.5 c SECRET SOUZA CRUZ GROUP TRANSDERIVIAL NICOTINE MAY 29th, 1992 Despite technology for transdermal administration of ethical I? harmaceuticals having been in use for over ten years in USAr it has never been marketed in Brazil. Available information about this subject comes from scientific literature and also from articles in magazines and newspapers. Tn December 1991 an article about the subject was published in "Veja", the most important magazine in Brazil. This article resumed these products and techniques used in USA as a way to help smokers to quit the habit. It was also mentioned in this article that Ciba Ceig asked federal health authorities for authorization to launc a t ransdermal icotine patch in Brazil. Until now they were n ot successful in obtaining this authorization. Three. other articles were published in April 1992, in other magazines and newspapers, mentioning the three major companies and products such as Ciba Geigy (Harbitrol), Marriew Merren Dow (Nicoderm) and Amer4can Cyanami (Prostep). All these articles mentioned the size of the U.S.A. market and that US analysts believe in 1995 this market will be around US$ 1.0 billion. With the information we have, it seems that from the technical point of view, mass production of these products is possible to support this v0 lume growth in USA. IS THE STOWIC PATCH A SIGNIFICANT TECHNICAL ADVANCE AND IS IT LIKELY TO BE DEVELOPED INTO A SALABLE PRODUCT FOR KASS MARKETS Scientific publications indicate that in terms of technology, the product developed by "Stowic Resources Ltd." shows a considerable advance against its c ompetitors, as nicotine de4*ver . radual, avoiding the negative effects of dermal y is g irritation, which is very common in other similar products. In fact, these products are being clearly positioned in the market as "medic ines", which are able to.reduce the symptoms of nicotine dependence such as anxiety, concentration difficulty and irritability, very commom amongst people who are trying to break the smoking habit. CD C:D BATCo document for Province of BritiSh Columbia 26 October 1999 DOES THE PATCH REPRESENT A SIGNIFICANT THREAT TO THE TOBACCO INDUSTRY ? As known, smoking and health controversies are gFowing considerably and the number of smokers trying to gave up smoking is increasing worldwide. Therefore, this kind of product will tend to be tried and depending on its effectiveness, should become a considerable sized market. The tobacco industry should consider these products as a threat, as they could help smokers to quit the habit, but not as a definitive substitute for cigarette th will never offer smokers attributes such as organosl:;tic:T sensations and.image support, which are very important in the individual decision on smoking. Even if this market were to grow considerably, we believe these type of products are not aviable option to be exploited by B.A.T., due to this type of product being diametrically o?posed tco.theo Com any's main business focus - explointing t e world t acc maNet. WHAT SHOULD BE THE REACTION, IF ANY, BY B.A.T. INDUSTRIES ? In view of the above consideration, the best route for B.A.T. to prepare itself to face this type of product and also new ones, whichiw4ll probably be introduced in the future, is by directing pr orities and incentive towards the development of safer cigarettes, e.g. cigarettes which maintain flavour, taste, mechanical and visual characteristics of existing products, but with benefits to consumers such as lower sidestream, less strong smoke aroma and lower quantities of controversial substances in the smoke. MTEHM2 HMA.PE1178 15/05/92 CD r\.) U-1 co _c::,. BATCo document for Province of BritiSh Columbia 26 October 1999