SUMMARY & CONCLUSIONS. B-A.T. Group Research Conference November 9th - l3th 1970 St. Adele, Quebec Present: H.D. Anderson (part time) Sir Charles Ellis D. G. Felton W.B. Fordyce R. M. Gibb S.J. Green (Chairman) 1.1-1. Hughes L.C. Laoorte A.D. McCormick H.F. Rance (part time) L.A. Rowell (part time) R.A. Sanford F. Seehofer 11. Sottorf R.S. Wade C. Warren (part time) C:) c0 c0 110 BATCo document for Province of British Columbia 9 November 1999 -low B-A.T. GROUP RESEARCH CM.FERENCE MOVE13ER 9TH - 13TH 1970 ST. ADELE, OUECEC I. The Marltra R & D paper was reviewed and discussed. The various postulates raised ret with general agreement and It wras recognised that certain items would be covered under other points in the agenda. 2. The assumptions underlying tobacco R & 0 identified In the 1967 Montreal Conference were re-examined. and it was agreed that.- a) Research can be profitable and that new products may ncrw be expected from research. The 1967 minute reads "Research can be profitable although we are in an industry where new products generally cannot be attributable directly to research". b) Uicotine is important, and there is Drobably a minimum level necessary for consumer aCCC.Dtance in any given market. The chemical form of nicotine has been sho-an to affect the rate of absorption by the smoker. The 1967 minute reads "Hicotine is irportant and there is probably a minimum level of nicotine to which for many people the habituated effects of smoking are attributable. The form of nicotine probably affects the rate of absorption by the smoker". c) Government involvement with the industry continues to increase. Th.e 1967 minute reads "rovernment involvenent in the tobacco industry will become greater in the future*. d) The smoking and health problem is at least partially amenable to a research solution. The 1967 minute reads "The smoking and health Problem is amenable to a researcfi solution. This is a sionificant i- thinkinn and is a direct result of research". c0 co NJ C)N 110 (ZD BATCO document for Province of BritiSh Columbia 9 November 1999 P) It is now accepted th'at an R'S D contribution to product characteristics is important. The 1967 minute reads 'Product characteristics am imoortant in maintaining sales and for improving the markee. f) It was accepted that, without inhalation. no association between smoking and respiratory disease could reasonably be alled4e. In 1967 the corresponding statement was not agreed. 3. The general objectives of R & D were agreed to be:- a) to contribute to the continuation of the industry and to the profitability of the company. This insurance aspect of research remains important. fj) To enhance the technotouical base of the company, and soecifically to create a fram.-work for nroduct design. 0 To provide a scientific advisory service in its widest asoects. In order to do this in any comnany it is necessary to maintain an aooropriatc level of research work. d) To provide a contribution to the strategic planning and develop- went of the company and to do so if necessary beyond its tobacco interests. 4. a) The main function of R & 0 in an operating company must be to serve the immediate interests of that particular company. b) In the case of B-A.T. (UK), the main function of R 0 is to serve the Group and to assist, advise and encourage the R 0 function in any operating ccmpany. -S'. It was emhasised that the ne-.1 product develooment facility at J. 1. - Southamoton will not detract from the total Group research effort but will in fact comolement it. CO CO NJ 6. Two papers on Research Planning were discussed. The expansion of Cr% Research Planninq was seen as potentially valuable, and a number of 13 ATCO document for Province of BritiSh Columbia 9 November 1999 7. The application of technological forccasting was discussed, with special reference to the techniques of Delphi and morphological analysis. S. The increasino complexity of product development will require a re-appraisal of the various functions involved, such as Leaf. Blending, Analytical, Research & Development, 6tc., and better integration will be necessary. 9. No simple formula exists to decide on R & 0 expenditure but this should at least match that of the competition. 10. It vias recoqnised that R & D could and should provide_a source of recruitrwnt for other positions within the company. It was agreed that, if and when total cigarette consumption declined, great opportunities for supplying the demands of other socially acceptable habits could follaw. Discussion fol-lowed on those opportunitie:; which miaht arise. Amongst those discussed were a) chewing products, and b) viet snuff. It was felt that this whole area, much of which is already in the tobacco industry, should be examined more thoroughly. Particular attention should be Oven to buccal administration of nicotine and other physiologically active ingredients. At the same time. it was re-affirred that we would not contein -late the incorporation of nicotine in edible products. 12. The current position on artificial smoking materials (S14) was reviewed. in additien to those already familiar manufacturers, AMCEL, IDL and Courtaulds, it was stated that BASF are known to be interested and probably involved with Reentsma. 13. OAC7i E51) CO ~ CO .r-j CN rki BATCo document for Province of British Columbia 9 November 1999 14. The subject of composition disclosure, by AMCEL, was considered. The formal agreement proposed to B-A.T. for this purpose by A11CEL is cOmPlex, and in view of this, before any associated comnany required disclosure of composition. it would be helpful if Millbank were informed. 15. The grouo pclicy on the introduction 'of this type of material was noted; i.e., that we should be technically ready to move quickly in this area should it be decided to do so and it was re-affirr4d that no non-tobacco material would be used without a demonstrable advantage on health Qrounds over tobacco or reconstituted tobacco. 16. It now appears likely that AMICEL will build a full-scale plant, and the news of their interest in this field will probably break before the end of 1970. 17. The latest CYTREL variant is now under test at H.C.I., and also by d- Wynder. in both cases, results are expected to be publishe in 1972 (late) or early 1973. 18. Tile addition of nicotine to SH was considered, and it was recomicnded that nicotine ner se, should not be used inside any t6bacco factory. However, high nicotine content tobacco extract might be-added. So long as SI-11 remains a blend constituent, it would not be considered desirable for the supplier to include nicotine in the formulation. Nevertheless, for nurposes, of laboratory experirmntation under suitable controls, nicotine-containing materials offered by suooliers may be used. There are indications (from laboratory werkers who have been in contact with it) that the side-stream smoke of CYTREL is noticeably irritant and unpleasant. The unusual smoke particle size distribution noted in Southampton, on smoPing CYTREL. is potentially very important. CD 19. The Canadian situation with regard to reconstitution was outlined. The current biolocicd] testing programm information is not sufficiently cc far advanced to dravi a firm conclusion on the relative biolooical activity of PCL and PRT. I'levertheless, it is considered unlikely that PRT will or--ve to be more active biologically than PCL. BATCo document for Province of British Columbia 9 November 1999 20. B-A.T. will investigate the provision. possibly with Wig-gins-Teape, of a development/production unit for PRT as part of a much wider study aired at the provision of modified tobacco based smokino materials. This is based on the view that such materials will be used increasingly. beyond wasta utilization requircrents, in future snoking- products. 21. It was recoanised that the oolicy of excluding additives from PCL could now reasonably be modified to allo,.4 minor proportions of binders approved by the AGP. 22. It was noted with interest that German regulations currently oermit up to 201. sheet in the blend, and that the sheet itself irust contain in excess of 751. tobacco. ,3. Before reconstitution requires the developm,.nt of high nicotine gro-wths, we should, through research, appreciate the significance of any other alkaioids. 24. It was agreed that Canada could, with benefit to the Grcup explore growing tobaccos specifically developed for use in reconstitution, with particular reference to nicotine content. 25. Chemical and physical leaf properties are often identified by leaf buyers with a useful degree of accuracy, and Canada's oroposed investioa- tion of the approach adooted by ITG was vielcomed. 26. The question of research on leaf tobacco should be re-examined to see if opportunities for useful additional work do exist. 27. The present status of the ALT project in Australia was reviewed, and its application to a wider range of grades mentioned. Consumer reacticr. was mixed, and obviously blend-dependent. 28. R & D E reported that tests on the saffples of freeze dried tobacco available have so far shotin that in cigarettes: a) there is a reduction in the ratio of benzpyrene to TPH. b) there is a chancie in smke taste detectable by WOODROSE at 10 - 25% incorporation; lot-ter "imoact' and hicher "irritation" nere indicated. c) there is also sere indication of hot collapse, and the aroma chanoon ar- i-4-4 t,, I- Oc cc M-) 'IC BATCo document for Province of BritiSh Columbia 9 November 1999 6 - d) With 25. incorporation, -TPM delivery would be lowered appreciably. but the effect on the ratio 'of benzpyrene to TPH would not be important. 29. The position on the Reynolds puffed tobacco process was reported. The expansion achieved is about 90% with flue-cured lamina, and 65% with burley. 110t COllaDse is not noticeable at 101. incorporation. The position with re spect to fluorine residues is still unde; investigation. Whether the Group has all the FP1 ability it needs is not clear as there is a conflict between FP1 utilisation and the rate of combustion. The use of burn retardants can be envisaced, and the whole area is one where careful investication of all aspects should be continued. 30. Wit), the developmnt of lighter weight cir!arettes it would be desirable I I I to re-establish c--thods for measurina hot-collanse, and considering methods to reredy this. R & D E Southampton will be asked to under- take tJiis initially. 31. The patent position on pauer filters is now confused. This area will not be free of patents in the USA in 1971 as previously expected. An atterm-t will be cade to clarify the position in other countries. 32. Considerable progress has been made on water filters using the ice-ball technique. Develoorent work to production level ~aill continue at Southamoton. This offers an important contribution to selective filtration, particularly for vapour phase comporents. 33. It was noted that while Vantage is showing sor.Le success, Pinnacle with a similar filter (but reversed) has been withdrawn from the market. The Vantaqe (SCS) filter does not infringe the single-pass patent in the U.S.A., but it =-y do so else-.-here. Such a possibility should be examined by individual companies in countries such as Canada and the cc CO UK. Attention was drawn to the "hourglass" filter which is similar N-) but cheaper than the SCS filter. BATCo document for Province of BritiSh Columbia 9 November 1999 . . - 7 - 34. The Chc-::kp-rboard developrent was descri."-d up to the test market positim. As far- as can be judged at present, the swoke chemistry is similar to that obtained by other ventilation techniques, but this pzxticular appreach is considered to be an attractive develop- ment ard one wrhich may be taken further by modification of the filter. 35. Examin-m:ion of coupetition cigarettes an a constituent (e.g. extractable nicotire) per puff basis may enable brands to be grouped in such a way as to saggest gans in the market not revealed in a sinle connarison on a ';er cigarette" basis. This might be a useful. way to identify market-:5q opportuni ties. '5. The C=adian exercise in analysinq competition leaf buying laid the basis ---ar matchino a commetition blend. Intrinsically there is little new in this approach and the Canadian example was simplUied because of the ane product position of the comoetitor. '.ut it is considered worth-;&fle examining the possibility of handling more complex situations using rdvanced computer techniques. 37. It vias reported that, when the WOODROSE procedure was apDlied to Vantace and Winston, it nave similar profiles despite differences in filtr-a--ion efficiency, TN., and other smoke components. This rray sugges: that Reynolds are using a technioue similar to 1400DROSE and aiming at a common pattern in their products. 38. The pr:ftlem of assessing cor.=rcial brands of cigarettes could perhaus be overcome by employing the highly developed senses of the blind. This is being considered by the Canadian company. Another approach used in Australia and in Canada, lies in maskino the brands under test by over-tipping on the Manuela. _39. R. & D.E. will be requested to draw up for circulation a draft list of a13 relevant features for which new products should be checked, regarzTess of t~e primary aim of the particular development. The list W include, for example, puff-by-puff deliveries of various smoke constituents, spotting, and so on. 4 fl. Snnth.-=tnn am invPqtinatinn nval r iza rt, .1 tp CX:) CO rl-i BATCo document for Province of BritiSh Columbia 9 November 1999 41. There is an important prioblem in improving the flavor character- istics of low TPH cigarettes. This can be approached in two ways'; by cigarette design factors (e.g., ventilation and tobacco distri- bution), and by flavour factors. These flavour factors can be directly affected by the blend or by added flavourants. The contribution to be expected from R & 0 E Southampton, at least for a year or so,. is limited largely to design factors. It was reconnended that other laboratories should with some urgency investigate particularly the leaf and added flavourant aspects. In addition to attempts to provide the traditional flavour of hin.her TRI oroducts, entirelY new flavours should be developed both by leaf blend changes and by the use of added flavourants. 4 _ The reduction in Germany of TPII vields in the last eight years has more than comaensated for the rise in per capita consu;nrtion of cigarcttcs. 43% A general discussion was held on so-called tar diets. B-A.T. policy is that in those countries where league tables are proposed or published, they should be neither opposed nor supported. The industry should however press for the sensible classification of different types of smoking article, for example, small cigars. At present the effect of cigarette design factors on smoking behaviour is not knonn; this will be explored at Southampton. 44. The problem of small cigars in Canada was discussed with reference to the likelihood of TP14 publications. This was considered to be a problem for the Canadian industry. 45. Vapour phase masurements may well be called for in the U.S.A. in 1971. The constituents to be reasured will probably be carbon monoxide, hvdrogeg cyanide, and acrolein. The Horn report is exoected in 1970. 46. Responses ti a vapoUr phase situation include the water filter, Duolita and charcoal filters, and possibly zinc oxide or zinc acetate filters. Codinations of these and other filters, hicher porosity papers, and ventilation of both or either of the filter and the -iqarette are oth-r nn-;qihi1iti- BATCo document for Province of BritiSh Columbia 9 November 1999 47. The 1:.Z. odor/taint problem was discussed at lenoth, and samoles of taintcd cicarettes circulated. Comparable experience was recorded by several present: In Germany a similar taint had emanated from the foil-tissue. It was suggested that the odor was characteristic of mould on board. The meeting further agreed that odour tests on incoming materials should be recormnded to the group as a whole. Details of the German and SCL tests will be sent to R & D Millbank for circulation. 48. There was a general review of all the relevant work in the field of smoking and health. In view of some evidence that Schweitzer material may not necessarily conforn. precisely to the desired formulation, the product will be rigorously examined to ensure conformity with specification before incorporation in Janus Progranne. Schweitzer sheet will be madde, Janus Exoeriment 810 will be performed on the new basis, and Experiment B6/7 will be terminated at 120 weeks. The mrits of a synthetic control in the Janus programm will be considered further with a view to maintaining a continuing point of reference. 50. After a full discussion of all aspects of the procedures involved the Conference agreed that it should keep abreast of all develop- ments in the field of inhalation studies. It is not intended to enter this field at present, but as and when suitable techniques become available experi=ntal work will begin immediately. 51. The possibility that nicotine may be inmilicated in the aetiology of cardiovascular disease -was discussed; close attention will be paid to develoomnts at'Harrouate and Huntingdon. N10 cc 52. It was agreed that insufficient work is being done on those benefits perceived by the consumer, and that psychological and pharmacological studies should he initiated, both at industry and group level, to identify the consumers' needs. BATCo document for Province of BritiSh Columbia 9 November 1999 lu 53. It was aqreed that the possible involvement of inorganic fibres in lung disease should be kept under constant scrutiny- 54. The importance of cartoon monoxide was re-affirmed and it was suggested that carbon monox4de should be "monitored on a recular basis. Efforts to reduce carbon =noxide both by de!Ogn and by filtration, should continue, although success by the latter method seems unlikely. 5 S. Work should continte on the residues from Phostoxin treatment and the results of this work published if they appear to be sufficiently important. 56. A recomn-endation is to be made to Leaf Department (Mil lbank) that they should establish an appropriate working party including representatives from R & 0 to look into the efficacy of disinfestation procedures, with emphasis an their costs and safety. 57. R & D(Millbank) will list approved pesticides, and pesticide residue determinations will be performed ir. the most anoropriate Group laboratory. 58. It was reported fr3n Germany that the lavi was having a good effect in reducing pesticide residues, but infestation problems. were increasing as a result. Equal emphasis and imortance should be given on the one hand to-aards directing R 5 0 resources to satisfying those needs perceived by the smoker, and on the other towards providing cigarettes of lower bio- logical activity. 60. The study of smoking behavioural patterns could lead to the identifica- tion of market seg;znts, for which cigarettes could well be desioned. A possible approach would be the use of panels who conformed to that particular pattern. 61. The Conference viclcmxd the Martet Pesearch (Millbank) paper, and several of the poinzs made will be discussed and developed further in 11illbank. 00 co BATCo document for Province of BritiSh Columbia 9 November 1999 62. The irprovem-nt in Group procedures wiO respect to patents should be continuod. In addition to ihe circulation of inforration from Millbank, operatinq company R & 0 denartments should make themselves awara of patents Qranted and should scrutinise group patents to make sure that onoortunities are not overlooked. 63. The recent arranqement to circularise R & 0 departments with infor- nation fed into Millbank on approaches from outside inventors was welcoped, and some imnroverents suggested. 64. The use of the U.K. Provisional Patent system, and the rapid publication of patents in some countries appears on i~nurrjcr of occasions to have alerted cor.-vetitors and to have r.^sulted in the weakening of the B-A.T. patent structure. This will be dealt with by careful consideration at the Provisional stace. In future, all patentable inventions should be considered, with other potential li~ensors, in addition to tobacco manufacturers, in mind. It is Mely that the SCS filter was developed after the issue of the sinole-pass Datcnt. 65. It would be desirable to circulate throuqh R & 0 denartimnts actual samoles of innovations in Dackaging. 66. In addition to information conveyed throunh norrel channels, it would be helpful if chanqes in k 0 organisation were advised directly to the main R & 0 departments. 67. It is undesirable for the results of partially completed projects to be handed to visitors to laboratories. R & D product as a general rule should be conveyed only in formal reports through the apprcoriate channels. 68. As far as visitors from outside the G-A.T. Group are concerned soire CD clarification is required as to the release of detailed information %10 CO CC) on certain toAcs. DO fi9. When visits are made from one laboratory in the aroup to another, C:) R & 0, (Millbank) should be informed. BATCo document for Province of BritiSh Columbia 9 November 1999 70. It was agreed that this series of conferences had been cf great value the the conference had enlarged and an attempt was being made to cover too wide a span. It was decided that the next meeting should be restricted to the laboratory nanagers and would be in Germany, about February or March. The host company would provide the Chairman and the meetings would be attended by the Manager -- Research Planning (Dr. Fordyce). The object of the meting would be to plan in more detail the implenentation of the approved laboratory oroarar-res "in the light of Group policy and recormndaticns arising from Group R & D conferences. It is envisacied that less frequently there will be further Group conferences concerned entirely with Group R & D policy strategy. CD CO CO BATCo document for Province of British Columbia 9 November 1999