Brown & Williamson) Public Affairs and R&D Departments. The conclusions have been: (1) Yes - the tobacco industry should try to create a better climate for its legitimate commercial operations. (2) The approach should be based on a more open dialogue with Governments, MP's, doctors, employees and shareholders. In stressing that Industry actions have been influenced both by the demands of consumers, and by the views of Governments, care must be taken not to be selective as to any evidence or third-party views that are discussed. co NJ Ln BAT Co LTD MINNESOTATOBACCOLITIGATION it is particularly vital that the tobacco industry should not adopt any third-party view as its own. Nor should there be Sony attempt to form an Industry judgement on the health implications of the scientific and medical evidence. The key points in any dialogue should be: (1) the changing interests/demands of consumers (2) the views of Governments (which are primarily influenced by published scientific and medical findings). (3) the opinions of independent third-parties as to product modifications (4) the detailed way in which product designs have changed over the past 20 years. The legal constraints in the USA continue to be the major concern. But BAT bole ives it is possible to discuss the various isues, to the longer term good of both consumers and industry, without jeopardizing the sensitive position of Industry. many of our detractors claim that we are non-caring. Our activities, however, prove that the accusation is false. BAT is a socially responsible Company - proud of its reputation and concerned about the wellfare of its consumers. it provides products that meet the changing consumer demands, and the stipulations of authorities where these are expressed. BAT be I that progress can come only from continued research - and from reasonable and open discussions about all the highly-complex issues. It believes that the tobacco industry should now attempt to generate a more balanced debate of the issues. January 1982 BAT Co LTD - MINNESOTATOBACCOLITIGATION