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PROJECT EMN
Presentation by C. Warren and P.J. Dunn
Millbank 22nd April, 1986
Present: C. Warren I.T.L. Montreal
P.J. Dunn
R.E. Thornton BATCa.
A. Johnson
C.C. Greig
E.D. Massey B.A.T (U.K. & E) R&D
G. Smith
C. Warren and P.J. Dunn presented their thoughts
on project
EMN, which was to be repeated at R&D Hamburg,
prior to their
presentation to the IMASCO board.
The part given by Cliff is designed specifically
to be in
"laymans" terms, and tries to address a concern
that the
tobacco industry is not being as responsive to
comments on
the toxicology of its product as is, for instance,
the food
industry. It centres on the views and opinions of
outside
sources in relation to the constituents of smoke
and their
deliveries to the smoker, and how, in the long
term, the
industry should understand and seek to modify its
product in
order to reduce the specific activity of
cigarettes.
However, relying solely on the views of outsiders
may be
seen as a source of weakness in the current
proposals!
The part given by Pat was more specific and
addressed the
evidence of the effects of product design on
activity. While
admitting that some of this evidence was dated, it
was possible
to indicate certain ways forward where a more
modern apprdach
and suitable test systems could be bought to bear.
For example:
(a) To address more directly the problem of
'thresholds' and
position in the dose response curves of toxic
components
in tobacco smoke. The modification of these
interactions
as a result of the complexity of the
multicomponents of CD
cigarette smoke would also be probed.
(b) To investigate the interaction of genetic
pre-disposition,
CD
toxicity of lifestyles and tobacco smoking. GN
110
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BATCo document for Province of British Columbia 28
October 1999


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(c) The use of up-to-date technologies e.g. Plant
breeding
and bio-technology at all levels of product
preparation,
to design low activity products as defined in the
bioassay
system currently available. The 'nettle' of
possible
addition to tobacco of neutralising or protective
agents
for delivery to the customer would also be
tackled.
This is undoubtedly a major undertaking, and
therefore beyond
the current resources of IMASCO. The project would
require
the co-ordinated resources of BAT worldwide. Of
the four
areas propounded (p. 18 of green booklet) it could
be argued
that BAT cannot, and possibly should not, try to
attack all
simultaneously. Indeed, smoke chemistry and
bioassays are
part of the current Research Programme, though not
in the
depth propounded by EMN. It could be argued that
it is more
sensible to concentrate BAT's efforts into these
areas using
outside resources for epidemiology and mechanistic
studies.
To do so would, however, tend to mean that BAT had
no internal
effort in these latter areas.
In terms of future progress, rough estimates on
time scales
were available, in the region of 10-20 years,
whilst manpower
requirements were not yet under consideration. The
present
proposals are to obtain BAT's commitment as a
whole. The
co-ordination and planning phase to consider
deta-iled proposals
and effort allocation would be the next and most
profound
step of the project.
In our opinion, EMN is a worthwhile overall
objective which,
if even it were unable to sell more products,
might assist in
lengthening the product life-cycle and maintain
company
integrity within the legal framework of product
liability.
For the latter reason it deserves support, even if
this
support must necessarily be qualified in some
areas.
E.D. Massey
C.C. Greig
28 th April, 1986
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BATCo document for Province of BritiSh Columbia 28
October 1999