SCIENTIFIC
RESEARCH
S%\ 6,
GROUP
NEWSLETTER
13 -.k- T)
CORPORATE RESEARCH AND DEVELOPMENT DEPARTMENT,
BATCO.LONDON
CD
CD
BATCo document for Province of British Columbia 29
October 1999


SRG NEWSLETTER - OCTOBER 1991.
Circulation List.
Dr S Appleton USA
Dr C J P de Siqueira Brazil
Dr H Died FRG
Dr P Madsen Denmark
Dr S R Massey Canada
Mr R Olsen Norway
Dr D Panaritz FRG
Dr S S Rao Kovalli India
Mr A Sarkar India
Mr T Wilson Australia
Dr R R Baker UK Southampton
Mr I C Brown LTK Southampton
Mr T G Mitchell UK Southampton
Dr G Smith UK Southampton
Dr S Boyse BATCo
Mr B Bramley BATCo
Mr N B Canriar BATCo
Mr H F D Dymond BATCo
Mr A L Heard BATCo
Dr R E Thornton BATCo
For further information, please contact:
Linda Rudge
Corporate R & D Department
British-American Tobacco Co. Ltd.
Millbank
Knowle Green
STAINES TW18 1DY
CD
CD
BATCo document for Province of British Columbia 29
October 1999


Subject areas.
I . Environmental tobacco smoke.
2. Other environmental factors.
3. Respiratory disease / lung cancer.
4. Other cancers.
5. Carcinogenesis general.
6. Cardiovascular disease.
7. Blood components / immunology.
8. Smoking and hormone-related diseases.
9. Smoking and reproduction pregnancy.
10. Gastroenterology.
11. Smoking and body weight.
12. Smoking and Alzheimer's Parkinson's disease.
13. Smoking and mental illness.
14. Other factors related to disease (diet etc.).
15. Other diseases.
16. Molecular biology.
17. Components of cigarette smoke.
18. Nicotine / pharmacology.
19. Theories of addiction / dependence.
20. Miscellaneous.
C-1
C,
CD
BATCo document for Province of British Columbia 29
October 1999


1. ENVIROINNIENITAL TOBACCO SMOKE. (page 1)
1. 1. Crawford,W.A., Holcomb,L.C. Envirorimental
tobacco smoke (ETS) in
airliners - A health hazard evaluation.
Aviat.Space Environ.Med. 32:580-586
(1991).
1.2. Gori,G.B., Mantel,N. Mainstream and
environmental tobacco smoke.
Relul.Toxicol.Pharmacol. 14: 88-105 (1991).
1.3. lwase,A., Aiba,M., Kira,S. Respiratory
nicotine absorption in non-smoking
females during passive smoking. Int. Arch. Occup.
Environ. Health 63: 09-143
(1991).
1.4. Kado,N.Y.,McCurdy,S.A., Tesluk,S.J.,et al.
Measuring personal exposure to
airborne mutagens and nicotine in environmental
tobacco smoke. Mut.Res.
261:75-82 (1991).
1.5. Whitej.R., Froeb,H.F., Kulik,J.A. Respiratory
illness in nonsmokers
chronically exposed to tobacco smoke in the work
place. Chest 100: 39-43
(1991).
1.6. Willers,S., Svenonius,E., Skarping,G. Passive
smoking and childhood nsthrna.
Allergy 46:330-334 (1991).
1.7. Oldigs,M., Jorres,R., Magnussen,H. Acute
effect of passive smoking on
lung function and airway responsiveness in
asthmatic children.
Pediatr.Pulmonol. 10:123-131 (1991).
1.8. Ogawa,H., Tomina.ga,S., Hori,K., et al.
Passive smoking by pregnant women
and fetal growth. J.Epidemiol.Comm.Health
45:164-168 (1991).
2. OTHER ENVIRONNMNTAL FACTORS. (page 6)
2.1. Children harmed by traffic fumes. Brit.Med.J.
303:329 (1991).
2.2. "PoUution figures" GLR radio programme
(August 28, 1991).
Z7 _
CD
BATCo document for Province of BritiSh Columbia 29
October 1999


2.3. Bakk-e,P., Eide,G.E., Hanoa,R., Gulsvik,A.
Occupational dust or gas exposure
and prevalences of respiratory symptoms and asthma
in a general population.
Eur.Respir.J. 4:273-278 (1991).
2.4. Behera,D., Jindal,S.K. Respiratory symptoms
in Indian women using domestic
cooking fuels. Chest 100:385-388 (1991).
2.5. Viegi,G., Paoletti,P_ Carrozzi,L., et al.
Effects of home enviroament on
respiratory symptoms and lung function in a
general population in North
Italy. Eur.Respir.J. 4:580-586 (1991).
2.6. Mumford,J., Chapman,R., Harris,D., 14e,X.,
Lee,X., Cao,S.An
interdisciplinary approach to investigate the
etiology of lung cancer in
Xuan Wei, China: A study on mutagenicity,
carcinogenicity, and human
lung cancer risk from indoor exposure to
combustion emissions.
Arch. Environ. Health 46:181 (1991) (Abstract).
2.7. LofroEh,G.,Stensman,C.,Brandhorst-Satzkom,M.
Indoor sources of mutagenic
particulate matter: smoking, cooking and incense
burning. Mut.Res. 261:21-28
(1991).
2.8. Annstron.O.R.M., Campbell,H. Indoor air
pollution and lower
respiratory infections in young Gambian children.
Int.J.Epidemiol. 20:424-429
(1991). .
2.9. Elements in soil may be key to illness
trends. The Independent (Au.-ust 3 1,
1991).
3. RESPIRATORY DISEASE / LUNG CANCER. (page 13)
3.1. Gillooly,M., Lamb,D. Microscopic emphysema in
relation to age and smoking.
Thorax 46:301P (1991) (Abstract).
3.2. Barker,l).J.P., Godfrey,K.M., FaII,C.,
Osmond,C., Winter,P.D., Shaheen,S.O.
Relation of birth weight and childhood respiratory
infection to adult lung
function and death from chronic obstructive
airways disease. BriE.Med.J.
303:671-675 (1991).
C-1
C"
BATCo document for Province of British Columbia 29
October 1999


3.3. Hopkin,J. Genetics and lung disease. Advances
our understanding of
emphysema, cystic fibrosis, and asthma.
Brit.Med.J. 302:1222-1223 (1991).
4. OTHER CANCERS.
(page 15)
4.1. Exercise may cut risk of colon cancer. USA
Today (September 19, 1991).
4.2. Double risk of cancer patients. The Standard
(September 4, 199 1).
5. CARCU40GENESIS GENERAL.
(page 16)
5.1. Gairola,C.G., Gupta,R.C. Cigarette
smoke-induced DNA adducts in the
respiratory and nonrespiratory tisssues of rats.
Environ.Mol.Mutag. 17:253-257
(1991).
5.2. Shimame-More,L. Smokeless tobacco extracts
mutate human ceUs.
Carcinogenesis 12:927-930 (199 1).
5.3. Ames, the Ames test, and the causes of
cancer. NUtogenesis v mutagenesis.
Brit.Med.J. 303:428-429 (1991).
5 A . Risk assessment. End of an era. Nature
(September 26, 1991).
6. CARDIOVASCULAR DISEASE.
(page 19)
6.1. Hilbert,P., Lindpaintner,K., Lathrop,G.M., er
al. Chromosomal mapping of two
genetic loci associated with blood-pressure
regulation in hereditary
hypertensive rats. Nature (October 10, 1991).
6.2. Gene discovery may point to cause of high
blood pressure.The Guardian
(October 10, 1991).
CD
CD
01
BATCo document for Province of British Columbia 29
October 1999


6.3. Rubin,EN., Krauss,R.M., Spangler,E.A.,
Verstuyft,J.G., Clift,S.M. Inhibition of
early atherogenesis in transgenic mice by human
apolipoprotein Al. Mature
(September 19, 1991).
6.4. Rimm,E.B., Giovannucci,E.L., Willett,W.C., et
aL Prospective study of alcohol
consumption and risk of coronary disease in men.
Lancet 338:464-468 (199 1).
6.5. Why men must not lose heart. The Times
(September 5, 199 1).
6.6. Smoking and angina. Brit. Med.J. 303:934 (199
1).
6.7. MRC findings on heart disease. BIBRA Bull.
30:195 (1991).
6.8. "FOREST" interview. LBC Talk-back, radio
programme (October 10, 1991).
7. BLOOD COM:PONF-NITS / UYEWUNIOLOGY. (page 25)
7.1. Thomas,A. E., G reen,F. R., Kelleher, C. H.,
et aL Variation in the promotor region
of the 0 fibrinogen gene is associated with plasma
fibrinogen levels in
smokers and non-smokers. - Thromb. Haem.
65:487-490 (199 1).
7.2. Heart disease/ fibrinogen and smoking. BBC
Radio 4 (October 9, 1991).
8. S.N1OKI?4G AND HORMON&RELATED, DISEASES. (page
29)
8.1. Smoking and piU alert after woman's death.
Eastern Daily Press (September 14,
1991).
8.2 . Heart benefit of hormone treatment. The
Daily Telegraph (September 12,
1991).
8.3. "Mistake" on hormone treatment.The
Independent (October 11, 1991).
8.4. Body type affects uterus cancer risk. USA
Today (October 3, 199 1).
Z:.-
C~
CD
CD
BATCo document for Province of BritiSh Columbia 29
October 1999


9. SMOKr~G, A.ND REPRODUCTION / PREGNANCY. (page 3
1)
9.1. Peacock,J.L., Bland,J.M., Anderson,H.R.,
Brooke,O.G. Cigarette smoking and
birthweight: type of cigarette smoked and a
possible threshold effect.
Int.J.Epidemioi. 20:405-412 (1991).
9.2. Bruner,J.P., Forouzan,l. Smoking and buccally
administered nicotine. Acute
effect on uterine and umbilical artery Doppler
flow velocity wayeforms.
J.Reprod.Med. 36:435-440 (1991).
9.3. Fer.-usson,D..N1., Lloyd,M. Smoking during
pregnancy and its effects on child
cognitive ability from the ages of 8 to 12 years.
Paediatr.Perinat.Epidemiol.
5 :189-200 (1991).
9.4. Cordier,S., Deplan,F., Mandereau,L.. Hemon,D.
Paternal exposure to mercury
and spontaneous abortions. Brit.J.Indust.Med.
48:375-381 (1991).
11. SMOKENG AND BODY WEIGHT. (page 33)
11.1. Townsend,J., Wilkes, H., Haines, A.,
Jarvis,M. Adolescent smoker-s seen in
general practice: health, Ufestyle, physical
measurements, and response to
smoking advice. Brit.Med.J. 303:947-950 (1991).
11.2. Fat, 12zy and ill .. profile of a teenage
smoker.Today (October 18, 1991).
11.3. Nicotine 'Islimming" claim goes up in smoke.
Bimingharn Post (October 18,
1991).
11.4. Danger in just one cigarette a week. Daily
Mail (October 18, 1991).
11.5. Moffatt,R.J., Owens,S.G. Cessation from
cigarette smoking: changes in body
weight, body composition, resting metabolism, and
energy consamption.
Metabolism 40:465-470 (1991).
C--
CD
BATCo document for Province of British Columbia 29
October 1999


12. SMOKV~G AND ALZHEEWER'S I PARKI!~SON'S
DISEASE. (page 36)
12.1. Graves,A.B., van Duijn,C.M., Chandra,V., er
al. Alcohol and tobacco
consumption as risk factors for Alzheimer's
disease: a collaborative re-analysis
of case-control studies. Int.l. Epidemiol. 20:
S48-S57 (199 1).
12.2. Defective gene identified in hereditary
Alzheimer's. The Guardian (October 5,
1991).
14. OTHER FACTORS RELATED TO DISEASE (DIET ETC.).
(page 37)
14. 1. Sen,S., Sharma,A. Inhibition of clastogenic
effects of nicotine by chlorophyWn
in mice bone marrow cells in vivo. Phytother. Res.
5:130-133 (199 1).
14.2. A cup of green tea 2 day may keep cancer
away.New Scientist (September 14,
1991).
14.3. Whichelow,M.J., Erzinclioglu,S.W., Cox,13.
D. A comparison of the diets of non-
smokers and smokers. Brit.J.Addict. 86:71-81
(1991).
14.4. Vitamin A "may help prevent lung cancer".The
Independent (September 27,
1991).
14.5. Vitamin C may lessen hazards of X-rays. Wall
Street Journal (October 2, 1991).
14.6. ;EI.65m research. The Grocer (September 21,
199 1).
14.7. Smith,G.D., Shipley,M.J. Confounding of
occupation and smoking: its
magnitude and consequences. Soc.Sci.Med. 32:
1297-1300 (1991).
14.8. Research suggests odds against cardiac
problems lengthen with height.
The Guardian (August 20, 199 1).
BATCo document for Province of British Columbia 29
October 1999


15. OTHER DISEASES.
(page 41)
15. 1. Bittoun,R. Recurrent aphthous ulcers and
nicotine. Med.J.Austral. 154:471-472
(1991).
16. MOLECULAR BIOLOGY.
(page 42)
16.1. Slebos,R.I.C., Hruban,R.H., Dalesio,O.,er
al. Relationship between K-ms
oncogene activation and smoking in adenocarcinoma
of the human lung.
JNCI 83:1024-1027 (1991).
16.2. Saranath,D., Chang,S.E., Deo,M.G.,er al.
High frequency mutation in codons 12
and 61 of H-ms oncogene in chewing tobacco-related
human oral carcinoma in
India. Brit.J. Cancer 63:573-578 (199 1).
16.3. The dole in your genes. The Times (August
23, 1991).
16.4. Benitez,J., Ladero,J. M., Jara,C., et al.
Polymorphic oxidation of debrisoquine in
lung cancer patients. Eur.J.Cancer 27:158-161
(1991).
16.5. The off-on switch for genes. International
Herald Tribune (September 19,
1991).
17. COMTONENTS OF CIGARETTE SNIOKE. (page 46)
17.1. Talmka,G., Al-Juburi,A.Z.S.S., Kadlubar,F.F.
Smoking related cardnogeo-DNA
aciducts in biopsy samples of human urinary
bladder: Identification of N-
(deoxyguanosin-8-yD-4-aminobiphenyI as a major
adduct.
Proc.Nad. Acad.Sci. USA 88: 5350-5354 (1991).
17.2. Smokers "better off with high-tar".Daily
Mail (September 20, 1991).
CD
CD
CD
00
BATCo document for Province of BritiSh Columbia 29
October 1999


18. INICOTUE.'PHARNIACOLOGY. (page 47)
18.1. Being naughty is good for you.The European
(September 20,1991).
18.2. And a Urtle of what you fancy helps. Daily
Mail (September 23, 1991).
18.3. Heishm2-n,S.J., Richards, L.M.,
Henningfield,J.E. Effect of aicotine on cognitive
and psychomotor performance in nonsmokers.
Pharmacol.Biochem.Behav.
39 :243 (1991) (Abstract).
18.4. Did you know...AARC Times (May, 199 1).
18.5. Chewing over the dangers. Standard (August
30, 1991).
18.6. Drug firm in nicotine-patch accord.
Int.-mat.Herald Tribune (August 22, 1991).
18.7. Norwav: New "smoke free" cigarette.
Aftenposten (August 15, 1991).
18.8. Smokeless cigarette. The Guardian (August
30, 1991).
19. THEOREES OF ADDICTION / DEPENDENCE. (page 50)
19. L Gritz,E.R., Carr,C.R., Marcus,A.C. The
tobacco withdrawal syndrome in
unaided quitters. Brit.J.Addict. 86:57-69 (1991).
19.2. Hard drugs "the leaA of three evils". Daily
Telegraph (August 27, 199 1).
19.3. Nbahs bide real addiction evils. The
Guardian (August 27, 1991).
20. MISCELLANEOUS. (page 52)
20. 1. No spUt sieeen over tobacco. New York Times
(September 24, 199 1).
20.2. B.NU to control tobacco. Marketing (October
3, 1991).
20.3. Smoking and combat training. Brit. Med.J.
33:688-690 (199 1).
CD
BATCo document for Province of BritiSh Columbia 29
October 1999