EXTRACTS FROM NOTES OF RESEARCH CONFERENCE MEETINGS CHAIRED BY DR. S.J. GREEN (In each case I understand that the other delegates present approved the notes). Januarv, 19~4 - Duck Kev, Florida i-~Of rasq4~r t0i~a4evel~ t s oinpames repre:sente, pment-in he vi~~o~ " t W-4-3- reii iii --?Td 1 The dec-:sion -.hat B-A. T. would not use non-tobacco =atarials without a demcnstrable advantage on health grounds has proved particularly effecti,,e in in-fluencing Amcel developments - and since I. T. L. at that tine concurred, probably in influenc4 ng the develo-)=ent of N. S.11W. The interpretation by R. & D. of "demoz~strable advantage" ivas a reduction in specific activity for smoke or condensate bv most or all relevant biological tests available. It is now recogrnised that the develooment of 7he non-tobacco materials and their pcssible "acceptance" by medical author-i-es may change the position. Also the non-tobacco materials may becorne cornrnerc:~_Ky very attractive on supply and orice arourds. It iE th-srefora p:-cpo:,e.,i that, althcugh reductior, in specific actvit, across 'he board would be most at,racti-;e and reduction in sp.ecif--X acIN~ItY 011 key tests desirable. in the absence of our-al'diffe rent e s, re pe.. - --cti6n LiCA&EVvity e P~ sufficien: f~r~`alternative smo rizterials, both tobacco an non-tobacco. /2... LD BATCo document for Province of BritiSh Columbia 4 November 1999 1976 - Montreal -The-lobacco Division Boa:rd planning papers-c tj2V'_-- cts, wer~k..Fe7iewq.~ljn_-6~~" QW~P&- SIX. jje . a Smoking a-nd Health b) Development of Products and Technology c) Production facilities It was felt that the following points had not been adequately covered:z. i) Although nicotine will be con sidered by some doctors to be less harmful than tar, there will be increasing recognition by some medical authorities that smoking is a nicotine dependent activity. This will, in part, condition attitudes to nicotine. ii) There will be an increasing tendency to associate specific smoke constituents with particular diseases. iii) Although medical authorities will continue to advise smokers not to inhale, they will not be inclined-to press for any specific developments such as products designed to limit inhalation. iv) Other than the sectors presently involved, the chemical industry is now expected to sit on the fence in relation to the introduction of new smoking materials. ICI and Celanese, on the other hand, are expected to seek avenues for a more agressive approach. v) Product modifications will be seen by the anti-smokers as an indication of increasing success, but a body of responsible practical doctors will recognise this as progress in the direction they desire. vi) In the foreseeable future, we shall be able to achieve, 'done.. with -garet.tes,: al da:17'~kn be- wl substit-utes fn- smokii7j -and.-health ?"S' ........... /3 .... CD 0 N BATCo document for Province of BritiSh Columbia 4 November 1999 vii) Although no sudden breakthrough is envisaged to solve the smoking and health problem, scientific research will give rise to products seen to be healthier by some authorities viii) There is a requirement for more work on the effects of smoking, in order that any benefits may be identified. This applies particularly in the social and psychological fields. ix) We must learn how to make ethical and sound health claims. ,x) More effort should be devoted to nicotine, its analogues and the identified iMDortant chemical substances in cigarette smoke. There is a good case for carrying out short term inhalation studies on nicotine for comT)arison with tobacco, and possibly for the development of very low nicotine cigar- ettes for the identified susceptible minority. xi) Consideration should be given to the problems arising from passive smoking. xii) It was felt that there was a need to pla-n activity in the following areas in order to meet with the requirements of the planning documents:- a) Clear and responsible statements on the case in favour of smoking b) Efforts to meet requirements for growing leaf with modified chemical composition c) Research generally into additives and flavours /4... BATCo document for Province of British Columbia 4 November 1999 Rio de Janeiro - 1977 ;here-.was unammous aqreeMenLthat the.!ieparatioq of. ;-is.kasse_,5rnent ya- t d . Aq;i;'!n - re consicferahle- ?Ld n. assessing risk were less competent to judge safety, indeed. in some circumstances they are eminently L-i a better position to do so. However, even when the same people both evaluate risk and judge safety, it makes for logical clarity and effectiveness to be aware of the difference in the functions. In discussion a particularly telling- point was made in regard to the present position of saccharin in the U.S.A. The application of the Delaney Amendment in effect means that safety is "decided" before the assessment ci A comparable separation of ffi:_nctions was seen between "the effects of smoke, on smokers" and the judgement of this as "benefits". While the effects could be determined objectively, the judgement as to whether.these were "beneficial" or not was a value judgement made bv zhe individual. It is therefore impossible'to decide in advance of a study whether the results will be a "benefit". rance should r:-;4~-,~14_ '-dt-waa wartTd that: the -bocik.-". Acceptable, &sk" by.W.W. LoV d: the, a~tenti6n_ of. q.6neral manag.ement,and consideratlon should to _~tl rn~l6:ttng,:'4'UpOqrtih c"ing.the conce2ts more widely g and 4wibli~ them generally adopted. L.C.F. BLACKMAN 18 th April, 1980. Z~b CD r111) CO- BATCo document for Province of BritiSh Columbia 4 November 1999