RESEARCH & DZVFL0P;-1T-7MT CONFERENCE 24-23 AUGUST 1981 BIOLOGICAL (Work Area 1) 1. There was considerable discussion as to the strategy that should be adopted by BAT in the -...,hole area of biological research and ~ S fl-,- C, hc testing. The way in which BLT could rwarp4vet low biological L activity products must be established. 2. There was some dLsappointment'as to tile lack of clear-o6jectives arisinq out of tile t y .Tcchnical F:;-:chanyr--, ;,.Ieet.1j, althourjh this was laraclv rectified by the su!)sr-qur-nt !ue 6ting in July. 3. The obliectives in the draft Research Programme eriphasi-ces the dc-velo;-).-m~nt of products --:ith lo,.: ;)iolo,--.icil activit-Y, whereas the rro-,),Ct!7 seem mainly concerne(l with toF;tiw; an(! method Cleve 1o-.-)men t .It was notc-c'~ tiiat no !iic-ntion woo mcido of how to c.--.I)loit thc- results oLE pact 4. It is neccFZary to have :~ stnn,3,5r(l I)i:,-.,tc)col o[ testin,~, at GR&DC, hut th(' 1"L1.11' Of the remainin, el'i-orf. r~:iould he clir,.,~ctc~d to a better understanding of cc?rt:iin comoonents (eq stein) or procosses sheet) lenrl to rQductions in hiological L', tl activit% z-Onlv in ~h7is -it h( IOS-11 le o prepare "decign manual" for 1011 t.CtiVit'..' "I-011L]ctrl. A wholly scientific a!7proach would involve a massive undertaking and, there[ore, nomo of cmpiricir;i~. z.-!ill il(- PC Cd 5. ProjectO,1(1)) concerning hronchitir; f~IIOL11(1z Cintil the proposQd wod,~l is substantiatc(i 0::;,( rt opinion. cx:) BATCo document for Province of BritiSh Columbia 5 November 1999 Ar,:~a 2) Tlic~ Stratr,lic Objective ohould bo r-%jr it--cn , "To develop novel filter-z and novel filtor tcc~hnolog-., 7iiiiw-c! at the developiticnt of marketabIc low-tar product7_ with particular regard to human smoking patterns" . 7. The Programme should be reshaped to give emphasis to fundamental principles. 8. Selective filtration may not be so important with low deliveries. I t w as ac ,roc,(I, however, that we must en7ure that the Group is n1 wayr, in o ponition tO h(' c0nIL3(-tiLiv,7- %jith rr-;.-.Ir(I to ;-Iny ~~i-.3nific,irit components - 1wrice is Th~ ourr,-nt priority is se--~n as: (it was recoqni!~cd that CO is not amen.-w5l.c- to selectiv,~ filtration.) 9. Particulz-ir noints were: - Zorhonite acoroach to NO. reJuction (01(a)) to be omittecl from the " Groun R&D 7,ro,:carmin." and chI-.r-,-i-_--d dir,7,c,t to interest od Oi)aratin; C,,:-,paniec. - The ;nro-jects on Pro~jr.7immed (02) zin(l Nct-., rilter Desi,Jn (03) should h,~ mcr,iori- of pro,!rz~iiiwod filtcr7. w:.!, !.-r(l should i)e given to LIII(IC'I:'--LLIII(IiMJ ho-..! -.,moker rczi ctr~ to an- in riltor dc5i,jn. '-;o r !,. on turbulence a t L GR&DC (03(l --hould conc:,~ntrnte on thr~ f'iltcr (,i.-: to ".&W work which roncentrates On turbul..-nt -ffoctc; in thr, I,r- 0.1 (b) shoti ld t- roncentratr~ on r(Aiv: i ivi product v ar i.~thi Ii ra, iwr than :-, Lilij,Ly on I-III'l i'"1' a0tomatin,; I*i I i!:-r 0 Z) BATCO document for Province of BritiSh Columbia 5 November 1999 -3- Diz;~.ppointment was expressed that the now between Souza Cruz and Hercules micht Iiinit BAT's central pozition in zol-:,ronylene filter technolocly. The (05(a)) should be re%-.,orded to h!:,)--:12n the basis of the acti-,rity that will continue at GR&DC. The HrE filter development (05(b)) should not c,3--it-inue with the objective of proving a viabl(- inachinr~. on principis:: ef aodi_L%,inc7 nuff Thc c,-,;-z:iluation of external i6le-is an~j materials care mu-.t !)(, ta!--an to continUe, but avoid cluplicating the activitic~c of Operating Conw~anies. !-.11PIUC, AND r-TT'J-.[Z (!.,Iorl, Are~i 3) 10. Approved. CIGARETTE DESIQN (Work Area 4) 11. Gericr:~l n:)proval of programine, but. T.Iorl- of chemical additives to rcduce NO, and CO r~;iould be deletr~cl. /I I FI)c th 7~!.,.:,:c)ject (04) on high riunlity/lo~-.r cost should forin part of the GrOLI,.) Avziilahle ri-~00rcr.- should (-c)i,,7:fi,itrate on tho Icsign oF ultra-low th, ,r J-~ired smokin,j iw~chanic!~. BATCo document for Province of BritiSh Columbia 5 November 1999 ~ON (1-lorl; Area 5) For tII0 L)r0rjr-,jjjjjjjr,, J~jjt pro-joct 07 on the of Other SMO;~C COMDonents" should be deleted. L attention should be given to evaluating the ii:-Huonce ).': fundamental changes in coi-,ibustion on the 1 A.-ological activity of smoke. o,d d Area 6) 7 1,-, :~,I:HTICYI (Uork Area 7) nooport of the progromme, but with tile following points: Pro-if.,ct02(c) should he broaCiened to assess patterns of a range of product rather than concentrate on tile B&II to participat(! in thn planned joint .-:ork on smoking b0haViQLIr between Cnnada and (-.c~rmany. Th~.- ncc~., for a professional r,.-~spirantory pf.ysioicgist was accepted, but tile work should be discussedl with external I t "; . ,:',,:CIIUT,0(7,y A111) !;i:J!',ORY TES,riii(~ (Uor!: Ar~-,a Pi ~1 :-rogramme wnF; approvcd, hut there was some concern t- 1h. !ije of proj,!(.*t:; CXD rNI-) BATCo document for Province of British Columbia 5 November 1999 warCi "nIncebo" in -project 02(h) was considered )[I rlv~ i ["I the project Should focuF; on what smokers believe wi-;n from smoking - with particular respect to ultra-low 6 c!Iivc!:-,-- nroducts. a split of opinion regarding projects 05(b) anC3 051,C) %:hich conctrn the influence of variability in physical attributes on the Suhjcctive assessment of cigarettes. Dr Oldman should cliscuns wiLh ITL and B&N their e~,nerience to date to decide th~'! projects are justified. (1-lork Arcn 9) pi.n~i- -r.n,n was apprcvc~l. The ininortance of broadening Wt:':I--;.--.--~-;.-- to include F."OLIth- feel, irritation, impact, was -etc T,",:% F71 Area 10) '0. Thnre wz,~- .Irneral support for the need for BAT to participate in Lh,-~ developing area of Biotechnology, and in 1-1,71rtiCLI1~1!- -.-.ingle cell culture. The e.-perience of BAT Germany 511OUld 1)(~ j--vi(-.-ied. L 21. There is --i nced to incrcase the rcsoarch inout into the Leaf Steering Comm i t t e e- vin the three GR&DC representatives. Project 0 1 (a) on the uE-we of specific varieties in cigarette rlo.-;ign r,-. litiref; clarification the research content. Past B&M ..'ork on the action of enz-,--mos on fermentation should ho thor()ii-ihI-v reviewed 1.,,:~,ore pr(,j(-ct 01 (c) is undertaken. Nj BATCo document for Province of BritiSh Columbia 5 November 1999 04 on a pressure trc-atment of qreen leaf wa~ accepted iL'~ exi-,loratioi:, but criti(:~-.l review of any rcl~ted should be (Uork Are,-, I I) support for both the objectives and the projects now i:.2flect more appropriately the Group need for a better of fundamontal principles. The emphasis should be 1,77,-.1 siLudies; rz!thr~r than commercial equipment. should be :-pecified for Project 01 ne phy~;Jcz-.! ):,c,)crti(,s of tobacco ri~li~ise(] bc~ci~: n3(i,!) f-11OUld rat-proceed VJ)'r"' pi"L.Ll. work (c-,q.. C. L n.2e<-.1 to corr.Tiion physical test :',7,: US(:? t!11:OW.:!:'1_)L1t t'.IIC? CO I)-, I I thn- prograrr.-~,.~~ oil curcd tohacco prior th;~i,. cowir~nt:ionzil comr.-iorcial rreverF:ii)1-. influence bo t I I ;I. 7icc.". and oroperties.) Aren 1:)) It war; fn].;: t;.--,t tlhe comm,2rcial c::i loitation of DIET GrO.U[~) ShOL116 bC CJ'CtZ1171V 10Clted ill C:> N-) BATCo document for Province of British Columbia 5 November 1999 !)~~.pzlrtment. and not locL)t,.,,(-l within the Group "!:oject 12ib) on alternative exp~incicn processes should be '-)ri'~ritv Th- u'vative '-7n - / - inn OffOrt ShOUld be ~~increased, bv the inclusion of Dr K Kilburn. Lp 2,- RAT Q (Work Arca 13) o'ff the programine was approved but it was felt that -t~oiir;ibility and the fun(ling should be firmly located r)epartment: GR&DC ~;houlcl Lict as contractor to the F~.- C:TC -~-'TTE TEC111101,017..'.' R`or!, Arna 14) Arp, 1'- r 1: a c-:-.nc~,r n:_ test meLhod develnt-m(~nt forming part of the Group Co 11 .11'C. ;;'L:-,j' '_~ n t .: Croll. - was accept'!(]. SP(-CiriC: L)OilltS worc: ~-.-tLion with CORPSTA, ISO otc was supported, profile -.hould be re,jarding ::jig methods for ncw "nantie-,", og acrolein. .--,-~Licn should bc SOLIUJIt' 011 Projoct 02 - J. wli of w.-I chc~miczi 1. iii-thods. 03(b) ~Illd 0"3(C) rI)C-1.1111 llf~ re-c.--imined `-ther thOy _'111,Llld b0 il)CILIOCCI ill the . 1) P1:091:11111i'lle. 06(a), (c) and (d) on o[f-line pcrmcability, CO CC) BATCo document for Province of BritiSh Columbia 5 November 1999 value and hot colianse stiould be deleted L,i~T Germany have methodc available. !~:,LiLirw analysis of -,~esticiOes -~;Iiould not form c,!' the Grour) R&D Proi~jromme, but research ::t-i,-c should bL2 mainta-in-d- 1-1 Cronshaw should prepare a critique of 111 111- A*j- 1'1.~)?~' :-'7m. cnn and shoulJ be done to-automate i.tv control in mal-ing i-ind packing. 'r[ L CD U~ BATCo document for Province of British Columbia 5 November 1999 i L, !-,ignificant rcdtiction in numbers over the past the total cor:t: of Grou:% 7,A) is higher in ISIB2 th:m in 11!5"1 - althouah it is bud~.,.Qt-ed to decline thereafter. in 1962 results fra:!z a more refined assessment --tivities whi(Al the GrOU R&D Prograinine. Draft 0.~ all technical effort ~,i '-,) thc Group JIr:D 203 tochnical r;taff ;,Or non-lek-.- cilicd -fo!: t!:o Cor.~t_,r,7mce wil..~nFln-nee the fooling ths'.".. w"? -ittempting to work on too P~ fl ~1,1 0 j C?'-- r._~Lh;.:r ccncentrating the effort ci~ c. r i a r T. 1')P '.3~ C-T'7:T~C' (inh:.ilation, Ames, etc) !.11- 1-:!Iative s'pocific activity T' -1 i I'll foz:i,, a basis for a c r~ i.,:- tiic- or oth;_-! .--..-_J.::--,, _:-'()r iliore Cxtensive I n f,-, i io-,I) -Iva i -inada z al)le in Cz eV31AlZlt(-II with respect f-?: l'! 1) r CL! C /L CO N.) BATCO document for Province of BritiSh Columbia 5 November 1999 opinion on the importance of CO varies bctwoen :Lt was agreed that GII&DC should continue to seek ~-oducin-:- the CO/tar ratio ~-',Jch oroducts are offered commercially,/the% should bc,~in (-:-a-mined in the conte.-t of human smoking paterns. C)--. - ich presen tly being adopted by BM-7 is tc- 7";'~ off filtration - accepting that lower -pressure now appear to be conimr!rciall-y tenable. --(l that there :.!ill h(- n tr,.-~n,! towards incrcalsing -~nportunities bar:od on tochnic:,11 13AT corini(Icration t-o thn relitive merits of I,; r;iflr~;trc-niii nnd CO) the Industrv. i 11 -;n:;v~ i nc- r r,. r~ i i, impor t-ra-icc, in product Lo th"111 u"Ill'i 1-c"mr, illy ly GP----DC shoulit i (-ritiquo covering past and -~:i----nce in Ili, Lm~l on the clozirance of H.- MUSEIC prnto,--ol for !)io1-D-:jical testing, and Lu 110W L)Lh,.'-r councri-!; 1,).oceed in this r1 Q. BATCO document for Province of BritiSh Columbia 5 November 1999 - 1 1 - RESTRICTIOI-If~ AND LIBAtTfl; -nresscd that LIAT haf7 not yet established a central "r), informinzI.-/updating Z~ssociates- on restrictions that I I in difforcn.t countrics, -nor-- h a ---the-tI-.i7I-1-bzin r;~O -p, --=cd . Tho current status will be ascorta-ined and communicated. .10. A 1. Conference %-.,ill he li-21cl in Germanv at the end of 1":32 to bri-nj Logether I)oth Elavourists and flavour r,, i-or!:ers. 2ar tic Fhotild 1)(~ at the bench level. -.1r:o be co:,.tr ib,ition7. from invitod hu-. noL from flavour housen.. Mombers r~-znonf;c' to P": E-6iin the end of CD -D CXD BATCo document for Province of British Columbia 5 November 1999 i),; 11 i n t e 11. i,,: T!!~1!--: su-verzil examples where Norris or hav!~- fol.lowcd one another in izs.wi-~:i! of a new r3ro,61s:ct conc-rt f7o rapidly (1 inonth) that 1 2 r (~ laust have !,c-n '-~l 2.0.- !-.nc)w-Lcd(-e. BAT doer, not 1'. informati-on competitors, nor process J -tined zmywhero throuyliout ioi attemi)t I-)n in at GIZ,~Dc a tr~chnical in~ormntion. Tit will :~n,l wi.11 rnric-r-ntrate nC,1L1j.r-. C1 T i s ni !-;ed that t:,,- Q,overnment agencies 11. i.:orn notic(-~ c- ;,Ill ill,, of i~h, of the [or a (" iv ::I ki--.: L , 1,(! 7.mol: ing "I"ll :~:l 7;s;:-!1,- 1 C~Clm i.,-nl fit--17,111-c'mont of 1.j. if for 11'.~ r - wo alust r.),Iy ne-a products 7 ~ . -:;),~r rescarch into j) L 06 LIC 1::'~ (Int'li 1(-(l I't, cil-c-111atc(l ;,wf~ t.;,r (1(,! -Al"! 1),11.-Ivioliral nroject QJ-1 Q-11 BATCo document for Province of BritiSh Columbia 6 November 1999 1 w jointly uri(lcrtzikf~n i,-:- PAT Germany, ITL of should be retained for form, this Research Con-f- 11 PI.2 ConFerence in Canada. A c7-n'--e in earl September is y Hentinq shoulcl i)o held each year in t--Iiy -Lt 111lic:11 r:~-~nior Po-.r,i ~.-rh ilan,-i,jor:-~ from the CAC i 1.1 rcview Ow . :w word-. for tfic, rl-ctinct i.Til proro!7~cd c-,-,i.-.l.v in HiQ -)I' meetinn irl LI 1J.-Lven imi)ortnrice ',--o the Group. F;Ubject for W -) in Ifaiiil)urc: , -Ind it is (71 the next me-ting 1027~ or 1983) 1, tontativ- o -,,-I I Cnr 1"M-1 is t.-) he held in Brazil. 00 BATCo document for Province of BritiSh Columbia 5 November 1999 Item 8 RESEARCH CONFEUNCIE 1981 - PT-CIILAR:,, AUSTRIA The following items are extracted from the minutes of the BATCo Chairman's Advisory Conference, Miy 1981, and represent topics which have a bearing on R&D policy. rxi:--act Pa e 8 PI Carbon Monoxide CO is considcred a Lhreat to be taken seriously. Companies must muster the arauments to resist showing CO contents on pac' CZ) 00 01 \ BATCo document for Province of British Columbia 5 November 1999