NEUROBIOLOGY: MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Delaloy, C.; Liu, L.; Lee, J.A.; Su, H.; Shen, F.; Yang, G.Y.; Young, W.L.; Ivey, K.N.; Gao, F.B. Cell Stem Cell. 6(4):323-35.

MICROBIOLOGY: Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. Zhang, S.; Kim, C.C.; Batra, S.; McKerrow, J.H.; Loke, P. PLoS Neglected Tropical Diseases. 4(3):e648.

DENTISTRY: Variations in human DEJ scallop size with tooth type. Brauer, D.S.; Marshall, G.W.; Marshall, S.J. Journal of Dentistry. Mar 29. [Epub ahead of print]

GENETICS: Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations. Rauen, K.A.; Tidyman, W.E.; Estep, A.L.; Sampath, S.; Peltier, H.M.; Bale, S.J.; Lacassie, Y. American Journal of Medical Genetics A. 152A(4):807-14.

CANCER BIOLOGY: Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts. Michaud, K.; Solomon, D.A.; Oermann, E.; Kim, J.S.; Zhong, W.Z.; Prados, M.D.; Ozawa, T.; James, C.D.; Waldman, T. Cancer Research. Mar 30. [Epub ahead of print]

IMMUNOLOGY: CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Zikherman, J.; Jenne, C.; Watson, S.; Doan, K.; Raschke, W.; Goodnow, C.C.; Weiss, A. Immunity. 32(3):342-54.

CANCER BIOLOGY: Antineoplastic effects of decitabine, an inhibitor of DNA promoter methylation, in adrenocortical carcinoma cells. Suh, I.; Weng, J.; Fernandez-Ranvier, G.; Shen, W.T.; Duh, Q.Y.; Clark, O.H.; Kebebew, E. Archives of Surgery. 145(3):226-32.

COMPUTATIONAL BIOLOGY: Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes: implications for classification of enzyme function. Almonacid, D.E.; Yera, E.R.; Mitchell, J.B.; Babbitt, P.C. PLoS Computational Biology. 6(3):e1000700.

IMMUNOLOGY: 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. Orr, M.T.; Murphy, W.J.; Lanier, L.L. Nature Immunology. 11(4):321-7.

BIOPHYSICS: Combined effects of polymers and KL(4) peptide on surface activity of pulmonary surfactant lipids. Lu, K.W.; Taeusch, H.W. Biochim Biophys Acta. Feb 25. [epub ahead of print]

BIOCHEMISTRY: Mutant Huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo. Legleiter, J.; Mitchell, E.; Lotz, G.P.; Sapp, E.; Ng, C.; Difiglia, M.; Thompson, L.M.; Muchowski, P.J. J Biol Chem. Mar 10. [epub ahead of print]

CANCER BIOLOGY: Serine proteases and protease-activated receptor 2-dependent allodynia: A novel cancer pain pathway. Lam, D.K.; Schmidt, B.L. Pain. Feb 26. [epub ahead of print]

NEUROBIOLOGY: Cortical Plasticity Induced by Inhibitory Neuron Transplantation. Southwell, D.G.; Froemke, R.C.; Alvarez-Buylla, A.; Stryker, M.P.; Ghandi, S.P. Science 327:1145-1148.

NEUROBIOLOGY: Neurogenic radial glia in the outer subventricular zone of human neocortex. Hansen, DV; Lui, JH; Parker, PRL; Kreigstein, AR. Nature. Feb. 14 (epub ahead of print).

CELL BIOLOGY: F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics. Angeli, S; Shao, J; Diamond, MI. PLoS One. 5(2):e9053.

CANCER BIOLOGY: TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients. Crane, CA; Han, SJ; Barry, JJ; Ahn, BJ; Lanier, LL; Parsa, AT. Neuro Oncol. 12(1):7-13.

CANCER BIOLOGY: Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner. Erez, N; Truitt, M; Olson, P; Hanahan, D. Cancer Cell. 17(2):135-47.

GENETICS: RNAa Is Conserved in Mammalian Cells. Huang, V; Qin, Y; Wang, J; Wang, X; Place, RF; Lin, G; Lue, TF; Li, LC. PLoS One. 5(1):e8848.

NEUROBIOLOGY: A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Endoh-Yamagami, S; Karkar, KM; May, SR; Cobos, I; Thwin, MT; Long, JE; Ashique, AM; Rubenstein, JL; Peterson, AS. Dev Biol. Jan 20 (epub ahead of print).

NEUROBIOLOGY: Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated {alpha}-synuclein gene mutations precede central nervous system changes. Kuo,YM; Li, Z; Jiao, Y; Gaborit, N; Pani, AK; Orrison, BM; Bruneau, BG; Giasson, BI; Smeyne, RJ; Gershon, MD; Nussbaum, RL. Hum Mol Genet. Jan 27 (epub ahead of print).

STEM CELLS: Adipose Derived Stem Cells Ameliorate Hyperlipidemia Associated Detrusor Overactivity in a Rat Model. Huang, YC; Shindel, AW; Ning, H; Lin, G; Harraz, AM; Wang, G; Garcia, M; Lue, TF; Lin, CS. J Urol. Jan 21 (epub ahead of print).

MICROBIOLOGY: Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome. Cox, MJ; Huang, YJ; Fujimura, KE; Liu, JT; McKean, M; Boushey, HA; Segal, MR; Brodie, EL; Cabana, MD; Lynch, SV. PLoS One. Jan 18;5(1):e8745.

NEUROBIOLOGY: Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden. Rabinovici, GD; Furst, AJ; Alkalay, A; Racine, CA; O'Neil, JP; Janabi, M; Baker, SL; Agarwal, N; Bonasera, SJ; Mormino, EC; Weiner, MW; Gorno-Tempini, ML; Rosen, HJ; Miller, BL; Jagust, WJ. Brain. Jan 15. [Epub ahead of print].

GENETICS: Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Melton, C; Judson, RL; Blelloch, R. Nature. Jan 6 (epub ahead of print).

CANCER: Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Costa, BM; Smith, JS; Chen, Y; Chen, J; Phillips, HS; Aldape, KD; Zardo, G; Nigro, J; James, CD; Fridlyand, J; Reis, RM; Costello, JF. Cancer Res. 70(2): 453-62.

NEUROBIOLOGY: Neonatal cerebral hypoxia-ischemia impairs plasticity in rat visual cortex. Failor, S; Nguyen, V; Darcy, DP; Cang, J; Wendland, MF; Stryker, MP; McQuillen, PS. J Neurosci. 6(30):81-92.

CANCER BIOLOGY: Sdc1 negatively modulates carcinoma cell motility and invasion. Ishikawa, T; Kramer, RH. Exp Cell Res. Dec 23. (epub ahead of print)

NEUROBIOLOGY: Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Shin, D; Shin, JY; McManus, MT; Ptacek, LJ; Fu, YH. Ann Neurol. 66(6):843-57 (epub ahead of print)

BIOCHEMISTRY: Interaction of PAN’s C-termini with archaeal 20s proteasome and implications for the eukaryotic proteasome-ATPase interactions. Yu, Y; Smith, DM; Kim, HM; Rodriguez, V; Goldberg, AL; Cheng, Y. EMBO. Dec 17. (epub ahead of print)

GENETICS: Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition. Charles, C; Lazzari, V; Tafforeau, P; Schimmang, T; Tekin, M; Klein, O; Viroit, L. PNAS. Dec 15. (epub ahead of print)

BIOCHEMISTRY: Chemical induction of misfolded prion protein conformers in cell culture. Ghaemmaghami, S; Ullman, J; Ahn, M; St. Martin, S; Prusiner, SB. J Biol Chem. Dec 7. (epub ahead of print)

CANCER BIOLOGY: Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Humtsoe, J.O.; Kramer, R.H. Oncogene. 2009 Nov 23. [Epub ahead of print]

GENETICS: The effect of telomere proximity on telomere position effect, chromosome healing and sensitivity to DNA double-strand breaks in a human tumor cell line. Kulkarni, A.; Zschenker, O.; Reynolds, G.; Miller, D.; Murnane, J.P. Mol Cell Biol. 2009 Nov 23. [Epub ahead of print]

BIOCHEMISTRY: Structural Bases for Stability-Function Tradeoffs in Antibiotic Resistance. Thomas, V.L.; McReynolds, A.C.; Shoichet, B.K. J Mol Biol. 2009 Nov 10. [Epub ahead of print]

NEUROBIOLOGY: Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Rau, V.; Iyer, S.V.; Oh, I.; Chandra, D.; Harrison, N.; Eger, EI 2nd.; Fanselow, M.S.; Homanics, G.E.; Sonner, J.M. Anesth Analg. 109(6):1816-22.

EPIDEMIOLOGY: Solvent exposure and non-Hodgkin lymphoma: no risk in a population-based study in the San Francisco Bay Area. Tranah, G.J.; Bracci, P.M. Cancer Epidemiol Biomarkers Prev. 18(11):3130-2.

IMMUNOLOGY/MICROBIOLOGY: Protective effects of affinity-purified antibody and truncated vaccines against Pseudomonas aeruginosa V-antigen in neutropenic mice. Moriyama, K.; Wiener-Kronish, J.P.; Sawa, T. Microbiol Immunol. 53(11): 587-94.

MICROBIOLOGY: Estimation of sensitivity and specificity of several Trypanosoma cruzi antibody assays in blood donors in Argentina. Remesar, M.C.; Gamba, C.; Colaianni, I.F.; Puppo, M.; Sartor, P.A.; Murphy, E.L.; Neilands, T.B.; Ridolfi, M.A.; Leuizamon, M.S.; Kuperman, S.; Del Pozo, A.E. Transfusion. 49(11):2352-58.

PHARMACOLOGY: Predicting new molecular targets for known drugs. Keiser, M.J.; Setola, V.; Irwin, J.J.; Laggner, C.; Abbas, A.I.; Hufeisen, S.J.; Jensen, N.H.; Kuijer, M.B.; Matos, R.C.; Tran, T.B.; Whaley, R.; Glennon, R.A.; Hert, J.; Thomas, K.L.; Edwards, D.D.; Shoichet, B.K. ; Roth, B.L. Nature. (epub ahead of print)

NEUROBIOLOGY: Retinoic acid from the meninges regulates cortical neuron generation. Siegenthaler, J.A. ; Ashique, A.M.; Zarbalis, K.; Patterson, K.P.; Hecht, J.H. ; Kane, M.A.; Folias, A.E.; Choe, Y. ; May, S.R.; Kume, T.; Napoli, J.L.; Peterson, A.S.; Pleasure, S.J. Cell. 139(3):597-609.

IMMUNOLOGY: Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream. Nozawa, N.; Fang-Hoover, J.; Tabata, T.; Maidji, E.; Pereira, L. J Clin Virol. (epub ahead of print) 

IMMUNOLOGY: A novel human CD4+ T cell inducer subset with potent immunostimulatory properties. Ndhlovu, L.C.; Leal, F.E.; Eccles-James, I.G.; Jha, A.R.; Lanteri, M.; Norris, P.J.; Barbour, J.D.; Wachter, D.J.; Andersson, J.; Tasken, K.; Torheim, E.A.; Aandahl, E.M.; Kallas, E.G.; Nixon, D.F. Eur J Immunol. (epub ahead of print)  

CANCER BIOLOGY: Increasing incidence of neuroblastoma and potentially higher associated mortality of children from nonmetropolitan areas: analysis of the surveillance, epidemiology, and end results database. Hsieh, M.H.; Meng, M.V.; Walsh, T.J.; Matthay, K.K.; Baskin, L.S. J Pediatr Hematol. (epub ahead of print)  

MEDICINE: Variability in interpretive performance at screening mammography and radiologists; characteristics associated with accuracy. Elmore, J.G.; Jackson, S.L.; Abrahan, L.; Miglioretti, D.L.; Carney, P.A.; Geller, B.M.; Yankaskas, B.C.; Kerlikowske, K.; Onega, T.; Rosenberg, R.D.; Sickles, E.A.; Buist, D.S. Radiology. (epub ahead of print)  

IMMUNOLOGY: A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. Hsu, Lih-Yun; Tan, Ying Xim; Xiao, Zheng; Malissen, Marie; Weiss, Arthur. J. Exp. Med. (epub ahead of print)  

MEDICINE: Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis. Schmidlin, Olga; Tanaka, Masae; Sebastian, Anthony; Morris, R Curtis Jr. J. Hypertension. (epub ahead of print)  

VIROLOGY: An enhanced single base extension technique for the analysis of complex viral populations. Webster, D.R.; Hekele, A.G.; Lauring, A.S.; Fischer, K.F.; Li, H.; Andino, R.; DeRisi, J.L.. PLoS One, 4(10):e7453.

CELL BIOLOGY: Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block. Chatelain, F.C.; Gazzarrini, S.; Fujiwara, Y.; Arrigoni, C.; Domigan, C.; Ferrara, G.; Pantoja, C.; Thiel, G.; Moroni, A.; Minor, D.L. PLoS One, 4(10):e7496.

NEUROBIOLOGY: Cortical representation of ipsilateral arm movements in monkey and man. Ganguly, K.; Secundo, L.; Ranade, G.; Orsborn, A.; Chang, E.F.; Dimitrov, D.F.; Wallis, J.D.; Barbaro, N.M.; Knight, R.T.; Carmena, J.M. J Neurosci. 29(41):12948-56.

GENETICS: Giardiavirus internal ribosome entry site has an apparently unique mechanism of initiating translation. Garlapati, S. Wang, C.C. PLoS One. 4(10):e7435.

PSYCHOLOGY: The relationship of multiple aspects of stigma and personal contact with someone hospitalized for mental illness, in a nationally representative sample. Boyd, J.E., Katz, E.P., Link, B.G., Phelan, J.C. Soc Psychiatry Psychiatr Epidemiol. (epub ahead of print)

MEDICINE: Effects of Cigarette Smoke Exposure on Clot Dynamics and Fibrin Structure. An Ex Vivo Investigation. Barua, R.S.; Sy, F.; Srikanth, S.; Huang, G.; Javed, U.; Buhari, C.; Margosan, D.; Ambrose, J.A. Arterioscler Thromb Vasc Biol. (epub ahead of print)  

CELL BIOLOGY: Axonal/Glial Upregulation of EphB/Ephrin-B Signaling in Mouse Experimental Ocular Hypertension. Fu, C.T., Tran, T., Sretavan, D.W. Invest Ophthalmol Vis Sci. (epub ahead of print)  

CANCER: A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme. Panner, A.; Crane, C.A.; Weng, C.; Feletti, A.; Parsa, A.T.; Pieper, R.O. Cancer Res. 69(20):7911-6.  

EPIDEMIOLOGY: Ventilator-Associated Pneumonia in a Neurologic Intensive Care Unit Does Not Lead to Increased Mortality. Josephson, S.A., Moheet, A.M., Gropper, M.A., Nichols, A.D., Smith, W.S. Neurocrit Care. (epub ahead of print)