~ It~du~b·ies El#rd ensaRatiaa Re~xllat~y Authcri~ies - I~aact · C~Parette Cesirm Increas~ Irgulatay F~Esnas dl Y ~ ct~arrJes ~ r ~urrent F~P~b~x~ts ~ ~1 ~ ~ dal~nt influerce · 1~I~b~re cisarette davclqant. L followi~ rrm~ies (areas) ~ fc~mulating regula~o?r re~lraerrts: ~nleFerdent Scientific Ormiss~ a ~ (wi~h frfl~r~ ~ concaneall caa~tries) Ellmpe Ge~a~F~ Federal Hoalth ~I~titute; Ge~Il t a~paiss~ (n~rcpe agairst Qrcer pr~dnru~)~ I CeFa~ent ~ I~ealth ~ f~Pa~ Ptraacesr ~ntre ~ Tcba~r~ Proc~ets (Kemo~l m) Q~da He~th ~ Wclfat~ Brada Middle ~ Swdl ~~ Stanlar~ls Orgarisatim ·---·· r·- ClibPDF - v~~fastio.soni _~__~ 1 s~Pa~y ~ b C ii b aarab ~ peposed rcgulatorl i~ntg i ~ irdivid~al rmrhics. ~ ~Plkvi~ t tepic~ ~ ~ a~bidered: 1, ~tiVGS 2. ~1 limtine, d gmF-l rcdcic rmpnents'~ ri~Psafe proSets ~idestrear enissicns ClibPDF - v~~fastio.soni 1Y~itiveJ ~ ~ q ei 8tprials r cfaicals ~ I Ecsat k cigare#es ~~ ~ ~ ~ ula~ ~ intrrest ~ L trajmlogical ~arrp~nt ~ st~ukn~ k SWDe 1. ~ L prceemaLJ + affrarirq ataia~ ~ ~ ~ ~~ ~ ~ other ~ Ird~strfeJ' Cpl~Z~O~, Y thess ~ beirq ti~fit~d~ Dqen3ern · Y I~val It~ eriiidrrL ~ a lenp ~1 ~, rmfD~vi~O~Y i ~ ~ issuef;, rciprtific ~ ~ d4sed b plblle p~oq~tlcrs ~ r t ~ retdy ~ ~ ~ ~ ~ t~tici~te po~ible ~iticis~J, ~ tere~ ~ wlne~ility based · L $nical st~ebn~e r 1~ d P s r: 1, ~retants · glyeerol, ~xq~cra Ebycol, sea~itol level aAP~D~, II. Pr~a: ~ b ~ eriticin ~ ~yceml ~ ~ ~ · ~ a~tczrativesl St~dics ~ticis~ t~rse ~e~t~nts I ~im ehallerged, f, h549 e~~s~ge-~l I~qucaice, cocoa, s~qar, Na~aal 1Pr~d~tst supr natuta~ ~ td~crrs, Teodcal ~ e~dsts + tfieso additives. 'O ClibPDF - v~~fastio.soni 3. Flavan materials - up to 0.3t ~smlie~tia~, Vast array (up to ZMXI )I Fail bm9 goal tcodcol data, ~8rrl tee naAaal; even to t~a~P, brt stipe will tYI dolbt be eballenled as requlatcas ~Pbe aa a~itiver;. ~itiera~Uy ue can e~q~e~t prt~ ii q mqfffflt is an irt·r~strial cf~ · werr)cer ~P#blI~ testkq. ~cetaValrfle is a Slavaa mmxru3nt ruk~ kw~ to be o~irrqenic: · it will rot he used in row ilmraas, Bei~ t~e~r~ved frcm ebstirg folaulaticns. (. Blsa~ pap~ - dioxin d mg~d~c~i. ~mpud~ aald Y En~swt a Foeblan. ~tla~ We are ceapletirg a register of all materials ~sed In manbaehae of or cigarettes, Pm Ipicaitise ;P~ FPPble~' in general ~ rust be prepared to awe f~ synthetics to nrae expersive Mt~raln~terials, ard ~ae pebsihle use t~ba~o Mt~lhd~ Fb~dLY~tS. bNL ~ULF~. OJ~9 ~uLnJ aAd*klr C: I i I; PDF -!::!!::!!::!.f3 StlC.i: 0111 'Tar. Niwtin ard a~ml "tmdc.~mxnentsr Pw ~we been owes to pot ceilirqe an Vie prirdpal amole c~pne~tr (tar anl nicotine) in nrwj mmhies fcr marq years. ~tJiticnaUy, there have been lin~itrd initiatiM by re~ulateas to ~a~t~ olrtao msrPdde deliwy leva~ far beards, interest in t~ mirnr ccwituents of saPke is gmrIrq (Kern~, etc,) Sirce tfrn are at least I,WO identifiable calx~nts of ~oke, any or which are amidd8red t~de or ~ at slfficiently blqb ~ose, the ct~allenle fea~ the re~atms will be ~eat. m anticipatirn oi Febsible rqulatcalloNes, a hwe identifi~d two tlpa oi cbaical ~i~h a seek a neee of re~einel, ~mese are: (a) ]a#Jn potent ca~ir~pss ~ those ~ase~twt c~aPnts ~hLfi are at le~els, axh t~t at a 60 cigarettes per day araPlptien, the i~aivi~al pqeaae kaJd be a~e t~ ao~d thre~old li~it value for ~9 ~aldrq er~irc~nt (40 bore week), pmse are s~ised m slide x, ·O Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 We have I Fulbatal licseanh Roq~ Y at rs~drq ~ cqments, Y this e largely larl ~ t ~~ initiativcJ ~ nekd · ~ Y to a uleetirn ~ Msa~o grades (,~I~ fa i" nltato ar pllyphmols) alte the pv el selc~tlvo fil~ati~n (cat~en). ClibPDF - v~~fastio.soni Pl~ssa~e Pre~ ~ drive to intrc~bre ra~latias in relaticn tP iaitabilitY oi iabrio bi ci4dRet~ is m3mffirq parttnUKly in tie Mi Mlavinl plbliedticn of tte Cigarette $ieDI k;t (198(1 ard a Ap~t $ a ndndcai Sh~lGmp (~IB1). ~wla b ,~ ~egiminl to frms on this s~jea~ ,~ of the 15G ~K~e: i, ~ reliable s~ard n~t~ is nrmded, PerIeam~8 data an ~nent yochu~s is neded, t certbin desi~pl iea~nes c~ d9arettes ~e ~tpbllity of Pd~ic~ (eire~fers~, ~PPded tobacm, Isfor fe~meability)~ i. Iha tmdmkgical data on p~c~Et~ so mrdi~i~d n~eds to be gathesedl No aclian is Lei~ ta~n by 16 Igticral Iastitrte c~ st~aa~d~ Ed pd~O~ In pna~i~ thess nc~medatlrm m~il w d b lieCeS (d Is~slatim relative to dgib~tt~s od iireafa9 are ~qaoved lard ba~ b~dirg ~grerd). Wlcnhile b~n~l " b$alf eb i~trjr L e~abli~irq a reliable neVlod - initially kh ultimately, 'diFoctA rml nirdlreet~~ BAT has leadirg role, Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 RaFg~ · b ~ ~ f ~ ~'\ i~tticn r iq~itabili~l ~ ~ ~ Y ~ disc~inirato i~brls, Y ~ 50lfeSFnce ~ Slido x, ClibPDF - v~~fastio.soni Sidestream n~nissians So far there have been lw) ICP~ IWIL~ to ~g~tlate tt~ ealsicn ct sideshe~ frrm cigarettes, alt~ the ISC~J ~Eda t~ iollarirg statspent: 'Ple t~twtrm i~st~y ~wld pn~e re~eaxd~ into ways ed re~irq t~e amant, Irritarcy rPd other delateric~s i~ertieF of sidestc~nn e9ke bna all tcbaem p~Pjrts"~ Rptberm~oe, as interest in DNirmPPntal Tebacce ~akr iraeases, tty~ dB~i~l for 1! definiti~ of t~ da ed miror ~ of S~p ~itte~ e~m the lit ed ~P th9 ahoe6pulra vill Snw· Intere~itirql~c, t~e reewt la~nfis of Iw vi~ible sfdes~pf~n cigarettes in IIS tave Mrmlatat t~ wti·sP~bq factic~ to ~astiol the rca~ibk sidestre~m~ c[m~me~t~~ rt is inpat~mt to stress the diflere~e In cheaisby ~een ER d sidestre~ ~ake - both sides~ ageirg ard t~u! eadritutien to ~ of ~a~d sok are often werlcP~d. ,,AgaJ~ (Ibtal ~i~hsam~ Dmaled SPlka) ·~ ngaatars will seek to relate e~I3 to cigarette sides~rP8n yield dra V~i~ fs di~etly~meaP;oable, L n38dtD distinpLh Total sidPstre~ yield ard tte visible Efdesha~ioa yield t$t ~ e~tPn ~s~d sc a base fcP. ~E~e~dal plq~uti(n. O Total sir~sh·eam· Visible sidestre~m+ I~Nisiblo si~estree~m Pn Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 g ~ ~ ~ ~ dcnlqr~~ ~ ~ yj~Jfbls si0etna ciqaret~a · ~ uhicipatrd L ~ ~ I · itae~ss ~ ir~isib~ sidc~ba (~ t ~ · ~ · i~p~cpi~n re~etle~~ f ~SC P121~ ClibPDF - v~~fastio.soni