Group Research & Development Centre, British-A.nerican Tobacco Co. Ltd., SOUTWIPTON. TCB REtONG, FILE CIRCULATED PROGRAMME OF 14ORK RESEARCH Issued by: C.I. Ayres Date: 8.10-1976 Distribution: Dr. S.J. Green 1,2 Dr. 1.W. Hughes 3 Dr. R.A. Sanford 4 R.M. Gibb, Esq. 5 R.S. Wade, Esq. 6 Herr H. Sottorf 7 Dr. F. Seehofer 8 R.G. Nicholls, Esq. 9 Dr. C.J.P. de Siqueira 10 Dr. D.G. Felton 11 Dr. C.I. Ayres 12 File 38A 13 C" C".0 BATCo document for Province of BritiSh Columbia 26 October 1999 BIOLOGICAL RESEARCH & INFORMATION 11.00.00 Review or Target Date Work by 11.01.00 Inhalation Toxicology 11.01.02 Histology of respiratory tract Oct. 1976 GS/LVW 11.01.03 Manual for B-A.T./Mason inhalation machine Report Oct. 1976 JLB 11.01.05 Comparison of BATFLAKE Mk.3, SC and WC Nov. 1976 LVW/WGDLjGS 11.01.06 Comparison of 5 and 7 day exposures Dec. 1976 LVW/GS 11.01.07 SEMAX of respiratory tract Dec. 1976 GS 11.01.08 11.02.00 Biochemistry 11.02.01 Lung biochemistry species comparison Oct. 1976 PSS 11.02.02 11.03.00 Smoke Dosimetry 11.03.01 Effect of smoke concentration and duration of Report exposure Oct. 1976 RB/WGDL/LVW 11.03.02 Long term dosimetry Dec. 1976 WGDL/LVW 11.03.03 11.04.00 Other Studies 11.04.02 Review of methods of statistical analysis of Report JANUS mouse skin painting experiment Dec. 1976 EBW 11.04.03 Method of analysis for sebaceous gland test Report Oct. 1976 TH 11.04.04 Glycoproteins in smoke Oct. 1976 GR 11.04.05 Haematology and clinical biochemistry Dec. 1976 LVW/PSS 11.04.06 11.05.00 Battelle, Frankfurt 11.05.01 Long term skin painting Experiment B8 Draft Report Experiment B9 Analysis Experiment B10 Terminated Experiment B11 Histology Q: 0 I, 1-0 N" co BATCo document for Province of British Columbia 26 October 1999 11-05.02 Promotion (skin painting) Samples B9-1 and B9-6 (extended test) 11-05.03 Inhalation Vitamin A project 11.05.04 11.06.00 BIBRA 11.06.01 11.07.00 Wickham Research Laboratory 11.07.01 Promotion skin painting B12/B13 samples B32 11.07.02 11.08.00 Life Science Research 11.08.01 Long term skin painting 11.08.02 Sebaceous gland tests Test on 4 JANUS samples BATFLAKE samples 11.08.03 Review or Target Date Draft Report Diaft Report 112EL bL Master file preparation In progress Analysis Analysis Q) ON \0 r\.) C BATCO document for Province of BritiSh Columbia 26 October 1999 PRODUCT RESEARCH 12.00.00 Review or Target Date Work by 12.01.00 Sensory & Preference Research 12.01.01 Relation between GLC scans and taste and flavour Oct. 1976 EBW/GOB/HFDD 12.01.02 Effect of blending on smoke taste Dec. 1976 RAC/TH 12.01.03 Project KEW, Phase II - Cigarette Report nanufacture and assessment Oct. 1976 DJW/GOB/AWGS 12.01.04 Project OSGOOD, Phase II - Examination Report of brand samples Oct. 1976 RGH 12.01.05 Effect of anethole, menthol and stem on Report irritation Oct. 1976 DEC/TH/JDB 12.01.06 Irr-tants in cigarette smoke - Phase II Oct. 1976 JDB/RAC/TH 12.01.07 Filtration and paper porosity effects on O/WP scan Oct. 1976 GOB 12.01.08 Effect of tobacco additives on the O/WP scan Nov. 1976 GOB 12.01.09 Objective characterisation of cigarette pack aroma Nov. 1976 SRM 12.01.10 Effect of paper porosity on sidestream smoke Oct. 1976 JDB 12.01.11 Fla7our materials ex Germany Oct. 1976 SRM/JGU 12.01.12 12.02.00 Cigarette De sign Studies 12.02.01 The control of cigarette puff number by Report paper additives Oct. 1976 FJD 12.02.04 N-nitrosonarnicotine in tobacco Nov. 1976 SRH 12.02.05 Further studies related to tobacco amino acid deoxyfructoses Nov. 1976 RAC .12.02.06 Diffusion of gases within a tobacco rod Nov. 1976 RRB 12.02.07 Variable porosity paper evaluation Report Oct. 1976 RRB 12.02.08 Gases from pyrolysis of smoking materials Report Nov. 1976 RRB 12.02.09 Effect of tobacco type on CO in cigarette smoke Oct. 1976 RGH 12.02.10 Total product design - Redesign of cigarettes - 1st series Oct. 1976 RAC/TH 12.02.11 Cigarette firmness - Further work Oct. 1976 DEC/AC/RHJ 12.02.13 Factors influencing uptake of water by smoke Dec. 1976 RBR 12.02.14 Total product design - Redesign of cigarettes 2 nd series Oct. 1976 RAC/TH 12.02.15 Cigarettes containing 0-13 tobacco Nov. 1976 HGH/PJN 12.02.16 ca BATCo document for Province of British Columbia 26 October 1999 Review or Target Date 12.03.00 Filters 12.03.02 Comparison of cigarettes with Duolite and Lewatit filters 12.03.03 Filtration of nitric oxide 12.03.04 Embossed end filters 12.03.05 Heat shaped filters for CO removal 12.03.06 Effect of temperature (storage) on shrink wrap filters 12.03.07 Evaluation of TFP filters 12.03.09 Filtration of nitro sonornico tine 12.03.10 Transfer of particles from cigarette filters (Review) 12.03.11 Production of pilot scale batches of coated carbon 12.03.12 Examination of filter additives by mercury porosimetry 12.03.13 12.04.00 Development of Techniques 12.04.02 A method for a,6 unsaturated compounds 12.04.04 Development of a CC method for individual tobacco sugar analysis 12.04.05 HPLC method for casings 12.04.06 Growth of fungi on tobacco - method development 12.04.07 Peak height detection (Fisons Scientific) 12.04.08 CO determination 12.04.09 Oct. 1976 Oct. 1976 Oct. 1976 Oct. 1976 Dec. 1976 Oct. 1976 Report Nov. 1976 Nov. 1976 Nov. 1976 Nov. 1976 Oct. 1976 Nov. 1976 Oct. 1976 Nov. 1976 Report Oct. 1976 Oct. 1976 Worrk by X-4PP/HGH JDG JDG/JAL JDG HGH/AC HCH/JWPP SRH RBR DJMjJDG JWPP/JDG HFDD RAC/COB CWA TGM DJ RHJ 12.05.00 Brand & Market Studies 12.05.01 Europe leaders 12.05.02 Examination of low tar brands on the 'U.S.A. market 12.05.04 Examination of Reemtsma R6 cigarettes 12.05.05 Report Oct. 1976 Oct. 1976 Nov. 1976 DEC RAC/JDB SRH Q-1) CN \0 r\-) C)o BATCo document for Province of BritiSh Columbia 26 October 1999 12.06.00 Microbiology 12.06.01 Effect of heat on microflora of tobacco - Further work 12.06.03 12.07.00 Contracts 12.07.01 Combustion studies (City University, London) 12.07.03 Interaction of aerosols and aqueous surfaces (Bristol University) 12.07.05 12.08.00 Tobacco Growing 12.08.02 Plant tissue culture 12.08.03 Deliberate browning of Virginia tobacco 12.08.04 Tobacco desiccants 12.08.05 Review or Target Date Work by Oct. 1976 TGM/PCS Dec. 1976 RRB/KDK April 1977 RBR/KDK Report Oct. 1976 RC Nov. 1976 RC Oct. 1976 RC C^\ cc 01 \ BATCo document for Province of BritiSh Columbia 26 October 1999 SMOKER RESEARCH 13.00-00 Review or Target Date Work by 13.01.00 Benefits of Smoking 13.01.01 A smoking survey Oct. 1976 DC/PHL 13-01.02 Application of puff duplicator Nov. 1976 DC 13.01.03 a waves - Further studies Oct. 1976 AKC/RET 13.01.04 Smoking behaviour effect of changing brands Report Nov. 1976 DC 13.01.05 Dependence on cigarette smoking - A review Report Dec. 1976 AKC 13.01.06 EEG studies - Second series Jan. 1977 AKC 13.01.07 a wave bio-feedback Nov. 1976 AKC 13.01.08 Smoking behaviour of women Report Oct. 1976 RET 13.01.09 Smoking behaviour (low delivery cigarettes) Nov. 1976 DEC 13.01.10 13.02.00 Contracts 13.02.01 EEG (Chronic studies) (St. Bartholomew's Hospital, London) Oct. 1976 RET/AKC 13.02.03 \0 r\,) C,3 BATCO doeUrnent for Province of BritiSh COIUMbia 26 October 1999 PROCESS & ENGINEERING RESEARCH 14.00.00 Review or Target Date Work by 14.01.00 Tobacco Proc essing 14.01.02 Investigation of cooling times for Report tobacco in cases Nov. 1976 DBN/RBD 14.01.03 A fluidised bed WTS process for CRS Further work Nov. 1976 DBN 14.01.04 Effect of NRS process on Virginia stem Report Oct. 1976 AWC 14.01.07 Stem processing as WTS and PRT Dec. 1976 RWH/CCG/?J.P 14.01.08 Moisture measurement using microwave techniques Dec. 1976 AEY 14.02.00 Cigarette Ma nufacture 14.02.01 Mark 8 MCM performance investigation using data-logger Oct. 1976 RGB 14.02.02 Machine fault diagnosis - Further work Dec. 1976 RGB 14.02.03 X-ray method for stem etc. in cigarettes Nov. 1976 AC 14.02.05 Tipping pliability Nov. 1976 FR/JKM/N-'.z 14.02.06 14.03.00 Filter Manufacture 14.03.01 Measurement of filter rod hardness Nov. 1976 JAL 14.03.02 Diffusion filters Nov. 1976 JAL 14.03.03 CO filters Nov. 1976 JAL 14.03.04 Further examination of Group R. & D. Centre equation for filter hardness Nov. 1976 JAL/TH 14.03.05 REX filter - Dependent on Cigarette Components JAL 14.03.06 HAF filter - Dependent on Cigarette Components DBN 14.03.07 14.04.00 Q-) Q~ Packaging 14.04.01 Pack design studies - Further work Report r\- Nov. 1976 NF cc 14.04.02 c0 BATCo document for Province of BritiSh Columbia 26 October 1999 NEW SMOKING MATERIALS RESEARCH 15.00.00 15.01.00 Non-Tobacco Smoking Materials 15.01.01 Factors affecting physical properties of foamed BATFLAKE 15.01.02 Alternative binder system in foamed BATFLAKE 15.01.03 Alternative fillers in foamed BATFLAKE 15.01.04 Band release agent system 15.01.05 Evaluation of cacao by-products in PRT 15.01.06 Spirit caramel in BATFLAKE 15.01.07 NCF - Ash improvement 15.01.08 Reduced density WCSM 15.01.09 O/WP comparison of SC, WC and BATFLAKE MK3 15-01.10 15.02;00 Tobacco-based Smoking Materials 15.02.01 Fractionation of tobacco extracts by RO 15.02.02 Effect of enzyme treatment of uncured tobacco on smoke properties of PRT - Further work awaiting outcome of 15.02.03 15.02.03 Modification of protein content of tobacco 15.02.04 PRT-71 - Product specification and test methods 15.02.05 Reduction of CO delivery of PRT by the use of additives 15.02.06 O/WP profiles of production RTS 15.02.07 Possible correlation between O/WP and biological tests 15.02.08 Examination of ITP cigarettes containing PJS and PCL 15.02.09 Review or Target Date Work by Report Oct. 1976 CCG Oct. 1976 RWH Nov. 1976 CCG Report Oct. 1976 DJM/CCG Oct. 1976 RLP Report Oct. 1976 CCG Report Oct. 1976 TWT Nov. 1976 CCG/RWH Oct. 1976 CWA Nov. 1976 DJM PJN/TGM Nov. 1976 TCH Oct. 1976 RLP Report Oct. 1976 RLP Nov. 1976 CWA Oct. 1976 CWA/RGH Dec. 1976 RLP \0 N) c0 \0 BATCo document for Province of BritiSh Columbia 26 October 1999