__ f I-e~--~C I ddvane6d Product ~~8src8 I __I 10: aicLlla i FROM: DA I_I__ICII__,,,,,.,,,I 11-1111-1-lell---1-1I--I -Il------------r----11-1 REFl Migtation Stud!ss I DATR: 14,6,90 Dbtailed belov Its e ssrfss of stptrf~sda ainsd It idantiiJinl tbs r~a It rhich nicotine ailrates irom difisrsnt materials, i, Materials Provision : (i) Filters - obtsiu 20r loll filters all with a M P1'L1 dl·efbr Oi II. Filter materials to include $ ~ cellplosl ~c~~t~ (unplasticissd), pllstieissd oslloloae scststs,and plnro~llenc. ~ I Istcr ·i;4pem~ishafaPulas may ba imsstigatsd, (ii) Slaavil I probed I procure suitsblt Iflsd slsslinl r material, 25n lop8, to bold tbs iilters, Materials to inclldd polpvinYl Let shrink, celluloJs aostate and PrW~ (ifi) Niootins solution - ~Pe P an dhsric nicatiPe solution of IPltlle ooacs~r~~on to ptovids I niootlue loadip( of '1Dll Icn 0.5ml Is spiksd on to ~ iiltar, (iv) Starsle area · provids a trqaratncs sud hurmiditV (20 claox a) conttollsd snvircnmsnt in licb the iiltsr ~6et~s can be stored, Each filter must be separated from djac8nt filters with the ends ai tbs iiltsr opsn to stmosphsrs snd not in clots proxinitP to ct s~ac~~~ 2. Prtli~lnaa Experiments (i) Ether I Filter Gr4viletric Studies - inject 0.5n1 of S sthst onto filter lstarisls and nonitot wsfPht loss ta Ithsr oaporata~, Rsplfcsts five tillss, ClibPDF - v~~fastio.soni B c c L4 fu C: Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 5 CenholS (ii) Nicotinel Filter studies - inject 0.5ml etheric nicotine solution onto filter matedais, monitor Sd/i~bAL~cy)~ ether loss and then insert filters iptO sleeve 5 cAI~C"~ ' ~ material,./Place iilters in controlled environment S ;s'if~4~!*lp ~" for 24hrs, separate filters and sleeving and S fP · separately extract and determine nicotine and triacetin levels, N,B, Sleeve materials to be considered are both the heat shrink and the cellulase acetate. Each measurement to be made o, five filter assemblies and duplicated f~e~ prepare ten filters and extract in tac groups of five~ lit the different stages determine the veight~ of the filters, 3, Storage Experiments (i) Cellulose acetate filters - prePare 25 CA filters Hith nicotine loadings of "10mg d sleeved in beat shrink material~ Store in controlled envirorune~t~ At 24hr intervals reweigh each filter/sleeve assembly - remove 5 filter assemblies, extract and determine nicotine and triacetin levels, In addition to nicotine loaded filters a control of 8 sleeved but unloaded set of filters should be stared along with the experimental samples and analysed in the manner~ ?~ 'ck,g-al (ii) poiypropylene filters - repeat as for (i) above. (iii) Filter i Rad Combinatlona . nptd as for (ii above but uith the filters connected to - an extracted tobacco rod - a Greendct sheet based rod - a reference flue·cured tobacco rod - a reference US blended tobacco rod, Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 Outline Filter Description for Project NDYA STUDY PRESSURE LENGTII CIRCUM PLASTICISER GEOMETRY DROP (mm)l (mm) (mm) PressureDrop 1~-360 126 24.5~ 1 ~flC~: 400 100 20,5r Triacetin Plasticiser i ~0'OI~~ljP9~29~ 2StlwooP 400 100.,.1,21.55, TEGDA s*··l'~" m~·.....~,r ~00 P~Jy. ~DFF Length 400 100 24,55 Triaeetin Circumference 400 100 2445S Triacetin 400 '1 100 22,0 Trfacetin 400 100 Triaeetin Section 400 ' 1 100 24,5fi Triacetin Annular j 400 100 24,5f Triaeetin Half- Section ~ BATCF, Hamb~J to provide i G hi hn d"l P(4; tSCc;V El*'"'f-' 1LOILI~L~I~ ah q0. " if a~s~9.6 /"I ~,, ~ 34 r*YG I rJ~$ 6kaL~ ~usn IL~LLL~E~~ 1 ,4 irj ib~f~ I, %v I SqOFb 64m 3~Y~' Co Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 THE EFFECTS Df nIGRATION AND ELUTION ON HarmOL DELIVERY IN erGARmES Albert S, Eble R, J, Reynolds Tobacco Company Winston·S~lep, North Carolina " Menthol is widely used a a cigarette flavorant and is thus a key ingredient In some top dressing formulations, The purpose of this work was to elucidate some of the mechanisms which control the delivery of menthol to smoke. Initial studies using 14C.labeled menthol injected into unf~ltered tobacco rods showed that menthol has a high transfer efficiency to mainstream (M~) smoke; about half of the applied radioactivity war recovered in the MS total particulate matter ('IPM), and most of the remainder was found in the sidestream (SS) TPM and gas fractions, Under the same smoking conditions, less volatile flavors were delivered less efficiently to HS smoke and more efficiently to SS smoke. Experiments were performed to measure the elution efficiency of the various flavors in an attempt to explain the observed differences in MS deliveries. Appt ication of radioactf ve flavors to the butt or unsmoked portion of an unfiltered tobacco rod demonstrated that about 32X of applied menthol was recovered in the HS TPM after 8 puffs, as compared to deliveries of less than 2X for the non·volatile flavors. More detailed experiments showed that only menthol which was located on tobacco less than 30 mm from the firecone was subject to elution by MS smoke. Previous studies have shown that menthol applied to tobacco in filtered cigarettes migrates to the filter and vice versa, Furthermore, it is known that MS menthol delivery decreases with time parallel to this migration from rod to fitter. Experiments designed to elucidate the mechanisms responsible for this decreased delivery showed that menthol in the filter is eluted less efficiently with increasing time due to absorption into the filter fibers, The age of the filter affected total menthol delivery but did not alter puff·by·puf: delivery profiles. The age of the tobacco rod had no effect on menthol delivery, In conclusion, the high volatility of menthol makes elution an important mechanism for menthol delivery and also causes rapid equilibration between rod and filter, This migration causes total menthol delivery to decrease with time due to absorption of the menthol by the filter fibers. Clit; PDF -!::!!::!!::!.f3 StlC.i: 0111 ~~ZQ 8~ - O~~Q galA i RICltlOP Studies TIfLg : lieot!ne ~igration Studies nB~Q ; 'Spln off" rron Blatian Studies : 001,06,100 ~paIn To Oetsmine the Rate of Nicotine Migration trot - Sp~td)iltets to Tobacco bds B1CRID : g!otion studies have shown that coPsiderablo - transter levels (~30T) of nicotine fron cellulose dcetate into snolie can be aebieted, Before further coasidera:ion can be given to the usa of filter spf;ting far enhancing nicotine deliverjr ir.formatian is r~oiced on ~a rates of nicotine ligratioa from the filter to the adjacent rod. such data will complenent those which already erist for menthol (1) end a range of ~del ilnolrs [])~ I1I Ire required for different filter naterials and different rod ~aterials including all-synthetic sheat neterial, nB~~gS : i) Tilter m~:erials to be investigated to include :- Cellnlosa acetata, P6lypropglene, Al·ina ii) Id Pterills to k investigated to include :· Tobacco (control), Extracted tobacco, G~Z~OOT Sheet, Pgf~eaCIP i, B I i) Be~t: r1129 2. acir~ng? zur Tab~:forschunq Int.,Ycl 12, lo, 1,(1983),p.l ClibPDF - v~~fastio.soni