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Code/
Researcher
7050
F.RF
M1111
I AN
T-7087
RLR
"PS
FPF
Project/objectives
Human S-nokinp Patterns as an
Alternative tri-Standard
I I." lt~l' I".. b
---
1. To find whether use of the
standard smoking regi-ne for bie-
assay work gives artificial,
elevated,levels of specific
activitv.
2. To find whether changes in
products to reduce tar deli-
verics are effe ~t ive in not-mal
human smoking.
3. To find whother combustion
controlling factor or factors,
eg. Puff velocity, affect the
specif*ic biological activity
of the snake.
Fortiftcacion of Vicotine in'S.1oi,
,,,e
Relative to its Tar Content
To increase the acceptable phvsio-
logical satisfaction of c.igarette
per unit of tar detivercd,
Particularly for low tar cl-~nr-
ettes. (see also projects T-64ni,
T-6533)
IR
Status
Plans f,,r
Ne Ou r:.:,r
A Tandherg tape recorder has heen
qi-ccssnii iv q n
SM01, hl'.
pattern generator for the Freiri
slave smoker.
A projzr
a"O CO ac!ileve
tile f-, helnq
orepared, prior to
recommenciflir. n
urchase
of the T3n,*err.
recorder to conniete
the smoking 7:!:ic'iine.
A data survey has Indicated that at From the
survcv,given
present PCL levels In blends, nod(- in Laboratir-,
!%-,crt
fications of sheet cannot be expected
No.ln4l-, n.,-.? ',,!I:lz
prepareJ, the -7~llovlng
to decrease tbe TPM/nicotine ratio of f reducinp.
the
the smoke frem the blends, tinless nico- wavl;
tine to added to tile abect. We are I
T]"Unirptin., r,!1.
studvLng the effects of additives to will be
cons!,!ored.
blends on deliveries'of t .otal and 1. Alkall
fil:ers
extractable nicotine and of TPm. should he rc-:j-~
d,
In otir tests sodium carbinaze is Si-%CV C 77
:-:"IC'~!


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R cs,:j r c li e r ProjectJobjectives,
9 Z6_7VTGT__
- 9
Stat'Is
the only one to date which dvcrcased
the TM/nicotine ratio, but thLs was
achieved hv a selective decrease in
T11M. The ,x(vnt of clwtwv 0%
extractable nicotine is affected
marked1v bv the mode of annlication
of the additive (syrintze Injection
of civarette, spraving of cut or
grants lated tobacco) Materials
which increased the extractable
nicotine are shown belour.
increase over that for the control,
given in brackets).
5% Nalcol (+2207)
3% NaiC03 (+120")
3% Urea (+90,1
37, CaO3102 (+1101,)
4 Z K citrate (+347)
27 tin aluninate (+Pr17')
Mien oxvnicotine wns added to tohac-
co, It gave nicotitte In the snoke
at a transfer rate of half thac
given 1)v normal nicacint. Thus.
additLon of 7.3" 6xvnicutine to a
.1 atinve blend increased the cirarcrte
Plans for
Next Ottarrer
this rat lo an-! inv"Val;c
the smoke's extract;qh1v
lovel
M Elw t-kiti'm
between nicotine fil-
tration and tvpc of
filter, it, prestirc
drop, and the tobiceo
tvPe is q1lizgested.
2. Non-polar extrac-
tion of tobacco to re-
duce TPII v[eid w4ll
be reexamined, to find
ways of minimising the
nicotine extraction.
(c.f. T-(t4nl). The
n1 cotfile may p"Ssihtv
be nd,!cd back v4a W:L.
3. The t%icot-n,- transfer
rates of diffcrent forms
of n1cot(tie fr.-7 ethanol
extracted tobacco -will
be rechaci-.ed aw! ex',,,n-
dC(! tL' Set- if thC
er nicotine transfer


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Code/ Plans for
Researcher Project/Objectives Status Next Qiiarter
nicotine delivery from 0.44 to holds when
extracted
0.96 mg/cigt. Old samples treated tobacco is only
a blend
with sodium silicate gave very constituent
(c.f.r-6401).
low extractable nicotine figures, It mav be
possible to
underlining the importance we change the p1l and
huf-
should attach to aging effects in fering capacttv
of the
additive studies. tobacco in other ways
At present the validity of our to increase
nicotine
extractable nicotine results Is transfer.
still unsure for low delivery 4. Nicotine will be
cigarettes, and checking of this added to PCL
until its
is In progress. TPH/ntcotine ratio is
lower than that from
lamina '(c.f.T-6535). A
reduction in TPM may
then be achieved b-,,
reducing the lanina
portion of the blend:
this would probablv
require increasinp. the
lamina filling power.
and reducing its btirn
rate.