r ii OZi NOTES ON MEFfINC BELD Oh' 13110193 TO DISCI~SS ~P~ROACBES tO MDD[P( IMP~cr: n~RITAnO~r runos Thosepresent: DrGHook Mr RFiebclkorn MrDIrwin DrMDixon The obj#dve dlhe meerin~ wu to dis~ an Nmnt tt~g antht mahairms af impact ad inidon ad to neormad potwial m#hods of red~jag briution without producing reductions i impact ad other dainbie xnss~m e,g mo~m9 and BdWIUr amplitude. It was ~d that pnviow ~a~dies on the genais of the ir~m sensation had ban pJecc~JI ad ha the r~itude of impact i dearly nlated to the alnpuna of 6a nicotine deiEiaed to the impan sasing region is thtdaou, Howmr in the ~w of ir6wiq i#pite may manpn to corrdate the la~ninde of percd~d irriruion with the drli~nr;cl of spde compounds or Igoups of compolmd5 there i no univasal approach fw m6dif~ing the sensation ofiniution, It i bdieved thu initatirm i I vwy mmpl# smPokn ad i W(dy to be aurnced by mslg fanors ad thus we cap see no fuD1R i Idoptine IfUndlll~t~ IpplOach to htvea'.gatine ~b~ rcatioaships between the delivaia otpa~mn~ly irritant canpounds ad peredved initaden Consequandy, wt Rconnncfd that we conduct amhsliy conwlled ~a~b~a an d~Penl dtdg factors which as baimd to in8uma percdwd ~irntioo Lg ~i~ns dreuaseracc, moiaure Imt, nieoohe~tlr ntio~p6sib~n alfihnvm~dw lo#J, ad condensate oil maaipulodons. May ottbae dnip hctors are beiievedto in8waee praind initl3'on but may Ilw auace Mba hws such a impact ad mo~nh~u. Our ulo~mne pi would be to daaaine those dedgn fieton which wuld be used to nduce pacdved ~it~don without conconnrdtat redudiom in $Ipn at, Our first problem concans the Iblitia of pnahu or consumers to didingJish between the sensations Ofimpst ad ini~dpn. ~U~hough both OntqIa padests ad connlmas panidpating in BTs are requedsd to score both sensations a are nncauin as to the de~k drpndon oft&se sensations. It i pordbie ha xnne eohRllficrJ~,~~ndlirt~ di&nntiate between the two saarions whaeds Mhm score than a one Im9hon it as an ind# oramgth We intend to eamiae indi~id~ui usessmenu ofthe oroducts wd'm the two WWBY rmdin (fun Iivmn ad lights) to determine the de~a ofspapion beov#n dr two sauPians. MD w31 approach Kdth Gtcenhoflfiom MSTS to obtain the individual us#smetds oftht pmduets and WDIwilt VIO~YK the reDlltt A dmil~ #erdst will be pelfonned on the OMECd pad data obUiDed fiOil the WWBY f0~itJ. Ciplrene Cimrnlennrl It i belirvcd tint inreuing d~prcar circumference reduces irritatiorl hnhnea It is not dear whether other scrwo~ons cgimpPd am also reduced by ttds rm~puluion. ReaFlly, R~Judw md Uid ~wm mlunrd u P olPmj~n Smrpio lad O~ information Dtlmoire ddiver;es ad scnrory mporaa were obtained MD his asked Bn Shcppcrd and Dave Dimieh to examine these results in orda to sssess the dl#U CI bPBF-··\:III·I::,:f ;Isii~!o~· CO~iFIDEl\ltUL · CATFC·ORY I: BB~ESOTA TOB.SCCO IIT1GAnON r ofiF~crtuing draunfmnle on impsa:initaoblndes. H6wcva in muR be misled that the Seorpio snmpia wert dedsPed to mat a ~pcdfie ddivstPget ad dnu at~w dt~gn featnre in addition to d~rmfiennce wee moled in this wadse. Tile~u orCnmrinr Tobacco and FiltH MaiRon Coattnll It is ~h~own that ineeadng wbicea Iroi~a~re #Inenr deaeue peraived irriaricn, md defresdng tobacco moisave coflmt herri~ paedvcd iniwior GeofHoak conduaed work on t~l pmblaa and eo~m~ed that the rmnipuation of tobaocc moiJIWe content i~uenc~d irritation and also noted thPt Other Kluorj 8bn'butcJ e,8 iapaa, mouthful] md &vcur pnpiinlde wat modified in 1 d~r Way to lmraoon GcoBconcludd Ihu tobtcco moisture so~nt in8uenad the tobncco comb~nioa groecP lad thu ehLlges h sawry pmpsda ~ac Rh~cd to gmssdunp $ anake delivaia It WY agr#d that ~Prhcr work should be eondwled in this an along the foiloaing lines: i) Daeraine the snsoly pro6]e clSESSS dguena conditioned at b~ma moisPm levds (both above sad below Icoatml levd). Pudeulu e~np~sil tdl be placed on exlr~dng the dftets of thee 3rocdwce on impm :irritltiiba ratios. n~ Dertr~nine the effeeu of 'ntoresing the water eoment of fihen utacbed to 'dr~ tobacco rods, We wc~d #p#r that a reduction in tobacco maisaue content would htaue both impact md iaindon Givm ttut daurion doe the addition of water to the filter decrease irritation more lo than impact ? iu~ Ifthe cpldicr in i3 above prcduee a desirable 1l in the impat : inmtion Rdo, thm we could innbigme the ei6cns oElddig hydrop~fie conlpounds to the filw~ The above 3 inveJdbdons ~ be pafonned bylncr BNUI sad r~d SheWerd Ellen olCh~nein~tr: Nicotine Ratios H is genhy lacpted that dese~siagasrirmine ndol inereun the rmgaitudt of impact. Iiowmr it k also beGmd that rsdudag T:N n~ios Win also inorese irritarica We ruradty have no h~ormdion on the rdadw change in impa ed irrittdcn ulednsequaee oletanping T~N ratios ad the we Ileed to cpmb~e tbs influcnee ofT:N Rdo change on the balnee bsma! impact Md i~idnlian fhis ura of work is cwrmt]y being invesdgated by Pda nan prirarily by adding aico~w to both armpdonl V~nia lad demieo~d~Jrd tobaELO binds. Eil~rO alChlneinPQndsB4R InPadng condensate pH via the addition oflluine materials to the toblte6, dhas and papas gcncnay resulu i a inane in pcmived impa ad irriudan Convardy, decreeing FondmPre pH by Iddig aids tnds to dcatrre ippe nd irriuticn Howevu, the cdnseottenoes of eondenuate pH modification on the bJonee berwrn hnpm ad irrilatig rifts furtha Work and it is m#nunneded that O addi~o~ wok s~wld he coFduacd in ttisttCh T~n Shcppad and Pea BNvn win a pmd~e plans L Nch work C~ R ~ T msttnNrr~l.. CjArJ~GORY I:MINEIESOf~ TOBACCO Lrrrc~no~ Clit; PDF -!:I!::!!::!.f3 StlC.i: 0111 I Effects of Moving the position olFilter 'Irtntilation Zones In Project Agua SESSS International sunpiea were lucrvffd9aeed wing di~ermt ventilation tone positiolu~ Moving the vrndation tone position ofd096 ventilated JMlpkS bm 12mm to 22nw hPm the monnh ad of the filter r#uited in I dgni~Pa~ nduetion in paerived initadon vlitbw~ I rednetion in impld i,e an nppumt nduaion in the irritation : imp ratio. It wee ~ed that tbie Lompuiton ~olld be repc~d and if the results are coF6rmed then vent gone mrjpulotion may indeed be a useful dc~g0 hW for modifying ~npM~i~i~ion radol in highly vsniloed pmduns. MD will cheJ; the availability of samples and oganise a repeat sensory test EifKn ofAnmeaants It her ban suggested that the ddition ofhumcswls tg glyarol ad proWlme ~yeot to the tobacco may reduce irritarjon and increase mouthful, Rec#tt worlr conducted by Jim Shepperd using glywa~ pronylette glyccl and bpitol added to V~ai~ dgarettes bar failed to demonmue q elm ndula~ons in intwian or i#nut~ in moulbti~ One of the mtim advocates of using humecpnu to reduce iatltion is Chnis ~my ~om Wills in Austrdir Quh c~ir~ that pmhmm low delivery Yirginh products ~rorporate humeeranu md are paaived u being smoother d highaia mo~dhfUl bdn ep~almt ddE~j ~Y~I~ pm~e~. ~ Ausmlian nroduda tad m incorporate high amounts of #pandcd tobacco, and ET h believed to introduce Iddi~ka?l irriratiolS t is possible that bumectants may ameieriote inintion when applied to pmducu iowrponting high INds orn. We wed to fip3srr invaaieae t~ i~e before we dtaw tho line on hnnnedant wo~le UD wig contact Chah hiurrsj w obtain sensory and product inforaution pertaining ta t~s issue, We also should obtain own tad EDmp~P~tion products from ~uffnli~ and conduct independant sensory assessments, If di&reno in irritation am observed We should endevour to apply hu~ertantl to those products Itc~ng in btnnectants and darm~ne the sensory eo~sequcnces, parricuhr i temu of impact irritation and mouthful, of hymeetrm addition Eflrct~:oTddinn DAP to Fil~r~ In cormmr~eations with Derde L~n, ~aodrew porter ~om Caluda reoerlly chimed t)at the addition of DAP to cigarette P~en reduces irritation, It t nor char whether the reduction in irrmaion is ~ccomp~ed by a eoneonunient reduction in impact We ~d that we should add D~ to filtcn and determine its dfca on impact and irritation, ~Eft~lJ el0xidntion Dcre~ Irwin bdievts there is a pobabk rduiomhip beonenn the d~ of oxidtdon oi smolte Md perceived irritation, ie higher olddation leads to higher irritation Indeed several factors which had to ~ghcr levels oliriadon e.g reduced drcurn/er#lce, iowa md dcnsilics, wpdcd tobwo and dcaeaud moi~re coltnn may act by inererring the amount ofolddation io the rmok~. O In order to test this idea we r#luirc: : a BI~T, CDNFID~TIAl · CA~E~ORY I: ~[IMJESOT~ TOBACCO I~G~'TIOP~ C: I IISP D F - !::!!::!!::!.f3 st I c.;: n ill r a) a measure of the degm of alddation of whole moire b) O;ddising and Reducing agents which could be introdu#d into the tobacco or filters to d#ermitle their irgucnee on impact:hrimdon ratios Obviously, any product development lads would be associated with ndudng agems i.e las ~iution, but we n#d to include both in order to test the olridadorluriuo:on theory. Parr Eevan, with Special Analytical Gtwp tslistur5 will loolr into the possibilities of mesouing levels of smoke oxidation and the incorporation ofolddisinBlreducing agents. Effects of ChanrinPLnmino Width Gcoff Haolr raised the ~jpoth#is that inerclling cut width may reduce peraived initation poliy i the idadon mcc~sm. 'Ihere is some historical nidaa to support this hypothesis, However, a innwsing lamiDn width is W;dy to inereare levels of objectionable aen ti~ approach tp init~on reduction is limited but could be included as one elanent in an irritation rcdue~on drsip strategy. Reconstituted Tobacco RTS is included into SUSS blend d around the 1 In indudon level. Projed Rhspsody is aimed at investigating the sensory propertes oflTR shat ad otha model of rceoFJtiD1~on ag DEER So L seuory assasmats have ban conducted on samples eomprisl~g of 10lr~ LTR standard shat, 10[r~ I'IR modified sbat ad 10(r~ DEER Tne results show that the DEER samples am las irrtating than the ~t~R standard sheet pmpiq and that the modibed ITR sheet is someway between the two in rams of inita~on SESSS blends incorporating 1T# of cleh of the 3 moeriJs oltl be compared in the naa plum of tbj~ project wt should ]rap in touch with the Rhapsody work to determine whether that man DlOdi~Clb'WU i~ue~fe impact : untwon ratios. StW.IAdllSi~ Several JruditJ have ban conducted on the mmmy df#ts of changing stat pmwriag t~guq stem i~duD~on Isvds tad the ~mwsponb~on of diffaau slrm tJlpes. MD will collate irfomution ~wn the rdnnat projets ad determine the in8un# of stem proass variants on impaR:irritadon rcb~S. Tri~nninll Stimulants Irrhation can be claai6cd a a crigrminnl a coannon cbemiul saw rcJpanse. It is possible dot the immduaion of another Ygh ilendrj ~ga~ul sensation may mui~ peraived initlo~dn, Wo~ is planned to add potential oiec~ stimuluns to tobacco pr;mari]y to inrroduce additional lauatios cg warnth or eooln#s. It was ypad that any 'trigeminal additivd will be assessed in 1#nu of their induenoe on impact and lmtanon sauauons. 9 It ha ban suggested that eugaol in Kretek dg;uc#cJ reduces perceived irritation. O Eugenol cM an, a a local anaesthetic and this is it's li~djl mode of action in a B~x~, Co~FTo~n~l· CA~EGORY I: bl~~Esor~J, ToeAcco IITIG~TIO~ ClibPBFTi:!!~li7~f3stlc.;:nlil amdiarating iniatinr Laeal u~aheda art pliFmdly by pmaning the eaFducdon of action potentials in the n#n fibrc. It is pkudble tb~t the nerve ~bres st~s~c~cd to nerve endings ~ing rise to the irrita~w sensation dif~ir in size and stn~aure to those urached to nwe endiag produdag the impart senrYion Thw it h peadbie that Bol anaesthetics r~y diff#entially block diffault fibre types and hence at law eoneentaPbns may Rduec initation without in8~neh~g impan A~haYg~ thia ids b plve pada6on we immd to ~e eugmol u an additive (~nhin pamined levdr) M tobacco, and determine its effed on impact and initation. Mike Dixon 18!10193 CI I:PUF - \:11I!::, fJsi~l!o~ CONFIDE~TIAl · CATEGORY I: ~11~7~ESOfi~ 'IOB~C~D Lmc~noN