PROJEb NOVA - OBJEC~IYE: S~EET ~ migration Studies
          TlTLB : Nicotine Migration Studies
          REPWENCE L "Spin off" from Elution Studies : 001,06.100

          OBJEaIVE : To Determine the Rate of Nicotine Migration from
               - Spiked Filters to Tobacco Rods


          BACKGROUND : Elution studies have shown that considerable
                c transfer levels (130%) of nicotine from cellulose
          acetate into smoke can be achieved, Before further
          consideration can be given to the use of filter spiking for
          enhancing nicotine delivery information is required on the
          rates of nicotine migration from the filter to the adjacent
          rod, Such data will complement those rhich already exist for
          menthol (1) and a range of model flavours (2), Data are
          required for different filter materials and different rod
          materials including all-synthetic sheet material,


          REMARKS I i) Filter materials to be investigated to include
                Cellulose acetate, Polypropylene, Alumina
                ii) Rod materials to be investigated to include
                Tobacco (control), Extracted tobacco, GREENDOT sheet,

          REFEREN~ISS


          1, R C D Report T,129

          2, Beirtage zur Tahakforschung lnt,,Vol 12, No, 1,(1983),pl1


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                                     1Gth June, 1989
                  pAPJECT NOVA WORK PROenA~4
          Slraleuic Obieclive~

          To provide the scientiiic and leclmological foundation for the development of
          alternative, cigarette-like products in which the combustion of lot~acco·based
          material is not be primary source ol smoker salis[aclion.

          in this context, an alternative product is smoker·acceplabie and its smoke has

          lowlzero biological activity in a defined series olbioarsays, This low activity is
          brought about by be generation of chemically simpliiied smo~e in mainstream

          andsideslream. The pioduclwould rlualily as a dgarelleby Regulatory Autilorities
          such as the U.S. Bureau ct Alcohol, Tobacco and Firearms.


          Aspects of the Worle

          1. To deternline Whether elulion is a practical path to the alternative producl.
            This will be done in·house and will be theprimary topic with target completion
            by Ivla~ch 1990,

          2. To delemline what heat is needed to eliicienlly transler substances into lire
            aerosol, including generation and managemenlol tile heal. Much of this will
            be done under conlract. This will be done as the secondary topic ct La

             project and will he pursued in pawllel wiih (Ij.
           3. To consider prototype concepts which opliaise results from (1) and (2).
           it. To delernline biological activity ol materials with promising Ppica~ and
             chemical properties from (1) and (2).
           5. To determine smoke chemistry and sensory assessment ol satislaclory
             Inalerials horn (4),


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                     TOPIC i; ELUTtON

        Elulion is delined as tile pid(up of nirotine and other components tom Ihe
        substrate when a s~bilised aerosol is passed ever it,


        Obiclctives ol Tonic 1
        (,) SOdeBm*wllelhe~euQn is apmclicslpalh ban alle~nalivepraducl.


        (b) To de~rm~e what is needed (subshl, condiliocs, tobacco additives,
           etc,) to best release nicotine and Ilavour components into a simple,
           non·tobacco derived aerosol,


         Milestones to be Accomdislled inT~cl
         11. Niwtine and [iavour release cha~aclerirliff as a lunclion ol aeroroi
           properties derived from nicotine-tree tobacco.

         1.2 Niwline and navaur release eha~aele~isiics as a lunciion of aerosol
           pro~e~es derived Irom GREENOOT material lormulalionr

         13 Niroline and Ilavcs release as a iuncbn or sub~ale matoral using
           acrosol Irom GREEN001 material,

            Nicotine and Ilavour release as a iunetion of substrate material, enhanced
       1'.4 by substrate geornelry,


          15 Tile ellecloldilleralpilysical lorms of aerosol·generaling material on 1.4.
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          Milestone 1.4 Nicotine and Ilavour release ' as a lunclion ct substrate
                  material ", enhanced by substrate geometry '"


                    Temperature and pufl·by·puft delivery measurements
                    for air and smoke at 25'C and lOO'C,

                    Substrate in polyelhylene tube attached to synthetic
                    sheet cigarette or nicotine free tobacco rod.


                    Materials will be those identified in 1.3 that offer the
                    greatest potenlial,

                    Substrate geometry effects to be considered:·

                    · length
                    · circumference
                    · free surface
                    · peripheral coating
                    · form (granule size, dpf, cpi, etc,)
                    · cut sheet v rolled sheet


          Reauiremetlts: Synthetic sheets
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