TOBACCO DOCUMiE~FI~CATIONCENTR~E Fax re n s m Is s ion C.J,P. uy rog5 To: CLris Proctor Company: B~T i Fax Number: 0784 448654 From: Nicdie Potulski, Researcher % Analyst Dale: 10 January ]995 Total Pages Sen: lir~' Message: Dear Chris, Re: i\loney expended on tobacco and health research 1 have now arrived at a summary of the available data on the tobacco and health research expenditure, and attach the tabulated fgures. A fuller explar,ation is in the mail, As you can see, there are huge holes in the information and although I am still awaiting further information ontheWHO (tobefonvarded toyou),lhavelittle confdence that we shall be able to fill in the rest, ·Information on health research expenditure is sparse, Toe data we are able to provide to you give an idea of the diversity and magnitude of the expenditure figures, but unfortunately only give an incomplete picture. In any case, 1 hope that ;he summary will be of some use to you, and please do not hesitate to get in touch again withanyqueries regarding the information, Yours sincerely, Nicole If you have any queries regarding this fax,piease call ~44 (O)pl 569 7788 ITHAvUjlOE CE~IRE, Krw IRIDGE ROAD, BREMFORD. MIDDIEEOI TwllHF. UC 1~ TELEPAONE ·vmill 16~1181 F~ ~U(OIRI R1 7011 O L;iltd li3ilily REpnnli~m No, FC16110. E~u~lilhed in Sviv.crbnJ. VAT num~a I~ll p?~jll' O BATCo document for legal Services : Health Canada 19 May 1999 SUMMARY ~OF AVAILABl.E INFORMATION ON MO~JEY WIPE~DED ON SMC)~~G ANDHEAITH RESEARCH SINCE 1964 Definitions: The detinition of'Researeh' used here includes medical, epidemiological and sociological aspects. Research expenditure islakm toinclude spending bygovernments, industry or non·governmtntal o~animtions such as charides and trusts, as well as institutes. Scoa of the reoort: There are no comprehensive data on a world·wide basis on smoldng and health research funding by the industry, or by anti-smoking bodies, 'Further, it is difitcult to identify all possible governmental and non governmental agencies (operating atnationai, regional and local level) who could haveeither givenorre~eived grants forsmoldng and health projects. Where figures are available these are often presented as totals and the percentage actually spent on tobacco and health research israrely identified. In a first attempt 16 geta handle on the range and magnitude of tobacco and health research funding I have concentrated an obtaining data for three countries (the UK, the USA, and Australia), all of which have a tobacco research body supported by the tobacco industry. In this report a brief overview for each of the three countries Of the information relating to expenditure is presented in the form of quotations and abstracts of papers, followed by a summary table of the available figures, 'There are however, numerous reports which identify national, regional and global health expenditure (e.g,Wodd Development Report 1993, Investing in Health. Oxford University Press (1993) 329 pp.) Extracts of such figures from the World Banic Report in 1993 (Appendix I) and from the WHO publicab'on of 1994 'Clobal Comparative Assessments in the Health Sector' (Appendir 2) art appended, Again, it is rare to find research expenditure, let alone expenditure on smoking and health research detailed, One paper which goes some way towards defining research expenditure onanli·smo~ng programme @ut not research on smoking and health) is by hlichaud and Murray, 1994,published in'Global Comparative Assessments in the Health Sector', WHO, 1994, This paper presents a table of estimated disburrements by external sources to the health sector indwcloping countries and features acolumn of disbursements to druglalcohol dependence in 1990.Details are presented on page 30f this report and thepaper isappoded (Appendix 3), --- · BATCo document for Legal Services : Health Canada 19 May 1999 EST~MTES OF4VERALI, TOTAL SPE~aYI'C O~QBACCD AND HEA1~T~f RESEARCH ABSTRACTS: T~tal Tobacceind~Lstrv~s~endine CORNER, Richard: industry expenditure on smoking and health research situation as of February 1987,1NFOTAB Telex, (Februarj 101198T), Ip~ The entire text reads as follows · i. There is no comprehensive data on a wotld·wide basis on smoking and health research funding by the industry. 2. The introduction to the 1984 report of the US Council for Tobacco Research (formed in 1954) contains the following paragraph "Asof the end of 1984,lhe Council's program had provided more than S91,SOO,ODOlo 526investigators for8970riginal projects in ZBS medical schools, hospitals and research institutions," 3. The US Tobacco Institute, in a 1986 brochure entitled 'Inthe Public Interest Three Decades of initiatives by a Responsible Cigarette Industry" writes *In 1985, after three decades of support, the Council for Tobacco Research alone had provide~ more than f100 million in smoking and health research.' 4. In the same brochure, the T1 states that in 19u,Lhe industry pledged separate funding to the Education and Research Foundation of the American Medical Association for a Smoking and Health Research Programme similar to the CTR's in its freedom and autonomy. And by I9'14,at the conclusion ofthis project grants totalling SL5 million had been awarded to S4ilscientisLS in 98 medical and research institutions, 5~ The only other figures we have for similar research expenditure featured in a January 1985 response to a similar cnquirj as follows UK f 8,5 million pounds sterling Canada f 3,5 million Canadian Australia $ 3 million Australian. INTCLASS 7263 CHAPMAN, Simon, BROWN, Robin, DAUBE, Michael MCMICHAEI, A,J. WOODWARD, Stephen:'Ihe Australian Tobacco Research Foundation, The Medical Journal of Australia, (]uly 4, 1988) Vo1,149, pp.4~47 This letter refers to a statement by the Scientific Advisory Committee (SAC)ofAustralian Tobacco Research Foundation that BATCo document for Legal Services : Health Canada 19 May 1999 smoking is'animponant causative factor in seved major diseases". It "commends (ttis) clarification of their position" hut questions the motives of the tobacco companits in funding such research and asks what the industry does with those research results. It quotes two statements, one from a (Sep!.1970) meeting at the Rothmans National Sports Foundation Office that "the research is of a highly technical nature which does not lend itself to such (me~ia) exploitation", and the other from Philip Morr~ land a~fobacco Institute of Audralia) executive J, Dollisson in 1985 that, despite research expenditure by the tobacco industrj of US1130 million in US, UX and Australia alone lover the last 10 years), "thisresearch is inconclusive and shows the need for more research". The writer believes this "more research isnelded" stance typifies the industry's position world·wide, "despite the overwhelming consensus about tobacco's causative role in prevalent diseases". INTCLASS 11312 Total non industry mending Michaud, C, and Murray C.J,L.External assistance to the health sector in developing countries: a detailed analysis, 1972·90, published in: Global Comparative Assessments in the Health Sector, WHO 199Q. ed C,J~1, Murray & A,D, lop~. 196 pp. Michaud and Murray state that no single database exists that provides a comprehensive view of health sector external assistance. Their primary means of data collection was through a qationnai$ visits and telephone contacts. Where such responses were insufficient they resorted to three major databases on development assistance: the OECD Development Assistance Committer (DAC) annual tables, the Creditor Repo~ng system (CRS] from OECD, and the Register of Development Activities of the I~ system, The paper presents a table orutimated disbursements by external sources to the health sector in developing contriw in 1990, detailing funding to communicable diseases, noncommunicable diseases, injuries and 'other'.The authors state that the estimated external assistance by health sector activity is more tcn~tive than other results and that the estimates are minimum rwu[ts, Accordingly, the total estimated disbursements in USS from all external sources in 1990 to druglalcohol dependence programmes in developing countries was as follows: Bilateral Mullilateral NGOs Total USS 6 950 000 2 786 000 7000 9 802 000 (Appendix 3 is a full copy of this paper) BATCo document for Legal Senrices : Health Canada 19 May 1999 THE UNITED_STATES OCA,MERIC~ Overview: The tobacco industry founded the US Council for Tobacco Research in 1954 and has provided its financial support ever since, In addition, there are numerous govemment·supported and non-governmental health groups in the USA, whose major or partial concern is smoiting and health research. We are aware of the major groups and have an idea of their spending on smoldng and health research (direct or in the form of grants to other institutions), There remain several problems with an overall spending figure for the USA, As already mentioned, accounts willoften quote total research spending rather than detail spending on smoking issues, and secondly wedo not have details of the spending of the smaller groups who are operating a~ rhgiond or local level. Tobacco industry soendine AOSTRACrS : CORNER, Richard: Industry expenditure on smoking and health research situation as of Fcbruar~ I987.INF~TAB Telex, February 10, 1987), 1 p. The introduction to the 1984 report of the US Council for Tobacco Research (formed in 1954) contains the following paragraph 'Asoflhe end of 1984, the Council's program had provided more than S91,5M,000te 526 investigators for 897 original projects in 285 medical schools, hospitals and research institutions," The US Tobacco Institute, in a 1986 brochure entitled 'In the Public interest Three I)ewdts of Initiatives by a Responsible Cigarette industry" writes "In 1985, after three decades of support, the Council for Tobacco Research alone had provided more than 5100 million in smoking and health research," In the same brochure, the TI stales that in 1964, the industry pledged separate funding to the Education and Rexarch Foundation oithe American Medical krsodation for a Smoking and Health Research Programme similar to the CTR's in its freedom and autonomy. And by 1974,at the conclusion of this pmject grants totalling S15 million had been awarded to 844 scientists in 98 medical and research institutions. INTC1ASS 7263 CROSSEN, Cynthia: Tainted truth. The manipulation of fact in America. Simon & Schuster (1994) 272 pp~ "Tainted truth. The manipulation of fact in America" concerns sponsored studies, which author Cynlja Crossen claims have become America's "most powerf31 and popular - ------ BATCo document for legal SeNices : Health Canada 19 May 1999 tool of persuasion". The author devotes a few pages @p. 66·69) to tobacco industry research and in particular the activities of the Council for Tobacco Research, who she says granted over S16S million to some 800 scientists to produce 1,200 studies between 1954 · 1990. During the first 20 years, studies reportedly found Iinks between smoking and discase, allegedly as a result of which the industry group stopped sponsoring such research in the 1970s,and concentrated on supposedly tangentially related orufirelated issues. IPS~CLASS 24354 1993 CTR Report: The introduction to the report slates that "the total amount of funds awarded as research grants amounted to USS 19 500 000 in 1993, hinging to more than US% 223 million the Council's support for its research program since it began operation in 1954","The recipients have been 985 independent scientists at more than 300 medical schools, hospitals and research centres." Non indudw saendin4 I. GOVERNMENT FUNDED AGENCIES: tall information is based an Smoldng and Tobacco Control Monograph No 1 1991. Strategies to Control Tobacco Use in the US.) National Cancer Institute The NCI began its Smoking and Tobacco Control Programme (STOP) in 1982, Ihe programme includes a comprehensive research programme fortesting the efficacy of a variety of smoking intervention strategies, Up to 1991 nearly US$ 300 million was allocates to smoking and tobacco control research for smoking intervention studies. The monograph provider a historical progression for research expenditure on intervention studies between 1982 and 1991, Centres for Disease Control (CDC) (Information presented here is bared on a publication by the Intwagcncy Committee on Smoking and h'ealth 1990) CT)C provides leadership and direction in the prevention and control of diseases and other preventable conditions, in response to public health emergencies, CDC actively supports epidemiological research and interventions in which smoldng is counted a major risk factor affecting health. Within CDC efforts to prevent the use oftobaccr, and evaluate the effects of tobacco use are concentrated in the Centre for Chronic Diseases Prevention and Health Promotion - -- BATCo document for Legal Services : Health Canada 19 May 1999 (CCDPHP) [conducn smoking education, intervention and cessation evaluation programmes], the Center for Environmental Health and Injury Control (CEHIC) (conducts rexarch and analyses projects related to passive smoldngl, and the National institute for Occupational Safety and Health (N7OSH) [conducts, among other things, resea~~h relating to problems oismoldng and clean indoor air], In addition, the Office on Smoldng and Health (OSH) is the focal point of the Department of Health and Human Se~icts actitrities related to smoking and health. OSH coordinates the Department's smoldng education, prwention and research efforts. An extract from the 19S7Smoking and Health National Status Repo~ 1nd Edition, is appended to illustrate the magnitude and breakdown of spending on anti·lobacco measures. (Appendix 4) Other Institutes are: National Institute for Health and Human Development One of the goals if the institute is to promote public awareness of the relationship between, among other things, cigarette use and sexual activity,and early fertility among young men and women. Several research studies are planned which aims at addressing this goal, e.g, the impact of cigarette smoking on the immune response in women with WIV infection, National Institute on Drug Abuse ~A) ..ronducts research into many arear related to nicotine addiction." National Health, lung and Blood Institute: Smoking Education Program (NHLBI: SEP) Continues to research 'CEnical Opportunities', a primary strategy to intervene with smoking patients, 2. NON GOVERNMENTAL ORGANIZATIONS: American Lung Association A1A'research' activities are reportedly restricted to providing seed grants to young scientists of promise in lung disease research, American Heart Association One ofAHA staluede aims isto "~mdertake and foster research into cardiovascular disease", The AHA "supports research, education and community services related to the cure, prevention and treatment of heart attack, stroke and cardiovascular diseases". Tnis is accompiiPed through, among others,'rescarch awards and grants for biomedical ---`- - BATCo document for Legal Services : Health Canada 19 May 1999 investigalion...",.,... [into the] "prevention and treatment of cardiovascular dismsl...". Re 1992·93 annual report stales that in 1992·93 the AHA spent USS 92.7million to fund 2904 scientists and their projects. (i.e, American Cancer Society "The ACS is the nationwide community·based voluntary health organization dedicated to eliminating cancer as a major health problem by preventing cancer, saving lives from cancer, and diminishing suffering from canctr through research, education and service," It isreported that ACS approved mom OSS 81 million in support of about 800 research grants and postdoctoral fellowships in the fiscal year 1986·87. The Joumal of The National Cancer Institute reported in 1991 that the ACS had approved funding for 321 grants. The grants, ranging from basic science to clinical research, totalled 540,112,000. The ACS has also collaborated with the WHO and other health organizations on cancer research studies, surveys and their publication. The 1993 Annual Report states that "inthe fiscal year 1993 ACS invested approximately USf 100 million in research, To date the Society has invested more than USf 1.5biliion in ancer research." American Association lot Cancer Research Professional organization of research workers for presentation and discussion of new and signifiant observations and problems in mncer. Among others, the AACP stales its aims as "~,~to foster research in cancer and related biomedical sciences; ~.'and bestows awards for wncet research. It is not specified if this includes funding for smoking and health research. American Health Foundation The ARF is a nan·profit autonomous organiza~on, incorporating several medical research institutes. The ARF undertaker a research programme directed towards the assessment of "the often complex risk factors and preventive elements for cancers of the lung, mophagus, stomach, colon, pancreas, breast, prosta~, ~dncy, bladder and also heart dis~dse", AHF believes that all of the above wnccrs ate for the major part lifestyle related, and are a tobacco and nutritionally linked discase. American Medical Association AMA Council on ~Rgistation reviews and suggests official positions on current federal legislation, including tobacco control measures and as such is not directly BA~Co document for Legal Services : Health Canada 19 IJlay 1999 involve~ in tobacco and health research, However, in the December 7, 1994 publication of IAMA AMA offered Policy Prorr,otion Grants of US5 500, intended to promote AMA policy in a wide range of areas, among them tobacco and substance abuse. Tne grants were to be paid to collaborating 'co· sponsoring medical societies'. "1USA: SUMMARY of a~aiIable data"' Industry nendine US Council for Tobacco Research TOTAL spending (US5) 1954 · 1984: 91.5 million 1954 · 1985: z 100 million 1953 · 1990: ~ 165 million 1994 · 1993: ~ 223 million Education and Research hundation @art of the Ameri~n Medical Association's Smoking and Health Research Programme: ) TOTAL spending (US%) 1964 · 1974: 15 million Non industry s~nsli?n i. GOVERNhlEF~ SPENDING National Csncalenitute Total research urpendihne (USS) 1982 · 91: 300 million t~jlin American Lung Association RESEARCH EXPENDtTURE (mostly seed grants to researchers) 1978: 3~0 USS million --- BATCo document for legal Services : Health Canada 19 May 1999 1980: 1,2 1982: 1.6 In 1983 it was reported that the A1A of Eastern Missouri granted S369000to Washington University researchers to conduct a threcyw experiment using work·site clinics and co·woricer support to help workers stop smoking, 1984: 1.4 1986: 4.0 1987: 4.2 The average B expenditure on research during 1978 · 87 amounted to behv#n I.llo 5,9 % of total expenditure, American Heart Association RESEARCH W(PENDITURE (no indication of percentage spent onsmokingand health research) 1978: 21.8 USS million 1980: 26.9 1982: 39.4 1984: 43,7 1986: 55.4 1988: 65,3 1992!93: 92,7 (31,81 of all expenses) The figures show that on average 30~ of AHA's income is spent on rc~eareh, American Cancer Society RESEARCH EXPEND~IZIRE (Cancer Researehj 1978 38.4 USS million 27,596 ofincome 1980 50.5 26.746 1982 57,3 25.746 ]984 ~.596 1986 77.1 25.046 1988 89.2 26.696 1992 100.2 26.6n 1993 10S,Q 26,596 ~otal up to 1993: > l,S billion Thr figures show Ihat on avlrage 25% oltht ACS'sincomt is spent on Cancer Research. BATCo document for Legal Services : Health Canada 19 May 1999 N.B, Research expenditure figures for the ALA, AHA, and ACS come from Bannet, J.T., 1990. Health Research Charities: Image and Realiq. Studies in Philanthropy, Capid Research Center. ed William T, Paole We have no data for speeding by(he following organizations: American Association for Cancer Research American Health Follndation American College of Cardiology American Council for Science and Health National Foundation for Cancer Research BATCo document for Legal Services : Health Canada 19 Nlay 1999 Sunmary of Knouln Raearch Spading in ~e USA (USS) Y~nry Spmdinl Non (nduul pndinl Council Mucnion Nuioul hrrrr;cla ~ieln ~mman br k QIKII IYls Ln CIHCI rO~lLEP Ruulch Iou. ~ID~L~D ~Jlaido So~hl R~rlrrh RrR. T~R TdB twi foul Totnl Ta3 Rtwph luud b~ueh Relud atmorrh slueh Spcpdint Sp~alinl Syrdins Spcrdinl Spmdinl Spcrdil 1954 1961 1974 Id II I 18 1 I I I 1.0m 11.lm Il.~m SD I I I ) llm Zb.9m IO.lm 82 1 I i 1 1·6 39·1" If.lm 84 Tout I.ln~ Il.ln~ M.lnt lioct 19~4: OI.Jm 85 ~OU' tim, 1PII: sloom 86 1 I I I 1·0' Sl,ln n.lm 87 1 I ( '''" 1988 1 I I I I bJ-l" 1989 1990 ~"U' irl ]95(; )l~m 1991 TW1 rplll doml 19P: liml 1911: >1Zlm 3Mlm 1992 1 1 ) ) ) 91''" 1W" 1993 1 I I I I I'""" TI1Jvp u1993; >IJ (Ilipp U1 O O 03 w C C BATCo document for Legal Services : Health Canada 19 May 1999 AUSTRALIA everview: The tobacco industry founded the Australian Tobacco Research Foundation (ATRF) in 1970 and bar provided its financial support ever since. The Australian trade association advises that the total monies given by the tobacco industry i.e. manufacturers in Australia, between ]970 and September 1994 was AUB 9.1 million. There are numerous government-supported health groups in Australia whose expenditure is detailed below, Accounts given in annual ~po~j often quote total research spending rather than detailed spending on smoking research. Industry_sDendi?e ABS'IRAC~S: CORNER, Richard: Industrj expenditure On smoking and health research situation as of February I48'I1INFOTAB Tclex,(Tebruarj 10, 1981), 1 p. This telex indicates that in 1985 overall industry spending on research was estimated at AUSS 3 million. DOYIE, A,E., RAND, M.,POWELL, I.W. SadMONL)S, W., WING, I. ZYLSTRA, W, SHAW, john, The Australian Tobacco Research Foundation. Medical ]ounnai othustralia, (Februarl 1,1988), 148 pp, 152. ABSTRACT Six members of the Scientific Advisory Committee of the Australian Tobacco Research Foundation write to clarify the function and attitudes of the Committee. They believe that research into the relationship between smoking and health is a malter of considerable public importance. I~e three major tobacco compaoiw provide about AUS$SOO,MHlannuaUy,nrpporting research in this area, The granting mechanism consists of open advertisements for applications, the review of submissions by the Scientific Advisory Committee, reports by outside experts, and where necessary, interviews. While members ofthe tobacco indusby sec all applications, the industry has not attempted -and indeed has no power - to influence decisions on individual projects, or to determine the direction of rtxarch or to innuence the publication ofresultr, INTCIASS 9068 ~1 ~- ---- BATCo document for Legal Services : Health Canada 19 May 1999 .ttt AI'STRA1IAS~M~MXY olapailable data'" Industry raendine Estimated TOTAL spending by Australian iodustr~ on the Australian Tobacco Research Folmdadon: 1970 - 1985: AUS$ 3 million. 1910·Scplcmber 1994: AUS% 9.1 million. 1970 · 1994: AUS f 12.0 million [Thisisthe overall total todate based on the Doyleet al.papct whjchquotes a figure of "AUSS 0.5 million annually"] ~o_n industry swndine Annual reports usually quote lotl research spending, Where detailed spending on smoking research was given this is specially indicated in the below table. Known Research Spending by Charities and Trusts Speeding kl""* HIW """ ''US G"' H"" H"" "X"NSw Canwl PI bllLil Saiay Fou~lion in AUS% Y,bh 1966 290 927 1967 1968 1963 303 916 1970 336 842 Iml /~mo 1972 454 542 1973 475 814 1974 1 581 806 1975 '1955·'75: 3 684 293 1976 1 1 208 259 391 413 1977 549 917 continued . PTO BATCo document for Legal Services : Health Canada 19 May 1999 1]978 681 038 1979 981200 2 203 0001 1980 1 146 600 2 578 000# 1981 2 872 000# 1982 j 419 0001 1983 2 2n 173 4541000# 1984 3 418 788 4 692 000# 1985 4 449 642 3 611000 5 sn 000# 1986 4 773 000 '1021000# 1 658 591 1981 4 533 000 391 954 12 281 100 1 962 431 1988 5 081 000 403 311 13 905 803 1989 5 295 000 471 463 1990 7 720 000 6 409 000 694 162 2 435 763 1991 7 562 000 7903 000 673 477 2 566 804 1992 13 742 000 9 642 000 2 544 887 1993 1 12 633 000 21 267 000 blanks · no figure available to us # = figure specifically refers to expenditure on research, eduwtion, rehabilitation, community and publicity, and community servicps. Figures conrinued m0 ·- - BATCo document for legal Services : Health Canada 19 May 1999 Known Research Spending by Regional Health Authoritiw Sprn· "C; V'' ""'' """"" "fW ~C[ PLO V'; W" T~S HoIL H1Jlh lioa S~ Huhh Hulb HuY HIIY H~lb Hullb HIIIL ding Rwnaipn ap ap D~p Rp Dls [kp In Funa t AUSS 1988 Ill$olll I I I ) I I Ibllbl 1989 16 ~WPXI ZWIWO I I ) ) ) lb9 86 1990 31160CCO 3016030 IIWWO I1IPBJ 2IPWO ax~ ooo ~o 1991 i '01 ]O"OR~O '1"WO 1011030 330109 167 OMI OCO 199: 11116000 6tuMIO 13 ~1 ~~I1M 1003106 ICO MXI 033 199! IIWd116 c~#IW 669 000 l;ev: * =Stated tobacco research expenditure We have no in[onnalion on the spending of the following organimtions: NSW Cancer Registry and Cancer Epidtmiology Research Unit: Royal Australian College of Physicians: National Health and Medical Research Council (NHMRC): Australian Federation of Consumers' Organimtions: No details of spending of these two, although these ccntres would already have been covered through the figures of their supporting Heath Authorities: Centre forBehavioulal Research inCanetr (CBRC) · (funded by vic Smoking and Health Pgm Australian Institute of8calth (Geniss 18338) U1 O O C3 u I~ L~ BATCo document for Legal Services : Health Canada 19 May 1999 ~~~ n~GPQY $eoC1: Several Tobacco Research bodies are in receipt of supported front me tohacco industry in the UK: i. in the pt the loblcco indutrrj suPPorlcd de UK roblcco Raarch Colld, r~cb is now db8nct L Be industri also ~bdb funds the Bdtbh Hatth Promotion PI~ Td,~Ych was founded jp 1982, 3, The Health Education Authority (HEA) is eamndy in receipt of both industry boblcca P*PtanP mi brewers) ad government ~ldhC It was abti8d in $81 It I Jpecial hdl AulhoritY rerpansibie br8dpd within the Netinlui HdL Scnia. The HEA's predecessor vp the Health Mu~~m Council (HECX which itself was based ooLeCad CoundlbrAdl Education, founded in1927, HEA Annuli Pepm provide 1 breakdown o[expenditurt on smoking research Id Le figures horn to us a semdsd below, There are also numcnrs govwma~lrpa~ and aoP·go~mea~ hdL groups i the Ug. Th, ~~II with IpdpC id identifying smoking and L~h a~d spending have already ban explained, Industrr loendinr ABSTRACTS I, UK Tlwel Bmreh C1PoeB (TRC) TU( did not get clearance 0 forward PlrmlCoa a, British Health RbmdBp Research Trust TMA did not getcleamncc 0 forward information CHAPMAN, Simon: Contrnentary Tobacco ipdl~ health research 'bY money',The Bdd$ Health PmmoLol RWWIeh Tnr Community ~1 Sbjl, ~913, it ~t R· 139·142 ~B~RA~ in October 1982, Be British govunlat maand be forrnltion ofle British Health Promobon Research Trust ~~, 1 body funded exclusively by Ic British tobacco idl!~~ leTdCld IlljllP pounds to ardb~all promet1onrexlr3t prd#b aver3 md 1 hnit lan, provided they id not include 'ICa designed directly or indirectly to alaie be use rd effects of tobacco products: 1161 informaonon on smoking wail "neccssarY lo rYac the purposes ofthe Rscarcl pgalc' i Icb areas as coronary risk factor research, lNTClASS 8029 3. Arlh Education Authority ~~) nM did not Id dwce to iunvvd h$d* on industry funding BATCo dbcument fer Legal Senleeg : Health Canada 19 May 19119 An article in the BM~ of 24 ]uiy 1993 stales that the HEA annual budget is f36 million. Of this 151 annually (5.i m) is spent on smoking issues. ~n·lndwstrv sDedinm Health Education Authority(HEA): Department of Health funding An article in the BMJ of 24 July 1993 states that the HEA annual grant received from the Department of Health is a6 million, Of this 151 annually (5.4 m) is spent on smoking issues. This will be cut from April 1996. Imperial Cancer Research Fund In 1991 ICRF spent 91.6lofincome from donations on research. (Other income sources are legacies, covenants, retail, fundFising, investments, regional activides)~ ICRF said of itself that it needs to raise over~0m a year to fund itscxtmsive research programme. Total income in 1991 was f 51,2 million. British Medical Association Recent income and expenditure accounts are available, stating expenditure on'National medical services' without further defrnition oflhese. '"UK SUMMARY of available datastt Industry snendine British Health Romotion Research Trust (BHPR'T) 1982·1985: f I 1,0 million lirnherinfonrnrion nor cleared Health Education Autharity(HE~A) (formerly the Health Education Council) Spending on Smoking and Health Campaign (UK q, as listed in the Annual Reports: 1980: 0,40 million 1981: 0.70 million 1982; 0.89 million 1983: 2,39 million 1984: 2,63 million 1985: 1.62 million 1986: 2.30 million 1990·91; 3~ 44 million 1991·92: 4,18 million -~-------- BATCo document for Legal Services : Health Canada 19 Yay 1999 Separate information indicated expenditure on smoking research as follows: 1992191: ~ 519 095 1992193: E 638 983 1993,94. E 867 561 Summary Estimated Overall TOTAL spending of tobaeco industry up to 1985: f 8.lmillion [based on~NFOTAB Telex, (February 10,1987)1 Fion industrrswndi?e i. GOVERNME~T: Health Uucation Authority(HEA) Total annual grant from the Department of Health for each of 1993,94,95 was E 36 million. 2~4as: lmperlal Cancer Research Fund Tne Annual Report for 1992193 indicates 'Dircct Research Expenditure' as follows (UKE): 1991: r 46 899 200 1992: E 49 992 000 1993: f49 961 MK) British BIedieal Association Income and apenditurt accwnts for 1991 and far 1992 state the following expenditure on 'National medical services' without further definition of these: 1989 1 913 000 E Sterling 17,2 Z of total income 1990. 2 277 000 18,1 1991: 2 685 000 1992: 2 736 000 17,1 Cancer Research Campaign ~xpendirun onallrcwrch (f): Tod Expenditure 1991: 42,1 million 47.2 million 1992 43,4 million 48,9 million BATCo document for Legal Services : Health Canada 19 May 1999 British Heart Foundation ]991 42.lm 4'1.2 m 1992: 43.4 m 48,9 m wt have no information on spending of the following organizations: British Heart Foundation: British Lung Foundation: British Thoracic Society: Cancer Research Campaign: Royal College of practitioners: TOTAL NON-GOVERYSIENTAl WPEND~RE The hsdenoa Top IO[klCharilics guide to IIK charities, an annual publication, dcdis UK Medical Research Charities' total expenditure overthelastyear, P~o details are given of the proportion spent on actual research or the proportion spent on smoking and health research. Such research might be carried out or funded by charities listed under any of the following subsections of Medical Research in the guide: Total research expenditure (f m~ by charities in subsection overthc pre~ous ~ancial year (1991) Speci~e conditionr: u.IQ fn~illion Alcohol and drug addiction: 5.50 Cancer: 171.'11 Drug addiction: 1.09 Heart disease: 27.43 lung conditions: 2,81 TOTAL 432,11 fmlon Source: Hendenon Top 1000 Charities 1993 guide to Ifl( charities N,B, the 1994 edition of Hcnderson's Guide lists the tap 2000 charities. BATCo document far Legal Services : Health Canada 19 May 1999 Summary oT Known Research Spending in the UK (f) Indunrr Spdiol Hon Lnlung Spdnl BHWIT HE~ 'I~ul HU ICRF CRC k 611 bhJ BHF" Mdir$ Olmi~l Toui Srm~nl taR 'TbH W Trul twl Twi ~lP' i Hald~ Rcumh R~uld tnnl Ruad UF AnurcA Rtru~L kmpln, tpd. E~nd. E~nd. E~c~i 1964 SO 0.4 R1 81 O.~Om SZ O.1Pm 83 1.1Pm 84 1.11m gg TPUI if. 1·dIlll ~d~l ulllil Il:llm I11I: 1Jm 86 2,111 1988 ]989 1990 1991 ~.4~~n IIPWJ 16.9m Illm Il.lm Ill.ln 211.0Rl" 10,1 m" 1992 I.l1m 019kl IP.Om Q,Om ~l.lm 11.01 19.6m" 1993 167111 31e Hl,Om 1994 16m O ill tJ BATCo document lor legal Services: Health Canada 19 Illay 1999 EXPE~DIT~RE ON_ S;CIOKING AND HEAITH_RESE~RCH BY INTERNATIONAL AND ~n~,TITATERAIORGANIZATIONS (wC are still awaiting further information on these) WHO The WHO Programme on Tobacco or Health Pgm was officially established in 1980 at the 33rd World Health Assembly. Prior to that date two Studies on lung cancer had been undenaken (Nonvay and Finland, 1960-62, and India and the USSR Asian counties, 1966). and a number of Expert Committee meetings on Smoldng and Health had taken place. Within the programme for the Promotion of Healthy Lifestyles, WHO addresses tobacco and health issues. WHD states its inten~on to build up raaorch copociry on the determinants of health and changes in behaviour, and for asstwmenl and evaluation of measures for health protection and promotion. In addition to this Eoeiologiwi research WHD also funds epidemiological culctr research at the IARC, and cpidcmioiogicdi Statistical evaluation of cancer research studies at the Imperial Cancer Research Fund's Cancer Studies Unit at the University of Oxford. HISTORICAL BUDGET PROGRESSION OF WHO'S 'loH SPENDING Toul wHo bdy USs ton ula mPP~ pm os curb epbr ~ db~ ~a~cd prajrm Q~lyla irrlull USJ (W c~i~lYICd II Pt 1980181 198US3 1984185 1986187 1988189 1 413.0 million 1.26 million 1990191 i 423. 3 million 1.63 million 199U93 1 2.39 million 1994195 1 BQ0.0 million 2,66 million 192 600' Key: = source is WHO daument EB95158 of II November 1994 of the 95lh Executive Board Session: Provisional Agenda item II. N.B, The Tobacco or Health IToH) budget 1994·95 amounts to USS 2.66 million which accounts for about 0,14 46 of the total WHO budget of about US$ 1840 million for the bnnium in 1994·95. Although the'loH Programme represents only a small percentage of be total WHO budger its funding base is extended beyond USf 2,66 million through overlap with other ptograrnmes byentra budgaarj contributions from individual member states BATCo document for Legal Services : Health Canada 19 May 1999 INTERYATIOSAI, AGENCY FOR RESEARCH O;Y CANCER, IARC and IMPERII11 CILI'CER RESEARCH RT~iD'S CANCER STUDIES ~nT AT OXFORD IARC undernkes epidemiological studies on cancer research, training of researchers and provides technical assistance to researchers through research agreements and by providing scientific tools forcanc~ research. Of importance to the tobacco industry is IARC'linvestigation of the problem of carcinogens in lifestyles: The Agency is involved in a series of studies which encompass cancer, alcohol and tobacco and an investigation of the alleged risks of passive smoldng, IARC is funded through the WHO, IARC member governments, the EU, the US National Cancer institute, etc. HISTORICc~l BUDGET PROGRESSION OFIAAC and Imperial CancerRexarch Fund's Cancer Studies Unit Taul IhRC b616 1155 nwnm ynl on TP~eeP toul ~udtcl I~niJ (apllr budsn aJI) rod HuWI r~ph pmjlru Goc~f Rtul~h Fund'l USf Claev SPldiU Uml 1 01W. 1980,83 1982,83 198w8S 1986187 52 600 1988,89 311 020 1990191 26 126 000 116 46o + 363 120 199:193 32 500 000 61 980 ~ 571 730 199495 3~ 000 000 198 900 (t 13 000 000 other sources) INTERYATfONALUKION AGAINST CANCER, UICC The objective of the UICC Tobacco and Cancer Programme is "topromole an agreed international policy on tobacco control and the provision of expertise to advise on the anaiyris ollom; problems and the development of national progmmmer'. One of UICC's stated aims is *To encourage and foster medical and scientific research into the causab:on, prevention, detection, diagnosis, classi~cation and treatment of WICtf,* Annual R(pon lin ~i~ UICC Tobacm an Cants Pro~amme and indiraus a U; commilmect to initiating research studies in developing countries, but no details of funding breakdorn are given. 3 BATC6 document for Legal Services : Health Canada 19 May 1999 Total Expenditure (USS): 1991: 3258 198 1992: 3 279 649 1993: 3 444 514 If the assumption is made that total Tobacco and Cancer Programme expenditure is determined by relative programme to oaffing levels, then spending on the T & C Programme would amount to about 1046 of total expenditure, i.e, ca. US% 345 000. No details oireiative research expenditure are available. EUROPEAN UNION P~-BIIC HEALTH PROCRA~IE DF ACTION AGAINST CANCER Established under the provisions of the First Europe Against Cancer Action Programme in r98'f,the programme actiondpriorities are nowawellestabiished element ofnationai health potty setting in Member States. The 3rd EU Action Plan Against Cancer is due to run from 1995 to 1999, At the 9th World Conference on Tobacco and Health, October 1994 the European Commissioner revealed that the Action Plan will receive an ECU 64 million (US% 83 million) budget. Budget in US$: 1987·89: ?1 1990·94: 45.4 million 1995·99: 83,0 million In a recent review of the EU's coordination of national research and development programmes, community sending on'Biomtdical rcuarch and health' for the period 1990-92 is given as 46,6 million Ecus. ~he % of this devoted to smoldng and health is not known) In addition the following bodies carry out research but we have no information on their spending: OVERA1LCO~C1USIOF~S Information an health research expenditure is sparse. The above figures give an idea of the diversity and magnitude of the figures, but unfortunately are only able to give an incomplete picture, Further sources of health research funding, on which we have no information, would obviously be the tobacco industry, govtmmcntl and NGDr of other counujes, and the cxpeodilure of certa~n ott;er inlemab~onal organizations sach u the Inemationai Association for the Study of Lung Cancer and the World Cancer Research Fund. BATCo document for Legal Services : Health Canada 19 May 1999 I'rlF COI!NLIII. FOR 1~ORIZC(!O RF,SF,hRCH·U.S.~., INC, Sll~lnmlno nl~lMslll~·~l~ Inu~PI·le~~~rlu OIlIlTIIIWIl ,\VEYI~): N~:w J'IIHK, N)' IIPI!~ '1 r*I: I'IIIIIIIYY*- WYYYlm'll IIICYfIYIII lllrY17(Iy LJ.R January 26, 1995 Bn JbN 1995 linda Rudse, Ph.D. Brilirh~mtrican hbllro Dmpmy, lid. 1 Frsa ··············-~-..' Millbank Knowle Green Stainn Middlercn TWLI IDY i ccW~·-··-c~"'"" ENGLAND I·C113d*llllllltl· Dear Dr, Rudst; I have received your recluert for an historical compilation of CfR budgets, As you point Out, that;nTOrmation is available in each of our annuli reports, Along with this letter, you sill find a copy of the appropriate pages from e3eh of those reports. I apologize that our copier is not able to fully compensate for the very dark background on some of the pages, ~cverthele, I think molt of the information you need is contained therein. Our most recent annual report (1994) is now being compiled; our research budget for 1994 was 519,550,000 and during that year 54 new research projects were funded. In case you do not have access to the ]993 report, I have enclosed a copy in this package. In the back of that book you will find a Ctlmulative list of pat CfR grantees as well as 1 list of projects active in that year, Irc.d please let me know if we can be of further assistanec, " ~o~· 5; Harmon McAllister HCMlwwp End. BATCo document for Legal Services , Health Canada 19 May 1999 REPORT of de SCIENTIFIC DIRECTOR CZbRENCE COOR LITTLE, SJ). Chl;~D1D1 SEiCOtifiF Sdri~orl Boud ·· I,~~ ·~ll·Yi~~ ::::~i:l: 1956 LL3~ TOBACCO INDUSTRY RESEhRCH CDM~TEE 150 East 42od Street, Ndll Yarlr 11, N, Y. ~,I?~· OV1 BATCo document for Legal Services : Health Canada 19 May 1999 The ReselIch Pro~am Two years ago, de kicnlihe Advisory Board to the Tobacco fndu~- try Research Committee waJ formally organiLed and uPdcdooir to create a progmm of research let would contribute constructively to oar search for answers to fundamental health problems. Specifically, the progam wat to develop facts reladvt to the e6#lr of tobacco use. Today, wed wet SU00,000 in 'I~,C, funds have already hems ~anted to more dan 55 scientists who, with their colleagues, are participat· ing in a carefully-piaao~d, wdCintegrated seicntme endeavor to help in the solving of important health (luestions. The Committee bar appropriated 51j00,000 for such ~ants and h pledged more funds as needed The program is still developing and ~awi~k This report dhmusa the Sdende Advisory Board's approach to its assignment and the current status of the research program. At de outset the Board recogaized that scimti~e ]motdSF con#m· ing health atptcu of tobacco mt was uncertain and spotty, Tobacco me, particularly cigarette smo~ing, bar become widespread throughout the world especially in the mom highly developed countries. Recently, them have been chare# that ~mo~iog is assoeiated wit cenain human ailments, among them caneerof the lunk The Board did not set wt to prove or dirproe anything. Its position was and is in apmePt with the vat majority of experimental scientists who concur in the view that out Imowlcdge of the formidable ~ha~ngm of human survival-such a sneer and heart disease-is far from Eondurin or complete.'lhe sole ~qosc, therefore, ara to encourage and support qna6 Ld reseamh scientists in their e~pm to lean motF about these Eompiex problems, meanwhile refraining from premature judgments. This approach ha proved sound and correct The need for fnrthn study is, if anything, mon compiling than it was two years ago. We have learned much in the pst two years, bur perhaps the most important thing toe have learned is how much more must he done before definitive answers can be given. PROGRESS hIADE IN nlillOR ARE~S At this stage, tbeabrs the accomplishments of the ressrch propam supported by the Tobaceo Industry Research Committee must be measured in terms of pro~a, nlba than in caaciusive Gnd;np, t~l LI~ t~CI U1 BATCo document for Legal Services : Health Canada 19 May 1999 REPORT of de SCIE~ITIFTC DIRECTOR CUREnCE COOK IrmE, Se.D, Chairman, Scia~ific Advisory Board :··;~·· July 1, 1956 · Juue 30, 19ji !~~·· D ,%n~~ w TOBACCO INDUSTRY IIESE~RCII CO~III~I~EE 1SO bat ~2ad Slrcel, 1Yev York ii, N, Y, I~ ocr, BATCo document for Legal Services : Health Canada 19 May 1999 Summary Dcrine the iZ mols ended lune 30, 1957, the Scientific Advisory Board Ippldnd SZ prsna·in·sij. including tmcwl, totaling SJ109000. Included is 535,000 Ior scholarships to medical school students for medical research work in any F~cld of their choosing. One scholarship is offered to each of the nation's ~cerediltd medical schools to encourage medical research acivjtia. Since the Itad of the gnnl·jo·aid research program in the 1954·55 fiscal year, the Scienti6e Advisory Board through lune 30, 1957, has allocated 51,715,200 in specific projects to 67 invcsti~lors in 52 of the nation's leading universities, hospitals and research ittstitutions, During this same period, the TPbx;o Indmtry Ruearch Committee has appropriated funds amounting to 12,200,000 for research grants, ia· ctuding a supplemcnlarj 5200,000 appropriation requested by the Scientific Advisory Bolrd in the 1956·57 fiscal rear to meet special needs for new grants. DIRE~IO~ OF BESE~IICII primary attention bas be~n given to developing research projects a· lating to ur;Eer and heart ailments, since tobacco use is one of many factors of modem·d~y life being generally investigated in the study of these diseases. Proerar of medical ~cJc3~eh is slow and painstaking Many promising Jvcnua;nun be lollo~vld before finding one that opens dr way to new and useful knowledge. ~Jo known formula will quickly work out the simple answer to human health problems. Advances are made by diCNlt stages, somewhat a one would cut his way through jungle undergrowth, Sound medical and experimental knowledge of tobacco use is da· liveiy limited. at times contradictory, and often conjecturai rather than factual. Too little is known about many factors, including why people smoke pr what kind of people become padeulary heayr smokers. (pjgeJ lell, Is.la. 29·lo., I Ir~ OA C~VCER RESEARCH 1he problem of causation of any type of cancer is complex and dilfiFult to analvze, All research on this fo~~ilcd constitutional disease is, and msa b~, painlt~kinb ~nd limctonsuming. ~hcre is not known today any simple or quick ~vq to answer the question of whe~er any one factor has a rot in causing human lung cancer, (pages I2·13,] C~F 4~Zf PI~U1 ---- BATCo document for Legal Services : Health Canada 19 May 1999 1958 REPORT of the SCIENTIFIC DIRECTOR TOBACCO MOUSTRY RESEARCH COIIMIT~E (iliE1CIcCS BATCo document f6r Legal Services : Health Canada 19 May 1999 Observations On Research INTRODUCTION Gratifying progress in the development of the research program into tobacco use and health can again be reported this year. As of September 30, 1918, de Scientific Advijorv Board to the fo· bacco Industry Research Committee has since its a;blishmmt in lune, 1954, reeommmded gJnsiniid to 15 scia~ir:r in 50 iol~itulionr.~ha: pants have all been approved by be T.I.R.C, As explained in detail in previous reports, the Scienli6e Adeiny Board does not merely review grant applications, lrh of its time, efforts, and thought are devoted to exploring promising avenues of research and or O( the encouraging grant applications from scientists to urry out needed ina~i· iopenriv~ pations. 01 Be 5!,200,000 in funds made avaii~ble by the Tobacco [cdunrl, Research Committee, indudiq 5500,000 for the coming year, the Board :IEEL*III has actually panted some 52,110,000 ID applicanu. A complete list of ~vho have current or recently completed projecls being supported is given in mother section of this report, About 535,0001 year is panted in research lellow· rhipl to rcdic31 school Illid#r uho devote their n[l·lc~ooi terms to re· tell, A110 search on problems seleacd and approved by their own institutions. :tsined an Elsewhere in this report arr;lbslnca of 31 research papers eDmTleted aal opcr for publication in scientific journals during the past year by scientists ulho acknowledge support of t~lir work, in whole or in pin, by the Tobacco Induay Research Committee. report the :he years. PRIRCIPIES AND RESPOiYSIDIIITIES ecord the \Vhen the Tobacco Indmln' Research Committee was organized in 1954 and a Scientific AdvirorJ Board of independent scientists was ap· naker le poLld, II confcmed, infiudibP IL Scientific Director, accepted certain :nlures as definite principles and responsibilities. It was recognittd that: (l)nte origin and nature of lung cancer and, in fact all types of cancer, present one of the most complex and difficult xientiSe problems that mankind has ever heed, (1) The complexity and subicty of cardiovascular dies art also evident and are admitted by the vast majority of those responsible for research, therapy and tduc;lion in that held, (3~ The n~n·acctptana of reported statistical associations as proof of 1 cause and effect relationship between tobacco use and these two groups of diseases is justified not only by acnpted seientific 10iT16c0S BATCo document for Legal Services : Health Canada 19 May 1999 TOZE~~~CS BATCo document for Legal Services : Health Canada 19 May 1999 DOZEL8COS t3ATCe d6cument fot legal Services : Health Canada 19 May 1999 1.960 REPORT If the SCIESTIFIC DIRECTO~ MR~IYCE C001E I~TT~ ScD~ I -r 47: _~o· C`B BATCo document for Legal Services : Health Canada 19 May 1999 Or~anization and Policy The ~obaceo industry Research Committee is the sponsoring agency 0[ a pf0$nm of research into quations of tobacco use and health. It was orqanittd in early 1954 by representatives of tobacco manulaclureo, growers, and wlrehouscmcn. Soon aftet, the T.I,RC, invited doctors and scientists well known for their work in cancer and other disease to serve on a Scientific Advisory Board Tnis Board curre~dy consists of nine scientists whP maintain their respective iosltulional a~liatio~s. The Scientific Advisory Board hn full raponsibiiity for research policy and programming. Ar a Board it doe not directly engage in research for the T.I.R.C, and the T.I.R.C, itself does not operate any research facility. Grdnls·in·aid for rcrcareb art made by the Board to independent scientists who are assured complete scientific freedom in eonducring their research, n~ry alone Ire rcspnsible for reporting or publishing their 6nd· in~ in the accepted Ici~nrific manner - through medical and scientific journals and societies. From the outset, the Tobacco industry Research Committee has made clear that It object of is research program is to encourage scientific Itudv for bets Ibou~ tobacco uM and human bcaL. ttl position rcmainl th; research will help provide the knowledge about lung cancer and heart disease for a full evaluation of all factors bring studied in connection with there discase, Granu recommended by the Scientific Advisor~ Board through 1960 bye been made to more than 100 scientists in about 70 hospitals, univmi· lies, and research institutions from funds that so far total 54,000,000 appropriated by the T,IB.C. A list of research projects supported by the T.I.R,C, is included in :B this Report. Also included are abstracts of 41 research papers, aFknowl· edging suppon by the T.~R.C., that have appeared in scientific journals :k li~p since the 1959 Report and through October 1960. A total of 137 papers acknowledging T.I.RC, support have now been abstracted in the Annual Reports, nlrOTHr V, H~RmErr Executive Oimbr jy W, T, HOYT Chlinnsa rOIIACCO MUSI~Y RESEARCH CDMM~ITEE 'Ji 150 East 42nd Street, New York 17, N,Y, Q B~BB~ O Q BATCo document for Legal Services : Health Canada 19 May 1999 4~ljii BEPOBT of the SCIgNTIFIC DIRECTOR CWRW~ COOL LfilZE, Sc.D. 19~·6j WE CO~CL FOE TOBACCO B~~Q-~.S,L i(Cilbuv~ BATCo document for legal Services : Health Canada 19 May 1999 Or~nizalion and Polieg The Council for Tobacco Rcseart·h-U,S.A, is the sponsoring agency of a pro~am of research into questions of tobacco we and health, It was organized hi cady 1954 by representatives of tobacco manufacturers, growers and warehouscmm. It supports such research through a program of prs-in·aid. A Schetifje Advisory Board to The Council administers this pnts· in-aid program. Tne Board currently consists of ten scientists and doctors who maintain their respective institutional affiliations. A list of the Board mtmbea appears on page Z The Scientific Advisory Board has full responsibility for research policy and programming. As a Board it does not directly engage in research for The Council, nor does The Council itselt operate any research facility. Cran~·;r·aid for research are madl by the Board to independent Ici· entists who are assured eompie!e scientific freedom in conducting ci~cir research. They slane are responsible for reporting dr publishing their finding in the accepted scientific manner-broa~ medical and scientific jounals and societies. Grants by thr Board through 1964 have ban made to ZiZ scienustr io over 100 hospitals, universities, and research jnsrialionr. These grant awards totaled 51,721,000. A list of research projects supported by The Council is included in this Report. Also included are abstracts of 62 research papers, aeknowirde- ing Council support, that have appeared in scientific journals since the 1963·64 Report and tough December 1964. A total of 401 such papers have been published by grant recipients. T~wo~Rr Y, BnRrnen Chdrmm Executive Dircetor THE COUNCIL FOR TOBACCO RESE~RCH-U,5A, 633 Third Avmue, New York, N,Y, 10017 CI1E;3DCG - · BATCD document for Legal Senices : Health Canada 19 May 1999 REPORT "$ dle SCIE~TIFIC DIRECTOB CURESCE COOh II~LE. Sc,O. 1963·6~ TIIE CO~~Cfl FOn TUDbCCO nE~EanCTI - U~S~1 H ~ia%· ~FS SL~~i~CCS BATCo document for legal Services : Heath Canada 19 May 1999 Oi~raoiantioll anti Poiil:~ The G,t~nrif lo; ~o~:c:o R:rc:%-II.S.~\. it lil: r~caorinf apncy n( n I`rn~ralrl nl rcr:lrcb into qarlir-; nl III/I;ICCII IIET :IIItI IIC;ljtt:. I~ :Ya! c~rr:!n:::d C31JP in yro~r:rr and ~var~ho·:;cm:n.~Rs!~3r~j is rupp~nl lilrou2!1 a procnm of s~~~a-is·n;d. h Scilnd5e ~d~iron Board :o Tile Cmlllcii :Ids;isklcrs Ihis cnnrs· ;n·;lid i''"c'~"'· ~l`jlC Uoard currclli~ c~lilci~l~ II1 ci·lll ·s:::rI~~F ~vl il~lciorr chu elim3in $ri: r:lpcc!kr inrtili~n:ll ;1Wliarionr, lirl oi Ille OJ~:d m·mi·rrs ap:~sa on a lubrcqocnt F"F:- Tllc ScicntiT~c ~drison· Dad liar iull rcs(!clnrihiiin iar rcsc~rch pPlic~ and ar~cmmmine r\~ a Board ii dor~ not dircrtl~ cnrl~e in rceJrch for I iilr G~;ncil, no;doer The Council iarif o~ctnre ally ~ie~rch iadlily. Grants·io-lid for research Jr: n~3e t!v (Ile Ilo;lrd :i~ ind~ysdcn! rci· cnlilll ~v110 are allured comoia· ai:n~il~ Ircalnlil ill cunduclin? lidr rclclrch. GranIr:r alone are rc!,nsi~i: ier rci~orlin~ r: pllhli\hinF tLir ilodin·r in die ncccF1:d rci·r,lZ; n::1·vt-;hraoeil nl:~ic:ll nnd ~cicniiiic jnuro; i 3nd rociclic!. Ctrlr;a i~r Il:r D~srd Ihmudl 10L: i::l~e I~ccn an:l: II~ 1Sn ~~icnlirn in flr:r 100 Ilorpilnls, ur,ircaili:I. and rc!::rcb in?liru:iclll~ ii:·i;~r3llla~ardr tflnird 58,700,1101). ~ lirl of rescsrcil yrojcca !upyf:rcd by 'r1lt rlluncil is inelud:d in Illi~ Rrron..-Zlro inc!udrd are 3bJ(i3C!I Elh~ rcrclrcil r;lycrr, rknn~icdr· i~ loancil roppon, iha: ha. a~F:::nl in ncicnlilic jound~ iinc: h 11(15·1~5 Rcpon ad rbrouch Dec:ml·: I'lh; i\ lo~ni ni:bi rcch p:Fnr $;ac Ircn pllliblrd hp rnnt rccipiTfil~. 'T`l!llm~r V. Il.~nnErr T, T, llo~T Clllirm~n Esrnlk· I)irFrtol Ls~i nlE COl'~fll. FOn TOD.\(:CO nESE,\n(:I(-~.~.~I (,33 Tllirll I\vlnuc. ~FH. rnrk, N, 1', 1001; C4 4·-~·; ~· TC~· BATCo document for Legal Services : Health Canada 19 May 1999 ·' I li!ij~ '1111ill~ Plie ; S : l·:'i :· ···;~!,. ,··:. ( .. I~ I~ I i'· ·: ;I~"I ·· ':"'"; ·i· ;i;i;···~ ''' ' :iijii* :"BO, II, L~-= ~BBk t~ Cil O 3 C3 l,\i 13 BATCo document for Legal Services : Health Canada 19 May 1999 " iii~ I ·. I I::eIII;iI II 1. I' lilt; iii:~itilijVI '' '' '' p·anli~tlon' ,ulu ~·· I·~ 1~ i~ i~bhcro as ni a FIOS'"" b[ mcucS~~lo '''· m~n~il?~w't~: orPaclz~d ~ci;riy~~pl~J~:PY · iFS~TF941UVql 01· grdren ?~liu:b.~mba4dd a !qplld Ihflugn t;ITO bi '' 13XS 1. ,, pants.; , ~', ~l:!AIScienlific ,?dvisprj~S;(!!::; ili:~:r ~I · liiii ;' .'' in·3id p~ognm:'~: Bolid c~i~cnly conllsa ol` ten 5.11 ~~O~if ··'-. " '· ·.. sa~iltio~l'A:list: %bb mainlaib~lir ii !)~mlmbe!r ?pdcjrs~''~'oa a scbslqye~ page. ''Ililt~"p~~c Fil; II '· i~~~6 ·i I 1:~1" '';,'~117~· Stiridfie Ads~ory jl:;,: .id~'hio:i;dirc~tly-:;.~ v :I I u]~eG:mIMar~ Iv! p(Ogl)~lp~· IA~s:~ lq03m Il Tb~ coclPln;r dorr~~: Col~j ;~~ apc"~ ::G~YltS·i0.3id [OIfCitifthale t;*yu the toIse~ ~II~·· ;,,, x~b at ~;a ~na~~- scicntific fr~riloin: ~lmnuucuug Itu~r; rcsc~;t~.' Gl~nle:l alone ye:~~o~;p!riol~b~b~~TaI· 6ndinSr ;h''ac i;~jhh ;Ei~EJi : '''~ ioum~sand soaeors.D9 ~ ·:·, c', Grlnlr~i.· III:III ~h~sojr~aiL~~lsa~.lI~' ~eto hiide tb` li~EcientL1U m III OIFI 100hOb~itdI,Unilmh;l;j~id ICI~ULbi~lllBC4·n*IC~p[?!~r"iol loded Si11800,00Q·':`i I" ·1 iirtblei~pi prol?ll~ i~ppoisd i~~COub31S~ljdd~l in " ~,:~· ·;:~ , '·' i".: ~J!i, 99rcstare~ P3P~! ~t~pw!co% ; 11'1·'L~·-··1· Ijl:l; Report: ~9 idcluata ye aolrr,, I , mg CoEqF~~~luppa~l~at ~haYe .~acnone lournlls~ IIIlcr. ~ne 6::a,~lai '1965·66 RFp,ert:~jj~~~~~a?~Rs~QI~U1'~$~'*;·"V* : bclh PUb~S~Fd by.pl3~t L~ I I Taonru J· R\RTam 4. ' '' Diietto`r CCO ···'% ~flE I:: :'';"'' ork,~ ' '',I/il ·?; I ··li C~z ··· r~9 C 13 ;2 C2 BATCo document for Legal Services : Health Canada 19 May 1999 ·· · , v· ~·~ ~·I~:( :.,·· .··· : i~··`u ~· L;~~i ~·· ~;,,, l'~r~~ ·;, i. ··'·'?::;r "' ""' :I··- ·' I:?~; 1 ?X~·-·;I'·'' ·'''·'' "'d " *-I"~ I ·.' "·" ·~ ~"` tnh~l~ .· ·. 1··' . ', ~.·~: ·,· ~"' :~i'' ''9111 ..;e 4 ·· - I: : ·' ' ~· ·;e-tll·? ·:~ .:···' '' " ::I I, ~;F~"~~ ·;·'·:·;·i·a*'"' .:I . *~ ~I~iz':· :::"1IiLI:li i~;ti~ll ''FOD~ :Sj;] '" .-,·:·· i ~!c·i -·'~ i" ;;i nr' 61 -r /i BATCo document for Legal Services : Health Canada 19 May 1999 OZ~~I~CGS BATCo document for legal Services : Heath Canada 19 May 1939 REPORT : Of the SCIENTIFIC DIRECTOR WIIRnl~E COOh tn~Z1El sc~n~ · THE COUNCIL FOR TOBACCO BESEdRCH-U,S,A, ~eps r~ BATCo document for Legal Services : Health Canada 19 May 1999 Organizltion and Palicl ?hl Council lol'Coblcro Research - U.S.A, is the sponsoring alene;r of a procnn of rerMrci into questions of tobacco use pod ilealrh. It was oranited 1Jrlv in 195! by rcprbena~ires of tobacco manufac~llrets, grow· ed and !vat;hocJtma. Rtmreh support has been mainly through a proSr3m of grants-in-aid snpplernented by contracts for research with insti· tutions and labonldra. A Scieile Advisory Board, currently consisting of ten scientists and doctors who maintain their respective institutional affiiiations, has full responribiiity for research policy and prognmmin$, As a Board it does not directly engage in research for The Guncil, nor does The Council itself operate my research facility. C;r~;rs·in·lid for research are mlde by the Board to independent scicnlisa rbo are assured complete scientific Iteedotn in conducting their rcsenrh. Grantees alone are raponibic for reporting or publishing their r~ndiner in rac acecp:td seien~iCe manner - through rnedical and scientific journ:ir jnd sorie~ia houci~ Juoc ]9;0 research projects have been approved by the Board to !;9 inrnlilalcrr it IS9 horpilali, univ~:li~ies ~nd rrw~~ch ir,sri- tulions. These 3lodl rolalcd 51'1,!6!,000. A list of renrd projas supported by'lhe Council is included in this Repott Also included are abstracts of 93 rcnrch papers, xlmewl- ,j cdpnS Council support, that be appenrcd in scientific journals Since the previous Report and thmu~ June 1970. A total of 821 such papers has been published by gnnt recipients. W. T, Ilorr Exlelllive Dimlor TIIE CD~CIL FOR TOohCCO RESEhRCII-US,~. IPI 110 East jbl Street, New York, N.Y, 1002? L~IC. ~B~B i~k OU1 -- BATCo document for Legal Services : Health Canada 19 May 1999 I:fl( ·1 iii ··'I .,.,, "':·' '*' '" ~t 1 I.i;ii~ ... ,,, ...... """ :::;;: TOB~B~1 1,11(1 rliii.cij '*' *' "'"' ~· '· :I;,, ·· 11··1· :rCar '' ·'··~:' iil:ll ..~:··I ''" ··I .YL :;E.~.Y~C I" ~~"i` "''""' 91:1 L'I· I ' :I :··:- I· ~n~ U1 O O Q h, N W BATCo document for Legal Services : Health Canada 19 May 1999 ~;(~II Onl,;an'a~011e I;; bbacca ·:ag&l~l~mam D,g~l~~"! i :rt rl the ~i~i~~th' a arm~~ c ~' """i~ii·; ::I'PPql'~~E; 1 ""'' I: :?by· FP9~~ 16LS not~~ · li8mnB w~ mu ~n ~~~""- " :L) '·I·: :hdi: ·'llnl ~e~'asritrcd;comb]ele t·j~l"~ Uanaauaacare lor :6~hi~;~Yb" "·i""l R~ti~'~f~a~Z~~~a~S~I I.-· iouroals and sou~a; ,,, ]udi: ~l~;mlrf~ II .. ·:mvaantoa'lk at ha~i :u~uvc~lll~s·snd I! ''~ij;AtSB p~lr~ ~~ ;i~it'b'~ib'4:';;3~", $p;~~;6:i'i"' i. "':betn f~p!eplS·i: ,I!r T~ri cr~e~ '''~eH: ·I·I ~'·!~~~i~b~'~!~3l~iXZF~;i~f~E~f~~G~!r,~!~f~I~~~"I~e~I~953HB3~1691 LL~"~ ''''i' ··-~1 L~Z s~tT: 6Ca Q O C3 L·i N IU Z BATCo document for Legal Services ; Health Canada ~9 May 1999 1912 IIEPORT THE COUNCIL FOR TOBACCO RESEBRCII-U.S~A., Inc, TIIF: COUNCIL FOE TOIL~CCO RESEARCII-U.S.~, InF. 110 LI~ 5hh S~~ecl, kw Ye4 N.Y, 10022 s~ BATCo document for Legal Services : Health Canada 19 May 1999 Introduction The CPuneii for Tobacco Rrsc3rch-tf.S.h., foe, is the sponsoring agency of a program of rclearch iao ~u~aionr of lobPeeP ule and health. It is Ihe outgrowth of an o~~niuion ionned early In 1954 by reprurnrsrivrr oI tobacco msuhc!urm. groum and o~rchou~cmen. Ral~~ch support has brcn mainly through 1 program pi Bnns·in~lid lu~pltmrolld by contracts for research wit institutions and !Ibora~orirs. The Council dan not itself operate any research facility. The SciriCe Advisory hoard mills regularly to evaluate applications for grants-in-aid and contracts IOr research, using scicntilc meril ad relevance as the 1011 crilent Research grants are made by The Qncil to independent scientists who am assured complete JciemiEc freedom in conducting their studies. Grantees alone re ru~eribll for reporting or publilhinr Ihejr findina in the accepted xj,,lific rnanner- through mrdtal and scientific journals ;nd locCliel. Through DKLmbcr 191!, research projeal be been ~pprovrd lor 183 investigators in 199 hospitals, universities and research ililulionr. There wards totaled more than St3,000.000. This report includes 1 brill summary of Ihe present research program of The Council as well as lisu oI Le current and previous research profch lup ported by'lhl Council. Also included Ire abstracts of 117 research papers, acltnowlrdging Council support, the have appeared in xicaide journals during the period covered by this Report. A total of 1,012sueh papers has bun pub· lished by project ~eipirnn. H, H. RIMH Chairman and president LCZIP I O~-L MBr rr- Ut BATCo document for Legal Services ; Health Canada 19 May 1999 1913 REPORT THE COWCIL FOR TOBACCO RESEARCR-U,S.A,, Ioc. nlE COMOI FOR TOBACCO RLSEhn(3[1U5~~~ InE 110 6n 59111 lrerl, sew York, N,Y. 10022 B Maarr Ibr OO BATCo document for Legal Services : Heath Canada 14 May 1999 k?'h~d 4 ?S;d~b~;?Yg;\·' Jn~a: C~ f~i~l g : ·~~~S~~~r$g·r.· ~~;O %d~K;~i~Yl~arl~ad. 61i :~~8Bb~*,~ ~tl~WI ~: e~~c~?~; u ~3~: : ·;;~~~~~~~e ~Cwn~il' br ·, i~~p hlviol 1 idd~e~i igsstr~ n,:~;~p~iils ,., · ~,I . lhl d~ a Sds~de leo m p?Ld bad ~pi vna i;lnl ··''' ~' . e ~lsrl CWi( U~L i 0~14 nA:D~ G;h~~l~~:r I :~~E K, Hunl hdmd'4 hiol! h'fJr UPtraIg LhclY' .·;,;he ~ad beo ~d~~r ea Plb· bl !be Daa·l Id )t hi ~I ~~4r~,az ~~~4~b:sa~aiQt~4me~P"' "'Dr, IPC; '~. ~d8;k. ~idb La ~L ne ~ :'bd~ ippbil~ laaEh Dien,.Be ~j boa Il~h;~i~b~dlpr~ : ~·:~'~P~e#o~ fDI ~e iul~o ym. I~yai~9~1 ·~·o d~illbh~~rtl~a ~dr ~: l9f3, ~dd~l Iwhff ~~a~L Ind Imx c.~l h~$9~n d~jr$~ .~' L ritaaw, ~~~r lid ~i ~ Le Ot~~nal.!b~Y· ~~i~ ...: ~:UJlqdg d CP~adl SchWl bl Ydidne in Q1D pjr4 old D4d ::i !~~pr~es PIO((ndi ii C~in·~ bl OeplrtePl ~ lp~4!~~~ ~~~yp: LU~ k.*.ii~al UnivcijitYSehpcl d Medicibr ~O~ ~_ ;~f d~~Dlbl ii ~4 t~e Lilic ·c~~n IBh~~~p~ C~: ~~ ~r!~~ ~1 L·ai Y~1~41d ~d been lelba CY :·bl Cblud dad t~,qrdrla d Loc pib mrp a[ ~·6 ·d sl~l; · did mPch ~ ~~1 ne CIPdl 6XIAh jm~l:f~ · 49e Q·i ~Ci~lldli Cq d Il·tPr 'ganla ol (IIPC~i id YC L b me p3~P'!Jlr?~~:;) ~~rmrd ndy!n~~l:by rl·?~ka d ~~ol !ilb~4~P·~ · I~nd b~cho~~~lh Rau~V ~ppon ha been mlinly lbmuph rplo~~~ .P~~P~JY~·Relmla ~ ll~*D ror ELil. ar e~, CbPngda, nl CIIPdl CP ~!~dt olena rl ~a Bdi~~ .i,~.ne ~tllSe ~~iaa a·d ~~II Cmld pad f~~f6 ~db' · ~~aibr r,, r~aiia ·~ LIll·41~!~ ,,,!eaig~~ bob d rC~le Idl ~d aealo. ~nr ~B 1~1~ ara~ ~·~ i~Lepbd ~~O~~ · Il*Ld ciCde p~a~le lreedem in eoldldil Idil~~~td~?iY~ · nr aeall·ir pnl~ ·.LYYli~i IIP'CL~~Y~ ; i ~de*~e mla--bP~L 16pI ·d da~b' ~'8~~a .ialireh ypb h* tia i~.~ I~ ~~;~Vn~(~P4 i nl mediUl ~Pr L~~ .a ~6 Lu~:edl '~':lrrdl~l~~'lar Lln!le!lPOC: ~ ~c~ ~~~b cpbd~~ada I~i~~,a~ OIPP~ rlS: !hc ~~;d ID~I'Yi?l~T~ ·~~en, c,,a. ui bd~~ iij~bl~ hllYid ~3r~eP~ :;,CPidl I~e ·sL;I pbulrl~h ·~pE ~;~1~819n b~~a~dp~l i;~i E I~i ·' ·' "I 1 ~:2 II~ c~~ _ ~~n r· a ·~~~~%~ I 4~ as o u a BATCo document for Legal Services : Health Canada 19 May 1999 19i4 REPOBT TflE COI~QL FOn TOBACCO nESWRCH-U.S.n., Inc, THE COUFICII FOR TOBACCO nESE~RCH-UJ.b., Inc. 110 %1~ jbl~ S~n~l,~cw York, iY.Y. 10022 1~ 1114F~ BATCo document for Legal Services : Health Canada 19 May 1999 ''i i" ~[ I:;i II i,ll: II II.4'''" ' ; ''' i ' I.(llllli!il;~:' I'"ii'I' ''' ·";!jl ·jj '"" '' ''' '''~''''' · ' ·'' · ;' ': ··i:~:il·l ':· ' '·'" ~'"' ''' :" " '"' ,, · ' :` i '''!`h' Ip!pg~[f~`~ 'L ,). I! · ~mluPgpl C: II ·I. I/` i. :·1 not i ii .. '~.; rl·! 1..1 I ~lilllllll dlill!(lld;l!l((l~)illllii[jllll·()i!'lilliidlll;~;lli;llI,~li:di·;ll;l~l'l Counra """ '' ':" ,I~ .~·~.~·. ·z~ ·~· I:~ t~· ;: i' ` lifts m~~~s. ~f?li jBntiii ·' "'' ..~.. U~'6 ~/Ydh~:184 '''" I"' :''' i i ·; lnYClllptOn::iP223m 1~ '!'lwlrd~ ibtal$ 616rC :I ' ~~epr! meu~a ~;',~" JYF!1I ildt " bl ;:~t~n~w~;db~gl '' '"' ' ":'~' '' ':idlrti~ab~bc'' " ''' '' ·~~ suPPotl I' ':'' '~ ' '' 'I' ·'· ''' '' : i' I IBI I:; ··:s;:I Ij/j(l c -- ~s cs ou7 o p IF~ N o BATCo document for Legal Services : Health Canada 19 May 1999 t ) ~· .. :;n*, 3 3 :2 'J 3 BATCo document for Legal Services : Health Canada 19 May 1999 TIIE Q BATCo document for Legal Services : Health Canada 19 May 1999 REPORT THE COUNCIL FOR TOBACCO BESEBRCH~U,S,d, Inc, TIIE COI'KCIL FOR TOBACCO nESEdnCB-U.S.I., Tne, 110 E311 j~lh Slrdl( ~rw York, N,Y, 1002? B ` rrz~ LZ~I: IHa ~I~ ov; BATCo document for Legal Services : Health Canada 19 hlay 1999 I'511:I 1111' '' ·· ~··I ; ·I·I ' · I··'·I·'···· I~I I;i :·I I '' 'I:I; ''·· ,,, I~ ~~I~ II: I, '''''' '' ~ ''';1,1.· 1 1..: aI ,,,, ~ ,. ,, , ,~~ ,, 'I''; I '* '1. 111 '' II"'''' " '' ''' : ': ;·'[ il!j i·i"" '' '` ''',, I:i::'I :!I i,iI i '''' ,·I·I,:,,~, ,,I~ Ji I~:I ajSs.1::I~::I ~ ,~,,,,,,i. L".''"' ;i'i ~·f ~:I· ~II t10nana ~oii I~ i I~ ',',I.': ~ :I;~:;:I:~i ;~~1 : ~\(i '''''liilii·:i:ii;l: ~···~·I The Counc~ for Tobacco " ~I ·I Ih~ is' le Ipo3pillglBIPEY '.ll:;:i/l of 1 program dI research inlo questions of lobJc~b use and health. It is the ou~· gowl6 of an brsmialion Idrmed.euly in iSSP by' tobacco' in~~bcturcrr;' I:lliiill:, I~P~~m ud vmhlulmm. Raalrh nppor( Lu bat mi;Ply t~ulh Iplo. ~:;;j:'' gram of grams-in-aid N~plrmtnted by conlrjcar for ruclicb &ilb inrtitutiem ,,, , ,:I Il: and ]lbO(atOtitl. The Council does not operate !oy research '' 'I, ·~· · b I ,'I'·;':: ihr Scicndje j~j~d~ao~ Board to The Cwneil'meeaa rcgubrlg Id evaluate. ~IIli ~;lj'appliuliPa fdr ~~·iP~aid add !111 cenllactr. ivdipg Lemrdltli oa 16ihlsic ,. ~ I ' · 'bl scienti~e rr,(rit and ~lrv~ec,''·' ;'' i, · I : III!.lii~li'''Silii~r!I··iTj i:4 ~·t ... :1;(~I'~Tht Couodl'lwards idcud gli~u to indlplodmt Iti~hiiru who are u·:; '' I'· sured rompicl: ~dcdtPE frerdon in conducting their Itudia;iG'ra~m alone i,i~~, are responsible foi !epdniag or publilhiny their findings in ~lbe'j~nplea ~eico· : i ;li~e manner - rhidugh medical apd dcnrifi; i~umais I~d roearr,.'·Y' '''1ii I · 1 !:La: ~i · Ii II Through Rambrr 1976,'Ihe Council a~piovtd'rtsarch ·pro~ccll lot 3SB IPv~lgalors in.U9'mcdic;i shcoli, hospitals and leauch imtilulions. These au~ad totaled more than 5Y1,000,000. ' ';'·' """"'"' !~I;.:! '~ fhh Ripen jpeluder a brief rumm~ry of The Cd;n;il'l present program lo , ,·I · the cardiovaseuIir vet as well as lists Of current and prrviour rtxih prolecti ''):I ruFporled by The Couaeil. Alla~ included In abstracts of BO research pipers; acknowledging Council appor!: hr were publkh~d m replse jpulD3f.dur: rg 1976. Project recipients have sd far published t,(tD rudt~peni,::l '·''I .,:,, ~~1·I:I~~~· !:i~is~iiiii~ \ I'. i 1~ 1111 11;11; i""F ri 'I""Chahanan and President ''" I );1111r;! I~ ';R i: ' ' ,, )I·1~"` .s ;'li '''; 'u ~II I;! :li1. Siii , , ~li··· c· ~liTI ' '' · ' I~'' B IL~ ,,,i ,'11111 · ~ '~""l:il '' ' ~iSi' ''' :'' ' .. . I;i:l ' %i is ~; I··I' 'I·r,,I,:,,:I'iI'I II ,,.,: 1''' '':'.' ·· ·i-'' ~il; se iji~~III li~M c~ .II , rl i ' ' 'I ;;r ' : i ~a TC~s O Vi O LI: Chi ·CI BATCo document for Legal Services : Health Canada 19 May 1999 rs;; REPORT TIIE COU~CIL FOR TOBACCO RESEIR~HIII.S~A., Ioc. ~i3 TAE CO~NCII FOR TODIICCO RESURCA-U,S,A,, Le. 110 Er 59111 Strccl, Nrv York, ~~Y. 10022 LSL L~n Ba~Aa~ 1]1 BATCo document for Legal Services : Health Canada 19 May 1999 I i·i·l II' '' ';E ,,115i '' ,,I 11:1 ·, :I I~ ·' "" ·I :: :"'~~ i·· '·' i··'" on :lan ·I .II,ili~~ ;ri :i "! `'''''''I ~I' '.~~d a: ~B~PcY'~ ~:l,:~i'i:;l~'bt proeun oi'ibb~h~ ~u~cl~pI~!~l~F~~(t:!Ittls~ ': · ' ' ' '' ' '"'''' ~'~5116 ~~boulYiaaut~ '" '' ' '':' ' ''' "''' lri4h~p~~l ht.~pUbF~~lll~tlljii~i, '':' '' I: ·~· I-.i: " -' 't 'blill !II Id.Wtdloda b: ~'' '' '"' ··~·· jB~~d~ ihrii II"' * '' ci~~b~blirs;nR Ih~~r:~ndinaii~;~hii~:; " ·-··.I ~, ··1 " '' '%ci~n!ihF~ournla.ano : I i~~ihe Mieal' iPPiorcp f3`ar I ~· ,, ~,' ' 1111 1;1 ~~~~ 'I " :t;mpiriirliba ; ''I I~vnlip~LonlP:l~!/: ~ii '' '':l~ardllb~~ more ;,o~h:'pg~'' ''''':; ''' "''''ind:preyllqul d~i~cltil ;'i UIUU$~ :irucuc~', ,;'1!1 acknowledgipg'Cbunci1 ~ppcn,~ Lb~t wra:rublilhc~ i :j~i,S~h~· :·' · ' I~ · ·?~~ i i iwva.ld .. ''~d' 1"1' 1:11' 1':iiiji 345'~;·'"' ''' '·' i: ·:'I ':'' I' ·~ ~··~~ '' ,.. ;. . II : i I · ;6 '' - r [sak vl o o a L·1 N c~ c\ BATCo document for Legal Serrices : Health Canada 19 May 1999 19;0 REroIlT ?AE mga Rln·cP ·LU~~UL ~· ~ coma FOE IOBICCO Rg5611d-OSI. br 110 B~ j~b hn~, F~~ YPrk,~.Z 1002? LIC e~39~ rClh rn BATCo document for legal Services : Heath Canada 19 May 1999 Ore~anization and Policy The Council Iol fobaceo RnateCII.S.A., lee. is 11 sponsoring agency II! 0[ a prol:am of research into Puesrionsof tobacco use and health, It is the oul· 3ii gronh of m organization formed early in 1954 by tobacco m3PutJara, plDu.(R sad WltebWICmlO, RIIC~TCh support has been mainly thtoughl pro· pam of ~aplf·in·sid supplemented by contracts for research with institutions aod laboratories. The Council does not operate my research facility. The ScientiL Advisory Bond to The Council meets regularly to evaluate applications for research suppon, judling them solely on the basis of Icirnii~e merit and relevance, ·, I I Ihr CPulcil aar~ r~l:a~h g·mml to indrpenhnt seieatiru who are al· lated complete scientiRe freedom in conducting their studies, OnPla alone are nrForuiblr for rtpofiip~ or publishing their ~nding in the sealed scien· ti6e manner - through mdol and xicnrihe journals and locielia, jl rhlcugh De:ember 1918, Thl Council approved research projects for ]19 invrrdp!cn in ?17 medical schools, hospitals and research institutions, Tbese au~lrdr totaled more than S11,900,OM). This Report includes lists of current and previous research projects lup ported b~ The Council. Also included are abstracts of 114 research papers, JckoPrlldgin~ Council support, that were puhiished in KirntiSe journals dur- ing 1919. project recipients have so far publisbed 1,6!1 such papers, Anorxll YelMm Chairman and president ::!i ·~;!·; · ··II,I:i .:1l51· e~.C·L """ aa~p BATCo document for Legal Services : Health Canada 19 May 1999 1979 BEPOIT TEE co~ca roR Tos~cco ~~~-n.s.l, T1L li;L~T3 TBR coaa FOR mBICCO RE5618CB-aS.A, IDC 110 Fjlr j91b SI~~, N~w Yor~, ~.Y, 10022 41 ~Ra- ~'Cs O HATCo documnt for Le9al Services : Heath Clnldl 19 Yly 189) 1. ·:1.11111 11 .L) Il i III!. : I .I Il. :1 ii i I: ·1 ..I ;. : ::: i;; I,,; ~ ; ·I :j Iji:il! I:i·1· ''' ', I " I 1] : i ·.· :1111 tion and PoliCrC I,:I~1I : i,: oil program of aateh Into 9uesrions of tobacco use and health. Itil the oul-i;j;:i The Council for TPbJceo Relcarch-U.S.h inc. Il'tbe Ipo~po~arifgfgcoey ::!:~II8: BIDll.lh of an orgmiratlon formed early in 19~4 by tobacco mlpuiacturen, g~o~en and ~va~houremen. Research support has ban mainly dtrough a pro· · :II:ll' gram of gnna·ia·lid supplemented by~ronlncu !pr r~lerFb pil inrlilu~jo~l ii,l;jl and Lbcnloria. The Cou?ei! does notopene sOY n~olrcificiljty: i~:~, Ij:: : II(: ~ ~'' ' 11''11 i;''''': ·, I~ The Scientilr Adviiary Board to ~he Council meets rc~ulqrly to evaluate · apTlicatiqns for research support, iu~BlqB~ Ikm solely ap the.buis of dlp;i~ ': t: li· meril and rrlcvanle I·:!i ~~' . .L .: i i.. Tnl:Cousil Iwlrdr Io mdlpmd~l~ rc~~liru shb m d:.i;l ''sured compbll rcienlile.fncdom in. condunag their Iludia. Gnnlees ilont ''· jj: are responsible Ior reporting or publirhins Ibc~pEpl~d li6e manner- Ibrwgh mlpi(~l and aientific iouroab and I!gle~u,.r Bii(:· ;; Through ~Lcrablr 19?9, The Council approved rcrranbpmycl;for 1PB inrcrtip~ors in !~9 mldical~lrhooll, hasp;l?l~ and ruc~rch.:I inr:audonr. ThlrlI ii :I: aalrd~ lotsled mote than SjB:~qO,P00: ·' 1;:i :11'1' 1 "L ''' 'I''''':~. ''I' This Re~on includes tills of current and previous research projects ap· Jcl;nonlldging Council fuppon,;ll were published in Icicnli6e journalt dur· ·1 ported by'tht ~ouncii. Mro included are:abslracts of 110 research papt"~ ing 19il. project recipieou have 10 IJI qublijhfd 1,7541uFi p3~ca. ~;I,': ' ·::j';ll i~lt:[ 'I" ;rlil I.·i;i'i 1.1;· i·llil Ij:, :~ ·li~· I:1:::::I;II I iili YEIMIN 1111l1(:11·) '::.Chinna and President ii '''· i' ''':~;' I,:I. · ··I I ·'~ I:1 ,,,~ ··:(·i;'' :I I :·I '· I I i;\l !1: ;I':·,, rj!rII:! I ''" \·'·''~ .i ;i;i 'I! i · ' ~I'~'' ,II I r ''I,I:I'!,II ijI 1'1il :I LI~L I...ll,i;' '''' Il! ?I, i!;j!]iill , ,la~II; ii~iif '' .~,,,., .~· ?: Il~.v 1!1 '''':'I',i!JI'`'IIIllI~I1.:;i. dl·I;I ~li II 'I 1ji/j II1'''''I"L' )·II~ . I II(L· I'· '. i . ''I ' ' `'` '' ,~··i·::ii i..... ·~ ··I ;II' ·;1/;:111 ': i''' 1980 REPORT TEE cot~ca FOR TOBACCO RFSEAIICA-U,S.A, Inc. TIIE COIJ~CIL FOE TOB~CCD RESE~RCII-U.S.A., he. 110 E~~~ jRh Street, Na York, ~,Y, 100?? ~R ~s OLn BATCo document for Legal Services : Health Canada 19 May 1999 i!, Introduction Since ill lowllion ?I yl.lll 3~90, IhC SCiCnli~C AdYilDIY Bdlld tO The Council for Tobacco Rmlrch·U.S,h.. inc., hnl reviewed m~nv iOrm~l and in- ~II formal ~pplic~lionl lor IMClfCh alppnrl, The Jirce~ raul~ is Ihll JI1Jill~tCn~ prPjccu have been lundrd hy'Thl Council. bJlcd upon Ihe rtrommend*iont ·O O( Ihr ~dvirorv Doard.lo luppon inarliplorr in !19 mediesl IthooiJ, bpinb j,d r~selr~h inllilu~lonr, Each ol Ihere projeca, whelher xlive or eom~lllcd. i) is iLd in Ihi~ yor'l Report, IPI~I lundine Ihrouch 1990 was S61,000,MK). The chill oulpol of The C~uncil`r linsnasl mppon no I,BS! sclen~ifie plpen and repo~lr, pabiirhrd hv ~hcrr invaiSaon in m3nv dibrRn~ medir3i and xitnlific journ~il.:o~enor o wide nnSe of subjceu, iL publiaicn of Pen racrch rauln JJdr to Ihe Icieno6e lienrure and to Ihr Qorlipile of inlormilion irom which. ii i~ hupcJ. wiil come ~awra to cPmplr~ probllml nlch a IhOJL ~IIOCI~I~J Wirh C~OEtl, C311JiOYaSFUIIT dircoJLI and pulmonl~ ~ilmcnn. ~b~lrxe of m~nuanp~l pllhiilhild Juring 1980 Ihat scknowhd5rd Council Juppon ~ompiw a rrc~ldn oi Ihifi Annual Rcpon. Durine 1980 I~o new members were ~ddcd to the Scimlifi~ ~dVilOF~ Goad to provide ~ddiliod clpenbe ID rh~t dirlincaikd body, They were RorMcli I;, Bbllnvrll. Ph,D.. I]~oler~or of Oncolocy o; ~he Llchrdlt Lbontorv for Cancer RLILJICh. UniQ11SilY of WilCOnljn, bbdiron, and Gordon H. SJIO, P&D,. Plolcrsor of BiolcSy, I;niveaily of Qlitorni, bn Oicgo. r"a~ Q BATCo document for Legal Services , Health Canada 19 May 1999 1981 REPORT TEE CDUN~L FOR TOBACCO TtESEAnCB-U.5L, lae, TEE CODNCR, FOR TOD~CCO RESEA~CII-U,S~~, Ine~ 110 tie jhh Strrel, Ne~v York, IY.Y. 100?? L"T ch~S (n BATCo document for Legal Senices : Health Canada 19 May 1999 -f·:: ·' '~· ;· : ii~j Introduction Ths rcrarch procnnl of Ihr Cuuncil ~o~ Tohaw Rcrc~rchU.S.~, fi,o\rd Ihrld rli~·Jli~ in 19SI with Ihe ~lnph~lh cunlinaing to bf JireclFd ro~v~rd :.limn~ aiJrlaI~I lino~lcd~r ol anFFr, ardiuuaallnr Jina ~na chraic ?illnlu;lsr\ .ili:;lcm;. The Scicnliiic ddvirorv ljf31310 Ihll CIJYnCil IIOIEIY ~2cia~i~d 'i~(L~~ 31 13pli01iUnl (IUI11 illdCPPnJ~n~ iRVClliEJIOII [ill IMI~ICh 'i'!\i~~'"· ·~'I b~ ~rlr.r rnli Ih~ Inmlhcr 1II ilrlElrlsl gr~na ;IPP~Ogd BY Ihe (~)ull::: i:;j rim ~o :S92 Cbulleil lundin: li,r Ihi: rcluar~b prugr:ilo since ia lo~;:·~:JI1 asw !I~J~ sl more lh:in ~b~.(Klll~00. CI~:llr rr;lpianr p~li$i\hcd II~ Illlculncnll ill 1qHI Ih31 ac~nuuledEtd IBi: I?SI jlil~lc;aaw ;Ire incla3sd in ~hir mF3n. qll\~l.:j :~~n:~s ~cllrrcd in Ihr coapo~ilion 31~ Inc AJvifory Bos~d dllr· i:l· Ihe \i'nr. ll,;nr i,. Sl~iv~, O.\'.~1.. di~d in illy. William U. G3rdncr. ai.n, rsV·:lv~:l! Sccnlllic UIICFIOI o( I1IE Council bur rcmin~ a mernber ,II ~~i· ~.l~j~ HE S~I)IICLL~dCd;lj SrlCPiliS DirECIOI by Skidsn C. Somacn, ai.!,,.;l i,!:r·li!i~e nl~nl~r shu Il~d been Ch~ml~o of de hdvi~ory Board. ~sav~dinr [jr, i~n:msrr n Ih:irnl;ln aas Iron O. Ilcoblon, al.D., 3 Board amoe~ ,loir IYI;. Rokr~ I, Hurbncr, 31.0., bccsme n mlmbcr ~mcdou JI 'r~u lll0re dj!ljn:LliShCI/ xi;n~irrr jan~J Ihe Uosrd, They were ~rum· w~~nJ H. Dnli:n. II.U·. Il~oiclaur aJ HC3d of rile Dcplnmml of Palholoey a Ihe fni~~rjila oi Ilsniah:l Hc~llh Seirnea Ccnlrr i Winnip~E. C:~3d~. JnJ Ili~h~~! I. ~irlnnln. ,Cl.D. PreiJcs~ anJ ~cdid Diredor ol' dr Ilich· i·Jn C:ll:cr Fuad~lion ill Dr~r~v. h; ~;I:·!nT 'u' ':·~~·~ .i· a a u L~i 5?, BATCo document for Legal Services : Health Canada 19 May 1999 5 -f '' '' y c 1982 REPORT I, .1. 1· ·I II ~i THE COUNCIL F(IR TOBACCO RESWICH-U,S.A., Inc. ii :e '' '·I '' c ·I :I ''' i' '' ' i e 1· i i··: I ·:' '' I:' I '' ~'· : '·' '' I· .C': 1 ( i, .~II( 'L: l!i i I!( TAE COUNCIL FOR TOBACCO n;ESEIRCII-USd., Inc · 1 110 Err SPlb Sma, Rlw Tpr~, N.Y, toO?? I "" "' ' · '''· ·'' · ' 4 1~8p i~p rr; O ca ~1 lu cn BATCo document for Legal Services : Health Canada 19 May 1999 Introduction i Tile Cuunlil for TuLlcco I(chl~rch;i plognm ap~ndcd lurthcr in 1982 in reupoll~ ~D ~ grwuin~ nunlber ol loiid ~nd ulren qaile inlPinlare Zr~n~ ~ppliclliunr th:ll conlimrd to collir Irom indvpcsden: ccicnura. It lermtd rlcar during Ihe rar Ihal even ~ri~h Ihe v;lll ~mOUI11 01 ICIE~ICh dent for tady IhlR IjCClldCI ;n(L) (IIICIIIUIII Il'j;llPd 10 ~motinb 3nd hc;llth, mao8 in Ibr w cmilic;olnaonll!· hdkve impon:aa;:lpr in ~nusild·e rrmaln to dr liibd. trhC.IL1IUle. ICIJlllln~ ~Fll;ll ;IPIY:lr~ II) bC ~n in~c~cd inlcrrll In Imnkiob ;Ind ili~~ilh r~#;lr:b :Ilnlln~ ~clmll~l~. Ihe ('ouotil alb~lPnlWliv cnisrcfd ilJ ~n· n11:11 cullll~lillnrnl. Ille rllsn ;Il\o rclicc~cd Ihe Gllncll'r Illppor~ ior lhl piw rnJ IIAilt'i 01 III Sclcnuiif ~ll~lu~ri IL;lrd, wllirh il;llw:lvr 011 Ihe 13ol;oul lor 4s;ilillcll Ill\ell~xar :I1 1IIII/Y ~IUClliC :IIP3I (h;ll IlrC IonridCICd imponsni. Slee I',I1. Ihe Ci~llncll II.It ~n~rlllud S7b.lllll)2Ollll 10r ill acreb pro?nm. bhi~h II hulivreli iu 4 Iho I;lr~c~l ;111j 11:11\1 L'\IVnlirr PI ill I;id in Ihe Fo~lJ. /'LIJ;II.;IE ill [hT 19il~rI. IhU PrU~r;llll ~lllp/l;lli%CI II·ILl;lrCh by indrpendcnl sci ~nlirl~ in lun~ ~;lllill. U;lldill~:1~UIII.II j;\U:lsR:IIIJ EhlUnlC PUJ[IIOII~(Y lilmtnu. Ihrw lundr \L'r~ Illr Si') 1'11"111:11 '11:11111;1111/ nulneroul r~ncrllr. Ilnc: Ill;lnr ut ihe prujccli svle lur 11ll1 ;;1111 11111~ VCllrY 1I1 IOnlPI. 1hC Council h~l, Ihrolleh ~R~ rc:lr·, hlndrli Ibh rr\c:lr~l~vrs i;l 1~~ m~Jir:ll Ichooll, holpl~sle :lllli r~\c;lrvh ;nllillllion\. ~lnC:I~UI~ 01 Ih~ ('ullnEir'~ Iulllli/)lll;iln II) Il:C ~dv311ccnlenl olltioli6e illlurnl;l~lun 1) vrn in Ihu nufili~~r ~II renllrli Plll~l;~hPJ bY CIJIIIKJ IhJI 3C· Lnorlcdbv I'uuncil oppon. III:1I lil~lru \~;1\ 3.1111( n~ or Ucrcnlhe~!l, 19S!. Shr Cuuncli runl~in; J~dic:l~~d to ronlilrl;rlce ul ill ruse~rch tl[orl. ~P I~b U1O - BATCo document for Legal Services : Health Canada 19 May 1999 I__ I* (( i;i I· (~· ~''' ''' '' !I '' '' '.'I' ' '' ~" '" i '' '' ~B~oey ~·i,ll · 1983 REPORT 4oul·::~~ ·,. lilll(l~PI '' ' 1,: nlE COUNCIL 101 IODICCO RbbRCB-USd., bC. ·% ~IIIOPC "\ ' 'I ···; ·7 :d sciln- ~wl LI' I I· i ~II (I~ :1l11HOBDS ~Iiijii 1 ~~'~ '' ':' ~ ,,,:, ,,, I ·~ ii :'i·I'i·\"riI::ilI!j/!j :'11111l11 '''·'';;'IliliI ;IjtjiljI ii LFs~ I;il i,CuuaCIL~oRToo~\C(O RE~WRCH-OS~A,, I"E, .Iltlli 900 Third ~.~nu~· I~~W ~1~1;1 'i jii1 1 li;iiiili/l~I/lil '" " c, In ~a C C C IV BAICo document for Legal Sewices : Health Canada 19 May 1999 f Introduction · ... !I In ~91i.:ha yc3rr Atrirr Inmlll;an, Ihe Cuuncl! I~rTobacco R~rcmn pliard ~nd diaribuud le 6rn o~ wh~l bean~e ~nnud rcponr to conl~in ;Ibrlnflr of p~pal ..... 50 Ih~ bd been publirhtd in vlriour rdeaific Incdis ailb~cl;nnrlrd*mrr of Council luppon. ThFff will Only 16 Jbslr~els in ht ionl3ro d~amenc, ii iwd, undtnhnd· 8U ably, 13ktn line for nrpninon, rcoier Ind :IbrrbP;i 01' rr31 JpplicJlions by Ihl Council's Scirnlilic ~d\aen Board, rerarch to be rumphd.;lnd mlourrnpa to br .,... Sh By mid·1\167. lbe rent nulnoer (li rcrn~i6e publialhns ~rl;no~riedSinp Caunt~ll :iE prrplnd, abmillcd znd :cecplcd Ibr pvhlialon. ruppor, ulr bC.:nd rtn vcrrr I~lcr thr h~ure had nrcn ill 1,1(31. In cite IYgl annual .3 rc~ort. iY6 rrirnlilic pllbij~~lionr sre Jbnbcled. Ihe I*crn nulllbvr io ~nv one rex. Thil li~u~e bnncs to ~~ lart !.15J Ihe lol~i numhcr Pi racnlilic p3pcrs ~ckr;oslcdrine · . · . I IR Counc;liu[lF~o7ubliJiu;jnn~~~heCounri18Earu~punmyac;irlhby id~pnjmr scnlia incll rlwliin~;mJ bilh. Thra pi~bliaar ire ~n inalu3bi~ Iwrce or' injom~3li~m Ind rel~nnce Ibr ..... ii! rcrrarrherr csrnhne Ind, Iha(brr. rcpercnl s map cunalalin to le Icienrilic i ilcnl.nn:, Thr~ ;I~o cln ~e EOnrijlrcd 3 r\mhol 01 3 ~crarcil pqnr h h~e brculns Li: m~la eaenv# cl.lan of is I;ind in I~e ~orld. ..... 131 b~ rcx Ihl Cuur:il incrll~cd 3w ~onu~l budn Ibr is rcrc:lah pnlmln 3nd m3iminvj Ih~ in0cul lur Ihil aJr. Thir lai~ ir Injiulire Illlhe C~~un~jil dcdlr3· .f ~ ~ ~ ~ ~ I1J sun to Ihe pm·nm. h~ ul Ih; und Pi IP113, Ibe Couai`l 30·*lr pn~~nm hs pmvilkj nlme 10 E93.ln,00(1 m JY7 iowrliastoa fur 861oncin;l projcclr In !71) livdial rchuulr, inrpil~ir;lnd ~ac~lch in~~huuonr. j ~L~P ij rl Z~ch BAtCo document for Legal Services : Health Canada 19 May 1999 ~--"- I .. 'I 881 REPO~ I I~b~m *bl·b ,, '' ~dl dorr .II, d ' ' T~Prtb Il it THE COUN~1 FOR TOD~CCD RESEIRCH-U~L, Lt r ~m~d 7poal~ P ..,. I % Hos~l ,:I''ilt P a* o: ·-I·· -":. "" -1 ~ir~i; ···~~ I 'Ikrr t 'I 'I ~'~ ~IBr ~RE co~al Fon ron~cco nn~itc~-us~, tr n, Is~ "i~6qi ~OOD~d Armu~ ~I* Yotk,~~Y. lOOt2 I I :· I I·~I .C I '' ~,~::::~~~ i I I 1 ·-- · --- I w Q (3 'J N BATCo doeumant for Lagal Sen~eJ : Haalth Canada 19 May 1999 1 Introduction u S b nl~ Lr C·ldi paH Yrd ~~ 1161p ill 1 na~~rr ud! in rkd~ lie rat 1 ~~p~d a dacne aaot~ lnhJlIlion. The alb Idldcd Lar lolr d Ic IPo~ca~id 3jljlJSrdO~ P)I· pn qmmoa cdl acidP~ art pamcd rib ~ pae arhnal Id II hr n dlmhclrk LERad hi! c3neen rpr pwbp?d ~p~~ apau; 3d be o~nO Ilbar o/pdmcl~ rqCllr J~~l~d rdC II If b101~ arnlc~lh C&P 61 m I it !~lkclprd Iw~ eonlmd u Le II~ IlO~bCleYd R Pdallff/ ah. 1! A Pmm:q d II nill ~pyla i Lb rpn be~Pilp nl pp 7. l1 is ohn sbtim 1~1 6e ~t'CLnir EIPh*C d ~~I * Ch~alr Lalic~ rYra b M Br lle;]l CPOG Or ~~dBI ~ U~ltidU~OI h'lOlS; ~C, II aJC~dL~ e· S6 xrch conpIn!' I Bd~~l UO, er Fat ~ a CP~ blr I~r ~ rulad *i~ Cc :: Cuuneil, *Y~ hid Le bot ~~Lb :: 97 b ~ ka.aJ a ne ~J, Dr ILUPI C. S·mml ~e GaldTI Sdtlbr BiAa*, rar: '~r tlmlrlr cpctad 3 ~mnwd dlFa b ~rdpa ~ ub i ~Ye ~ia~ model nwhLL dnlroacPr ~·t~ n~hle ~ kbd solR ~nrr 117 Lnorl D ~udop pdoa iaoprrl;r ~~r d CP: Ilannl ~pr rma~~ ~dm~~~~on oipur c~m~i a~~o~~. ~ ~ ~~~~d ~~ ~pn ~ al be ~ ~K~~ .~L I:0 D Lar mlrrd I ihj~on n*~rl ad i bF idd d lemanlr )II~I PP~e ~; IP1 ~jmtd~qllPL. '3 1!3 air ryr cou~a ~~br6 of ~i p~n L* b~r~ ~p~~rl i LL Lt~ZC IFCJ ~~ *IIDIC(P~~~ dCPlrd Ippn, ne ~rrr bnn~ u r ~~I '511 ~e nwnbn ul ~km~e pIpetr rknu~ldpn~ ~ch PR*n PY drd ~lre Lr G~, I! ljj ol ~an nppmll rlath is uo6al ~~ ~~L hy idepade~ rrr*r Ai on~ e~l an~a4 lhe ClrTr pblns hlld mn~rd mue L~ IH31aml 117 m 5~ ~~n~~l~n lor dY7 o~~n~ p~a~ M 1IE ma~~i ~L~~ ha~mk ~1 ;~ arrrl uiluopr :: ig jtI I I 1~ le ~rc· L BATCo document for Legal Services : Health Canada 19 May 1999 198j REPOR'I ilri~ ~I ier THE COUNCIL TOR TOBACCO RESEARCH·L1S.~,, 15C. 'e :'PPft~9t~,BInd hc~i~':II11 ='" i opcnlr:i ·'r7 i: agIthsl :s· iai I ~t~ TtrE CovNcII Fon ronr\cc0 nEsE~ncR-v,s,~., Isc, 900 Tbild ~lcnuc. ~IW YO~li, N.Y, 100Z2 BATCo document far legal Services : Health Canada 19 May 1999 ISTROI)UCTION Thil apo~l rtcordI re*nl n~ePorrhy evmu in r~prd lp The Council. i ; Firtl,;l er~l Council I?Illd 1~1 J ~ingC )nr bcUs~ ;( r0nllinl 3bllarll of 1:1 Fublilhtd llienlj[iC doeumrnl~ JclrnpwieOginl Couoeil ]UPPPtl. hlOll 01 I :' Ihar ~rDpra rcr~ Fublilhed in I11) ullilr o~hm are oublilhed lat rlcesly. hi Inrl I,b11 ~~pom sekno*4dg;nl Caurillug~or~ bvr a~~clrld in Ihe :% I i;eRnre limr The Council brpn gov;ninl lund~ la indrptndcnl invcllipion dPinl rlPrch in ImPking end hr~llh. Thil indial~~ Ih~l The C~unlil'~ ongoinl ranch pr0gnn ii one oC Ihe moll acnivl of in kind Inywi~crc, One or Ihe ahllnelr afrrl~nu ·h~ mlv he Jnalhrr Ikrr: puhlkl~ion of ~ .. 31 COunCil·l~pporled Iludy in I~ecnl;l;e iournll ill Ik fmpie'r Rr~ubliF of Chin~. Ourinl 1911, William U. G13lr. Fh.D, Rlied Iron Ihl Sri.lilL 12 Advirl I]oJI1 which he joined in 1911; Ilr ll:o Irrvtd lubanucndy n She CovPcil'l 5citnli(ie Diree~or. i~sl· .. . lP loinin~ the nerl in Iltl v% ~nnlher diclinlui~[lrd ~ci~nlilt, M~ni~ed i. K?lnpv~?. PL.D., who is Ihrold t, \Yhil I'roblor of Iliulolial Chcmilry JI ::.: Ibrvtrd Ll~dhl School, OPllon, ... In Since:u nl~bli~hmml in 195J. Thr Coumil bl mllde ~vJilJ8le more Ikn '5 i llW,OOO,WO (or rcs~s~ch by III aicnliw for P11 or;~insl projrcllin 50 m~dinl .' . Ijli xkb, bnlp;l~b JJ ~Lrr,r~h inailaln*~ I ... Ilo :,· ·e ... I~I ·:~* r':~ ...III u:l -..111 Il*l~k~J( A ~s''' · O O a3 u ru ul h, BATCo document for legal Services : Health Canada 19 May 1999 fI ncy of a ,I Ihclyl rbousc· . -I ',* ~cil ~ 1986 REPOBT B Ipplicl enl ~nd d ~lrurcd son~lbie ihmuih THE COUNCIL FOR TOUr\UCO RESEAIICH- U.S.~., INC. Hosts :IJn ·:·· ··· ~· ·· ·~:··~· ... i.? i F''· :1 )Ih· I'· '··1·It! I~ I TIIE I'OBCI1 FOI('TOMCCO RT~:EI\IICII-USn., INC. ·· " s00 Third ~nur, Krv rork, N.Y. IW!! '~· ·I .·... 1 :1· · i . ::r:~ .·~ I· ---,r. -·-- ···- .. 4 I~ :' ~s C1 O 13 LJ F3 In BATCo document far Legal Services : Health Canada 19 May 1999 7 Intoduc~on P 7 L~ fkl ~Loxa i Ba Ilu~ ~~n bm! m ~ ~~ ~(RX lhc Imhr dpb~~Ld 1~ ~~~~e docu~ms ~~uvCd~ne Cuua3 nppn. Pr Co·nl L~ ~a lundinT F4 ~3~r I,rhr;, t~L 6 r~C1~1 r,lara br P ,on e: Tra Laur;~d ~~lk~a*d ~~So~rde AJiur! e;ul PlrCa*i CL II 6e ~lul~ it ut he b~ 1 b.omri i Wd~anl Tna Sl~~r ~d~a i Be Rp~nlen d Apr~*do:);P. U1~~ a Rsei Ydi~ khi. ~d·. 6~~131 Pied L I·~·.~. Y j. ii P~ b , ~LI wara Phd r Oraanrle ImPur ~r OI*d Raat h i PY b~~ ~II ~d b or ~ibld ·i~ ~ ~n ~al Clm Cace h~o ~~n~ lhu !n~ ~nu~ ii. Du~wdl. ~~Z ~q~~d lhc Oo~~ ~~~ qramnl In, !aa a 6mP~1 a Qid d R~aah d Le R~hpl Bkar Rr rid ~und~al Hv blcam~ c ~I bnrr 1~~~1. Pt Ucl~L Llbn~a liC~K* Pacrrh y L1 UIPa~ ~ Fbprul a ~liur P~n ~. ~u~~u ~,D,. ~~l~d h~n ~ ~a~ ~aah~ d~e ~XL ~~r~d ~nle I~~or ttmun C YoUbtr ~. PLR. uLIPird It ~1*CI ~rrir ~~T i Mi RI~ r m ~a~rbr R~~rel ~ra·, ra p*·3td b Roaah ~Laa YRC LII 51 P~ll.ld bl ~~I m~~ I~t)~ h\' nX CPIKI Y*L R!~ hi a*lra a~#blcl iur awrd br 14! p~~~l hr 9bP opli pqaa 1 ~b odr~ ~&*b, hapwr lad calffb i~~u~b, ... 176 jE f3 Cr~ BATCo document for Legal Services : Health Canada 14 Yly 1999 "II I' ,I ·-· ~k~%~~i~F~f~~llliW11itlHltll~g ; '~r~RR~UBI~WIIWI I~hn; PrE rR~PV~ L·ntlR~Hlt~WIIIRlfb ~r ~ :P%~~I,~HUl~nWnl~A~8~I~II~W~OI~P~~·IHII~U1~~1~~· i ·. . I id al~!i~~~nt~'~il~flP~6118l~iMIIIE~: !~n 1 ;0 "' ·, ~I :d s~ 1B~iR~taB~il~R~illll~tH~l~~~ll~e;~ g ~41~1Y UU· ··IYYbt·l~ U·U·~·YY[lnYMIM~UnmnInUYn ~TC._-l :~F~al ~ll~llt~l.Uiflf~i~l~t~H~~il~~l~lll~f#U1&~8~Ja~ic~,~~~c~i~: - ii: ? ; ' ·~·~~ yn~7 ~~d·~ . ~L~~ '* ·~j; ~· ,*ad~r ,·- w~i· : ~cL ~lu ,, r~n~nr S~iZ~Ou~~ BATCo document for Logal Services : Health Canada 19 May 1999 3 7 Int~oduction Tllir rlaal cp~a intlug:\ !50 ~h\lrJcll d puhlihod aicmilif ~pc~ns xborl· ii dgil~g I'aun~il wppla Ihe nelblll rcK'b dlruma~s L;ll I1:lrr:~pllarc~d ~i~K~v Illr GlunLii bC"30 funds:! rtJel ilrllloi;iq ad hll in Ic)iJ DUF is ~I k~al 1.1JY: iir rrlrcl;mr a ruh\slnlbl cllnlribu~ioo l;lhe 4irnlilic litcaurc. I'aur K, Vila, I'L.O.. Qllirmln ~~1' le Drp~nwr (1( SIRtllika nl Ihu Uni\cnilv ~~I'Snulh~m tli~rnn Srhal ul' SICJiliM'. LII ~n~~b.juid it Sri~n· ... 1j IlliC ~IIYi;llrY Oll~rd 10 WC truncil dunnS lhr rar. ]~nsr F. Gicnn.ll.U.. I~rowrk rr~iJal I1I 3111111115iPi ~ICJiCill CCnlCr, ~flY I~llh, str sppllnl~d :\~lllej3$ licl~lilic' Ui~u~Plr 111'nlL· G~unctl durinF II1I1. I)r. .. 91 TII~ Cllunuil i~ll yru illcd ale lil;lll gllil.lllki.lnX) &r r~l~~rrh by ind~(k~ndml ICi) ,.. ) E4~f j ~S* ' i.F~· ~kl !I :7~.i1·; · r; ·· · ··· ~1. ~·: · aC7CICi1~7C l~~L i.. uvvJ BATCo document for Legal Services : Health Canada 19 May 1999 :ynCu II1 :1 Ilu~lhul an ~,ubu~·Id ,upplr·~uooi Jar 1355 REPORT g al :ma nd .sr arur$ THE COUNCIL FOR TOU~CCO RESWIRCH- US~~~I INC, ~\P ihle .I U. I[l~sUS .;dmlo I~ TIIE COUNCIL FOR Tnn:\CCO RESEaRCH-U.S,b., INC. YiiU Ybird h~mur, ~w ~orli. S,Y. IOUZ? 1~1 ig· c~ ~7nFH1 U1 BATCo document for Legal Services : Health Canada 19 May 1999 ~airuduction ~he Cuunril's paleta concinuer to con~nbue rubserbiiv ~o le scirai6e lile:3turc Ihroueh le pubiic~lionr of ~he xse~rchen it Ibdr, ihe iud (or such publiearilns xinurldcio~ Council ruppon linre Ihe urcmilsiiln war rclJblirhrd in IYSi nov, is a Ica~ 1.MII, ~hir ~nnuJI spun conlanr L13 ~bnnctr o( published pJpen· In 1'181, Dr. hmer F. Glcnn, ~uho bed joined le CpunCII the previous ~ar ~I AIIOCi3[: Sliln(i(iC Direetot, beame Scicnliiic Dirraor. He rutcce~ Dr, ShrUon C, Sommtrr. FhO remains on le Srirnrihr Advisor? noad to le Council. Dr, Gknn,