R A D Programme - Imperial Tobacco Limited GR & DC Programme Sheet I Smoking & Health A) Monitor scientific and medical literature relating to smo.king, and health. B) Maintain liaison with CTMC grantees and some Federal Department of Health grantees. C) Review and make recommendations regarding applications for CTMC grants. GR & DC-frequently consulted. Sheets 2 & 3 Biological Studies A) Use of microbial mutagenicity (Ames) test as modified for smoke condensates for the comparison of tobacco products, both experimental and commercial, and for the detection of potential mutagens and carcinogens in smoke. V B) Study the effect of tobacco smoke on drug metabolizing enzymes (up to present time - aryl hydrocarbon hydroxylase) in mammalian tissues. In future other enzyme systems will be examined. A study has now been startedofthe effect on :uch enzyme systems in pregnant rodents and their pups after exposure of the former to cigarette smoke. C) Study changes in permeability of bronchial eDithelium of rodents upon exposure to cigarette smoke using the horseradish perfusion technique. (Experimental work almost completed). *'ITL personnel on assignment to University Research teams which are sponsored by CTMC. 4 Filter Research A) Develop a charcoal filter compatible with Canadian Flue 6red cigarettes - see also no. 26 C(O Product Development. /2 cc Oc Lr BATCo document for Province of British Columbia 9 November 1999 -2- B) Determine the effect of Alkaline Filters on Canadian Flue Cured cigarettes. See also no. 26 C(b) Product Development. C) Evaluate HEE Filters supplied by GR & DC. See also 26 C(d) Product Development. D) Routine determination of optimum combinations of Filtration and Ventilation during-development of new products. See Sheet no. 26 - Product Development. E) Relationship of T & N & Pressure Drop Puff Profiles to subjective acceptability of low tar cigarettes. 5 Papqr & Tipping Research A) Determine the effect on smoke deliveries of a) paper additives - (types & level) b) paper furnish - (Flax, Esparto, Kenaf) 0 paper suppliers - Schweitzer, Ecusta, De Mauduit, Wattens B) Determination of the interaction of Tippings, Plugwraps Filters and assembly machinery on smoke Deliveries. C) Determination of the causes of variation in smoke deliveMes of ventilated cigarettes produced in regular commercial production. W Evaluation of Tippings. Papers, Filter lows and Plugwraps in order to qualify alternative suppliers. E) Comparison of macro & micro laser perforated tippings with electostatically & mechanically perforated tippings. F) Explore the possible advantages of the use of perforated cigarette papers in Canadian cigarettes. 6 Combustion studies - No work planned. 7 Total Product Design. A) Redesign of the computer programme used by Imperial Tobacco to predict the Physical Properties & Smoke deliveries of- CC) CO U-4 BATCo document for Province of British Columbia 9 November 1999 Canadian cigarettes. Factors to include, Crop Analysis Data, Filtration efficiency, Porosity of cigarette paper, type of % and quantity of paper additive, paper furnish, cigarette Pressure Drop, type of Tipping, type of Plugwrap, % Ventilation, Tobacco Filling Power, cuts/inch etc... B) Determination of the relationship between OW/P analyses of Canadian Tobacco and the classification of leaf as used by Leaf Blending. 8 Cigarette Design A) Expanded Tobacco - Programme depends on obtaining a supply of expanded Canadian Tobacco where the chemical constituents responsible for taste and satisfaction have been altered as little as possible. a) Explore the design of low tar (< 9 mg. tar) using expanded tobacco. b) Use of expanded tobacco to permit the substitut4on of Phosphate cigarette papers for Citrate cigarette papers. c) Economic exploitation of expanded tobacco. 9 Side stream - no work planned. Sheets 10 & 11 Smoke Retention Studies and Human Smoking Studies A) Study if and how smoking patterns change when smokers are presented with products in which ventflation, pressure drop, tar, nicotine etc. have been altered. Techniques used are puffing profiles, butt analyses, alveolar carbon monoxide. puff duplication. 12 Sensory & preference research - psychology - no work planned. ... /4 Z~H68601 BATCo document for Province of British Columbia 9 November 1999 -4- 13 Sensory & preference research Smoke assessment A) Development of techniques training of in plant panels for t~e assessment of taint in packaging materials using Jar tests. B) Training of new panellists in the"Expert Panel technique" used ir Imperial's Product Development. 14 Smoke Taste & Flavor Improvement. A) Assessment of tobacco enhancers & flavors from commercial flavor houses. B) Assessment of tobacco enhancers & flavors prepared by GR & DC Scuthampton. See also no. 26 C(c) - Product Development. 15 Leaf Studies A) Develop and assess new blend formulations using substitute tcbaccos to overcome low leaf inventories resulting from Blue ftld. damage to the Ontario Crop. B) Assessment of Blue Mould damaged leaf. C) P--present ITL's interests on various government agricultural research committees concerned with varieties, cultural practices, diseases such as blue mould, agricultural chemicals, harvesting and curing techniques. D) In collaboration with other Canadian companies, manufacture cigarettes and cigars from experiments conducted by government agriculture research stations and evaluate for physical, chemical and/or subjective characteristics. E) Assist in planning and evaluating ITL's experiments on modifying ciltural practices to achieve a riper. more flavourful flue- cured tobacco in Canada. 16 Microbiology - A) Activities resulting from Blue Mould damage to Ontario Flue Cured Crop. OH88601 BATCo document for Province of British Columbia 9 November 1999 -5- 17 Tobacco Processing - A) Evaluation & OptiMi2ation of Hauni KTC cutter for CRS A WTS in Quebec City Plant. Includes determination of the effect of cheese pressure & height, moisture content & stem thickness on Filling Power, cutslinch variation & quality. B) Evaluation & optimization of Dickenson CCM's in Quebec City and Guelph Plants. a) Initial evaluation - complete. b) Optimization - Effect of strengthing of components. - Reduction in bale density variation. - Reduction of particle size degradation. C) Evaluation of Hauni steaming & wetting tunnel W.D. a) Evaluation with CRS/WTS - efficiency of moisture addition - efficiency of heat transfer - effect on filling power. D) Optimization of WTS process a) Montreal Plant b) Quebec Plant E) ITM dryers/coolers a) Optimization of filling power improvement & moisture de control. Determination of the effect of temperature, time & moisture on the physical, chemical & subjective properties of tobacco. G) Improvement in the manufacturing process for Snuff. H) Process Control Improvement. a) Assessment of variability at each process step. b) Recommendation of improved control procedures & equipmcnt. c) Evaluation of Eastman Plasticizer Monitor on KDF-2/ Mini E-10 & KDF-2/AF-2 equipment. A cc cc BATCo document for Province of British Columbia 9 November 1999 -6- d) Determination of the factors responsible for an increase in cigarette end stability fall out in I.T.L. cigarettes. Investigation to include all steps from green leaf to packaged cigarettes. e) Computer based Process Control to reduce energy demand in PCL manufacture. f) Evaluation of R.I.D.I.P. instrument designed by Rupert International for the automatic measurement of indi- vidual weight, pressure drop and circumference of filter cigarettes. 9) Modification to ITL ventilation meter to measure leaks between tipping & paper in both ventilated & unventilated cigarettes. h) Evaluation of Filtrona Tape circumference gauge. i) Evaluation of Filtrona Automatic Pressure Drop instrument. j) Evaluation of Hauni on-line dilution monitor on MAX S. 18 Tcbacco expansion processes - no work planned. 19 Cigarette ventilation (on machine perforation) - no work planned. 20 Filter technology - A) Evaluation of new cigarette tows from Eastman & Canadian Celanese - (Eastman High Yield & Celanese Improved Yield). B) Determination of optimum D/F & T/D/F of new tows as required for new or modified cigarettes. 21 Expansion - Diet (Instalation of Diet Plant) - no work planned. CO CO BATCo document for Province of British Columbia 9 November 1999 22 Secondary automation (strategy 1) - no work planned. 23 Packaging - . A) Evaluation of new materials, printing processes alternative suppliers - continuous. B) Evaluation of lower cost alternatives for existing materials continuous. 0 Trouble shooting - continuous. 24 Product Quality Instrumentation See 17 H c) ie) M (9) (h) 0 01 25 Sample manufacture - A) Manufacturing of samples - continuous. 26 Product Development A) Modification of existing products to maintain or lower T & N deliveries - continuous. B) Modification of existing products to lower CO deliveries continuous. C) Design of new cigarettes to meet marketing requirements. a) To fill gaps in T/N delivery sequents on request. b) Project Viking - 9 mg. lovtT/N ratio cigarette. c) 9 mg. charcoal filtered cigarette. 8 CO CX:) CD LIJ Un BATCo document for Province of British Columbia 9 November 1999 -8- d) Level delivery cigarette - held pending the solving of problems with HEE filter. e) Project Gourmet - a flavored low tar cigarette. 27 Analytical methods development. A) Complete installation of method for simultaneous determination of nicotine and water in smoke by single GC injection. B) Evaluation of autoanalyzer method for determination of nicotine in cigar Smoke. Introduction of GR & DC's Cryogenic Head space analytical method for helping assess odour and taint problems. D) Adaptation of B & W's technique to measure coal retention of Canadian cigarettes. E) Introduction of an on-line automated data collection and processing system in Analytical Services Dept. First phase provides for collection of data related to smoke analyses for tar, nicotine, & CO and print-out of data in organized formats. 28 Analytical Services A) Provide routine analytical services for nicotine and sugar in tobacco, nicotine, tar and CO in cigarette smoke, and a number of physical measurements including filling power, firmness, ends stability, pressure drop, percent ventilation, etc. on own and opposition brands, product development samples, leaf purchase etc. B) Cigarette paper & tipping analysis - routine. 29 Mathematics & Statistics. GR & DC project sheet 29. No work planned. ..49 C=:) CO CO c::) U., BATCO document for Province of British Columbia 9 November 1999 -9- 30 Computing Services. N/A 31 Engineering Services. N/A /sbp I October 10, 1979 C=) c0 co C=D LIM L.1-4 BATCo document for Province of British Columbia 9 November 1999