B.A.T (U.K. & Export) Ltd.,
Research & Development Centre,
SOUTHAMPTON.
EDMITJU46D
AMES ACTIVITY, TOBACCO AND CONDENSATE
CHEMISTRY OF 37 SINGLE GRADE TOBACCOS
REPORT NO: RD.2130
11 November 1988
AUTHOR: E. D. MASSEY
CO-WORKERS: A. E. HILL
K. K. KALIRAI
SECTION LEADERS: T. G. MITCHEH
W. D. E. IRWIN
ISSUED BY: R.R.BAKER
DISTRIBUTION:
Dr. R. Binns I
Mr. A.L. Heard 2
Mr. M.L. Reynolds 3
Mr. M.L. Reynolds 4
Dr. P.J. Dunn 5
Dr. S.R. Massey 6
Mr. T.1. Wilson 7
Mr. T.1. Wilson 8
Harm E. Rittershaus 9
Dr. E. Kausch 10
Dr. C.J.P. de Siqueira 11
Mr. H.V. Thomsen 12
Mr. R.F. Gilderdale 13
Library 14
Library 15
FILE: 46D
COPY NO.
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0 1908 BATILIKE. Do not copy or show to
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BATCo document for Province of BritiSh Columbia 28
October 1999


B.A.T (U.K. & Export) Ltd.,
Research & Development Centre,
SOUTHAMPTON.
EDWTJU46D
11 November 1988
AMES ACTIVITY, TOBACCO AND CONDENSATE CHEMISTRY
OF 37 SINGLE GRADE TOBACCOS
REPORT NO. RD.2130
SUMMARY:
The Ames specific mutagenic activity of cigarette
smoke condensates (CSC)
from 15 flue-cured, 10 Burley, 6 Oriental and 6
high nicotine single grade tobacco
cigarettes has been measured. For each tobacco
type, the relationship between
plant position, geographical origin and Ames
activity was examined. The
correlations between tobacco chemistry, smoke
chemistry and Ames activity
have also been investigated.
For the flue-cured and Burley tobaccos, there was
a trend towards decreasing
Ames activity for lower plant position grades.
Grades of equal smoking merit
from different geographical locations also
produced CSC with different Ames
activities. Therefore, the potential to substitute
tobacco grades in a cigarette to
produce lower Ames activity CSC does exist,
although other aspects of such
grade substItutlon have not been addressed.
In correlations of Ames activity with tobacco and
smoke chemistry the best guide
to the relative Ames specific activity was found
to be tobacco total nitrogen,
protein nitrogen or condensate total nitrogen.
C)
CD
0 1988 BATUKE. Do not copy or show to unauthorised
persons. CZ)
(-P4
BATCo document for Province of British Columbia 28
October 1999


INDEX TERMS:
Mutagenicity
Ames test
Tobacco Grades
Experimental cigarettes
Flue-cured tobacco
Burley tobacco
Oriental tobacco
Nicotine
Tobacco chemical properties
Smoke chemical properties
Nitrogen
Nitrogen heterocyclic aromatic compounds
CD
0 1988 BATUKE. Do not copy or show to unauthorised
persons.
Ui
BATCo document for Province of British Columbia 28
October 1999