j. tis I I --A ii-j.' i.c:,n Ttpljacco Cc iiii I,;
tny Sut I L I I itill I) ton .
sh."DOX TO:
DR. S.3. GREV4 DR. D.G. 17.LTON
SITIMMARY OF JANUS LONG-TERM EXPERIMENTS
DATI.,
15. Q -I
DO Fluo-curod blend, no CRS. Control.
BI Puff volumes 10, 25 and 50 ml. Trend in results
indicates higher
activity for smaller puffs - but effect would be
masked on a
ciGarette basis by effect of puff volume on
condensate yield.
D2 US Blend - slightly less active than DO.
i3 100% PCL made from DO blend - significantly
less active than BO.
So far the lowest activity in any comDleted
experiment.
B4 50% DO lamina, 50S' CRS. Less' active than
130;probably same activity
as D2.
B.5 Repeat of BOr B2 and B3 at one dose level -
excellent repeatabilit)..
B5/triple = BO smoked at 3 puffs per minute, same
activity as BO.
B6/B7 Combined experiment investigating BO tobacco
(=B7) and ye-t
formentad DO (=B6) and effects of widzq of cut
(30, 6o, 12o cpi).
No effect of fermentation on activity. Probably no
effect due to
width of cut.
These experiments all terminatE~d and await
detail2d statistical analysi-4
,ising 'computer programmes. Suzimary quoted in
JANUS Progress Report of'
'.-Januar)-/April 1971. A further useful summary
in terr.. of standardised
extrapolated respons(r (S-ER) f- ~,O me dose la-1
onJv is pi-,-n iii 131'C
49 cument 200/9. The followinZ are in progress:
B8 (X-PCL-5 and 1-308)
B8-1 Control. Equivalent to B4.
B8-2 6o% X-PCL-5, 40% BS-1.
B8-3 100% X-PCL-5.
B8 _4 6o% 1-308 (Cytrel), 40% B8_1.
B8-5 100% 1-308.
B8-6 B8-1 with silica gel filter.
X-PGI-5 gives reduced activity, pro r-!Ia i-.-ith
percenTage content.
1-308 no clifference from 'but frreatly'red-t-d
cojId--at(- vield.
Sio fitter - increast~d activity over BS-1.
2 gal
r,nj (Gerlach process, ethanol -.xtraction)
- Continued On Ilext _,dioct
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0 DR. GRF 1-:N : JANTIS I,ONr,.-TIIRNI EXPEnrmENT
SUMMANY CONTiNI;I-::). PAI;E'
DS~_ ICon tro L .60% BO lamina, IjQ% CR5.
B9-2 B9-1 extracted with ethanol.
B9-3 As B10-2, but c:ztract returned.
B9-4 B9-1 M~Lde into Gerlach shect.
B9-5 B9-2 made into Gerlach sheet.
B9-6 B9-1 made into PCL, with Gerlach additives.
No interpretation yet possible.
B10 PCL and non-combustible filler.
BIO-I Control - as for B9-1.
BIO-2 100% PCL (Canadian) from B10-1.
BIO-3 25% NCF, 75% BIO-1.
Bio-6 5o% NcF, 5o,,~. Bio-1.
B10-5 50% CF, 50% DIO-1.
Ncr contains 12% SCNIC; CP contains 25% SCMC.
(B10-6 = remade B10-4)
No results vet.
B11 PCL vs. Schweitzer (LTHF) Sheet. Still in
planning stage.
MES'AGE SENT
15 SEP 1971
TME ...........
CD
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November 1999


190/6
LONG-TERM TESTS : LATEST RESULTS
EXPERIMENTS BO - B5. 252 MICE PER GROUP
N1, AP
P N PTI
Experiment BO 156 weeks
(CN102 lamina)
25 mg i 0 106 218 218
50 mg 0 177 493 493
75 mg 0 127 478 478
Experiment Bl 136 weeks
-------------
(puff volume)
10 M1 0 131 581 581
25 .1 0 !'~-2 324 .524
30 m! 0 1~8 475 475
Experiment_B2 160 weeks
- ---------- --
(U.S. blend)
25 mg 0 39 161 161
50 mg 0 183 444 1 444
75 mg 0 179 480 480
~jcp2rime t B3 152 weeks
(1-00% PCL)
25 mg 0 44 76 76
50 mg 0 141 281 281
75 mg 0 172 373 373
Experiment B4 124 weeks
-------------
(50% CRS)
25 mg 23 9%~ 68 125 138
50 mg 3~1% 162 375 38o
171
73 mg 0 4.39 439
Experiment-B5 124 weeks
(repeat)
BO 0 161 491 1 491
B2 0 190 523 523
B3 9 (4%)i 132 281 i 292
BO triple 0 172 536 1, !536
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BATCo document for Province of British Columbia 2
November 1999


EXPERIMENT B6,/B7 : 80 WEEKS. 84 MICE PER GROUP
N fl, P
~ PTI
H -
N H
B6-1
----- Yeast7j-E!.2j!5__22
-----
25 mg i 42 27 Z.- 420
50 mg 6 32 371 400
75 mg 2 8 223 230
B6-2 Y.
~2 ~:jr2ated 60
--------
cp'
----
25 mg 36 28 208 362
50 m 9 30 340 1 381
75 mg 7 18 269 293
B6-3
25 mg 53 18 122 330
50 mg 10 37 411 466
75 mg 7 29 286 422
B7-1
----- Control 30 cpi
--------------- i
25 mg 38 30 223 4o6
50 mg 6 40 516 555
75 -g 4
.31
412 4
.3
B7-2
----- Control 60 cpI
---------------
25 mg 42 26 179 358
50 mg 7 48 47? 514
75 mg 2 36 40.5 41.5
B7-3 Control 120 coi
25 mg 37 22 162 289
50 mg 9 49 1 4859 548
73 mg 8 38 420 464
EXPERIMENT B8 : 24 WEEKS
There is only one tumour-bearing animal in this
experiment.
CIA/SEW/1.1-1-3 CD
30 th April, 1970 -P-
BATCo document for Province of British Columbia 2
November 1999