Kii~~
BALT (U.K. and Export) Limited
RESEARCH & OEVELOPMENT CENTRE
50 VTH-ON ENGLAND
TO Mr. A.L. Heard FROM I.C. Brown
Corporate R&D
Millbank
SE~RET
REF ICB/PMW/ DATE 16th August 1988
NT^,OTINE ADDITION IN GREENDOT PRODUCTS
Thank you for your note of 22nd July. I share your
concern regarding the possible regulatory and
legislative
constraints on the incorporation of nicotine salts
into
tobacco reconstituted or synthetic, non-tobacco
materials.
In order fully to address this important issue, I
shall
set out the current short-term technical
objectives of the
GREENDOT team and'the reasoning behind our present
technical
options.
In the four months of the project to date, we have
been
carrying out a range of experimental studies to
gain the
information we require to select our most
promising technical
approaches to the GREENDOT objectives. In terms of
the
original objectives, we are seeking ways to
produce a highly
modified tar delivery in terms of dose,
composition and
quality. Our work has led us to define three broad
technical
options to meez this objective. We are pursuing
these in
order to produce our best prototype examples of
each option by
the end of the year (best, I hasten to add, in
terms of
quantitative delivery and smoke composition,
rather than
smoking qualiti).
Technical Options
A. All tobacco
The prolect proposal is to construct the
ultimately
modified delivery product using 100% tobacco
materials.
The purmose of this project is to ascertain how
far we
can progress to meeting the GREENDOT objectives
using
only tobacco. As we have little chance of meeting
the
numerical 1.0/0.8 ratio, the emphasis is on
achieving
modified delivery in terms of tar quality and Qom-
position. The Canadians in Project DAY are using
the
exhaustive extraction/add back route.
In CREENDOT we are looking at tobacco materials
which
give a low tar potential (treated or extracted
tobaccos), blended with relatively small
quantities of
high n-ic.otine-containing lamina (we have
examples of
Y1, fire cured, Burley and Rustics, for this). In
the
short term, we are aiming at a tobacco rod which
will
give an overall delivery profile of 0.6-0.8 mg
nicotine,
2-3 mg water, 2-3 mg glycerol and 3-5 mg PMWNGF.
Un
BATCo document for Province of BritiSh Columbia 27
October 1999


-2-
This prototype will have a tar/nicotine ratio of
approximately 5:1, should have significantly
reduced
biological activity as measured by AMES activity,
and
reasonable sensory smoking properties. The
advantages
of this option are that it will be non-infringing
(patents), non-contentious from legislative or
regulatory constraints and a very useful starting
material for cigarette design research (as well as
a
suitable vehicle for flavour formulation work).
B. All Synthetic
In the first months of the project we have learnt
a
great deal about the behaviour of smoke enhancers
such
as glycerol as well as nicotine transfer and
incorporation
from our work on synthetic sheet materials. We
have in
the last month been able to fabricate a prototype
product
which will deliver 4-6 mg TPM of which 2-3 mg is
water, 2-
3 mg is glycerol, 0.4-0.6 mg is nicotine and
0.1-0.5 mg is
unindentified condensate. These prototypes have
been A14ES
tested and show no detectable activity. The
nicotine in
such material has been added as a complex with
alginate.
For pragmatic reasons of speed and simplicity, we
are
using "bought" nicotine from chemical suppliers.
P.C.
Bevan is, however, investigating nicotine recovery
routes
as part of his tobacco extraction studies.
We are not suggesting at this early stage in the
project
that this is our major technical option; rather we
are
using it as a learning exercise for understanding
the
mechanisms of generation and control of smoke
components.
This work has, however, allowed us in a relatively
short
time to achieve and even "better" our GREENDOT
technical objectives in terms of delivery, smoke
composition and ntar" quality.
As a product optionj however, it may be highly
contentious with regard to regulatory or
legislative
constraints.
C. Synthetic/Tobacco
The objective of this option is to utilize the
knowledge
gained from the other two options to pursue a more
pragmatic approach to innovative product design.
We
are investigating the use of combinations of
tobacco
and non-tobacco materials to meet our smoke
delivery
and quality targets. We are using sheet materials
with
indigenous nicotine as well as "added" nicotine to
give
prototypes covering a range of deliveries.
Once we have the technical ability to manufacture
reasonable quantities of materials, we shall place
more
effort into the product design and sensory aspect
of
prototype products. Hopefully the infbrmation from
the
market research and concept testing will help in
guiding
our proposed product definitions. C:)
Qrl
00
BATCo document for Province of British Columbia 27
October 1999


-3-
I hope this gives a clearer picture of the
technical
options we are currently taking in Project
GREENDOT and
demonstrates that we are not relying solely on
nicotine from a
bottle to provide the required levels in our
prototype
products.
We are hoping to provide four prototype products,
which will cover the range of technical options
outlined above,
for the RPG Meeting in September.
I.G. BROWN
cc: Dr. R. Binns
CD
Ln
VI
BATCo document for Province of l3ritiSh Columbia
27 October 1999


Part 1
GROUP-FUNDED WCn< IN R&DC
Progress will be described under Work Areas given
in the Work Prog-e or
formulated at the March Review Meeting. 1his will
not be a Sect ion-by-Section
Review.
Time
(minutes)
0900-0905 Introduction - Project areas foll=wing
the March Review kAB 5
`00~
0905-0935 Smoke Oualitv Prod,.:ct Freshness D PR
10
Elut--*.n KjHM 20
0935-1020 Cicarette Phvaical Oualitv Water/solvent
loss :AW 20
Particle si.e/density studies NB 15
Combt:stion control PDC 10
PRODUCT R-- SEARCH FOR P~GULATORY AUTHOR ITY
ISSUES
1020-1110 Passive Smokina Issues Total 3idestream
reduction ?!)C 2 0
ETS CjF/NDW 3 0
1110-1240 Reduction of 'Other Noxae" Introduction
WDEI
'
Nit-samine research DAM 0
General reduction ?LLP is
Reduc--ion by enzymes DM 15
Ames, activity and .,:..L/F.DM 20
smoke chemistry
Pyro_-r3is studies "KDEI 10
Analytical development GAr 15-
A
1400-1414 Fire Safe Ciaarette
_?R
__?R is
1415-1445 Alternative Bioassavs in vizzo bioa3says
__:~M
Z:~_ 15
15
In v_-vo, genotoxic activity
G _3
G-3)
1 15
5
Smoke toxicology research
1445-1455 Tobacco & Smoke Database 7=
.-M/GAF
10
Part 2
OTHER WORK IN PFSEARCH DEPARTIArNT
1455-1520 Comvutincr GRP database and current BMW
e: al 25
projects
1520-1545 Library Progress in Central Records Ar
is
& Information Services Spectrum of LIS users 7a 10
1545-end Non Groun-Funded Proiects A/MG? 7 __M 15
Radicactivity in tobacco DPR 15
Nitrcsamines in snuff D;L4 15
C-)
.CN
BATCo document for Province of British Columbia 27
October 1999