GROUP RtD CONFERENCE HELD IN RIO DE JANEIRO 12 - 15 November 1985 Delegates: Messrs. E.A.A. Bruell (part-time) A.L. Heard (Chairman) Australia: P.M. Denton R.G. Nicholls Brazil: C.J.P. de Siqueira I. Pedro Canada: P.J. Dunn S.R. Massey Germany: E. Kausch E. Rittershaus U.S.A.: E.E. Kohnhorst U.K.: R. Binns R.S. Thornton (part-time) Miss A. Johnson (Millbank) I.G. Hacking (Millbank-part time) Aims 1. Agreement on Definition of Group Research Progr e 2. Agreement on a common set of Research Objectives 3. To initiate discussion on Priorities and Effort Allocation 4. Agreement on establishing a shared information system covering Projects, Reporting etc. 5. Agreement on future role and organisation of Conferences/ Technical Meetings C~:) I'D 00 BATCo document for Province of British Columbia I November 1999 2 - Research Rationale/ Objectives ALH presented a Research Rationale which makes a clear distinction between Product Research (to be done internally) and Smoking and Health Research (to be done externally) in future. Based on this rationale, a set of Research Objectives for the Group in the area of Product Research was proposed. They recognise the purpose of our research in relation to the demands of the consumer or of Regulatory Authorities. This rationale was accepted as a working basis by the Conference Members. The Research Objectives were also accepted following amendments and now read:- Response to Consumer Demand M Subjective Smoke Improvement: "To have the technology to enable Group Companies to achieve superiority over leading competitive brands and to be able to maintain smoke quality whilst responding to other probable restrictions. This will include the need for reliable methods of measuring consumer assessments." (ii) Subjective Cigarette Physical Parameters: "To identify consumer standards for performance and to be able to achieve these both efficiently and consistently whilst responding to other probable restrictions." (iii) Control of Smoke Levels/Smoke Components in Both Mainstream and Sidestream: "To ensure that the Group is technologically prepared to adapt products to respond to consumer requirements with respect to smoke levels and constituents without impairment of consumer acceptance in other respects." Uv) Cost Reduction: "To have the technological capability of being the lowest cost producer for corresponding styles of products in Group markets whilst maintaining quality standards." (v) Social Aspects: "To develop products which will reduce the social concern for smoking through modifications which are aimed at alleviation of 'nuisance' aspects." CX) BATCO document for Province of BritiSh Columbia 1 November 1999 (vi) Novelty/Distinctiveness: "To develop technology which enables the Group to introduce new products appropriate to identified market segments." (vii) Alternative Products: "To position the Group with appropriate technology in the event that alternative products to conventional cigarettes either become a significant threat to our business or constitute an appropriate diversification." (viii) Tobacco Agrotechnology: ** "To have the technology to allow maintenance and/or improvement of both tobacco quality and productivity in order to meet the needs of the leaf market and thereby the ultimate needs of the consumer." Response to Regulatory Authorities W Control of Principal Smoke Deliveries in Both Mainstream and Sidestream: "To ensure that the Group is technologically prepared to adapt products to meet standards imposed on the industry, without impairment of consumer acceptance." (ii) Control of Minor Smoke Components in Both Mainstream and Sidestream: "To ensure that the Group is technologically prepared to adapt products to meet standards imposed on the industry, without impairment of consumer acceptance." (iii) Performance Against Biological, Tar Quality or Composite Indices: "For those indices which have a high probability of being introduced, to acquire the technology to permit Group products to be optimally positioned." (iv) Legislative/Administrative Standards for New or Modified Materials or Processes: "To be aware of all legislative/administrative standards affecting present or proposed future Group products/ processes and to ensure that technology exists to enable these standards to be achieved." C:D This is an additional objective raised by Dr. Siqueira to cover 110 research which is leaf sales/usage oriented and was developed CO jointly between us subsequent to the Conference. BATCO document for Province of BritiSh Columbia I November 1999 4 - 2. Strategy on Smoking and Health Related Research The key objective is to determine the health consequences. if any, of smoking to the smoker. All relevant external research should be monitored and, if necessary, studies should be commissioned to supplement or clarify this research. In particular, it is necessary to monitor work in key scientific areas (notably in molecular biology) which might ultimately affect the tobacco business. Direct discussions with the Regulatory Authorities are possible in some countries and the above activities should enhance these discussions. While there was broad agreement with these proposals, a view was expressed that the implementation would be difficult due to limited availability of key personnel. Action It was agreed that a Scientific Advisory Group would be set up which would review work being carried out externally relevant to the smoking and health issue. Dr. Thornton will convene this Group, which would take advice from consultants. The function of the reviewing Group would be to identify and ensure that it is familiar with all external research which would be relevant to the health issue, to evaluate the quality of that research and any conclusions based upon it and, when in its view supplementary or clarifying work is required, to recommend the allocation of funds for that purpose. The Tobacco Group will be able to call upon the expertise and knowledge of the Advisory Group to assist in evaluating medical and scientific developments in establishing product development policy, and in formulating a position in discussions with Governments and in public debate. Each company must consider means of developing staff with appropriate skills to steer external programmes on Smoking and Health. 3. Tobacco Processing The Souza Cruz Research Programme has produced much basic information and is now focussing on the processing steps which offer maximum potential to influence the product. A specialist group from various CAC countries, under the leadership of Iran Pedro, will meet to maximise transfer of results to Operating Companies (thus ensuring the application of this work) and to set its future direction. -4 BATCo document for Province of British Columbia 1 November 1999 4. Leaf Projects (Brazil) Dr. Siqueira reviewed past work and then presented a suggested work programme in two main areas: - Genetic Engineering including possible transfer of low alkaloid genes to commercial Burley tobacco and the transfer of "flavour genes" to new flue-cured varieties. - The reduction of nitrosamine levels through the addition of reducing agents to growing tobacco or modification in the air- curing treatment. Delegates are asked to submit to Dr. Siqueira, by early 1986, any alternative/additional projects which they consider suitable for inclusion in a future Leaf Research Programme at Souza Cruz. 5. Leaf Projects (U.S.A.) The B&W contract with DNAP to produce high nicotine varieties is progressing well and promising subjective smoke performance has been noted. We must now resolve any problems arising through the current BAT Industries master agreement with NPI covering Latin America in order that this Project may be commercialised in Brazil. 6. Consumer Testing Techniques It was agreed that there is no requirement for techniques relating to market research to be part of the Group Research Programme. The Market Research Meeting held in Hamburg in September addressed this question; individual countries will depend upon the existing close relationship between their Product Developers and Market Research to ensure that latest techniques are being used. 7. Subjective Attributes: Smoke Quality Improvement B&W have a comprehensive high priority programme to explore means of improving smoking quality and now are concentrating their efforts on reconstituted materials, leaf/blend variations and ammonia treatments. So far only blend changes and EBR (Extracted Burley Stem based sheet) have been implemented in commercial products. All other developments are being tested in consumer trials. In the case of menthol, superior products in relation to traditional styles have been implemented in Kool and key competitive comparisons are in progress. BAT-CF have a parallel although smaller programme. A progress meeting will be held early in 1986 between B&W and BAT-CF to pool available information and to ensure maximum transfer of results which can be applied in the short term. Conclusions will be summarised Oc and circulated to the other R&D Centres. BATCo document for Province of British Columbia 1 November 1999 6 - The thrust behind both the U.S.A. and German programme is to achieve an advance over dompetitive products, guided initially by the character- istics of the existing important competitive brands. The Conference acknowledged the considerable B&W effort in this area. 8. Flavour Research The Group clearly recognises Germany and Brazil to be the centres of expertise in the broad area of flavour research. The German effort is now seen in the light of taste modifiers rather than simply flavour research recognising the separate contributions from volatiles, norr-volatiles and polymeric materials. Cocoa hulls, pectins and sulphur compounds are all showing considerable promise and several of these innovations have found application in our existing brands on the German market. The Brazilian flavour programme, by contrast, takes advantage of Souza Cruz expertise in, and access to leaf, and is substantially related to natural tobacco flavour e.g. Amarelinho. Curing experiments with Comum tobacco are being carried out to attempt to intensify natural flavours. Additionally, Souza Cruz is exploring the potential of fruit extracts for improvements to butt aroma, ambient smoke and smoking qualities of low grade tobaccos. All companies have received fruit extracts for assessment but so far Souza Cruz have had little response. This is now urgently needed. The ultimate rationalisation of subjective smoke character and various flavours (treatments) may emerge from chemo-sensory research now being expanded within B&W and for which BAT-CF have already established two projects. In the meanwhile, the other R&D Centres depend heavily on communication of findings. There is an established CAC group of flavourists that ensures coordination of the total flavour/taste modifier work through the flavourist workshop held on a regular basis. Discussions have already taken place during the visit of Dr. Galina (S.Cruz) to Hamburg to ensure that programmes are complementary and not duplicating effort. 9. New Product Design U.S. New Product Development is targetted short-term: - to develop improved Barclay products - to develop a superior quality, female specific, slim cigarette (Beta) - to develop an ultra-slim new product (Visa) C:D 1-0 CO BATCo document for Province of BritiSh Columbia 1 November 1999 The Barclay development as ACTRON PLUS delivers Img with grooves open and -C 6mg when blocked. The product is currently in test market. The Beta development has drawn heavily on the German experience with Kim and is achieving parity with Virginia Slim Lights in consumer testing. Visa is demanding a heavy development effort and is currently at the stage of Dupont testing against potential competition. Longer term B&W product see technology opportunities in: - Chemo-sennory Research aimed at a better understanding of the physiological/pharmacological action of smoke - Genetic Engineering Research on Leaf - Filter Developments Celanese: amine functionality to modify smoke chemistry Eastman: alternative tows/blends - Reduced sidestream - Reconstituted cigarette technology Kimberly-Clarkq aimed at exploring 100% reconstituted sheet material The common objective of these ideas is to improve smoke subjective character. However, the joint-venture with Celanese producing special tows capable of removing aldehydes may also offer an opportunity for Hamburg who wish to remove these materials in anticipation of regulatory requirements. The German initiative on Biotechnology based on plant cell cultures may offer opportunity for the introduction of new techniques for the product developer. A large scale fermentation plant at Ahrensburg will be in operation at the end of 1986. This will be the only plant of its kind in Germany. The experience gained from small scale systems will be used when the plant can be turned over for work on tobacco products. Current estimates are that material produced will have a high cost relative to tobacco. This will limit usage but such applications as the introduction of selected (unstable) flavours, nicotine, vitamins, caffeines by "entrapping" these in tobacco cells may offer new possibilities. Smokeless products may also offer an opportunity. The range of opportunities for using the new material is potentially very wide and some prioritisation is needed: BAT-CF are concentrating on: C=) 110 CO ON BATCo document for Province of British Columbia 1 November 1999 8 - 1) Vitamins (C & E) 2) Flavours 3) Smokeless products 10. New Product Discussion In future, product modifications of cigarettes will follow patterns established in the past. Changes will be introduced gradually either in response to market pressure or the availability of new techniques or regulations. Our Product Development must proceed in anticipation of such requirements. The new Scientific Advisory Group will indicate directions for product modification which will be implemented providing commercial support is obtained within the Group. We must be aware that external research on S&H issues may call for radical alteration to product i.e. a discontinuity in the general evolution of products. 1990's Products There was considerable discussion on the issues of radically changed or completely Alternative Products for the longer term. Although desirable, indeed essential, that we keep such possibilities in our thinking and review the situation regularly, it is not possible to set terms of reference for a project at present. The view was expressed was that in several of our areas of current or planned research (simple aerosol delivery system, chemo-sensory research, biotechnology) we have initiatives which at least offer base technology for radically changed products should these start to become more probable. 11. Human Smoking Behaviour Canada summarised the past work on Human Smoking Research and indicated the future directions being pursued at ITL. The major application of existing techniques is in the guidance of product development: important linkages between subjective judgements and smoking pattern are being pursued. With the exception of BATUKE R&D which has retained the techniques previously developed for the purpose of product development, no other R&D centre is pursuing human smoking studies. 12. Biological Research Canada presented a review of past studies (both internal and external) relating biological activity by various tests to cigarette design parameters. The thrust behind the future biological programme at ITL is in line with the Group Research Objective of having knowledge enabling products to be optimally positioned should Regulatory Authorities introduce a biological index. The Conference view is that the Ames Test is the most probable of such tests and thus forms the basis of CD c0 --J ---J BATCo document for Province of British Columbia 1 November 1999 9 the majority of this in-house programme. Opinions differ on the merit of including other biological test methods and it was concluded that the Scientific & Advisory Group should give direction on such issues. BAT-CF have already established a project to be able to position commercial projects against a biological index. 13. Product Physical Attributes Theoretical studies on physical attributes of tobacco particles have started in Southampton. There is good support for this revised research programme, particularly for Australia and Canada. The Australian work related to improved tobacco usage is recognised as the centre of B.A.T. expertise in this area. 14. Group Programme In total there are 606 projects distributed across the Research Programmes of individual companies, 153 of which are agreed to be of Croup interest, being either fundamental or applied research. For clarity the "Group Research Programme" comprises these latter projects. The total list will be designated "The Group Research, Development and Technical Programme" i.e. Group R. D and T Programme. In future, the scope of programme documents may extend to include process and engineering developments work which is not currently part of the research resource (for example, in B&W and Australia). It is now essential that within the Group we use agreed definitions of various research categories, not only in communications between scientists but in relating R&D to business activities and functions. Proposals for such definitions covering "exploratory", "fundamental", "applied research" and "technical support" were accepted with the provision that the "applied research" category was redefined as "applied research/ development". These definitions now read:- Exploratory Research: Scope: Free ranging experimentation. Timescale: Short. Output: New ideas/concepts. Fundamental or Basic Research: Scope: Knowledge seeking but unlike academic research is confined to subjects of business relevance. Timescale: Long. cc Output: Scientific Information. co BATCo document for Province of BritiSh Columbia 1 November 1999 10 - Applied Research/Development: S2 ye: Application of knowledge gained from fundamental research to highly-targeted goals. Timescale: Short-medium. Output: Products, processes or techniques. Technical Support: Scope: Use of available techniques to solve problems. Timescale: Short. output: Data, advice .... 15. Research Planning It was proposed and accepted by this Conference that a team formed from the Research Heads of individual companies and the Research Coordinator should constitute the Research Policy Group. Its function will be to review research activities and to guide the development and implementation of the Group Research Programme. It was agreed, however, that the process of deciding which projects are run in the individual R&D Centres is a local matter between the General Manager and the Research Director/VP who will convey the recommendations of the Research Policy Group. (Mr. Bruell, at the conclusion of the Conference, fully endorsed the formation and constitution of the Research Policy Group). The proposal to set up a Research Strategy Team for each major R&D Objective was not accepted, alternative mechanisms being preferred (see later). 16. Communication of Progress It was agreed that the level of reporting of progress and of final results must be raised, particularly from the larger R&D Centres. Attempts will be made to standardise format and style of all documentation. Six-mouthly Status Review Notes will be prepared where possible by business objective rather than technology. It was also agreed that a move towards pxoducing the final project reports based on the GR&DC style should be initiated in all the laboratories. 17. Staff Exchange There may be limited opportunities for exchange of staff between the laboratories. C:D I'D BATCo document for Province of BritiSh Columbia 1 November 1999 18. Development of Group R, D & T Programme information System The Conference agreed that the development of a computer-based information system, the initial usage of which was demonstrated in the meeting, was a high priority in view of the scope and complexity of the Group R. D and T programme, Delegates from each country were nominated to form an Information System Group and a meeting will be convened with minimum delay (Dee 85/Jan 86). Particular care will be needed to standardise format, language, classification of projects and allocation of effort. The Group must consider data security as a priority topic. The availability of such a data-base to provide management information e.g. on effort allocation across the Group by various project classifications was agreed to be an essential tool for the Research Policy Group. The Information System Group should also be responsible for bringing any written reports to a standardised format where possible. 19. Technical Specialist Meetings The Conference agreed that as we decentralise R&D it is increasingly essential that technical specialists from individual companies meet to exchange results and plan the detail of the research projects. In 1986, meetings were proposed as follows: Subject Host Country Suggested Timing 1) Flavourist Workshop Germany September/October 2) Tobacco Processing Brazil October 1st week + (chemistry, engineering, impact on product development) 3) Chemo-sensory attributes U.K. September nicotine in smoke 4) Product development U.S.A. March 5) Competitor Intelligence* Germany May/June Dr. Kausch will consider whether it is feasible to hold such a meeting and if so, will circulate its terms of reference. + Change of proposed date. 20. Future R&D Conferences C~o __4 This Group decided that the annual R&D Conference in future should be in two parts: A Technical Review lasting three days which will be attended by the RPG together with possibly two Senior Technical rQ CD BATCo document for Province of British Columbia 1 November 1999 12 - Managers from each R&D Centre and a RPG Meeting to follow, lasting two days. At the Research Conference, Smoking and Health research will be a regular feature and Dr. Thornton will be alloted probably half a day. It was agreed that his attendance throughout the whole of the Technical Meeting would be mutually beneficial. It is proposed to hold the next Research Conference in the first week of September '86, in Australia. An RPG Meeting may be held early in 1986, if the Scientific Advisory Group on Smoking Issues produces any comment or recommendation which needs early consideration or if the Information Systems Group has made sufficient progress for resource allocation/priorities to be considered. 21. Marketing As an innovation, a Marketing presentation was made to this Conference by I.G. Hacking. He outlined statistics for annual growth rates in world cigarette markets and indicated the areas of opportunity for BAT. The principal consumer needs identified at the 1984 Marlow Conf--erence were reviewed; they are basically unchanged and are covered in the new Research Objectives of the Group but it was noted that the Marlow decision to pursue a feminine style product looks far less certain for most countries, with the possible exception of U.S.A. In conclusion, the Conference believed that considerable progress was made towards meeting its initial aims, a view endorsed by Mr. E.A.A. Bruell in his closing remarks. He also supported the various initiatives recommended including the formation of a Scientific Advisory Group on smoking and health matters, but stressed that it should be small (6 or 7 people), its members carefully chosen and, above all, its terms of reference clearly defined from the beginning. (These will be circulated for clearance with individual C.E.O.s before the proposal is adopted). Mr. Bruell encouraged delegates to surface any problems immediately to the Co-ordinator, who should visit each Centre twice each year. He endorsed the need for more formal reporting of research and, recognising that there may be certain commercially confidential information, asked that the Co-ordinator should have total access and could advise on distribution. AL HEARD 3 RD DECLIGER 1985 Distribution: Mr. Mr. Mr. Dr. Dr. Dr. Dr. Dr. E.A.A.Bruell P.M.Denton R.G.Nicholls C.J.P.de Siqueira I.Pedro P.J.Dunn S.R.Massey E.Kausch Mr. E.Rittershaus Mr. E.E.Kohnhorst Dr. R.Binns Dr. R.E.Thornton Miss A.Johnson Mr. I.G.Hacking Mr. A.L.Heard (ZD 1 ~ co BATCo document for Province of British Columbia 1 November 1999