GODUP
RESBAh
afidgevelopment
GROUP RESEARCH 10~0 DEVELOPNIFNT CFNIFit 111:11
15,11-Ar-.4FRICAN IOL,A(:[:O 170r.'P/111~ t.tmilf
REGENT'S PARK RC-r3. SOUTHAMPTON. ENGLAND. S09 IPE
Telephone (0703) 7776--t Tele- 477269
Pleaw eply to R & D Dep C..
7 th May, 1976
D.C. 1- --'P,h e S - Louisvi lle
II R - M - G;!7,b - Montreal
Mr. R. G. R rholls - Sydney
Dr ' C.J.11~. de. S -i )-FL -
J qti( Rio do Janeiro
Mr. A. J. a s; 2. y rj s I z i -
Ccpc!;jliag(--:.,n
Dr. F. - Southampton
Lol,,Stedt
T-;.,o further ppplcrs h.-ve reccntly been
published -in
Z. Krebs fo-i-3ch. by 0~-,nitekni.111 ard h--;s
Copies of
"t-lies-c (and transiatioas pro(hiced b-y TIRC)
are attached for your
inforinai-ion..
TLese papers c,-)v,-), work which had bcon
completed and
1 cr i)ublic..,ition LeVore Lhu clostire of Lokstc
t was
announced.
'The papers deal with
Par t 5 A compariSOD of cl groi f*-ette d2.;ifris
1. rgely based on
the use of recor)stituted tobacco and the relitive
nxtivities
of lviniaa and stein frow Virginia, Burley and
black tobaccos.
Two reconst-L
processes are considered: the Schveitzer
paper process (S-slieot) and the Borgwaldt
calendering
procciss (13-shect). As might have been expected,
the
S-process shov-s -, reduction in tupioriEcnic
activity, while
the B-process does not (only 207, incorporation
anyway).
The in ter-- co,rpari son of the various samples;
is rot
fully f~-:.-isiblo-, because of the observation
yet again of
a high-diose anowaly and Hie. Iack of par, lelism
in tht!
dose-re-spons.-D ov.-ing to Hic eniployrnent. Of
0n1.V tV()
. 3 - tht~ J.'jrc-:I time,
dose lovolq "0 L Dolitonwill has acknoviedged
the Ur adoptirg a toi~l- design tf, that
tised I-x- TIN' (,-,nd B-AT), ram~--Jy n1 loast
thc
of must i1of be too. 111*,gh 12 cal
tran.sL,~-'i on) ON
ON
incorpo(ated in Lorldon -No -a"-74 C)., L,,:,
BATCO document for Province of BritiSh Columbia 9
November 1999


-2-
Part 6 deals with a study of further fractionation
of the
nitromethane fraction of smoke condensate on a
Sephadex
LH-20 column, to separate polar (promotor?)
compounds
and to give a concentrated APH fraction.
Recombinations
of fractions did not reveal a statistically
significant
loss of activity, but only 60-7076 of the activity
of the
nitromethane fraction was conpentrated in the APH
fraction. This may, perhaps, be taken as evidence
for
the separation of initiators and promotors.
These are immediate comments based on an initial
perusal of the papers, which will. now be studied
in greater
detail. It was felt you would wish to have copies
as soon as
possible.
Any comments you may have would be greatly
appreciated.
With kind regards,
Yours sincerely,
D. G. FELTON
Encs.
cc: Dr. S. J. Green
Mr. G. C. Hargrove
Herr. H. Sottorf
Q)
U1
0 \
'i
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BATCo document for Province of BritiSh Columbia 9
November 1999