DR A F T
Research Policy Group Meeting
18-22 September 1989
Pan Pacific Hotel, Vancouver, Canada
Present: Mr. A.L. Heard RATCo.
Dr. R.E. Thornton BATCo.
Dr. R. Binns BATUXE
Dr. P.J. Dunn Imperial Tobacco
Dr. S.R. Massey Imperial Tobacco
Dr. E. Rittershaus BAT-CF
Dr. E. Kausch BAT-CF
Dr. J.S. Wigand B&W
Mr. G. McGregor WD & HO Wills
Dr. C.J.P. do Siqueira Souza Cruz
Guests: Mr. J.-L. Mercier, Imperial Tobacco,
Tuesday, September 19,
P.m.
Guest Speaker: Professor Jeffrey Idle, U.K.,
Wednesday, September 20, a.m.
Introftetion
ALH welcomed delegates to Vancouver, noting that
the circumstances of this
meeting were unique in view of the takeover bid.
It is even more important
that the strategic issues of R&D are addressed and
that we focus activities
accordingly. Delegates agreed that the aims of the
meeting should be as
follows:
To agree priorities for external S&H research.
To agree research response to probable regulatory
pressures.
To agree future coordination on regulatory issues
(residues,
additives).
To agree strategy for product innovation for
1990s.
To share current approaches to ETS and to identify
new
i,Otiatives, if any.
To review current status of Group R&D and to
identify
i=provements in coordination.
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Defensive Stratecies
Smokinq and Health
RET introduced the draft discussion document
"Smoking and Health: Future
Strategies for Research." This was a critical
review of the main smoking and
health work areas. After review, it was felt that
the Group's historical
concentration on detailed analysis of
epidemiological data (by various
consultants) had achieved most of the original
objectives, so that a reduction
in this direction now seems appropriate. It was
noted that the industry is
collectively funding substantial amounts of
research in the area of disease
mechanisms. Accordingly, it was recommended that
the few group research
projects related to mechanisms of smoking
associated diseases, should be phased
out in favour of research which would be more
obviously related to the
possibility of product modification based on
directions suggested by regulatory
authorities.
A key area identified for additional work was the
effects of nicotine. In
addition, work in the following areas was
considered to marit consideration:
possible identification of susceptible minorities,
confounding factors in heart
disease and environmental tobacco smoke and
examination of trends in various'
sub-types of lung cancer. However, it was also
accepted that some work in:
additional areas, such as epidemiology, would
still be required, particularly
in refuting unsound statements made by the critics
of the industry.
The current research projects supported by the
Group through the SRG were then
reviewed against the objectives described above;
for example projects by
Professor Idle and Dr. Hin&=ch addressed areas
identified above. Since the
SRG were meeting in October, RET was asked to
review existing projects and make
recommendations for work to meet the new
reqairements. In particular, S.R.G.
was requested to consider further work related to
nicotine, recommending
possible projects with cost estimates.
The financial commitments for the current SRG
projects were as follows:
E
1989 330,000
1990 294,000
1991 150,000
1992 71,000
1993 57,000
Assuming the existing level of funding, this would
allow now projects to be
phased in from 1990 onwards.
However, the probable requirement for additional
projects, e.g. nicotine
suggested a budget of E344,000 would be
appropriate for 1990.
Additives
Proposals for standardizing and coordinating the
Group approach to
additives were considered. The increasing trend
for regulatory authorities
to requi=e and to approve information on additives
used by the tobacco
industry 9.g. in Europe and in the U.S.A., made it
increasingly necessary
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to have a coordinated Group approach in th4s area.
Delegates were in
agreement that the evaluation of additives fall
within the area of
responsibility of the SRG. RET was asked to
produce a draft paper
clarifying working practice in this area and
reporting procedures, although
it was anticipated that clearance of
straightforward additives would
continue to be handled by the AGP and similar
Group committees. It was
also anticipated that the AGP would, in future,
check that recommendations
were implemented.
It was accepted that individual Group companies
would be working within
existing legislation, which might vary from
country to country, but that a
common approach to additives could now be
introduced.
in further discussions on the SRG activities, it
was confirmed that the
review of scientific literature would be carried
out within Millbank,
possibly augmented by specialists in Southampton.
Millbank staff would
also keep an updated data bank of external
research, funded directly, or
through manufacturers' associations of all Group
companies.
Given these changes in the role of SRG, Group
companies were asked to
reconsider their representation at the meetings.
Potential Imalications for Modification of
existinq Products
RET described the current work on DNA adducts
which had involved compounds
which were present in C4 garette smoke. Scientific
aspects of this work
would be monitored on an ongoing basis by the SRG.
Product Performance Requirements
RET reviewed the existing performance requirements
in Group manufacturing
countries. It was suggested in future that such
review should be extended
to include all markets in which the Group
operates. It was noted that the
requirements were most extensive in European
countries and the trend was
for them to increase in all.
Biological Testing
The work by RJR in support of Premier has set a
precedent for future
biological testing of tobacco products and this
may be reinforced by
U.S. requirements for additives testing.
Currently, RAT has under
development a range of bio-assay tests, but as yet
these are not
available on a large-scale routine basis. The aim
should be to
achieve at least a capability equivalent to the
U.S. National
Toxicology Programme (N.T.P.) "Routine" schedule.
A technical specialist meeting of Group experts
will be arranged
under JW to identify how this will be achieved in
BAT. This will
include consideration of automated test systems to
achieve rapid
throughput of samples.
To avoid any conflict of interest with other
tobacco companies
through sharing a common test house, it was
decided that BAT should
use the in-vivo toxicology facility for product
screening available
at Bio Research in Montreal.
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Smoke Chemistry
For future product and process developments, e.g.
Greendot, EPCOT, DEER,
and for the evaluation of additives, more precise
information on tobacco
and smoke chemistry is required. Data is needed on
pyrolysis and
interactions between smoke components and
adventitious chemicals. Our
research results generated internally must stand
up to external review.
A more detailed work plan and estimates of the
resources required need to
be defined and the meeting agreed that Mr. T.G.
Mitchell would be asked to
draft a position paper before final endorsement.
Proposals for Co-ordination on Aqrochemicals
includinq Residues Analysis
CJPS reviewed the present situation on legislation
affecting agrochemicals,
principally the U.S.A., Germany and Italy. It was
likely in the future
that restrictions on the use of agro-chemicals
would increase, for example
in the EEC, yet registration of new pesticides or
retrospective
registration of existing pesticides against new
regulations would be very
costly.
It was therefore recommended that there should be
a Group policy an
agro-chemicals and after discussion, delegates
agreed that this would
become the responsibility of the AGP and SRG, as
agreed earlier at the
meeting for additives. (See Annex: Agrochemicals).
it was noted that
Souza Cruz R&D Department has facilities for the
analysis of many
agrochamicals.
After discussion, it was further agreed that
CORESTA would not be an
appropriate forum for discussion of toxicological
testing of pesticides.
Specific Smoke Constituents (defined as "Other
Noxal' by Requlatorv
Authorities
Against the overall work programme for reducing
minor constituents of smoke
that are of regulatory concern, RB described three
possible goals:
1. Maintain a knowledge base on factors
influencing specific
constituents.
2. Provide background on the opportunities for
removing specific
constituents.
3. Develop products with reductions in specific
constituents.
The meeting unanimously agreed that the
Southampton work should
concentrate an I and 2 leaving 3 to the operating
companies.
Offensive strateQies
General Innovative Concepts: Flavours
CJPS described research in Brazil with respect
botli to natural and
synthetic tobacco flavours. The wide range of
products included
terpenic extracts, distillation and extraction of
natural products,
casings from tobacco dust and synthesis of
compounds. Facilities
existed for large scale production of such
materials at Suvalan and C~)
materials were already in major use in Brazil
itself, and Chile,
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Argentina and Australia were sampling.
Surprisingly, there was no other
Group usage. By contrast, there was strong
interest from the French and
Japanese monopolies. ALH asked all companies to
re-look into the possible
use of Suvalan flavo=s, casings, etc., in their
development work.
Environmentally- improved Products
Environmental issues represent one of the biggest
concerns of people in
Germany and in Europe as a whole. As a result,
various attacks on the
tobacco industry are possible besides perceived
health issues. These could
be based on water pollution, waste of
non-renewable material and the
accumulation of rubbish (e.g. filter). BATCF were
aimed at establishing a
competitive point of difference' in comparison to
competitors.
Biodegradable products represent one approach to
meet these concerns and
the current status of filters manufactured from
polyhydroxybutyric acid (in
conjunction with ICI) was described. 10%
biodegradation was claimed for
this filter after some months, but delegates
questioned whether this was
sufficiently fast to represent a marketing edge.
Tobacco Biotechnoloav - (Yoportunities
Brown & Williamson's programme for introducing now
varieties of nicotiana
were described. Both genetic breeding and the use
of molecular biology had
been used: there were advantages and disadvantages
with both techniques,
although molecular biology, with the possibility
for specific gene
identification, showed the greater potential. So
far the programme had
produced Y-1, a high nicotine flue-cured tobacco,
which was now being grown
in commercial quantities. However, there were same
problems in producing
in the U.S.A. and it was necessary to grow
off-share to maintain
proprietary control. Regulatory problems might
also occur with genetically
altered material.
Tobacco Biotechnolocy - Co-ordination
ALH described progress in the BAT Group in
biotechnology. Studies were
first carried out on new tobacco varieties by
BATCF during the period
1979-198S. In 1983, BAT Industries commenced
investment of venture capital
into plant biotechnology although with no emphasis
on tobacco. This
culminated in 1988 in the acquisition of ATC
laboratories at Cambridge, a
wholly owned subsidiary of BATCo., whose research
projects centered on
eucalyptus, potatoes, and tobacco. Currently this
programs is augmented
by work at Brown rx Williamson (already described)
and in Canada. Brazil is
assessing the potential for biotechnology. So far
the techniques and goals
are not overlapping but it was agreed that a
co-ordinating meeting would be
hold in late 1990.
Tobacco Extrusion
Tobacco extrusion to sheet using tobacco dust is
gaining wide interest in
the Group through Project DEER developed by
BATUKE, R&D. Capital running
costs are low with the possibility of an R.O.I. of
between 6-10 months.
Possibilities of adding flavourings and casings
and ammonia treatments,
immediately- prior to extrusion, are now being
investigated and submission
to the regulatory authorities in the United
Kingdom is in hand. BATCF also
outlined the successful commercialisation of their
extrusion process and
its development programme, with a capacity of
450kg/h. The physical
properties have been improved considerably,
including filling power. There
has been no effect on positive test
characteristics. The process has been
patented by BATCF. C)
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As a further develo-oment of the use of extrusion
technology, BATUY--- R&D is
actively pursuing Project EPCOT, aimed at
cigarette manufacture by direct
extrusion and wrapping. This greatly simplifies
the processing necessary
for cigarette production and good progress has
been made in Producing
products which behave like conventional
cigarettes. Fowever, regulatory
aspects of such products may need investigation.
Low Nicotine Ciaarettes
P.M. had introduced a low nicotine cigarette in
the U.S.A. EK reviewed
German experience in producing low nicotine
cigarettes which had originated
in the brand Auslese in the 1970s. Modern
technology (based on the use of
super-critical carbon dioxide and potassium
hydrogen citrate) could be used
to extract nicotine at 80% efficiency and was
possibly patentable as an
independent process to that already patented by
P.M. It was noted that
additional product advantages could arise from
n1cotine ext-raction
processes eg. nitrosmmines were reduced by up to
72%.
Delegates were not convinced that there was a
substantial market for such
products, but agreed the desirability of having
such tec:Mology available.
Both BF.W and BATC7 are developing products for
consumer research in 1990.
Ammonia Technoloqy
There was a widespread feeling that the success of
Marlboro is due to
ammonia treatment at some stage in the process.
Studies in Brown &
Williamson had indeed confirmed that ammonia
treatment of tobacco increased
consumer acceptance and current studies were aimed
at obtaining a better
understanding of the process and the processing
options. BATCF sees in the
exchange of ammonia and nicotine an important
element of ammonia
technology.
EMERGE is flexible and simple applications system
for ammonia. Its use in
current product development led to an increased
consumer preference with
noticeably stronger resemblance to Marlboro.
EMERGE is now being used in
an increasing number of brands for both the
domestic and the foreign
markets.
B&W Export is interested in EMERGE for those
countries where DAP cannot be
used.
Oblectives for Product Innovation
ALM introduced this topic with a review of
opportunities in what was
largely a diminishing market. The major
international companies were
competing in this arena with minor product
innovations, but there were a
large number of former smokers who were potential
customers, if some of the
health issues that concern them could be
addressed. Concepts in the Group,
such as project EMN, addressed these issues and
R.J. Reynolds had attempted
a revolutionary solution with Premier. Favor was
an even more extreme
response but for various reasons, both products
had failed in the market
place. Premier, in particular, had extremely low
biological activity and
Sidestr:am it was unsmokeable, overtly
technologicall and In reaching too
far, wa challenged as being a cigarette.
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ALF proposed a strategy for product innovation
that responded to the
neqa,:_*Ve perceptions of regulators and
consumers. Dialogue with regulators
is of great importance if the product modification
route is to be kept
open.
In consideration of external evaluation of
evolutionary products, delegates
noted that approval by regulatory authorities was
mandatory in several
cc=r_-ies, notably in Europe. R.J. Reynolds had
attempted to solve a
potential problem in the United States by the
formation of a panel which,
however, had only commented an the quality
of'methods (rather than the
S, 9:Lificance of the results), and this had not
prevented a hostile reaction
to '-'is product. Indeed RJR had claimed that one
lesson learned from the
Pre=i,er exercise was the hostility of
anti-smoking authorities to a product
which met criteria that they had themselves
suggested.
Delegates agreed that, where possible, we should
talk to regulators an the
bas--s that they should accept the wishes to
smokers to continue to smoke
but with products that they have an opportunity to
influence. Such
d1 scussions were ongoing in the United Kingdom
and in Germany and it was
agreed that it should be part of the Group
strategy to expand the scope of
such discussions wherever possible.
Based on lessons learned from the failure of
Premier and Favor (both of
wh--&. attempted to make a huge leap in product
modification) it was
proposed that BAT pursue an evolutionary route to
a Premier-like product by
year 2000. Our approach will be responsive to
regulatory concern and will
be founded upon delivery reduction, 9.9. it will
gradually reduce tar/nic,
biological activity, 'other Noxal , CO and
sidestream but avoiding overtly
technological product designs. Paramount will be
the requirement of
retaining consumer satisfaction in taste and
flavour terms.
Nicotine is seen as key to our evolving products
and the meeting agreed to
taking steps to establish proposed further
nicotine-related projects (SRG
projects will reflect this).
The broad aims of the Product Innovation Strategy
were agreed and our
cu_-_-ent new product technology portfolio
(Greendot (I-111), Day, Coaxial
and Neva) was considered appropriate to realising
the. aims of this prop_osed
strategy. JW asked that ignition propensity be
included in the overall
I=ovation Strategy.
New Proiect Guidelines
C=:pany guidelines for novel products were
proposed. In the context of
nicotine members agreed that products should not
increase toxic potential,
as compared to existing products and that this
point should be incorporated
into the final version of any such guidelines
which would also address
issues such as the requirements for toxicological
evaluation.
Review of Proiect Greendot
R3 described. progress on Project Greendot, noting
that there was to be a
meeting between technical and marketing functions
in Southampton (luring
october 1989. Research had shown that tar and
nicotine deliveries of 1 mg
each could be obtained, albeit with approaches not
all of which are likely
to receive clearance by regulators. Current work
was focused on three
targets as follows: 1, Nicotine 0.4 - 0.7 mg, Tar
6-7 mg: 2, Nicotine C__
0.-1-0.6 mg, Tar 6 mg: 3, Nicotine 0.4-0.5 mg, Tar
5 mg.
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It was to be noted that options 2 and 3 would
probably require the use of
sheet, of which 90 prototypes bad been made so
far.
RB br--efly introduced Projects NATO and WARSAW,
both sub-projects of
Greendot. NATO is a short-term project
incorporating into products a high
inclusion of expanded tobacco. Targets were 4 mg
tar, 0.6 mg nicotine and
1-1.5mg glycerol. Targets for WARSAW were similar
but with greater options
on product design. The current prototype had met
most objectives (tar,
nicotine, taste and conventionality) and had
produced substantial reduction
in specific mutagenic activity as defined by the
Ames test, although much
of t!ie reduction is attributable to glycerol
dilution. In terms of
approaches to regulatory authorities, there was
considerable discussion on
likely requirements for the specific biological
activity of products In
which the smoke was diluted with glycerol (even if
it met existing
requirements as to the amount of glycerol).
Delegates agreed that the
specif4c activity of the condensate from any
product should not exceed that
of a reference cigarette when allowance is made
for the dilution factor
arising from the use of glycerol.
A recent study on glycerol inhalation toxicology
by Battelle conducted for
the U.S. manufacturers has produced a confusing
result due to poor
exper!mental design. JW will pursue this topic
with the other U.S.
companies with a view to a further study. If high
levels of glycerol are
not acceptable to regulatory authorities, other
materials might be needed
to support nicotine in an aerosol, it being felt
that glycerol had no
unique properties per as.
It was agreed that RET would seek external
opinions on any work necessary
to validate the properties of smoke containing
increased levels of
humactants.
The meeting agreed that in Greendot 2+3 steps are
taken to reduce the
specific biological activity of the tar by use of
'Other Noxal or DAY
technology.
in discussion, delegates agreed that work related
to "all synthetic"
product options should be transferred to project
Nova which is concerned
with materials technology.
Prolect Day
SRH described progress on Project Day. Low
biological activity had been
obtained for products made from Gerlach sheet (a
process in which methylene
chloride is used to extract tobacco). Further work
had been aimed at
removal of major precursors of smoke components by
the use of solvents more
polar than methylene chloride. Target precursors
included steroids and
polyphenols. The use of proteases to further
reduce deliveries of target
smoke components was also under way. SRH stressed
the importance of human
nw*ting behaviour studies in evaluating prototypes
and illpstrated some
work in progress. It was also agreed that elements
of the Day programs,
as it developed, be built into the Greendot
programme. ITL will also
investigate -smoking behaviour on Greendot
prototypes.
C3
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Proiect Coax
This was introduced by BY--- The technology all
the coaxial cigatette, which
had been patented, offers opportunities in meeting
consumers' attitudes
towards cigarette development. Through the
combination of a coaxial rod
and filter and with different materials for the
care and periphery, the
smoke from which can be filtered differently, a
very flexible approach is
available. Work has concentrated on the effects of
different densities and
on sheet materials for the inner wrapper. Results
to date show potential
in the regulation of specific smoke components and
in reducing biological
activity. Such cigarettes also have low ignition
propensity, a feature of
increasing importance in North America.
Airbus
JW briefly described the problems associated with
Project Airbus during the
one-year period in which work was carried out and
confirmed that the need
for basic research had been highlighted, this is
now undertaken at
Southampton as Project Nova. The Project A.1ebus
itself had been terminated
because it was technologically impossible to
construct acceptable =Ving
furnace devices. After considerable debate it was
resolved that the tex-ms
of reference of Nova should be re-written to
ensure that they embrace
technology but not product goals. It is probable
that B&W would pursue the
product work once basic research has shown
di-rections.
Environmental Tobacco Smoke (ETS)
The current position on ETS in the countries
represented was summarised.
In all countries, the position was worsening with
regard to the
introduction of legislation controlling smoking,
for example in Public
buildings or on aeroplanes. Extreme cases included
the 11tyranny" of one
concept applicable in Toronto and the position in
Now York City where
smoking areas were getting vanishingly small,
necessitating people to smoke
outdoors. In the U.S.A., pressure did increase
after the recent E.P.A.
study which had ascribed a large element of
sick-building-syndrome to ETS,
rather than to poor ventilation, etc. as shown by
other studies. only in
Brazil was the situation less developed and
undoubtedly, the situation
there would tend to worsen. In Australia, the
issue was the subject of
-c centered an a misleading advertising claim by
the
litigat, n originally
Australian T.I. (based on a study by P.N. Lee) but
which now centered on
the opponents having the onus "to prove the
scientific care" against ZTS.
This case is likely to come to trial in spring
1990.
Group strategies against these pressures were
discussed. Strategies for
using scientific informtion externally had been
suggested by BATCo. in the
document "ETS - Improving the Quality of Public
Debate". Delegates were
asked to keep Dr. Boyse of Millbank informed on
the use of the document and
on any problem encountered. CJPS stated that the
associated document "ETS
- The Science" had already been translated into
Portuguese. Much
re-analysis of epidemiological data had already
been carried out and this
area now seems capable of generating diminishing
returns. In any event,
P.M. were -now very active in this area. Residual
epidemiological studies
would have a greater emphasis on studying
confounding factors which could
explain some of the weak associations claimed.
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Delegates agreed that high quality Internal work
was also required, for
example in refuting unwarranted external claims on
levels of smoke
components in ambient air, or to support external
projects. Knowledge of
smoke chemicals was usually greatest within the
industry.
A key objectve of the current Group research
programme on ETS being carried
out in Southampton had been defining levels of ETS
constituents in real
life situations. Environments included betting
shops, offices in air
conditioned buildings, train compartments, buses
and private homes. Six
papers had been published, three were in
preparation and presentations had
been made at seven international conferences. A
brief account of the work
had been given on British television, in a
programme addressing the issues
of ETS. BATCo. is also producing a video on ETS.
It was now proposed to extend this work by means
of a survey of 500
non-smoking women (who would wear a personal
monitor for 24 hours) together
with two subsidiary studies. After discussion,
delegates recommended that
a study of this size would be best carried out
externally (albeit with
advice from Dr. Proctor) and a possible venue was
the Gage Institute at the
University of Toronto. This would be investigated
together with the
possibility of industry rather than Group funding.
However, in view of the
complexities of this area, it was agreed that Dr.
Proctor would be asked to
convene a Group meeting, to be held in Canada in
November 1989, to propose
a programme for external ETS research showing
projects broken down by topic
and location.
Strateav for Low Sidestream
PJD described work in Canada focused an a low
sidestream product. Consumer
research suggested a poor demand for a low
sidestream product but after
discussion, delegates agreed that there was
probably sufficient potential
demand to support a research effort. In any event,
P.M. had marketed a
reasonably acceptable low sidestream ultra-slim
(double-wrapped) product
with explicit claims as to the extent of
reduction. The success or
otherwise, of the cigarette in the marketplace
would indicate the real
demand - as opposed to views based on market
research for such products.
BATUKE R&D had developed a strong patent portfolio
around low sidestream
products and through a joint collaboration with do
Mauduit have achieved a
product with good taste and ash character. This is
to be consumer tested.
EX noted that substantial reductions in sidestream
deliveries could be
achieved by alterations to the paper making
process rather than by
incorporating additives into the paper and will
keep the Group informed of
this very interesting new initiative.
Genetic Pre-disposition
Professor J. Idle addressed the meeting on the
subject of genetic
pro-disposition.
orqanisation and Co-ordination of R&D in Group
ALE reviewed the resource allocation within the
current and proposed total
Group research programme which was based on
approximately 403 professional
staff in the Group (equivalent to UK grade 5 and
above). It was stressed
that quality of this management data is determined
by tightness of
definition of project descriptors and by the care
used in defining C)
(_-4
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11
-il----'Vidual projects. The proportion of
Fundamental work will a-rop, slightly
1989 to 1990 mainly due to the transfer of
Greendot as kpplied. The
c===apt of Exploratory Research covering the more
empirical innovative
research was re-introduced (from 198S) and an
estimate for 1990 shows that
a:-7---cximately 10% of total effort falls in this
category. Companies will
be asked to refine this estimate.
cf projects described as for Group benefit (rather
than for a specific
rating company) 50% are done by Southampton and
25% by Souza Cruz.
1989, Wills will not be shown in the Group R&D
programme.
T'- e total cost of Group Fundamental Research at
Southampton (plus Greendot
end- Nova) will exceed 1989 only by inflation.
Contributiors by the four
C;~C contributors are recommended as follows (with
BATCo. accepting the
-f==er 7% paid by Wills):
BATCo. 32%
Brxw 30%
ITL 19%
BATCF 19%
=-e content of the Fundamental Programme
(attached) was agreed, subject to
refLiament in detail. The funding requirement is
in line with individual
=pany expectations.
regard to the SRG funding, the minimum commit- nt
for 1990 was
.4,000 but as the SRG had been asked to recommend
additional projects,
--e minimum budget proposed was E344,000 which
BATCo. managa=ent recommend
s~iculd be divided equally amongst the four
contributors (S86,000). This
was agreed.
=-e meeting agreed future Technical and
Specialists meetings according to
I
.~:e following schedule.
Product Testin Southam
ton Dec 89
g p
2. ETSExternal Programme Canada Nov 89
Biological Methodology U.S.A. I Q 90
4. Flavour Ma--
Ct (ag-reed 1988)
Product Development incl.
ammonia technology, filters U.S.A. Mid 90
sidestream, etc.
6. Tobacco Biotech Europe 4 Q 90
-
SRG Copenhagen oc~ 89
Canada Apr 90
Fundamental Research Review Southampton Maz 90
(incl. Coresta position)
RPG Germany .1un qO
BATCo document for Province of BritiSh Columbia 27
October 1999


- 12 -
Del eca~as also discussed the need for better
coordination of BAT delegates
to ;r=--'zations such as CORESTA, where for
instance, P.M. had a very well
organ;--ad presence. it was agreed that this was
best done by RPG members
giving clear instructions to the participating
members from their cc=any.
Guide* ---es would be agreed at the Southampton
Review in March 1990.
The =ex-- meeting of the RPG was arranged for June
1990 with the venue
Hac~r.ur:-, Germany.
The =as-:--ng concluded with a critique of its
activities and a vote of
tha;-ks = the Canadian host.
AT:-: / A:Z-
28 Sev:.~er 1989
BATCo document for Province of British Columbia 27
October 1999