[B) A SAT VIEW ON THE SCIENTIFIC & MEDICAL ASPECTS OF SMOKING ISSUES Despite the almost unprecedented amount of worldwide research on many aspects of smoking and health - both by the tobacco industry and by scientific laboratories, universities and hospitals - the overall picture remains inconclusive. The research findings continue to raise further questions, and to maintain the 'general controversy'. It is not simply a question of the precise definition of causation - as stated, for example, in the Sth Edition of the Van Norstrand Scientific Encyclopedia: 'Causality is the hypothesis that a precisely determined set of conditions will always produce precisely the same effects at a later time." but it is the direct result Of the conflicting nature of the evidence. Over the past twenty years, the Tobacco Industry has successfully defended more than 100 law suits In the USA. An Important aspect has been the lack of proof of causation. But throughout th Is period, the tobacco industry has remained essentially quiet on the basic issue - and this attitude has been widely interpreted by the external world as a sign or an admission of guilt. In reality, however, as indicated above, much of the publicized evidence produced in this period -has been and still is inconsistent and inconclusive. In raising, as it does, further questions, the research to date serves to continue the general controversy on the smoking and health issue. Notwithstanding the contradictory nature of the evidence, certain views have been advanced that there is a risk to health that is related to t.ho number of cigarettes smoked per day. As a result of these views [albeit challenged in certain medical/scientif ic circles], many Government and health authorities have recommended that cigarettes should be modified to give lower deliveries of tar, nicotine and other smoke components. co C=) BAT Co LTD - MINNESOTATOBACCOLITIGATION -2- The public have heard these views, and a substantial number of consumers have also shown an interest in products with lower smoke deliveries. Accordingly, the Industry has developed and marketed an expanding range of products, including those of low delivery, to serve the evolving markets. Now, after some 10-20 years of increasing use of lower delivery products, many Governments and health authorities believe that there is evidence from epidemiological studies that such products are indeed associated with reduced risk. [Fig 11 If this is in fact so, one should note that only future studies can q4 ve evidence about present day products. [Figs 2 & 31 At complete variance with the hypothesis that lower delivery products are associated with lower risk, is the view of some medical authorities that there are reasons to expect the reverse, ie that lower delivery products might carry a higher risk. Such attitudes might partly be motivated by an overwhelming desire to discredit smoking: but over-compensation by the smoker for the lower smoke content, and the inability of filters without ventilation to reduce carbon monoxide, have been cited in support of the view. While an the subject of carbon monoxide, it is pertinent to note that with the advent of ventilation - which started more than 10 years ago In the USA, but rather more recently in the UK - the carbon monoxide [and indeed all other gaseous components of cigarette smoke) falls directly in line with the reduced tar content [Fig 41. One may also note the authoritative conclusions of both the UK Hunter Committee 1979 (Fig 51 and the US Surgeon General 1981 (Fig 6]. Returning now to the epidemiological studies, it is a fact that neither the statistical evidence, nor the alleged link between smoking and health, is universally accepted. Thus, .,a number of eminent scientists, past and present, believe that the association may be explained by, for example: - genetic predisposition) [Fig 71 =0 - personality type. I %%0 - environment/nationality [WHO Europe Study Fig 81 co - vitamin A (Fig 93 -z:M' BAT Co LTD - MINNESOTATOBACCOLITIGATION -3- Moreover, some US and UK researchers, who in the 1950 , and 1960 1 noted that in some age groups of white males the lung cancer rates had already started to decline, predicted that the lung cancer rate of other age groups would start to fall in the 1970's - irrespective of any change in smoking habit. [Notably Dr G Gilliam in the US, and Dr T W Lee& and Dr J R Belcher in the UK-] Other examples of the confounding evidence relate to the fact that incidence of lung cancer and heart disease does not show a simple relationship with smoking incidence. Thus comparisons may be made of, for example: Continent to continent - heart disease vs smoking incidence [Fig 101 Country to country -WHO study of lung cancer in European countries (Fig 8 - repeat] State to state in USA -heart disease and lung cancer vs smoking incidence. Notwithstanding such examples of genuine confounding evidence, the critics of smoking often compound the situation with statements or claims that are either unsubstantiated or - in some cases - blatantly false. Some relevant examples are given below: 1) A medical A-Z Encyclopedia that is currently being published in weekly issues in the UK by Marshall Cavendish Ltd states - apropos cholesterol and heart disease - 'that there is no point in doing anything Pabout diet)] until a person stops smoking, as this will counter the good effects of any other measures". This seemingly authoritative recommendation to the public is certainly at variance with the results of the recent Norwegian study repeated in 'The Lancet", P 1503, Dec 12th 1981, which showed that while the risk of heart disease decreased when serum cholesterol was reduced, there was no such pronounced decline as a result of reduction of cigarette consumption. 2) The same medical Encyclopedia specifically indicts nicotine as the cause of arterosclerosis and heart disease. But in another recent article in 'The Lancet" [page 77S, October loth 19811 Dr Nicholas Wald et al reported findings under the title 'Serum Cotinine Levels in pipe smokers: evidence against nicotine as cause of coronary heart disease. C=) co co BAT Co LTD - MINNESOTATOBACCOLITIGATION -4 - 'The Times' report of the article on 13th October completely changed the emphasis, however, by using two sub-headings purporting. that carbon monoxide was the cause. frig 111 3) Finally, for truly outrageous reporting, we may refer to the Editorial article from the OSunday Observorl of 6th December 1981. (Fig 121 And then contrast this statement with the real-life measurements of Hinds and First taken in typical smoking environments. [Fig 131 THE ABOVE IS MERELY A FRAME-WORK OF A TYPICAL TALK. IN PRACTICE OTHER ASPECTS WOULD BE COVERED, EG THE DESIGN OF MODERN CIGARETTES CHANGE IN SALES WEIGHTED AVERAGE TAR/NICOTINE PASSIVE SMOKING AS MUCH AS POSSIBLE WOULD BE AS PER THE PARLIAMENTARY BRIEFS AND (WHERE STILL APPROPRIATE) THE 'BLUE BOOKLET'. January 1982 C= BAT Co LTD MINNESOTATOBACCOLITIGATION